225
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Development and evaluation of a gastro-retentive delivery system for improved antiulcer activity of ginger extract (Zingiber officinale)

&
Pages 741-751 | Received 14 Oct 2010, Accepted 01 Feb 2011, Published online: 14 Mar 2011

References

  • Ahmed MG, K BP S, K GB K. (2010). Formulation and evaluation of gastric-mucoadhesive drug delivery systems of captopril. J Curr Pharm Res, 2, 26–32.
  • Akiyama Y, Nagahara N. (1999). Novel formulation approaches to oral mucoadhesive drug delivery systems. In: Mathiowitz E, Chickering DE, Lehr CM, eds. Bioadhesive drug delivery systems-fundamentals, novel approaches and development. New York: Marcel Dekker, pp. 477–505.
  • Banerjee RK, Das D, Bandyopadhyay D, Bhattacharjee M. (1997). Hydroxyl radical is the major causative factor in stress-induced gastric ulceration. Free Radic Biol Med, 23, 8–18.
  • Bechgaard H, Nielson GH. (1978). Controlled release multiple units and single unit doses. Drug Dev Ind Pharm, 4, 53–67.
  • Bhandari U, Khushtar M, Kumar V, Javed K. (2009). Protective effect of ginger oil on aspirin and pylorus ligation-induced gastric ulcer model in rats. Indian J Pharm Sci, 71, 554–58.
  • Bilgin HM, Tumer C, Diken H, Kelle M, Sermet A. (2008). Role of ghrelin in the regulation of gastric acid secretion involving nitrergic mechanisms in rats. Physiol Res, 57, 563–568.
  • Choi BY, Park HJ, Hwang SJ, Park JB. (2002). Preparation of alginate beads for floating drug delivery system: effects of CO(2) gas-forming agents. Int J Pharm, 239, 81–91.
  • Cuppett SL, Wijeratne SSK, Schlegel V. (2005). Hydrogen peroxide induced oxidative stress damage and antioxidant enzyme response in caco-2 human colon cells. J Agric Food Chem, 53, 8768–8774.
  • Curatolo WJ, Lo J. (1995). Gastric retention system for controlled drug release. US Patent 07/200801, 443–45.
  • Demirbilek S, Gürses I, Sezgin N, Karaman A, Gürbüz N. (2004). Protective effect of polyunsaturated phosphatidylcholine pretreatment on stress ulcer formation in rats. J Pediatr Surg, 39, 57–62.
  • Deng C, Luo WS, Li GX. (2007). [Morphological observation on gastric mucosa membrane of patients with gastric ulcer treated with combined use of Qifang Weitong Powder and omeprazole]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 27, 610–612.
  • Ding GH, Naora K, Hayashibara M, Katagiri Y, Kano Y, Iwamoto K. (1991). Pharmacokinetics of [6]-gingerol after intravenous administration in rats. Chem Pharm Bull, 39, 1612–1614.
  • El-sokkarya GH, Cuzzocreab S, Reiterc RJ. (2007). Effect of chronic nicotine administration on the rat lung and liver: Beneficial role of melatonin. Toxicology, 239, 60–67.
  • Goel RK, Tandon R, Khanna HD, Dorababu M. (2004). Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma. Indian J Physiol Pharmacol, 48, 115–118.
  • Gornall AG, Bardawill CJ, David MM. (1949). Determination of serum proteins by means of the biuret reaction. J Biol Chem, 177, 751–766.
  • Goto C, Kasuya S, Koga K, Ohtomo H, Kagei N. (1990). Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro. Parasitol Res, 76, 653–656.
  • Ishak RA, Awad GA, Mortada ND, Nour SA. (2007). Preparation, in vitro and in vivo evaluation of stomach-specific metronidazole-loaded alginate beads as local anti-Helicobacter pylori therapy. J Control Release, 119, 207–214.
  • Jiang SZ, Wang NS, Mi SQ. (2008). Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats. Biopharm Drug Dispos, 29, 529–537.
  • Johji Y, Michihiko M, Rong QH, Hisashi M, Hajime F. (1988). The anti-ulcer effect in rats of ginger constituents. J Ethnopharmacol, 23, 299–304
  • Kasugai K, Watson SJ, A Flavell R, J Davis R, Todisco A. (2007). Crucial role of c-Jun NH2-terminal kinase 1 (JNK1) in cold-restraint stress-induced gastric lesions in mice. Dig Dis Sci, 52, 1698–1705.
