Professor Mitsuru Hashida: His outstanding achievements in drug delivery research

References

• Atsumi R, Endo K, Kakutani T, Takakura Y, Hashida M, Sezaki H. (1987). Disposition characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing muscles of rabbits. Cancer Res, 47, 5546–5551.
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• Fujita T, Nishikawa M, Tamaki C, Takakura Y, Hashida M, Sezaki H. (1992). Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives. J Pharmacol Exp Ther, 263, 971–978.
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• Hashida M, Egawa M, Muranishi S, Sezaki H. (1977). Role of intramuscular administration of water-in-oil emulsions as a method for increasing the delivery of anticancer agents to regional lymphatics. J Pharmacokinet Biopharm, 5, 225–239.
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• Kakutani T, Yamaoka K, Hashida M, Sezaki H. (1985). A new method for assessment of drug disposition in muscle: Application of statistical moment theory to local perfusion systems. J Pharmacokinet Biopharm, 13, 609–631.
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• Kawakami S, Yamashita F, Nishikawa M, Takakura Y, Hashida M. (1998). Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes. Biochem Biophys Res Commun, 252, 78–83.
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• Kojima T, Hashida M, Muranishi S, Sezaki H. (1980). Mitomycin C-dextran conjugate: A novel high molecular weight pro-drug of mitomycin C. J Pharm Pharmacol, 32, 30–34.
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• Mahato RI, Kawabata K, Takakura Y, Hashida M. (1995). In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes. J Drug Target, 3, 149–157.
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• Mihara K, Hojo T, Fujikawa M, Takakura Y, Sezaki H, Hashida M. (1993). Disposition characteristics of protein drugs in the perfused rat kidney. Pharm Res, 10, 823–827.
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• Miyao T, Takakura Y, Akiyama T, Yoneda F, Sezaki H, Hashida M. (1995). Stability and pharmacokinetic characteristics of oligonucleotides modified at terminal linkages in mice. Antisense Res Dev, 5, 115–121.
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• Nishikawa M, Miyazaki C, Yamashita F, Takakura Y, Hashida M. (1995). Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties. Am J Physiol, 268, G849–G856.
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• Nishikawa M, Takemura S, Takakura Y, Hashida M. (1998). Targeted delivery of plasmid DNA to hepatocytes in vivo: Optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties. J Pharmacol Exp Ther, 287, 408–415.
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• Noguchi A, Takahashi T, Yamaguchi T, Kitamura K, Takakura Y, Hashida M, Sezaki H. (1992). Preparation and properties of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate. Bioconjug Chem, 3, 132–137.
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• Ohkouchi K, Imoto H, Takakura Y, Hashida M, Sezaki H. (1990). Disposition of anticancer drugs after bolus arterial administration in a tissue-isolated tumor perfusion system. Cancer Res, 50, 1640–1644.
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• Okamoto H, Hashida M, Sezaki H. (1988). Structure-activity relationship of 1-alkyl- or 1-alkenylazacycloalkanone derivatives as percutaneous penetration enhancers. J Pharm Sci, 77, 418–424.
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• Sasaki H, Mukai E, Hashida M, Kimura T, Sezaki H. (1983). Development of lipophilic prodrugs of mitomycin C. I. Synthesis and antitumor activity of 1a-N-substituted derivatives with aromatic pro-moiety. Int J Pharmaceut, 15, 49–59.
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• Sato K, Itakura K, Nishida K, Takakura Y, Hashida M, Sezaki H. (1989). Disposition of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the perfused rat liver. J Pharm Sci, 78, 11–16.
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• Sato A, Takagi M, Shimamoto A, Kawakami S, Hashida M. (2007). Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice. Biomaterials, 28, 1434–1442.
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• Takakura Y, Matsumoto S, Hashida M, Sezaki H. (1984). Enhanced lymphatic delivery of mitomycin C conjugated with dextran. Cancer Res, 44, 2505–2510.
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• Takakura Y, Fujita T, Hashida M, Sezaki H. (1990). Disposition characteristics of macromolecules in tumor-bearing mice. Pharm Res, 7, 339–346.
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• Tanigawa N, Shimomatsuya T, Takahashi K, Inomata Y, Tanaka K, Satomura K, Hikasa Y, Hashida M, Muranishi S, Sezaki H. (1987). Treatment of cystic hygroma and lymphangioma with the use of bleomycin fat emulsion. Cancer, 60, 741–749.
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• Un K, Kawakami S, Yoshida M, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M. (2012). Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation. Hepatology, 56, 259–269.
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• Yamashita F, Wanchana S, Hashida M. (2002). Quantitative structure/property relationship analysis of Caco-2 permeability using a genetic algorithm-based partial least squares method. J Pharm Sci, 91, 2230–2239.
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• Yamashita F, Fujiwara S, Wanchana S, Hashida M. (2006). Quantitative structure/activity relationship modelling of pharmacokinetic properties using genetic algorithm-combined partial least squares method. J Drug Target, 14, 496–504.
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