41
Views
20
CrossRef citations to date
0
Altmetric
Research Article

Intra-Hepatic Arterial Drug Delivery

&
Pages 341-347 | Received 19 Jun 1995, Published online: 28 Sep 2008

References

  • Allen-Mersh T G, Earlam S, Fordy C, Abrams K, Houghton J. Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases. Lancet (1994); 344: 1255–1260
  • Anderson J H, Kerr D J, Setanoians A, Cooke T G, McArdle C S. A pharmacokinetic comparison of intravenous versus intra-arterial folinic acid. Br J Cancer (1992a); 65: 133–135
  • Anderson J H, Kerr D J, Cooke T G, McArdle C S. A phase I study of regional 5-fluorouracil and systemic folinic acid for patients with colorectal liver metastases. Br J Cancer (1992b); 65: 913–915
  • Blesing C H, Julyan P J, Barnwell J M, Parker D J, Mountford P J, Kerr D J, Harding L K. Quantitative whole body counter biodistribution studies of 18F-5-fluorouracil following hepatic arterial and intravenous infusion. Br J Radiol (1995), Submitted for publication
  • Campbell K A, Burns R C, Sitzmann J V, Lipsett P A, Grochow L B, Niederhuber J E. Regional chemotherapy devices: Effect of experience and anatomy on complications. J Clin Oncol (1993); 11: 822–826
  • Chang A E, Schneider P D, Sugarbaker P H, Simpson C, Culnane M, Steinberg S M. A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. Ann Surg (1987); 206: 685–693
  • Chen H-S G, Gross J F. Intra-arterial infusion of anticancer drugs: Theoretic aspects of drug delivery and review of responses. Cancer Treat Rep (1980); 64: 31–40
  • Collins J M. Pharmacologic rational for regional drug delivery. J Clin Oncol (1984); 2: 498–504
  • Cunningham V J, Pike V W, Bailey D, Freemantle C AJ, Page B C, Jones A KP, Kensett M J, Bateman D, Luthra S K, Jones T. A Method of studying pharmacokinetics in man at picomolar drug concentrations. Br J Clin Pharmac (1991); 32: 167–172
  • Dakhil S, Ensminger W, Cho K., Niederhuber J, Doan K, Wheeler R. Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer (1982); 50: 631–635
  • de Takats P G, Kerr D J, Poole C J, Warren H W, McArdle C S. Hepatic arterial chemotherapy for metastatic colorectal carcinoma. Br J Cancer (1994); 69: 372–378
  • Dimitrakopoulou A, Strauss L G, Clorius J H, Ostertag H, Schlag P, Heim M, Oberdorfer F, Helus F, Haberkorn U, van Kaick G. Studies with positron emission tomography after systemic administration of fluorine-18-uracil in patients with liver metastases from colorectal carcinoma. J Nucl Med (1993); 34: 1075–1081
  • Dimitrakopoulou-Strauss A, Strauss L G, Schlag P, Helus F, Lorenz W J, Maier-Borst W, van Kaick G. Prediction of therapy outcome in patients with liver metastases from colorectal carcinoma. Eur J Nuc Med (1994); 21: 856
  • Ensminger W D, Rosowsky A, Raso V, Levin D C, Glode M, Come S, Steele G, Frei E. A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2-deoxyuri-dine and 5-fluorouracil. Cancer Res (1978); 38: 3784–3792
  • Evans W E, Relling M V. Clinical pharmacokinetics-pharmacodynamics of anticancer drugs. Clin Pharmacokinetics (1989); 16: 327–336
  • Findlay M PN, Leach M O, Cunningham D, Collins D J, Payne G S, Glaholm J, Mansi J L, McCready J R. The noninvasive monitoring of low dose infusional 5-fluorouracil and its modulation by interferon-alpha using in vivo 19F magnetic resonance spactroscopy in patients with colorectal cancer: a pilot study. Ann Oncol (1993); 4: 597–602
  • Fortner J G, Silva J S, Golbey R B, Cox E B, Maclean B J. Multivariate analysis of a personal series of 247 consecutive patients with liver metastases from colorectal cancer. Ann Surg (1984); 199: 306–316
  • Frei E, Canellos G. Dose: A critical factor in cancer chemotherapy. Am J Med (1980); 69: 585–594
  • Goldberg J A, Kerr D J, Willmott N, McKillop J H, McArdle C S. Pharmacokinetics and pharmacodymamics of locoregional 5-fluorouracil (5-FU) in advanced colorectal liver metastases. Br J Cancer (1988); 57: 186–189
  • Goldberg J A, Kerr D J, Watson D G, Willmott N, Bates C D, McKillop J H, McArdle C S. The pharmacokinetics of 5-fluorouracil administered by arterial infusion in advanced colorectal hepatic metastases. Br J Cancer (1990a); 61: 913–915
  • Goldberg J A, Kerr D J, Willmott N, McKillop J H, McArdle C S. Regional chemotherapy for colorectal liver metastases: a phase II evaluation of targeted hepatic arterial 5-fluorouracil for colorectal liver metastases. Br j Surg (1990b); 77: 1238–1240
