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Endothelium
Journal of Endothelial Cell Research
Volume 7, 2000 - Issue 4
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Original Article

Regulation of Endothelial Barrier Function by the cAMP-Dependent Protein Kinase

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Pages 287-308 | Received 13 Aug 1999, Accepted 26 Feb 2000, Published online: 13 Jul 2009

References

  • Ades E. W., Candal F. J., Swerlick R. A., George V. G., Summers S., Bosse D. C., Lawley T. J. HMEC-1 - Establishment of an immortalized human microvascular endothelial cell line. Journal of Investigative. Dermatology 1992; 99: 683–690
  • Alexander J. S., Blaschuk O. W., Haselton F. R. A N-eadherin-like protein contributes to solute barrier maintenance in cultured endothelium. Journal of Cellular Physiology 1993; 156: 610–618
  • Alexander J., Hechtmun H., Shepro D. Phalloidin enhances endothelial barrier function and reduces inflammatory permeability in vivo. Microvascular Research 1988; 35: 308–331
  • Amano M., Chihara K., Kimura K., Fukata Y., Nakamura N., Matsuura Y., Kaibuchi K. Formation of stress fibers and focal adhesions enhanced by Rho-kinase. Science 1997; 275: 1308–1311
  • Amano M., Ito M., Kimura K., Fukata Y., Chihara K., Nakano T., Matsuura Y., Kaibuchi K. Phosphorylation and PKA activation of myosin by Rho-associated kinasc. Journal of Biological Chemistry 1996; 271: 20246–20249
  • Arimura S., Nakata H., Tomiyama K., Watanabe Y. Phosphorylation of H-ras protiens by protein kinase A. Cell Signalling 1997; 9: 37–40
  • Burridge K. G., Nuckolls C., Otey C., Pavalko F., Simon K., Turner C. Actin-membrane interaction in focal adhesions. Cell Differentiation and Development 1990; 32: 337–342
  • Chrzanowska-Wodnicka M., Burridge K. Rho-stimulated conractility drives the formation of stress-fibers and focal adhesions. Journal of Cell Biology 1996; 133: 1403–1415
  • Cohen P., Hardie D. G. The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase. Biochimica Biophysics Acta 1991; 1094: 292–299
  • Day R. N., Walder J. A., Maurer R. A. A protein kinase inhibitor gene reduces both basal and multihormone-stimulated prolactin gene transcription. Journal of Biological Chemistry 1989; 264: 431–436
  • Farrukh I. S., Gurtner G. H., Michael J. R. Pharmacological modification of pulmonary vascular injury: Possible role of c AMP. Journal of Applied Physiology 1987; 62: 47–54
  • Flinn H. M., Ridley A. J. Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130, and paxillin. Journal of Cell Science 1996; 109: 1133–1141
  • Garcia J. G.N., Davis H., Patterson C E. Regulation of endothelial cell contraction and barrier dysfunction: Role of myosin light chain phosphorylation. Journal of Cellular Physiology 1995a; 163: 510–522
  • Garcia J. G.N., Patterson C. E., Bahler C., Dukes R., Aschner J., English D. Thrombin receptor activating peptides induce Ca2+ mobilization, barrier dysfunction, prostaglandin synthesis, and PDGF mRNA expression in cultured endothelium. Journal of Cellular Physiology 1993; 156: 541–549
  • Garcia J. G.N., Pavalko F. M., Patterson C. E. Vascular endothelial cell and permeability responses to thrombin. Blood Coagulation and Fibrinolysis 1995b; 6: 609–626
  • Garcia J. G.N., Schaphorst K. L., Shi S., Verin A. D., Hart C. M., Callahan K. S., Patterson C. E. Mechanisms of ionomycin-induced endothelial cell barrier dysfunction. American Journal of Physiology: Lung Cellular Molecular Physiology 1997; 273: L112–L184
  • Gotheb A. I., Langille B. L., Wong M. K., Kim D. W. Biology of Disease: Structure and function of the endothelial cytoskeleton. Laboratory Investigation 1991; 65: 123–137
  • Graham F. L., Smiley J., Russell W., Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. Journal of General Virology 1977; 36: 59–74
