Development of Transferrin-Polycation/DNA Based Vectors for Gene Delivery to Melanoma Cells

References

• Abdallah B., Hassan A., Benoist C., Goula D., Behr J. P., Demeneix B. A. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethyleni-mine. Hum. Gene Ther. 1996; 7: 1947–1954
   PubMed Web of Science ®Google Scholar
• Behr J. P. Gene transfer with synthetic cationic amphiphiles: Prospects for gene therapy (Review). Bioconj. Chem. 1994; 5: 382–389
   PubMed Web of Science ®Google Scholar
• Belli F., Arienti F., Sule-Suso J., Clémente C., Mascheroni L., Cattelan A., Sanatonio C., Gallino G. F., Melani C., Rao S., Colombo M. P., Maio M., Cascinclli N., Parmiani G. Active immunisation of metastatic melanoma patients with interleukin-2-transduced allogeneic melanoma cells: Evaluation of efficacy and tolerability. Cancer Immunol. Immunother. 1997; 44: 197–203
   PubMed Web of Science ®Google Scholar
• Boussif O., Lezoualc'h F., Zanta M. A., Mergny M. D., Scherman D., Demeneix B., Behr J. P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo - polyethylenimine. Proc. Natl. Acad. Sci. USA 1995; 92(16)7297–7301
   PubMed Web of Science ®Google Scholar
• Cotten M., Saltik M., Kursa M., Wagner E., Maass G., Birnstiel MX. Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid. Virology 1994a; 205: 254–261
   PubMed Web of Science ®Google Scholar
• Cotten M., Baker A., Saltik M., Wagner E., Buschle M. Lipopolysaccharide is a frequent contaminant in plasmid preparations and can be toxic to primary cells in the presence of adenovirus. Gene Ther. 1994b; 1: 239–246
   PubMed Web of Science ®Google Scholar
• Dranoff G., Jaffee E., Lazenby A., Golumbek P., Levitsky H., Brose K., Jackson V., Hamada H., Pardoll D., Mulligan R. C. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA 1993; 90: 3539–3543
   PubMed Web of Science ®Google Scholar
• Erbacher P., Remy J.-S., Behr J.-P. Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther. 1999; 6: 138–145
   PubMed Web of Science ®Google Scholar
• Fearon E. R., Pardoll D. M., Itaya T., Golumbek P., Levitsky H., Simons J. W., Karasuyama H., Vogelstein B., Frost P. Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 1990; 60: 397–403
   PubMed Web of Science ®Google Scholar
• Felgner J. H., Kumar R., Sridhar C. N., Wheeler C. J., Tsai Y. J., Border R., Ramsey P., Martin M., Felgner P. L. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 1994; 269: 2550–2561
   PubMed Web of Science ®Google Scholar
• Golumbek P. T., Azhari R., Jaffee E. M., Levitsky H. I., Lazenby A., Leong K., Pardoll D. M. Controlled release, biodegradable cytokine depots: A new approach in cancer vaccine design. Cancer Res. 1993; 53: 5841–5844
   PubMed Web of Science ®Google Scholar
• Goula D., Remy J. S., Erbacher P., Wasowicz M., Levi G., Abdallah B., Demeneix B. A. Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther. 1998a; 5: 712–717
   PubMed Web of Science ®Google Scholar
• Goula D., Benoist C., Mantero S., Merlo G., Levi G., Demeneix B. A. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther. 1998b; 5: 1291–1295
   PubMed Web of Science ®Google Scholar
• Herlyn M., Koprowski H. Melanoma antigens: Immunological and biological characterisation and clinical significance. Ann. Rev. Immunol. 1988; 6: 283–308
   PubMed Web of Science ®Google Scholar
• Kircheis R., Kichler A., Wallner G., Kursa M., Ogris M., Felzmann T., Buchberger M., Wagner E. Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther. 1997; 4: 409–418
   PubMed Web of Science ®Google Scholar
• Kircheis R., Küpcü Z., Wallner G., Wagner E. Cytokine gene-modified tumor cells for prophylactic and therapeutic vaccination: IL-2, IFNγ, or combination IL-2 + IFNγ. Cytokines, Cell. Mol. Ther. 1998; 4: 95–103
   PubMedGoogle Scholar
• Kircheis R., Schüller S., Brunner S., Ogris M., Heider K.-H., Zauner W., Wagner E. Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. J. Gene Med. 1999; 1: 111–120
   PubMed Web of Science ®Google Scholar
• Koppenhagen F. J., Küpcü Z., Wallner G., Crommelin D. J.A., Wagner E., Storm G., Kircheis R. Sustained cytokine release for anticancer vaccination: Liposomes as alternative for gene-modified tumor cells. Clin. Cancer Res. 1998; 4: 1881–1886
   PubMed Web of Science ®Google Scholar
• Macfarlane M. P., Yang J. C., Guleria A. S., White R. L., Seipp C. A., Einhorn J. H., White D. E., Rosenberg S. A. The hematologic toxicity of interleukin-2 in patients with metastatic melanoma and renal cell carcinoma. Cancer 1995; 75: 1030–1037
   PubMed Web of Science ®Google Scholar
• Nabel G. J., Nabel E. G., Yang Z. Y., Fox B. A., Plautz G. E., Gao X., Huang L., Shu S., Gordon D., Chang A. E. Direct gene transfer with DNA-liposome complexes in melanoma: Expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. USA 1993; 90(11)307–11; 311
   PubMedGoogle Scholar
