45
Views
36
CrossRef citations to date
0
Altmetric
Editorial Article

Antisense Technology: Selection and Delivery of Optimally Acting Antisense Oligonucleotides

Pages 225-234 | Received 27 May 1997, Accepted 31 May 1997, Published online: 26 Jun 2009

References

  • Akhtar S., Juliano R. L. Cellular uptake and intracellular fate of antisense oligonucleotides. Trends Cell Biol. 1992a; 2: 139–144
  • Akhtar S., Juliano R. L. Liposome delivery of antisense oligonucleotides: adsorption and efflux characteristics of phosphorothioate oligodeoxynucleotides. J. Controlled Release 1992b; 22: 47–56
  • Akhtar S., Lewis K. J. Antisense oligodeoxynucleotide delivery to cultured macrophages is improved by incorporation into sustained release biodegradable polymer microspheres. Int. J. Pharm. 1997; 151: 57–67
  • Akhtar S. Delivery Strategies for Antisense Oligonucleotide Therapeutics. CRC Press, Boca RatonUSA 1995
  • Akhtar S., Agrawal S. In vivo studies with antisense oligonucleotides. Trends Pharmacol. Sci. 1997; 18: 12–18
  • Akhtar S., Rossi J. J. Anti-HIV therapy with antisense oligonucleotides and ribozymes: realistic approaches or expensive myths?. J. Antimicrobial Chemotherapy 1996; 38: 159–165
  • Akhtar S., Routledge A., Patel R., Gardiner J. M. Synthesis of mono- and dimannoside phosphoramidite derivatives for solid-phase conjugation to oligonucleotides. Tet. Lett. 1995; 36: 7333–7336
  • Alahari S. K., Dean N. M., Fisher M., Delong R., Manoharan M., Tivel K. L., Juliano R. L. Inhibition Of Expression Of The Multidrug Resistance-Associated P-Glycoprotein By Phosphorothioate And 5'-Cholesterol-Conjugated Phosphorothioate Antisense Oligonucleotides. Mol. Pharmacol. 1996; 50: 808–819
  • Aoki M., Morishita R., Higaki J., Moriguchi A., Kida I., Hayashi S., Matsushita H., Kaneda Y., Ogihara T. In vivo transfer efficiency of antisense oligonucleotides into the myocardium using HVJ-liposome method. Biochem. Biophys. Res. Comm. 1997; 231: 540–545
  • Ballas Z. K., Rasmussen W. L., Krieg A. M. Induction Of Nk Activity In Murine And Human-Cells By CPG Motifs In Oligodeoxynucleotides And Bacterial-DNA. J. Immunol. 1996; 157: 1840–1845
  • Barry E. L.R., Gesek F. A., Friedman P. A. Introduction of antisense oligonucleotides into cells by permeabilisation with Streptolysin O. Biotechniques 1993; 15: 1016–1020
  • Bennet C. F., Chiang M-Y., Chan H., Shoemaker J. E.E., Mirabelli C. K. Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol. Pharmacol. 1992; 41: 1023–1033
  • Bennett C. F. Intracellular delivery of oligonucleotides with cationic liposomes. Delivery strategies for antisense oligonucleotide therapeutics, S. Akhtar. CRC Press, Boca Raton 1995; 223–232
  • Bergan R., Connell Y., Fahmy B., Neckers L. Electroporation enhances c-myc antisense oligonucleotide efficacy. Nucl. Acids Res. 1993; 21: 3567
  • Bergan R., Kyle E., Connell Y., Neckers L. Inhibition of protein-tyrosine kinase activity in intact cells by the aptameric action of oligodeoxynucleotides. Antisense Res. Dev. 1995; 5: 33–38
  • Bergan R., Hakim F., Schwartz G. N., Kyle E., Cepanda R., Szabo J. M., Fowler D., Gress R., Neckers L. Electroporation of synthetic oligodeoxynucleotides: A novel technique for ex vivo bone marrow purging. Blood 1996; 88: 731–741
  • Bergan R., Connell Y., Fahmy B., Kyle E., Neckers L. Aptameric inhibition of p210bcr-abl tyrosine kinase autophosphorylation by oligodeoxynucleotides of defined sequence and backbone structure. Nucl. Acids Res. 1994; 22: 2150–2154
