Polymeric carrier-mediated intracellular delivery of phosphatidylinositol-3,4,5-trisphosphate to overcome insulin resistance

References

• Prestwich GD. Phosphoinositide signaling: from affinity probes to pharmaceutical targets. Chem Biol 2004;11:619–37
   PubMed Web of Science ®Google Scholar
• Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997;387:673–6
   PubMed Web of Science ®Google Scholar
• Czech MP. Dynamics of phosphoinositides in membrane retrieval and insertion. Annu Rev Physiol 2003;65:791–815
   PubMed Web of Science ®Google Scholar
• Rameh LE, Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999;274:8347–50
   PubMed Web of Science ®Google Scholar
• Alessi D, Downes C. The role of PI 3-kinase in insulin action. Biochim Biophys Acta Mol Cell Biol Lipids 1998;1436:151–64
   PubMed Web of Science ®Google Scholar
• Shepherd P, Withers D, Siddle K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998;333:471–90
   PubMed Web of Science ®Google Scholar
• Draznin B. Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin. Diabetes 2006;55:2392–7
   PubMed Web of Science ®Google Scholar
• Le Marchand-Brustel Y, Tanti J, Cormont M, et al. From insulin receptor signalling to Glut 4 translocation abnormalities in obesity and insulin resistance. J Recept Signal Transduct Res 1999;19:217–28
   PubMed Web of Science ®Google Scholar
• Bridges D, Saltiel AR. Phosphoinositides: key modulators of energy metabolism. Biochim Biophys Acta 2015;1851:857–66
   PubMed Web of Science ®Google Scholar
• Wishart MJ, Dixon JE. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol 2002;12:579–85
   PubMed Web of Science ®Google Scholar
• Nakashima N, Sharma PM, Imamura T, et al. The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes. J Biol Chem 2000;275:12889–95
   PubMed Web of Science ®Google Scholar
• Ijuin T, Takenawa T. SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. Mol Cell Biol 2003;23:1209–20
   PubMed Web of Science ®Google Scholar
• Wada T, Sasaoka T, Funaki M, et al. Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5′-phosphatase catalytic activity. Mol Cell Biol 2001;21:1633–46
   PubMed Web of Science ®Google Scholar
• Sasaoka T, Hori H, Wada T, et al. SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes. Diabetologia 2001;44:1258–67
   PubMed Web of Science ®Google Scholar
• Ijuin T, Takenawa T. Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP). J Biol Chem 2012;287:6991–9
   PubMed Web of Science ®Google Scholar
• Sweeney G, Garg RR, Ceddia RB, et al. Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake. J Biol Chem 2004;279:32233–42
   PubMed Web of Science ®Google Scholar
• Jiang T, Sweeney G, Rudolf MT, et al. Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998;273:11017–24
   PubMed Web of Science ®Google Scholar
• Manna P, Jain S. Effect of PIP3 on adhesion molecules and adhesion of THP-1 monocytes to HUVEC treated with high glucose. Cell Physiol Biochem 2014;33:1197–204
   PubMed Web of Science ®Google Scholar
• Strawbridge AB, Elmendorf JS. Phosphatidylinositol 4,5-bisphosphate reverses endothelin-1-induced insulin resistance via an actin-dependent mechanism. Diabetes 2005;54:1698–705
   PubMed Web of Science ®Google Scholar
• Jelinek R, Kolusheva S. Biomolecular sensing with colorimetric vesicles. In: Schrader T, ed. Creative chemical sensor systems. Berlin, Heidelberg: Springer Science & Business Media; 2007:155–80
   Google Scholar
• Werth S, Urban-Klein B, Dai L, et al. A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes. J Control Release 2006;112:257–70
   PubMed Web of Science ®Google Scholar
• Patnaik S, Gupta KC. Novel polyethylenimine-derived nanoparticles for in vivo gene delivery. Expert Opin Drug Deliv 2013;10:215–28
   PubMed Web of Science ®Google Scholar
• Geresh S, Dawadi R, Arad S. Chemical modifications of biopolymers: quaternization of the extracellular polysaccharide of the red microalga Porphyridium sp. Carbohydr Polym 2000;43:75–80
   Web of Science ®Google Scholar
• Amar-Lewis E, Azagury A, Chintakunta R, et al. Quaternized starch-based carrier for siRNA delivery: from cellular uptake to gene silencing. J Control Release 2014;185:109–20
   PubMed Web of Science ®Google Scholar
• Kachko I, Maissel A, Mazor L, et al. Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate. Endocrinology 2009;150:2618–26
   PubMed Web of Science ®Google Scholar
