260
Views
38
CrossRef citations to date
0
Altmetric
Research Article

Enhanced cytotoxicity of optimized liposomal genistein via specific induction of apoptosis in breast, ovarian and prostate carcinomas

, , &
Pages 1001-1011 | Received 06 Aug 2013, Accepted 17 Sep 2013, Published online: 24 Oct 2013

References

  • Rosenberg Zand RS, Jenkins DJ, Diamandis EP. Flavonoids and steroid hormone-dependent cancers. J Chromatogr B Analyt Technol Biomed Life Sci 2002;777:219–32
  • Wang H, Li J, Gao Y, et al. Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. Asian J Androl 2010;12:535–47
  • Jian L. Soy, isoflavones, and prostate cancer. Mol Nutr Food Res 2009;53:217–26
  • Akiyama T, Ishida J, Nakagawa S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 1987;262:5592–5
  • Spinozzi F, Pagliacci MC, Migliorati G, et al. The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leukemia Res 1994;18:431–9
  • Pavese JM, Farmer RL, Bergan RC. Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev 2010;29:465–82
  • Banerjee S, Li Y, Wang Z, Sarkar FH. Multi-targeted therapy of cancer by genistein. Cancer Lett 2008;269:226–42
  • Lamartiniere CA, Moore JB, Brown NM, et al. Genistein suppresses mammary cancer in rats. Carcinogenesis 1995;16:2833–40
  • Davis JN, Kucuk O, Sarkar FH. Genistein inhibits NF-kappa B activation in prostate cancer cells. Nutr Cancer 1999;35:167–74
  • Hussain A, Harish G, Prabhu SA, et al. Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinase-1 expression. Cancer Epidemiol 2012;36:e387–93
  • Gercel-Taylor C, Feitelson AK, Taylor DD. Inhibitory effect of genistein and daidzein on ovarian cancer cell growth. Anticancer Res 2004;24:795–800
  • Nagao T, Yoshimura S, Saito Y, et al. Reproductive effects in male and female rats of neonatal exposure to genistein. Reprod Toxicol 2001;15:399–411
  • El Touny LH, Banerjee PP. Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis. Cancer Res 2009;69:3695–703
  • Yoshimura FK. Genistein induces apoptosis via mitochondrial damage in acute lymphoblastic leukemia T-cell lines. Cancer Ther 2004;2:429–40
  • Li HQ, Luo Y, Qiao CH. The mechanisms of anticancer agents by genistein and synthetic derivatives of isoflavone. Mini Rev Med Chem 2012;12:350–62
  • Gong L, Li Y, Nedeljkovic-Kurepa A, Sarkar FH. Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 2003;22:4702–9
  • Wu JG, Ge J, Zhang YP, et al. Solubility of genistein in water, methanol, ethanol, propan-2-ol, 1-butanol, and ethyl acetate from 280 to 333 K. J Chem Eng Data 2010;55:5286–8
  • Cassidy A, Brown JE, Hawdon A, et al. Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 2006;136:45–51
  • Whaley WL, Rummel JD, Kastrapeli N. Interactions of genistein and related isoflavones with lipid micelles. Langmuir 2006;22:7175–84
  • Tang J, Xu N, Ji H, et al. Eudragit nanoparticles containing genistein: formulation, development, and bioavailability assessment. Int J Nanomed 2011;6:2429–35
  • Kwon SH, Kim SY, Ha KW, et al. Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery. Arch Pharm Res 2007;30:1138–43
  • Arora A, Byrem TM, Nair MG, Strasburg GM. Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids. Arch Biochem Biophys 2000;373:102–9
  • Pawlikowska-Pawlega B, Misiak LE, Zarzyka B, et al. Localization and interaction of genistein with model membranes formed with dipalmitoylphosphatidylcholine (DPPC). Biochim Biophys Acta 2012;1818:1785–93
  • Elbayoumi TA, Torchilin VP. Current trends in liposome research. In: Weissig V, ed. Liposomes, methods in molecular biology. New York: Humana Press; 2010;605:1–27
  • Gabizon AA. Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet. Clin Cancer Res 2001;7:223–5
  • Pham J, Phan V, Brownlow B, Elbayoumi T. 4th International Conference on Drug Discovery and Therapy; 2012 Feb; Dubai, UAE, 29–30
  • Jordan M, Nayel A, Brownlow B, Elbayoumi T. Development and evaluation of tocopherol-rich argan oil-based nanoemulsions as vehicles possessing anticancer activity. J Biomed Nanotechnol 2012;8:944–56
  • Bhavsar MD, Tiwari SB, Amiji MM. Formulation optimization for the nanoparticles-in-microsphere hybrid oral delivery system using factorial design. J Control Release 2006;110:422–30
  • Elbayoumi TA, Torchilin VP. Enhanced cytotoxicity of monoclonal anticancer antibody 2C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines. Eur J Pharm Sci 2007;32:159–68
  • Yang T, Cui FD, Choi MK, et al. Enhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluation. Int J Pharm 2007;338:317–26
  • Paul M, Durand R, Boulard Y, et al. Physicochemical characteristics of pentamidine-loaded polymethacrylate nanoparticles: implication in the intracellular drug release in Leishmania major infected mice. J Drug Target 1998;5:481–90
  • Nie S, Hsiao WL, Pan W, Yang Z. Thermoreversible Pluronic F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies. Int J Nanomed 2011;6:151–66
  • Hazra B, Biswas S, Mandal N. Antioxidant and free radical scavenging activity of Spondias pinnata. BMC Complement Alternat Med 2008;8:63
  • Qin Y, Lu M, Gong X. Dihydrorhodamine 123 is superior to 2,7-dichlorodihydrofluorescein diacetate and dihydrorhodamine 6 G in detecting intracellular hydrogen peroxide in tumor cells. Cell biology international 2008;32:224–8
  • Tsuchiya H, Nagayama M, Tanaka T, et al. Membrane-rigidifying effects of anti-cancer dietary factors. Biofactors 2002;16:45–56
  • Sroda K, Michalak K, Maniewska J, et al. Genistein derivatives decrease liposome membrane integrity--calcein release and molecular modeling study. Biophys Chem 2008;138:78–82
  • Raghunathan M, Zubovski Y, Venable RM, et al. Structure and elasticity of lipid membranes with genistein and daidzein bioflavinoids using X-ray scattering and MD simulations. J Phys Chem 2012;116:3918–27
  • Alwarawrah M, Dai J, Huang J. A molecular view of the cholesterol condensing effect in DOPC lipid bilayers. J Phys Chem 2010;114:7516–23
  • Greenwood AI, Tristram-Nagle S, Nagle JF. Partial molecular volumes of lipids and cholesterol. Chem Phys Lipids 2006;143:1–10
  • Thaipong K, Boonprako U, Crosby K, et al. Comparison of ABTS, DPPH, FRAP and ORAC assays for estimating antioxidant activity from guava fruit extracts. J Food Comp Anal 2006;19:669–75
  • Zand RS, Jenkins DJ, Diamandis EP. Steroid hormone activity of flavonoids and related compounds. Breast Cancer Res Treat 2000;62:35–49
  • Dong JY, Qin LQ. Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat 2011;125:315–23
  • Shu XO, Zheng Y, Cai H, et al. Soy food intake and breast cancer survival. JAMA 2009;302:2437–43
  • Lian F, Bhuiyan M, Li YW, et al. Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line. Nutr Cancer 1998;31:184–91
  • Lian F, Li Y, Bhuiyan M, Sarkar FH. p53-independent apoptosis induced by genistein in lung cancer cells. Nutr Cancer 1999;33:125–31

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.