  • Berton M., Sixou S., Kravtzoff R., Dartigues C., Imbertie L., Allal C., Favre G. Improved oligonucleotide uptake and stability by a new drug carrier, the SupraMolecular BioVector (SMBV). Biochim. Biophys. Acta- (Mol. Cell Res) 1997; 1355: 7–19
  • Bertram J., Killian M., Brysch W., Schlingensiepen K. H., Kneba M. Reduction of erbB2 gene product in mamma carcinoma lines by erbB2 mRNA-specific and tyrosine kinase consenus phosphorothioate oligonucleotides. Biochem. Biophys. Res. Commun. 1994; 200: 661–667
  • Bielinska A., Kukowska-Latallo J. F., Johnson J., Tomalia D. A., Baker J. R. Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acids Res. 1994; 24: 2176–2182
  • Bonfils E., Depierreux C., Midoux P., Thuong N. T., Monsigny M., Roche A. C. Drug targeting: synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates. Nucleic Acids Res 1992; 20: 4621–4629
  • Bongartz J., Aubertin A., Milhaud G., Lebleu B. Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide. Nucleic Acids Res 1994; 22: 4681–4688
  • Brand R. M., Iversen P. L. Iontophoretic delivery of a telomeric oligonucleotide. Pharm. Res. 1996; 13: 851–854
  • Carmichael E. P., Chiou H. C., Findeis M. A., Spitalny G., Merwin J. R. targeted delivery of anti-hepatitis B antisense oligonucleotides. Delivery Strategies for Antisense Oligonucleotide Therapeutics, S. Akhtar. CRC Press, Boca RatonUSA 1995; 1995
  • Chavany C., Le Doan T., Couvreur P., Puisieux F., Helene C. Polyalkylcyanoacrylate nanoparticles as polymeric particles for antisense oligonucleotides. Pharmaceutical Research 1992; 9: 441–449
  • Chavany C., Saison-Behmoaras T., Le Doan T., Puisieux F., Couvreur P., Helene C. Adsorption of oligonucleotides onto polyisohexylcyanoacrylate nanoparticles protects them against nucleases and increases their cellular uptake. Pharm. Res. 1994; 11: 1370–1378
  • Chin D. J., Green G. A., Zon G., Szoka F. C., Straubinger R. M. Rapid nuclear accumulation of injected oligonucleotides. The New Biologist 1990; 2: 1091–1100
  • Chiou H. C., Tangco M. V., Levine S. M., Robertson G., Kormis K., Wu C. H., Wu G. Y. Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglyco-protein-polylysine carriers. Nucleic Acids Res. 1994; 22: 5439–5446
  • Chollet A. Nucleosides and Nucleotides 1991; 9: 957–966
  • Citro G., Perrotti D., Cucco C., D'Agnano I., Sacchi A., Zupi G., Calabretta B. Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci, USA 1992; 89: 7031–7035
  • Cortesi R., Esposito E., Menegatti E., Gambari R., Nastruzzi C. Gelatin microspheres as a new approach for the controlled delivery of synthetic oligonucleotides and PCR-generated DNA fragments. Int. J. Pharm. 1994; 105: 181–186
  • Coulson J. M., Akhtar S. A c-myc phosphorothioate oligonucleotide protects U87-MG cells from toxicity at high concentrations of lipofectin and steptolysin O. Pharm. Sci. 1997, in press
  • Coulson J. M., Poyner D. R., Chantry A., Irwin W. J., Akhtar S. A non-antisense sequence-selective effect of a phosphorothioate oligonucleotide targeted to EGFR in A431 cells. Mol. Pharmacol 1996; 50(2)314–325
  • Deshpande D., Toledovelasquez D., Thakkar D., Liang W. W., Rojanasakul Y. enhanced cellular uptake of oligonucleotides by egf receptor-mediated endocytosis in A549 cells. Pharm. Res 1996; 13: 57–61
  • Fell P. F., Hudson A. J., Reynolds M. A., Usman N., Akhtar S. Cellular uptake properties of 2′-amino/2′-O-methyl modified chimaeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA. Antisense Nucl. Acid Drug Develop. 1997; 7: 319–326
