Endothelium-Dependent Vasorelaxation in the Aorta of Transgenic Mice Expressing Human Apolipoprotein(a) or Lipoprotein(a)

References

• Ross R. The pathogenesis of atherosclerosis. N Engl J Med 1986; 314: 488–500
   PubMed Web of Science ®Google Scholar
• Henderson A H. Endothelium in control. Br Heart J 1991; 65: 116–125
   PubMedGoogle Scholar
• Rubanyi G M. Role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol 1993; 22(suppl.4)S1–S13
   PubMed Web of Science ®Google Scholar
• Moncada S., Palmer R MJ, Higgs E A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109–142
   PubMed Web of Science ®Google Scholar
• McLenachan J M, Vita J A, Fish R D, Treasure C B, Cox D A, Ganz P., Selwyn A P. Early evidence of endothelial dysfunction at coronary branchpoints. Circulation 1990; 82: 1169–1173
   PubMed Web of Science ®Google Scholar
• Harrison D G, Armstrong M L, Freiman P C, Heistad D D. Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis. J Clin Invest 1987; 80: 1808–1811
   PubMed Web of Science ®Google Scholar
• Fish R D, Nabel E G, Selwyn A P, Ludmer P L, Mudge G H, Kirshenbaum J M, Schoen F J, Alexander R W, Ganz P. Responses of coronary arteries of cardiac transplant patients to acetylcholine. J Clin Invest 1988; 81: 21–31
   PubMed Web of Science ®Google Scholar
• Bostom A G, Cupples L A, Jenner J L, Ordovas J M, Seman L L, Wilson P WF, Schaefer E J, Castelli W P. Elevated plasma lipoprotein(a) and premature coronary heart disease in Framingham men: a prospective study. JAMA 1996; 276: 544–548
   PubMed Web of Science ®Google Scholar
• Assmann G., Schulte H., Eckardstein A V. Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men. Am J Cardiol 1996; 77: 1179–1184
   PubMed Web of Science ®Google Scholar
• Grainger D J, Kirschenlohr H L, Metcalfe J C, Weissberg P L, Wade D P, Lawn R M. Proliferation of human smooth muscle cells promoted by lipoprotein(a). Science 1993; 260: 1655–1658
   PubMed Web of Science ®Google Scholar
• Miles L A, Fless G M, Levin E G, Scanu A M, Plow E F. A potential basis for the thrombotic risks associated with lipoprotein(a). Nature 1989; 339: 301–302
   PubMed Web of Science ®Google Scholar
• Nachman R L. Thrombosis and atherogenesis: molecular connections. Blood 1992; 79: 1897–1906
   PubMed Web of Science ®Google Scholar
• Nandate H., Kawashima T., Yashiro A., Nakashima Y., Kuroiwa A. Atherosclerosis X., Montreal 1994; 83: 281
   Google Scholar
• Sorensen K E., Celermajer D S., Georgakopoulos D., Hatcher G., Betteridge D F., Deanfield J E. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J Clin Invest 1994; 93: 50–55
   PubMed Web of Science ®Google Scholar
• Lawn R M., Wade D P., Hammer R E., Chiesa G., Verstuyft J G., Rubin E M. Atherogenesis in transgenic mice expressing human apolipoprotein(a). Nature 1992; 360: 670–672
   PubMed Web of Science ®Google Scholar
• Hajjar K A, Gavish D., Breslow J L, Nachman R L. Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature 1989; 339: 303–305
   PubMed Web of Science ®Google Scholar
• Chiesa G., Hobbs H H, Koschinsky M L, Lawn R M, Maika S D, Hammer R E. Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a). Biol Chem 1992; 267: 24369–24374
   Web of Science ®Google Scholar
• Callow M. J., Verstuyft J., Tangirala R., Pulanski W., Rubin E M. Atherogenesis in transgenic mice with human apolipoprotein B and Lipoprotein(a). J Clin Invest 1995; 96: 1639–1646
   PubMed Web of Science ®Google Scholar
• Rubanyi G M., Freay A D., Kauser K., Sukovich D., Burton G., Lubahn D B., Couse J F., Curtis S W., Korach K S. Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. J Clin Invest 1997; 99: 2429–2437
   PubMed Web of Science ®Google Scholar
