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Research Article

Stable phosphatidylcholine-bile salt mixed micelles enhance oral absorption of paclitaxel: preparation and mechanism in rats

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Pages 901-912 | Received 22 Apr 2014, Accepted 12 Jul 2014, Published online: 31 Jul 2014

References

  • Mo R, Jin X, Li N, et al. The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles. Biomaterials 2011;32:4609–20
  • Yao HJ, Ju RJ, Wang XX, et al. The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery. Biomaterials 2011;32:3285–302
  • Mahmud A, Xiong XB, Aliabadi HM, Lavasanifar A. Polymeric micelles for drug targeting. J Drug Target 2007;15:553–84
  • Mazzaferro S, Bouchemal K, Ponchel G. Oral delivery of anticancer drugs III: formulation using drug delivery systems. Drug Discov Today 2013;18:99–104
  • Nornoo AO, Zheng HA, Lopes LB, et al. Oral microemulsions of paclitaxel: in situ and pharmacokinetic studies. Eur J Pharm Biopharm 2009;71:310–17
  • Agüeros M, Zabaleta V, Espuelas S, et al. Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly (anhydride) nanoparticles. J Control Release 2010;145:2–8
  • Yoncheva K, Calleja P, Agüeros M, et al. Stabilized micelles as delivery vehicles for paclitaxel. Int J Pharm 2012;436:258–64
  • Duan R, Sun X, Liu J, et al. Mixed micelles loaded with silybin-polyene phosphatidylcholine complex improve drug solubility. Acta Pharm Sin 2011;32:108–15
  • Mrestani Y, Behbood L, Hartl A, Neubert R. Microemulsion and mixed micelle for oral administration as new drug formulations for highly hydrophilic drugs. Eur J Pharm Biopharm 2010;74:219–22
  • Tang N, Du G, Wang N, et al. Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin. J Natl Cancer Inst 2007;99:1004–15
  • Zhang ZW, Gao F, Jiang SJ, et al. Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats. Int J Pharm 2013;452:374–81
  • Krishnadas A, Rubinstein I, Oenyueksel H. Sterically stabilized phospholipid mixed micelles: in vitro evaluation as a novel carrier for water-insoluble drugs. Pharm Res 2003;20:297–302
  • Rupp C, Steckel H, Müller BW. Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine. Int J Pharm 2010;395:272–80
  • Rege BD, Yu LX, Hussain AS, Polli JE. Effect of common excipients on Caco-2 transport of low-permeability drugs. J Pharm Sci 2001;90:1776–86
  • Varma MVS, Panchagnula R. Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro. Eur J Pharm Sci 2005;25:445–53
  • Smedt DSC, Demeester J, Hennink WE. Cationic polymer based gene delivery systems. Pharm Res 2000;17:113–26
  • Li Y, Bi Y, Xi Y, Li L. Enhancement on oral absorption of paclitaxel by multifunctional pluronic micelles. J Drug Target 2013;21:188–99
  • Wang Y, Yu L, Han L, et al. Difunctional pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and pluronic-mediated overcoming multidrug resistance in tumor cell lines. Int J Pharm 2007;337:63–73
  • La SB, Okano T, Kataoka K. Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly (ethylene oxide) – poly (β-benzyl l-aspartate) block copolymer micelles. J Pharm Sci 1996;85:85–90
  • Roger E, Lagarce F, Benoit JP. The gastrointestinal stability of lipid nanocapsules. Int J Pharm 2009;379:260–5
  • Agüeros M, Ruiz-Gatón L, Vauthier C, et al. Combined hydroxypropyl-β-cyclodextrin and poly (anhydride) nanoparticles improve the oral permeability of paclitaxel. Eur J Pharm Sci 2009;38:405–13
  • Dabholkar RD, Sawant RM, Mongayt DA, et al. Polyethylene glycol–phosphatidylethanolamine conjugate (PEG–PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux. Int J Pharm 2006;315:148–57
  • Issa C, Gupta P, Bansal AK. Implications of density correction in gravimetric method for water flux determination using rat single-pass intestinal perfusion technique: a technical note. AAPS PharmSciTech 2003;4:44–9
  • Iqbal J, Sarti F, Perera G, Bernkop-Schnürch A. Development and in vivo evaluation of an oral drug delivery system for paclitaxel. Biomaterials 2011;32:170–5
  • Mazer NA, Benedek GB, Carey MC. Quasielastic light-scattering studies of aqueous biliary lipid systems. Mixed micelle formation in bile salt-lecithin solutions. Biochemistry 1980;19:601–15
  • Guo QF, Shi S, Wang XH, et al. Synthesis of a novel biodegradable poly(ester amine) (PEAs) copolymer based on low-molecular-weight polyethyleneimine for gene delivery. Int J Pharm 2009;379:82–9
  • Godbey WT, Mikos AG. Recent progress in gene delivery using non-viral transfer complexes. J Control Release 2001;72:115–25
  • Woo JS, Lee CH, Shim CK, Hwang SJ. Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031. Pharm Res 2003;20:24–30

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