  • Flory C. M., Pavco P. A., Jarvis T. C., Lesch M. E., Wincott F. E., Beigelman L., Hunt S. W., Schrier D. J. Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint. Proc. Natl. Acad. Sci, USA 1996; 86: 6454–6458
  • Giles R. V., Spiller D. G., Tidd D. M. Detection of ribonuclease H-generated messenger-RNA fragments in human leukemia-cells following reversible membrane permeabilization in the presence of antisense oligodeoxynucleotides. Antisense Res. Develop. 1995; 5: 23–31
  • Ginobbi P., Geiser T. A., Ombres D., Citro G. Folic acid polylysine carrier improves efficacy of c-myc antisense oligodeoxynucleotides on human melanoma (M14) cells. Antican. Res. 1997; 17: 29–35
  • Godard G., Boutourine A. S., Saison-Behmoaras E., Helene C. Antisense effects of cholesterol-oligodeoxynucleotide conjugates associated with poly(alkylcyanoacrylate) nanoparticles. Eur. J. Biochem. 1995; 232: 404–410
  • Grimaldi S., Lisi A., Pozzi D., Santoro N. Attempts to use liposomes and RBC ghosts as vectors in drug and antisense therapy of virus infection. Res. Virology 1997; 148: 177–180
  • Guy-Caffey J. K., Bodepudi V., Bishop J. S., Jayaraman K., Chaudhary N. Novel polyaminolipids enhance the cellular uptake of oligonucleotides. J. Biol. Chem. 1995; 270: 31391
  • Ho S. P., Britton D. H.O., Stone B. A., Beherens D. L., Leffet L. M., Hobbs F. W., Miller J. A., Trainor G. L. Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selceted by mapping of RNA-accessible sites with oligonucleotide libraries. Nucl. Acids. Res. 1996; 24: 1901–1907
  • Hudson A. J., Lewis K. J., Rao V. M., Akhtar S. Biodegradable polymer matrices for the sustained exogenous delivery of a biologically active c-myc hammerhead ribozyme. Int. J. Pharm. 1996; 136: 23–29
  • Kabanov A. V., Vinogradov S. V., Ovcharenko A. V., Krivonos A. V., Melik-Nubarov N. S., Kiselev V. I., Severin E. S. A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus production and synthesis of virus-specific protiens in MDCK cells. FEBS Lett. 1990; 259: 327–330
  • Kreig A. M., Tonkinson J., Matson S., Zhao Q., Saxon M., Zhang L., Bhanja U., Yakubov L., Stein C. A. Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesterol moiety increases cellular association and improves efficacy. Proc. Natl. Acad. Sci, USA 1993; 90: 1048–1052
  • Leonetti J-P., Degols G., Le Bleu B. Biological activity with oligonucleotide-poly (1-lysine) conjugtaes:mechanism of cell uptake. Biocon. Chem 1990; 1: 150–153
  • Leonetti J. P., Degols G., Lebleu B. Biological activity of oligonucleotide-poly(L-lysine) conjugate: Mechanism of cell uptake. Biocon. Chem. 1990; 1: 149–153
  • Leonetti J. P., Mechti N., Degols G., Gagnor C., Lebleu B. Intracellular distribution of microinjected antisense oligonucleotides. Proc. Natl. Acad. Sci, USA 1991; 88: 2702–2706
  • Lewis J. G., Lin K-Y., Kothvale A., Flanagan W. M., Matteuchi M. D., De Prince R. B., Mook R. A., Hendren R. W., Wagner R. A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynulcelotides and plasmid DNA. Proc. Natl. Acad. Sci, USA 1996; 93: 3176–3181
  • Lewis K. J., Irwin W. J., Akhtar S. Biodegradable poly (L-lactic acid) matrices for the sustained delivery of antisense oligonucleotides. J. Controlled Release 1995; 37(1–2)173–183