• Koschinsky M L., Tomlinson J E., Zioncheck T F., Schwartz K., Eaton D L., Lawn R M. Apolipoprotein(a): expression and characterization of a recombinant form of the protein in mammalian cells. Biochemistry 1991; 30: 5044–5051
   PubMed Web of Science ®Google Scholar
• Janero D R. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radie Biol Med 1990; 9: 515–540
   PubMed Web of Science ®Google Scholar
• Galle J., Bengen J., Schollmeyer P., Wanner C. Oxidized lipoprotein(a) inhibits endothelium-dependent dilation: prevention by high density lipoprotein. Eur J Pharmacology 1994; 265: 111–115
   PubMed Web of Science ®Google Scholar
• Galle J., Bengen J., Schollmeyer P., Wanner C. Impairment of endothelium-dependent dilation in rabbit renal arteries by oxidized lipoprotein(a), role of oxygen-derived radicals. Circulation 1995; 92: 1582–1589
   PubMed Web of Science ®Google Scholar
• Galle J., Mülsch A., Busse R., Bassenge E. Effects of native and oxidized low density lipoproteins on formation and inactivation of EDRF. Arterioscler Thromb 1991; 11: 198–203
   PubMedGoogle Scholar
• Drexler H., Zeiher A M. Endothelial function in human coronary arteries in vivo: focus on hypercholesterolemia. Hypertension 1991; 18: 90–99
   Web of Science ®Google Scholar
• Drexler H., Zeiher A M., Meinzer K., Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet 1991; 338: 1546–1550
   PubMed Web of Science ®Google Scholar
• Chin J. H., Azhar S., Hoffman B B. Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J. Clin Invest 1992; 89: 10–18
   PubMed Web of Science ®Google Scholar
• Plane F., Bruckdorfer K R, Kerr P., Steuer A., Jacobs M. Oxidative modifications of low-density lipoproteins and the inhibition of relaxations mediated by endothelium-derived nitric oxide in rabbit aorta. Br J Pharmacol 1992; 105: 216–222
   PubMed Web of Science ®Google Scholar
• Shimokawa H., Vanhoutte P M. Hypercholesterolemia causes generalized impairment of endothelium-dependent relaxation to aggregating platelets in porcine arteries. J. Am Coll Cardiol 1989; 13: 1402–1408
   PubMed Web of Science ®Google Scholar
• Simon B. C., Cunningham L. D., Cohen R. A. Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J Clin Invest 1990; 86: 75–79
   Google Scholar
• Yiä-Herttuala S., Palinski W., Rosenfeld M. E., Parthasarathy S., Carew T E., Butler S., Wizum J L., Steinberg D. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 1989; 84: 1086–1095
   PubMed Web of Science ®Google Scholar
• Vita J A, Treasure C B, Nabel E G, McLenachan J M, Fish R D, Yeung A C, Vekstein V I, Selwyn A P, Ganz P. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990; 81: 491–497
   PubMed Web of Science ®Google Scholar
• Lamping K G, Nuno D W, Chappell D A, Faraci F M. Agonist specific impairment of coronary vascular function in genetically altered, hyperlipidemic mice. Am J. Physiol 1999; 276: R1023–1029
   Google Scholar
• Bonthu S., Heistad D. D., Chappell D. A., Lamping K. G., Faraci F. M. Atherosclerosis, vascular remodeling and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice. Art. Thromb Vase Biol 1997; 17: 2333–2340
   PubMed Web of Science ®Google Scholar
• Naruszewicz M., Selinger E., Davignon J. Oxidative modification of lipoprotein(a) and the effect of β-carotene. Metabolism 1992; 41: 1215–1224
   PubMed Web of Science ®Google Scholar
• Hansen P R, Kharazmi A., Jauhiainen M., Ehnholm C. Induction of oxygen free radical generation in human monocytes by lipoprotein(a). Eur J Clin Invest 1994; 24: 497–499
   PubMed Web of Science ®Google Scholar
• Tsurumi Y., Nagashima H., Ichikawa K., Sumiyoshi T., Hosoda S. Influence of plasma lipoprotein(a) levels on coronary vasomotor response to acetylcholine. J Am Coll Cardiol 1995; 26: 1242–1250
   PubMed Web of Science ®Google Scholar