  • Konturek SJ, Konturek PC, Brzozowski T. (2006). Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers. J Physiol Pharmacol, 57 Suppl 5, 51–66.
  • Martin A, Bustamante P, Chun AHC. (2005). Micromeritics. In: Lippincott Williams, Wilkins, eds. Physical Pharmacy. USA: Maryland, pp. 492–521.
  • Meyre-Silva C, Petry CM, Berté TE, Becker RG, Zanatta F, Delle-Monache F, Cechinel-Filho V, Andrade SF. (2009). Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers. Nat Prod Commun, 4, 911–916.
  • Moes A. (1993). Floating delivery and other potential gastric retaining systems: Current status on targeted drug delivery to the gastrointestinal tract. J Capsugel Lib, 97–112.
  • Narayan S, Devi RS, Jainu M, Sabitha KG, Devi CSS. (2004). Protective effect of a polyphenol drug, ambrex in ethanol induced gastric mucosal lesions in experimental rats. Ind J Pharmacol, 36, 34–37.
  • Pan MH, Hsieh MC, Hsu PC, Ho SY, Lai CS, Wu H, Sang S, Ho CT. (2008). 6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. Mol Nutr Food Res, 52, 1467–1477.
  • Radenovic L, Vasiljevic I, Selakovic V, Jovanovic M. (2003). 7-nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure. Comp Biochem Physiol C Toxicol Pharmacol, 135, 443–450.
  • Rao ChV, Verma AR, Vijayakumar M, Rastogi S. (2008). Gastroprotective effect of standardized extract of Ficus glomerata fruit on experimental gastric ulcers in rats. J Ethnopharmacol, 115, 323–326.
  • Repetto MG, Llesuy SF. (2002). Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res, 35, 523–534.
  • García Rodríguez LA, Jick H. (1994). Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet, 343, 769–772.
  • Sachs G, Spenney JG, Lewin M. (1978). H+ transport: regulation and mechanism in gastric mucosa and membrane vesicles. Physiol Rev, 58, 106–173.
  • Schinella GR, Troiani G, Davila V, Buschiazzo PMD, Tournier HA. (2000). Antioxidant effects of aqueous extract of Ilex paraguariensis. Biochem and Biophy Res Commun, 269, 357–360.
  • Scott K. (2006). Ginger - powerful antioxidant for alzheimer’s, cancer and heart disease. [Online] Available at: http://medspice.com/content/view/132/69/. Accessed on 24 May 2010.
  • Siddaraju MN, Dharmesh SM. (2007). Inhibition of gastric H+, K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale. Mol Nutr Food Res, 51, 324–332.
  • Siddaraju MN, Harish NMA, Shylaja MD. (2009). Gastroprotective effect of ginger rhizome (zingiber officinale) extract: Role of gallic acid and cinnamic acid in h+, k+-atpase/h. Pylori inhibition and anti-oxidative mechanism. Evid Based Complement Alternat Med, 1, 1–13.
  • Singh B, Kaur T, Singh S. (1997). Correction of raw disolution data for loss of drug during sampling. Indian J Pharm Sci, 59, 196–199.
  • Singh B, Singh S. (1998). A comprehensive computer program for study of drug release kinetics from compressed matrices. Int J Pharm Sciences, 60, 313–317.
  • Talley NJ, Zhang L, Eslick GD, Harry HX, Chengqiu W, Nghi P. (2009). Relationship between alcohol consumption and active Helicobacter pylori infection. Alcohol and alcoholism, 44, 1–6.
  • Vervaet C, Baert L, Remon JP. (1995). Extrusion-spheronization: A literature review. Int J Pharm, 116, 131–146.
  • Wong PSL, Theeuwes F, Larsen SD. (1993). Self-retaining gastrointestinal delivery device. US Patent 07/710607, 198–229.
  • Ye YN, So HL, Liu ES, Shin VY, Cho CH. (2003). Effect of polysaccharides from Angelica sinensis on gastric ulcer healing. Life Sci, 72, 925–932.
  • Yoshikawa T, Naito Y, Kishi A, Tomii T, Kaneko T, Iinuma S, Ichikawa H, Yasuda M, Takahashi S, Kondo M. (1993). Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut, 34, 732–737.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.