  • Goldberg JA, Murray T, Kerr D J, Willmott N, Bessent R G, McKillop J H, McArdle C S. The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour. Br J Cancer (1991a); 63: 308–310
  • Goldberg J A, Thomson J AK, Bradnam M S, Fenner J, Bessent R G, McKillop J H, Kerr D J, McArdle C S. Angiotensin II as a potential method of targeting cytotoxic-loaded microspheres in patients with colorectal liver metastases. Br J Cancer (1991b); 64: 114–119
  • Goldberg J A, Kerr D J, Blackie R, Whately T L, Pettit L, Kato T, McArdle C S. Mitomycin C loaded microcapsules in the treatment of colorectal liver metastases. Pharmacokinetics of regionally administered particulate chemotherapy. Cancer (1991c); 67: 952–955
  • Grage T B, Vassilopoulos P P, Shingleton W W, Jubert A V, Elias E G, Aust J B, Moss S E. Results of a prospective randomized study of hepatic artery infusion with 5-fluorouracil versus intravenous 5-fluorouracil in patients with hepatic metastases from colorectal cancer: A central oncology group study. Surgery (1979); 86: 550–555
  • Hohenberger P, Strauss L G, Lehner B, Frohmuller S, Dimitrakopoulou A, Schlag P. Perfusion of colorectal liver metastases and uptake of fluorouracil assessed by H2 15O and [18F] uracil positron emission tomography (PET). Eur J Cancer (1993); 29A: 1682–1686
  • Hohn D C, Stagg R J, Friedman M A, Hannigan J F, Rayner A, Ignoffo R J, Acord P, Lewis B J. A randomized trial of continuous intravenous versus hepatic intra arterial floxuridine in patients with colorectal cancer metastatic to the liver: The northern California oncology group trial. J Clin Oncol (1989); 7: 1646–1654
  • Hunt T M, Flowerdew A DS, Birch S J, Williams J D, Mullee M A, Taylor I. Prospective randomized controlled trial of hepatic arterial embolization or infusion chemotherapy with 5-fluorouracil and degradable starch microspheres for colorectal liver metastases. Br J Surg (1990); 77: 779–782
  • Jenkins S A, Day D W, Mooney B, Devitt P, Taylor I, Shields R. The effect of vasopressin and hepatic artery ligation on the blood supply to normal and metastatic liver tissue. Br J Cancer (1984); 50: 785–791
  • Kemeny N, Daly J, Reichman B, Geller N, Botet J, Oderman P. Intrahepatic or systemic infusion of fluorodeoxyuri-dine in patients with liver metastases from colorectal carcinoma. Ann Int Med (1987); 107: 459–465
  • Kemeny N, Niedzwiecki D, Shurgot B, Oderman P. Prognostic variables in patients with hepatic metastases from colorectal carcinoma. Cancer (1989); 63: 742–747
  • Kemeny N, Cohen A, Bertino J R, Sigurdson E R, Botet J, Oderman P. Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma. Cancer (1990); 65: 2446–2450
  • Kerr D J. 5-Fluorouracil and folinic acid: interesting biochemistry or effective treatment. Br J Cancer (1989); 60: 807–808
  • Kerr D J, Kaye S B. Chemoembolism in cancer therapy. Critical Reviews in Cancer (1991); 8: 19–39
  • Kerr D J, Los G. Pharmacokinetic principles of locoregional chemotherapy. Cancer Surveys (1993); 17: 105–122
  • Konno T, Maeda H, Iwai K, Tashiro S, Maki S, Morinaga T, Mochinaga M, Hiraoka T, Yokoyama I. Effect of arterial administration of high molecular weight anticancer agent SMANCS with lipid lymphography agent on hepatoma: a preliminary report. Eur J Clin Oncol (1983); 19: 1053–1065
  • Lokich J J, Ahlgren J D, Gullo J J, Philips J A, Fryer J G. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A mid-Atlantic oncology programme study. J Clin Oncol (1989); 7: 425–432
  • Lotze M T, Flickinger J C, Carr B I. Hepatobiliary neoplasms. Cancer, Principles and Practice of oncology, VT De Vita, S Hellman, SA Rosenberg. JB Lippincott Co, Philadelphia, 883–914
  • Martin J K, O'Connell M J, Wieand H S, Fitzgibbons R J, Mailliard J A, Rubin J, Nagorney D M, Tschetter L K, Krook J E. Intra-arterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal carcinoma. A Randomized trial. Arch Surg (1990); 125: 1022–1027
  • Mayer R J. Chemotherapy for metastatic colorectal carcinoma. Cancer (1992); 70: 1414–1424
  • Niederhuber J E, Ensminger W, Gyves J, Thrall J, Walker S, Cozzi E. Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer (1984); 53: 1336–1343
  • Peters G J, Lankelma J, Kok R M, Noordhuis P, van Groeningen C J, van der Wilt C L, Meyer S. Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumours as compared with plasma. Cancer Chemother Pharmacol (1993); 31: 269–276