  • Lewis K. J., Irwin W. J., Akhtar S. Development of a sustained release biodegradable polymer system for site-specific delivery of oligonucleotides: characterization of of P(LA-GA) copolymer microspheres in vitro. J. Drug Targeting 1997, in press (this issue)
  • Liang W. W., Shi X. L., Deshpande D., Malanga C. J., Rojanasakul Y. Oligonucleotide targeting to alveolar macrophages by mannose receptor-mediated endocytosis. Biochim. Biophys. Acta-Biomem. 1996; 1279: 227–234
  • Lima W. F., Brown-Drivers V., Fox M., Hanecak R., Brucie T. W. Combinatorial screening and rational optimization of hybridization to folded hepatitis C virus RNA of oligonucleotides with biological antisense activity. J. Biol. Chem. 1997; 272: 626–638
  • Lyngstadaas S. P., Risnes S., Sproat B. S., Thrane P. S., Prydz H. P. A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo. EMBO Journal 1995; 14: 5224–5229
  • Ma D. D.F., Wei A. Q. Enhanced delivery of synthetic oligonucleotides to human leukaemic cells by liposomes and immunoliposomes. Leukemia Res. 1996; 20: 925–930
  • Meiden V., Irwin W. J., Akhtar S. The effects of ultrasound on the stability of Oligodeoxynucleotide in vitro. Int. J. Pharm 1997; 152: 121–125
  • Milner N., Mir K. U., Southern E. M. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nature Biotechnol. 1997; 15: 537–541
  • Monia B. P., Johnston J. F., Geiger T., Muller M., Fabbro D. Antitumor-activity of a phosphorothioate antisense oligodeoxynucleotide targeted against c-raf kinase. Nature Med. 1996; 2: 668–675
  • Monia B. P., Sasmor H., Johnston J. F., Freier S. M., Lesnik E. A., Muller M., Geiger T., Altmann K. H., Moser H., Fabbro D. Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc. Natl. Acad. Sci, USA 1997; 93: 15481–15484
  • Moore V., Dunnion D., Irwin W. J., Akhtar S. Interaction of lipophilic oligonucelotide conjugates with the dipeptide transporter in Caco-2 cells. Biochem. Pharmacol. 1997; 53: 1223–1228
  • Narayanan R., Akhtar S. Antisense Therapy. Current Opin. Oncology 1996; 8: 509–515
  • Nestle F. O., Mitra R. S., Bennett C. F., Chan H., Nickoloff B. J. Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes. J. Invest. Dermatol. 1994; 13: 569–575
  • Noonberg S. B., Garovoy M. R., Hunt C. A. Characteristics of oligonucleotide uptake in human ketainocyte cultures. J. Invest. Dermatol. 1993; 101: 727–731
  • Oldenburg K. R., Vo K. T., Smith G. A., Selick H. E. Iontophoretic delivery of oligonucleotides across full thickness hairless mouse skin. J. Pharm. Sci. 1995; 84: 915–921
  • Partridge W. M., Boado R. J. Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein. FEBS lett. 1991; 288: 30–32
  • Pichon C., Arar K., Stewart A. J., Dodon M. D., Gazzolo L., Courtoy P. J., Mayer R., Monsigny M., Roche A. C. Intracellular routing and inhibitory activity of oligonucleopeptides containing a KDEL motif. Mol. Pharmacol. 1997; 51: 431–438
  • Rojanasakul Y., Weissman D. N., Shi X. L., Castranova V., Ma J. K.H., Liang W. W. Antisense inhibition of silica-induced tumor necrosis factor in alveolar macrophages. J. Biol. Chem. 1997; 272: 3910–3914
  • Schwab C., Chavany C., Duroux I., Goubin G., Lebeau J., Helene C., Saison-Behmoaras T. Antisense oligonucleotides adsorbed onto polycyanoacrylate nanoparticles specifically inhibit mutated Haras mediated cell proliferation and tumorigenicity in nude mice. Proc. Natl. AcadSci (USA) 1994; 91: 10460–10464
  • Shea R. G., Marsters J. C., Bischofberger N. Synthesis, hybridisation properties and antiviral activity of lipid-oligodeoxynucleotide conjugates. Nucl. Acids Res. 1990; 18: 3777–3783