• Tirosh A, Potashnik R, Bashan N, Rudich A. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation. J Biol Chem 1999;274:10595–602
   PubMed Web of Science ®Google Scholar
• Kozlovsky N, Rudich A, Potashnik R, et al. Transcriptional activation of the Glut1 gene in response to oxidative stress in L6 myotubes. J Biol Chem 1997;272:33367–72
   PubMed Web of Science ®Google Scholar
• Rudich A, Konrad D, Török D, et al. Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues. Diabetologia 2003;46:649–58
   PubMed Web of Science ®Google Scholar
• Patel N, Rudich A, Khayat ZA, et al. Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells. Mol Cell Biol 2003;23:4611–26
   PubMed Web of Science ®Google Scholar
• Huang C, Somwar R, Patel N, et al. Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity. Diabetes 2002;51:2090–8
   PubMed Web of Science ®Google Scholar
• Ringsdorf H, Schlarb B, Venzmer J. Molecular architecture and function of polymeric oriented systems: models for the study of organization, surface recognition, and dynamics of biomembranes. Angew Chem Int Ed Engl 1988;27:113–58
   Web of Science ®Google Scholar
• Orynbayeva Z, Kolusheva S, Livneh E, et al. Visualization of membrane processes in living cells by surface-attached chromatic polymer patches. Angew Chem Int Ed 2005;44:1092–6
   PubMed Web of Science ®Google Scholar
• Charych D, Cheng Q, Reichert A, et al. A ‘litmus test’ for molecular recognition using artificial membranes. Chem Biol 1996;3:113–20
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Yasuda M, Okada S, et al. Femtosecond spectroscopy of a polydiacetylene with extended conjugation to acetylenic side groups. Chem Phys Lett 1997;267:472–80
   Web of Science ®Google Scholar
• Kolusheva S, Shahal T, Jelinek R. Peptide-membrane interactions studied by a new phospholipid/polydiacetylene colorimetric vesicle assay. Biochemistry (NY) 2000;39:15851–9
   PubMed Web of Science ®Google Scholar
• Okada T, Kawano Y, Sakakibara T, et al. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem 1994;269:3568–73
   PubMed Web of Science ®Google Scholar
• Katz M, Ben-Shlush I, Kolusheva S, Jelinek R. Rapid colorimetric screening of drug interaction and penetration through lipid barriers. Pharm Res 2006;23:580–8
   PubMed Web of Science ®Google Scholar
• Dobrosavljević V, Stratt RM. Role of conformational disorder in the electronic structure of conjugated polymers: substituted polydiacetylenes. Phys Rev B 1987;35:2781
   PubMed Web of Science ®Google Scholar
• Kleinschmidt JH, Mahaney JE, Thomas DD, Marsh D. Interaction of bee venom melittin with zwitterionic and negatively charged phospholipid bilayers: a spin-label electron spin resonance study. Biophys J 1997;72:767–78
   PubMed Web of Science ®Google Scholar
• Bayley PM, Dale RE. Spectroscopy and the dynamics of molecular biological systems. London: Academic Press; 1985
   Google Scholar
• Singh A, Kasinath B, Lewis E. Interaction of polycations with cell-surface negative charges of epithelial cells. Biochim Biophys Acta 1992;1120:337–42
   Google Scholar
• Godbey WT, Wu KK, Mikos AG. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc Natl Acad Sci USA 1999;96:5177–81
   PubMed Web of Science ®Google Scholar
• Klarlund JK, Tsiaras W, Holik JJ, et al. Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs. J Biol Chem 2000;275:32816–21
   PubMed Web of Science ®Google Scholar
• Friedman DL. Role of cyclic nucleotides in cell growth and differentiation. Physiol Rev 1976;56:652–708
   PubMed Web of Science ®Google Scholar
• Holz GG, Chepurny OG, Schwede F. Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors. Cell Signal 2008;20:10–20
   PubMed Web of Science ®Google Scholar
• Ozaki S, DeWald DB, Shope JC, et al. Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers. Proc Natl Acad Sci USA 2000;97:11286–91
   PubMed Web of Science ®Google Scholar
• Falasca M. PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs. Curr Pharm Des 2010;16:1410–16
   PubMed Web of Science ®Google Scholar
• Rudich A, Klip A. Push/pull mechanisms of GLUT4 traffic in muscle cells. Acta Physiol Scand 2003;178:297–308
   PubMedGoogle Scholar
• Rudich A, Klip A. Putting Rac1 on the path to glucose uptake. Diabetes 2013;62:1831–2
   PubMed Web of Science ®Google Scholar
• Sylow L, Jensen TE, Kleinert M, et al. Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle. Diabetes 2013;62:1865–75
   PubMed Web of Science ®Google Scholar