• Ogris M., Steinlein P., Kursa M., Mechtler K., Kircheis R., Wagner E. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 1998; 5: 1425–1433
   PubMed Web of Science ®Google Scholar
• Ogris M., Brunner S., Schuller S., Kircheis R., Wagner E. PEGylated DNA/Transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 1999; 6: 595–605
   PubMed Web of Science ®Google Scholar
• Plank C., Zatloukal K., Cotten M., Mechtler K., Wagner E. Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjugate Chem. 1992; 3: 533–539
   PubMed Web of Science ®Google Scholar
• Plank C., Oberhauser B., Mechtler K., Koch C., Wagner E. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem. 1994; 269: 12918–12924
   PubMed Web of Science ®Google Scholar
• Plank C., Mechtler K., Szoka F., Wagner E. Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery. Hum. Gene Ther. 1996; 7: 1437–1446
   PubMed Web of Science ®Google Scholar
• Plautz G. E., Yang Z.-Y., Wu B.-Y., Gao X., Huang L., Nabel G. J. Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc. Natl. Acad. Sci. USA 1993; 90: 4645–4649
   PubMed Web of Science ®Google Scholar
• Rosenberg S. A., Yang J. C., Topalian S. L., Schwartzentruber D. J., Weber J. S., Parkinson D. R., Seipp C. A., Einhorn J. H., White D. E. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA 1994; 271: 907–913
   PubMed Web of Science ®Google Scholar
• Schmidt W., Schweighoffer T., Herbst E., Maass G., Berger M., Schilcher F., Schaffner G., Birnstiel M. L. Cancer vaccines: The interleukin-2 dosage effect. Proc. Natl. Acad. Sci. USA 1995; 92: 4711–4714
   PubMed Web of Science ®Google Scholar
• Schreiber S., Kämpgen E., Wagner E., Pirkhammer D., Trcka J., Korschan H., Lindemann A., Dorffner R., Kittler H., Kasteliz F., Küpcü Z., Sinski A., Zatloukal K., Buschle M., Schmidt W., Birnstiel M. L., Kempe R. E., Voigt T., Weber H., Pehamberger H., Mertelsmann R., Brocker E. B., Wolff K., Stingl G. Immunotherapy of metastatic malignant melanoma by a vaccine consisting of autologous interleukin 2-transfected cancer cells: Outcome of a Phase I Study. Hum. Gene Ther. 1999; 10: 983–993
   PubMed Web of Science ®Google Scholar
• Sencer S. F., Rich M. L., Katsanis E., Ochoa A. C., Anderson P. M. Anti-tumor vaccine adjuvant effects of IL-2 liposomes in mice immunized against MCA-102 sarcoma. Eur. Cytokine Netw. 1991; 1: 311–318
   Google Scholar
• Simons J. W., Jaffee E. M., Weber C. E., Levitsky H. I., Nelson W. G., Carducci M. A., Lazenby A. J., Cohen L. K., Finn C. C., Gift S. M., Hauda K. M., Beck L. A., Leiferman K. M., Owens A.H., Jr., Piantadosi S., Dranoff G., Mulligan R. C., Pardoll D. M., Marshall F. F. Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo Granulocyte-Macrophage Colony-Stimulating Factor gene transfer. Cancer Res. 1997; 57: 1537–1546
   PubMed Web of Science ®Google Scholar
• Soiffer R., Lynch T., Mihm M., Jung K., Rhuda C., Schmollinger J. C., Hodi F. C., Liebster L., Lam P., Mentzer S., Singer S., Tanabe K. K., Cosimi A. B., Duda R., Sober A., Bhan A., Daley J., Neuberg D., Parry G., Rokovich J., Richards L., Drayer J., Berns A., Clift S., Cohen L. S., Mulligan M. C., Dranoff G. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc. Natl. Acad. Sci. USA 1998; 95(13)141–13; 146
   Google Scholar
• Tang M. X., Redemann C. T., Szoka F.C., Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconj. Chem. 1996; 7: 703–714
   PubMed Web of Science ®Google Scholar
• Van Slooten M. L., Kircheis R., Koppenhagen F. J., Wagner E., Storm G. Liposomes as cytokine-supplement in tumor cell-based vaccines. Int. J. Pharmaceutics 1999; 183: 33–36
   PubMed Web of Science ®Google Scholar
• Vile R., Hart I. In vitro and in vivo targeting of gene expression to melanoma cells. Cancer Res. 1993; 53: 962–967
   PubMed Web of Science ®Google Scholar
• Wagner E., Cotten M., Mechtler K., Kirlappos H., Birnstiel M. L. DNA-binding transferrin conjugates as functional gene-delivery agents: Synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety. Bioconj. Chem. 1991; 2: 226–231
   PubMed Web of Science ®Google Scholar
• Wagner E., Zatloukal K., Cotten M., Kirlappos H., Mechtler K., Curiel D. T., Birnstiel M. L. Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc. Natl. Acad. Sci. USA 1992; 89: 6099–6103
   PubMed Web of Science ®Google Scholar
• Zatloukal K., Schneeberger A., Berger M., Schmidt W., Koszik F., Kutil R., Cotten M., Wagner E., Buschle M., Maass G., Payer E., Stingl G., Birnstiel M. L. Elicitation of a systemic and protective anti-melanoma immune response by an IL-2 based vaccine. J. Immunol. 1995; 154: 3406–3419
   PubMed Web of Science ®Google Scholar
• Zauner W., Blaas D., Küchler E., Wagner E. Rhinovirus mediated endosomal release of transfection complexes. J. Virol. 1995; 69: 1085–1092
   PubMed Web of Science ®Google Scholar