532
Views
26
CrossRef citations to date
0
Altmetric
Original Article

Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells

, , , , , , , , , & show all
Pages 934-942 | Received 22 Sep 2015, Accepted 21 Feb 2016, Published online: 27 Mar 2016

References

  • Wang Y, Levy DE. Comparative evolutionary genomics of the STAT family of transcription factors. JAKSTAT 2012;1:23–36.
  • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798–809.
  • Bromberg JF, Wrzeszczynska MH, Devgan G, et al. Stat3 as an oncogene. Cell 1999;98:295–303.
  • Niu G, Wright KL, Huang M, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002;21:2000–8.
  • Sellier H, Rebillard A, Guette C, et al. How should we define STAT3 as an oncogene and as a potential target for therapy? JAKSTAT 2013;2:e24716.
  • Macias E, Rao D, Carbajal S, et al. Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes. J Invest Dermatol 2014;134:1971–80.
  • Inghirami G, Chiarle R, Simmons WJ, et al. New and old functions of STAT3: a pivotal target for individualized treatment of cancer. Cell Cycle 2005;4:1131–3.
  • Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs 2005;16:601–7.
  • Mukherjee A, Khuda-Bukhsh AR. Quercetin down-regulates IL-6/STAT-3 signals to induce mitochondrial-mediated apoptosis in a nonsmall- cell lung-cancer cell line, A549. J Pharmacopuncture 2015;18:19–26.
  • Tao L, Fan F, Liu Y, et al. Concerted suppression of STAT3 and GSK3β is involved in growth inhibition of non-small cell lung cancer by Xanthatin. PLoS One 2013;8:e81945.
  • Pandey MK, Sung B, Ahn KS, Aggarwal BB. Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Molecular Pharmacol 2009;75:525–33.
  • Lee J, Hahm E-R, Singh SV. Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis 2010;31:1991–8.
  • Shin DS, Kim HN, Shin KD, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res 2009;69:193–202.
  • Chen L, Wang HJ, Xie W, et al. Cryptotanshinone inhibits lung tumorigenesis and induces apoptosis in cancer cells in vitro and in vivo. Mol Med Rep 2014a;9:2447–52.
  • Chen L, Zheng SZ, Sun ZG, et al. Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. Cancer Chemother Pharmacol 2011;68:17–27.
  • Lu L, Li C, Li D, et al. Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling. Mol Cell Biochem 2013;381:273–82.
  • Chen X, Guo J, Bao J, et al. The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review. Med Res Rev 2014b;34:768–94.
  • Zhang X, Luo W, Zhao W, et al. Isocryptotanshinone induced apoptosis and activated MAPK signaling in human breast cancer MCF-7 cells. J Breast Cancer 2015;18:112–18.
  • Tang ZH, Li T, Chang LL, et al. Glycyrrhetinic acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells. J Agric Food Chem 2014;62:11910–16.
  • Becker S, Groner B, Muller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998;394:145–51.
  • Chinthala Y, Thakur S, Tirunagari S, et al. Synthesis, docking and ADMET studies of novel chalcone triazoles for anti-cancer and anti-diabetic activity. Eur J Med Chem 2015;93:564–73.
  • Xu W, Lucke AJ, Fairlie DP. Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets. J Mol Graph Model 2015;57:76–88.
  • Zhou J, Xu XZ, Hu YR, et al. Cryptotanshinone induces inhibition of breast tumor growth by cytotoxic CD4+ T cells through the JAK2/STAT4/ perforin pathway. Asian Pac J Cancer Prev 2014;15:2439–45.
  • Park IJ, Yang WK, Nam SH, et al. Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma. Apoptosis 2014;19:615–28.
  • Hu T, To KK, Wang L, et al. Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza. Phytomedicine 2014;21:1264–72.
  • Ge Y, Yang B, Xu X, et al. Cryptotanshinone acts synergistically with imatinib to induce apoptosis of human chronic myeloid leukemia cells. Leuk Lymphoma 2015;56:730–8.
  • Debnath B, Xu S, Neamati N. Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J Med Chem 2012;55:6645–68.
  • Li W, Saud SM, Young MR, et al. Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro. Mol Cell Biochem 2015;406:63–73.
  • Yu HJ, Park C, Kim SJ, et al. Signal transducer and activators of transcription 3 regulates cryptotanshinone-induced apoptosis in human mucoepidermoid carcinoma cells. Pharmacogn Mag 2014b;10:S622–9.
  • Yu H, Lee H, Herrmann A, et al. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer 2014a;14:736–46.
  • Jarnicki A, Putoczki T, Ernst M. Review Stat3: linking inflammation to epithelial cancer-more than a “gut” feeling? Cell Div 2010;5:14–27.
  • Hu T, Wang L, Zhang L, et al. Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity. Phytomedicine 2015;22:536–44.
  • Hao W, Zhang X, Zhao W, et al. Cryptotanshinone induces pro-death autophagy through JNK signaling mediated by reactive oxygen species generation in lung cancer cells. Anticancer Agents Med Chem 2015. [Epub ahead of print].

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.