154
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Tumor-preferential sustained drug release enhances antitumor activity of block copolymer micelles

&
Pages 619-628 | Received 13 Feb 2014, Accepted 30 Mar 2014, Published online: 28 Apr 2014

References

  • Rubin EH, Gilliland DG. Drug development and clinical trials – the path to an approved cancer drug. Nat Rev Clin Oncol 2012;9:215–22
  • Siegel R, Naishadham D, Jemal A. Cancer statistics 2012. CA-Cancer J Clin 2012;62:10–29
  • Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov 2003;2:347–60
  • Musacchio T, Torchilin Vladimir P. Recent developments in lipid-based pharmaceutical nanocarriers. Front Biosci 2011;16:1388–412
  • Mahon E, Salvati A, Baldelli Bombelli F, et al. Designing the nanoparticle-biomolecule interface for “targeting and therapeutic delivery”. J Control Release 2012;161:164–74
  • Maeda H, Matsumura Y. Tumoritropic and lymphotropic principles of macromolecular drugs. CRC Rev Ther Drug Carrier Syst 1989;6:193–210
  • Jain RK, Munn LL, Fukumura D. Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer 2002;2:266–76
  • Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation 2010;17:206–25
  • Jain R, Gutierrez J, Narang J, et al. In vivo correlation of tumor blood volume and permeability with histologic and molecular angiogenic markers in gliomas. Am J Neuroradiol 2011;32:388–94
  • Wojtkowiak JW, Verduzco D, Schramm KJ, Gillies RJ. Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm 2011;8:2032–8
  • Ostman A. The tumor microenvironment controls drug sensitivity. Nat Med 2012;18:1332–4
  • Cukierman E, Khan DR. The benefits and challenges associated with the use of drug delivery systems in cancer therapy. Biochem Pharmacol 2010;80:762–70
  • Ruenraroengsak P, Cook JM, Florence AT. Nanosystem drug targeting: facing up to complex realities. J Control Release 2010;141:265–76
  • Bae Y, Kataoka K. Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers. Adv Drug Deliver Rev 2009;61:768–84
  • Ponta A, Bae Y. PEG-poly(amino acid) block copolymer micelles for tunable drug release. Pharm Res 2010;27:2330–42
  • Eckman AM, Tsakalozou E, Kang NY, et al. Drug release patterns and cytotoxicity of PEG-poly(aspartate) block copolymer micelles in cancer cells. Pharm Res 2012;29:1755–67
  • West KR, Otto S. Reversible covalent chemistry in drug delivery. Curr Drug Discov Technol 2005;2:123–60
  • Kaneko T, Willner D, Monkovíc I, et al. New hydrazone derivatives of adriamycin and their immunoconjugates – a correlation between acid stability and cytotoxicity. Bioconjug Chem 1991;2:133–41
  • Binauld S, Stenzel MH. Acid-degradable polymers for drug delivery: a decade of innovation. Chem Commun 2013;49:2082–102
  • Lee ES, Gao Z, Bae YH. Recent progress in tumor pH targeting nanotechnology. J Control Release 2008;132:164–70
  • Hillaireau H, Couvreur P. Nanocarriers' entry into the cell: relevance to drug delivery. Cell Mol Life Sci 2009;66:2873–96
  • Duncan R, Richardson SC. Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: opportunities and challenges. Mol Pharm 2012;9:2380–402
  • Forrest ML, Pack DW. On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector design. Mol Ther 2002;6:57–66
  • Bareford LM, Swaan PW. Endocytic mechanisms for targeted drug delivery. Adv Drug Deliver Rev 2007;59:748–58
  • Becelli R, Renzi G, Morello R, Altieri F. Intracellular and extracellular tumor pH measurement in a series of patients with oral cancer. J Craniofac Surg 2007;18:1051–4
  • Sauvant C, Nowak M, Wirth C, et al. Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38. Int J Cancer 2008;123:2532–42
  • Zhang X, Lin Y, Gillies RJ. Tumor pH and its measurement. J Nucl Med 2010;51:1167–70
  • Bae Y, Fukushima S, Harada A, Kataoka K. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed 2003;42:4640–3
  • Bae Y, Jang WD, Nishiyama N, et al. Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Mol Biosyst 2005;1:242–50
  • Cao P, Bae Y. Comparison between microplate spectrometry and LC/MC chromatography for facile pilot pharmacokinetics and biodistribution studies of doxorubicin-loaded nanoparticle drug carriers. J Appl Pharm Sci 2012;2:1–9
  • Decuzzi P, Godin B, Tanaka T, et al. Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release 2010;141:320–7
  • Bae Y, Nishiyama N, Fukushima S, et al. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem 2005;16:122–30
  • Bae Y, Nishiyama N, Kataoka K. In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments. Bioconjug Chem 2007;18:1131–9
  • Crommelin DJ, Park K, Florence A. Pharmaceutical nanotechnology: unmet needs in drug delivery. J Control Release 2010;141:263–4
  • Caron J, Maksimenko A, Wack S, et al. Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene. Adv Healthcare Mater 2013;2:172–85
  • Lee HJ, Bae Y. Pharmaceutical differences between block copolymer self-assembled and cross-linked nanoassemblies as carriers for tunable drug release. Pharm Res 2013;30:478–88
  • Scott D, Rohr J, Bae Y. Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity. Int J Nanomed 2011;6:2757–67
  • Akter S, Clem BF, Lee HJ, et al. Block copolymer micelles for controlled delivery of glycolytic enzyme inhibitors. Pharm Res 2012;29:847–55
  • Veronese FM, Schiavon O, Pasut G, et al. PEG-doxorubicin conjugates: Influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity. Bioconjug Chem 2005;16:775–84
  • Min KH, Lee HJ, Kim K, et al. The tumor accumulation and therapeutic efficacy of doxorubicin carried in calcium phosphate-reinforced polymer nanoparticles. Biomaterials 2012;33:5788–97

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.