  • Slepushkin V. A., Simoes S., Dazin P., Newman M. S., Guo L. S., de Lima M. C.P., Duzgunes N. Sterically stabilized pH-sensitive liposomes—Intracellular delivery of aqueous contents and prolonged circulation in vivo. J. Biol. Chem 1997; 272: 2382–2388
  • Southern E. M. DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale. Trends Genet. 1996; 12: 110–114
  • Southern E. M., Case-Green S. C., Elder J., Johnson M., Mir K., Wang L., Willimas J. C. Arrays of complementary oligonucleotides for analysing the hybridization behaviour of nucleic acids. Nucl. Acids Res. 1994; 22: 1368–1373
  • Spiller D. G., Tidd D. M. Nuclear delivery of antisense oligodeoxynucleotides through reversible permeabilization of human leukemia-cells with streptolysin-O. Antisense Res. Develop. 1995; 5: 13–21
  • Stewart A. J., Pichon C., Meunier L., Midoux P., Monsigny M., Roche A. C. Enhanced biological activity of antisense oligonucleotides complexed with glycosylated poly-L-lysine. Mol. Pharmacol. 1996; 50: 1487–1494
  • Symons R. Small catalytic RNAs. Ann. Rev. Biochem. 1992; 62: 641–671
  • Thierry A., Takle G. B. Liposomes as delivery system for antisense and ribozyme compounds, in Delivery Strategies for Antisense Oligonucleotide Therapeutics, S. Akhtar. CRC Press, Boca RatonUSA 1995; 1995
  • Vlassov V. V., Nechaeva M. V., Karamyshev V. N., Yakubov L. A. Iontophoretic delivery of oligonucleotide derivatives into mouse tumour. Antisense Res Develop. 1994; 4: 291–293
  • Walker I., Irwin W. J., Akhtar S. Improved cellular delivery of antisense oligonucleotides using transferrin receptor antibody-oligonucleotide conjugates. Pharm. Res. 1995; 12: 1548–1553
  • Wang S., Lee R. J., Cauchon G., Gorenstein D. G., Low P. S. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc. Natl. Acad. Sci USA 1995; 92: 3318–3322
  • Williams S. A., Chang L., Buzby J. S., Suen Y., Cairo M. S. Cationic lipids reduce time and dose of c-myc antisense oligodeoxynucleotides required to specifically inhibit Burkitt's lymphoma cell growth. Leukemia 1996; 10: 1980–1989
  • Wu-Pong S., Weiss T. L., Hunt C. A. Calcium Dependent Cellular uptake of a c-yc antisense oligonucleotide. Cell. Mol. Biol. 1994; 40: 843–850
  • Wyman T. B., Nicol F., Zelphati O., Scaria P. V., Plank C., Szoka F. C. Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochemistry 1997; 36: 3008–3017
  • Yamada K., Moriguchi A., Morishita R., Aoki M., Nakamura Y., Mikami H., Oshima T., Ninomiya M., Kaneda Y., Higaki J., Ogihara T. Efficient Oligonucleotide Delivery using the HVJ-Liposome Method in the Central-Nervous-System. American J. Physiol. (Regul. Integ. Comp. Physiol.) 1996; 40: R1212–R1220
  • Yamamoto T., Yamamoto S., Kataoka T., Tokunaga T. Antisense Res. Dev. 1994; 4: 119–122
  • Yazaki T., Ahmad S., Chahlavi A., Zylberkatz E., Dean N. M., Rabkin S. D., Martuza R. L., Glazer R. I. Treatment of Glioblastoma U-87 by Systemic Administration of an Antisense Protein-Kinase C-Alpha Phosphorothioate Oligo-deoxynucleotide. Mol. Pharmacol. 1996; 50: 236–242
  • Zelphati O., Szoka F. C. Mechanism of oligonucleotide release from cationic liposomes. Proc. Natl. Acad Sci., USA 1996; 93: 11943–11948
  • Zewert T. E., Pliquett U. F., Langer R., Weaver J. C. Transdermal transport of DNA antisense oligonucleotides by electroporation. Biochem. Biophys. Res Commun. 1995; 212: 286–292

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.