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Original Article

Studies on Uptake, Sub-Cellular Trafficking and Efflux of Antisense Oligodeoxynucleotides in Glioma Cells using Self-Assembling Cationic Lipoplexes as Delivery Systems

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Pages 373-382 | Received 14 Jan 1999, Accepted 21 Jul 1999, Published online: 26 Jun 2009

References

  • Akhtar S. Antisense technology: Selection and delivery of optimally acting antisense oligonucleotides. J. Drug Targeting 1998; 5: 225–234
  • Akhtar S., Agrawal S. In vivo studies with antisense oligonucleotide. Trends Pharmacol. Sci. 1997; 18: 12–18
  • Akhtar S., Juliano R. L. Cellular uptake and intracellular fate of antisense oligonucleotides. Trends Cell. Biol. 1992; 2: 139–144
  • Akhtar S., Kole R., Juliano R. L. Stability of antisense DNA oligodeoxynucleotide analogs in cellular extracts and sera. Life Sci. 1991; 49: 1793–1801
  • Armbruster B. L., Carlemalm E., Chiovetti R., Garavito R. M., Hobot J. A., Kellenberger E., Villiger W. Specimen preparations for electron-microscopy using low-temperature embedding resins. J. Microscopy-Oxford 1982; 126: 77–85
  • Beltinger C., Saragovi H. U., Smith R. M., Lesauteur L., Shah N., Dedionisio L., Christensen L., Raible A., Jarett L., Gewirtz A. M. Binding, uptake, and intracellular trafficking of phosphorothioate modified oligo-deoxynucleotides. J. Clin. Invest. 1995; 95: 1814–1823
  • Bennett C. F., Chiang M. Y., Chan H., Shoemaker J. E.E., Mirabelli C. K. Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol. Pharmacol. 1992; 41: 1023–1033
  • Chin D. J., Green G. A., Zon G., Szoka F.C., Jr., Straubinger R. M. Rapid nuclear accumulation of injected oligodeoxyribonucleotides. New Biol. 1990; 2: 1091–1100
  • Farhood H., Bottega R., Epand R. M., Huang L. Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity. Biochim. Biophys. Acta 1992; 1111: 239–246
  • Fell P. L., Hudson A. J., Reynolds M. A., Akhtar S. Cellular uptake properties of a 2′-amino/2′-o-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA. Antisense Nucleic Acid Drug Develop. 1997; 7: 319–326
  • Guy-Caffey J. K., Bodepudi V., Bishop J. S., Jayaraman K., Chaudhary N. Novel polyaminolipids enhance the cellular uptake of oligonucleotides. J. Biol. Chem. 1995; 270: 31391–31396
  • Juliano R. L., Alahari S., Yoo H., Kole R., Cho M. Antisense pharmacodynamics: Critical issues in the transport and delivery of antisense oligonucleotides. Pharm. Res. 1999; 16: 494–502
  • Loke S. L., Stein C., Zhang X. H., Mori K., Nakanishi M., Subasinghe C., Cohen J. S., Neckers L. M. Characterisation of oligonucleotide transport into living cells. Proc. Natl. Acad. Sci. USA 1989; 86: 3474–3478
  • Nellen W., Sczakiel G. In vitro and in vivo action of antisense RNA. Mol. Biotech. 1996; 6: 7–15
  • Puyal C., Millhaud P., Bienvenue A., Philippot J. R. A new cationic liposome encapsulating genetic material. A potential delivery system for polynucleotides. Eur. J. Biochem. 1995; 228: 697–703
  • Quattrone A., Papucci L., Schiavone N., Mini E., Capaccioli S. Intracellular enhancement of intact antisense oligonucleotide steady-state levels by cationic lipids. Anti-Cancer Drug Design 1994; 9: 574–579
  • Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual.Second Edition. Cold Spring Harbor Laboratory Press, NY 1989; 11.20–11.28
  • Shoji Y., Akhtar S., Periasamy A., Herman B., Juliano R. L. Mechanisms of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages. Nucleic Acids Res. 1991; 19: 5543–5550
  • Stegmann T., Legendre J.-Y. Gene transfer mediated by cationic lipids: lack of correlation between lipid mixing and transfection. Biochim. Biophys. Acta 1997; 1325: 71–79
  • Tarrason G., Bellido D., Eritja R., Vilaro S., Piulats J. Digoxigenin-labelled phosphorothioate oligonucleotides. A new tool for the study of cellular uptake. Antisense Res. Dev. 1995; 5: 193–201
  • Tonkinson J. L., Stein C. A. Patterns of intracellular compartmentalization, trafficking and acidification of 5′-fluorescein labelled phosphodiester and phosphorothioate oligodeoxynucleotides in HL-60 cells. Nucleic Acids Res. 1994; 22: 4268–4275
  • Wagner R. W. Gene inhibition using antisense oligodeoxynucleotides. Nature 1994; 372: 333–335
  • Zabner J. Cationic lipids used in gene transfer. Advanced Drug Delivery Rev. 1997; 27: 17–28
  • Zelphati O., Szoka F.C., Jr. Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids. Pharm. Res. 1996; 13: 1367–1372
  • Zhou X., Huang L. DNA transfection mediated by cationic liposomes containing lipopolylysine:. Characterization and mechanism of action. Biochim. Biophys. Acta 1994; 1189: 195–203

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