  • Piedbois P, Buyse M, Rustum Y, Machover D, Erlichman C, Carlson R W, Valone F, Labianca R, Doroshow J H, Perrelli N. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol (1992); 10: 896–903
  • Present C A, Wolf W, Albright M J, Servis K L, Ring R, Atkinson D, Ong R L, Wiseman C, King M, Blayney D, Kennedy P, El-Tahtawy A, Singh M, Shani J. Human tumor fluorouracil trapping: Clinical correlations of in vivo 19F nuclear magnetic resonance spectroscopy pharmacokinetics. J Clin Oncol (1990); 8: 1868–1873
  • Present C A, Wolf W, Waluch V, Wiseman C, Kennedy P, Blayney D, Brechner R R. Association of intratumoral pharmacokinetics of fluorouracil with clinical response. Lancet (1994); 343: 1184–1187
  • Price P, Grifiths J. Tumour pharmacokinetics?—we do need to know. Lancet (1994); 343: 1174–1175
  • Rougier P, Ducreux M, Pignon J P, Elias D, Tigaud J M, Lumbroso J, Ruffie P, Lasser P H. Prognostic factors in patients with liver metastases from colorectal carcinoma treated with discontinuous intra-arterial hepatic chemotherapy. Eur J Cancer (1991); 27: 1226–1230
  • Rougier P, Laplanche A, Huguier M, Hay J M, Ollivier J M, Escat J, Salmon R, Julien M, Audy J CR, Gallot D, Gouzi J L, Pailler J L, Elisa D, Lacaine F, Roos S, Rotman N, Luboinski M, Lasser P. Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: Long term results of a prospective randomized trial. J Clin Oncol (1992); 10: 1112–1118
  • Safi F, Bittner R, Roscher R, Schuhmacher K, Gaus W, Beger G H. Regional chemotherapy for hepatic metastases of colorectal carcinoma (continuous intraarterial versus continuous intraarterial/intravenous therapy. Cancer (1989); 64: 379–387
  • Sasaki Y, Imaoka S, Hasegawa Y, Nakano S, Ishikawa O, Ohigashi H, Taniguchi K, Koyama H, Iwanaga T, Terasawa T. Changes in distribution of hepatic blood flow induced by intra-arterial infusion of angiotensin II in human hepatic cancer. Cancer (1985); 55: 311–316
  • Schlemmer H P, Semmler W, Bachert P, Hohenberger P, Schlag P, van Kaick G. Evaluation of early response parameters for in vivo F-19 MR spectroscopy in therapy monitoring of patients with liver metastases of colorectal carcinoma. Radiology (1991); 181: 210
  • Shepard K V, Levin B, Karl R C, Faintuch J, DuBrow R A, Hagle M, Cooper R M, Beschorner J, Stablein D. Therapy for metastatic colorectal carcinoma with hepatic artery infusion chemotherapy using a subcutaneous implanted pump. J Clin Oncol (1985); 3: 161–169
  • Stagg R J, Lewis B J, Friedman M A, Ignoffo R J, Hohn D C. Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver. Ann Int Med (1984); 100: 736–743
  • Stevens A N, Morris P G, Iles RA, Sheldon P W, Griffiths J R. 5-Fluorouracil metabolism monitored in vivo by 19F NMR. Br I Cancer (1984); 50: 113–117
  • Strauss L G, Conti P S. The applications of PET in clinical oncolgy. J Nucl Med (1991); 32: 623–648
  • Sullivan R D, Norcross J W, Watkins E. Chemotherapy of metastatic liver cancer by prolonged hepatic artery infusion. N Engl I Med (1964); 270: 321–7
  • Wagner J S, Adson M A, van Heerden J A, Adson M H, Ilstrup D M. The natural history of hepatic metastases from colorectal carcinoma. Ann Surg (1984); 199: 502–508
  • Wagner J G, Gyves J W, Stetson P L, Walker-Andrews S C, Wollner I S, Cochran M K, Ensminger W D. Steady-state nonlinear pharmacokinetics of 5-fluorouracil during hepatic arterial and intravenous infusions in cancer patients. Cancer Res (1986); 46: 1499–1506
  • Warren H W, Anderson J H, O'Gorman P, Kane E, Kerr D J, Cooke T G, McArdle C S. A phase II study of regional 5-fluorouracil infusion with intravenous folinic acid for colorectal liver metastases. Br J Cancer (1994); 70: 677–680
  • Weiss L, Grundmann Torhorst J, Hartveit F, Moberg I, Eder M, Fenoglio-Preiser C M, Napier J, Home C HW, Lopez M J, Shaw-Dunn R I, Sugar J, Davis J D, Day D W, Harlos J P. Haematogenous metastatic patterns in colonic carcinoma: An anylsis of 1541 necropsies. J Pathol (1986); 150: 195–203
  • Wolf W, Presant C A, Servis K L, El-Tahtawy A, Albright M J, Barker P B, Ring R, Atkinson D, Ong R, King M, Singh M, Ray M, Wiseman C, Blayney D, Shani J. Tumor trapping of 5-fluorouracil: In vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits. Proc Natl Acad Sci (1990); 87: 492–496

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.