  • Hormia M., Bradley R. A., Lehto V., Virtanen I. Actomyosin organization in stationary and migrating sheets of cultured endothelial cells. Experimental Cell Research 1987; 157: 116–126
  • Kobayashi J. J., Kobayashi T., Fukushima M. Effects of dibutyryl cAMP on pulmonary air embolism-induced lung injury in awake sheep. Journal of Applied Physiology 1987; 63: 2201–2207
  • Koga S., Morris S., Liao H., Bilezikian J. P., Chen G., Thompson W. J., Ashikaga T., Brett J., Stern D. M., Pinsky D. J. TNF modulates endothelial properties by decreasing cAMP. American Journal of Physiology 1995; 268: C1104–C1113
  • Lampugnani M. G., Corada M., Andriopoulou P., Esser S., Risau W., Dejana E. Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. Journal of Cell Science 1997; 110: 2065–2077
  • Lampugnani M. G., Corada M., Caveda L., Breviario F., Ayalon O., Geiger B., Dejana E. Molecular organization of endothelial cell to cell junctions. Journal of Cell Biology 1995; 129: 203–217
  • Lampugnani M. G., Giorgi M., Gaboli M., Dejana E., Marchisio P. C. Endothelial cell motility, integrin receptor clustering, and microfilament organization are inhibited by agents that increase intracellular cAMP. Laboratory Investigation 1990; 63: 521–531
  • Lampugnani M. G., Resnali M., Dejana E., Marchisio P. C. The role of integrins in the maintenance of endothelial monolayer integrity. Journal of Cell Biology 1991; 112: 479–490
  • Lampugnani M. G., Resanti M., Raiteri M., Pigott R., Piscane A., Houen G., Ruco L. P., Dejana E. A novel endothelial-specific membrane protein is a marker of cell-cell contacts. Journal of Cell Biology 1992; 118: 1511–1522
  • Lim L., Manser E., Leung T., Hall C. Regulation of phosphorylation pathways by p21 GTPases. Review European. Journal of Biochemistry 1996; 242: 171–185
  • Lincoln T. M., Cornwell T. L. Toward and understanding of the mechanisms of cyclic AMP and cyclic GMP in smooth muscle relaxation. Blood Vessels 1993; 28: 129–137
  • Lum H., Aschner J. L., Philips P. G., Fletcher P. W., Malik A. B. Time-course of thrombin-induced increase in endothelial permeability: relationship to Ca2+1 and inositol phosphates. American Journal of Physiology: Lung Cellular Molecular Physiology 1992; 263: L219–L225
  • Lum H., Jaffe H. A., Schultz I. T., Masood A., Raychaudhury A., Green R. D. Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction. American Journal of Physiology: Cell Physiology 1999; 111: C580–C588
  • Manolopoulos V. G., Fenton J. W., Lelkes P. I. The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein. Biochimica Biophysics Acta 1997; 1356: 321–332
  • McDaniel N. L., Rembold C., Richard H., Murphy R. Cyclic AMP relaxes swine arterial smooth muscle predominantly by decreasing cell calcium concentration. Journal of Physiology 1991; 439: 147–160
  • Moy A. B., Shasby S. S., Scott B. D., Shasby D. M. The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells. Journal of Clinical Investigation 1993; 92: 1198–1206
  • Nishikawa M., Delanerolle P., Lincoln T., Adelstein R. S. Phosphorylation of mammalian myosin light chain kinase by the catalytic subunit of cyclic AMP-dependent protein kinase and by cGMP-dependent protein kinase. Journal of Biological Chemistry 1984; 259: 8429–8436
  • Ogawa S., Koga S., Kuwabara K., Brett J., Morrow B., Morris S. A., Bilezikian J. P., Silverstein S. P., Stern D. Hypoxia-induced increased permeaiblity of endothelial mon-olayers occurs through lowering of cellular cAMP levels. American Journal of Physiology 1992; 262: C546–C554
  • Patterson C. E., Davis H. W., Schaphorst K. L., Garcia J. G.N. Mechanisms of cholera toxin prevention of thrombin-and PMA-induced endothelial cell barrier dysfunction. Micro-vascular Research 1994a; 48: 212–235
  • Patterson C. E., Garcia J. G.N. Regulation of thrombin-induced endothelial cell activation by bacterial toxins. Blood Coagulation and Fibhnolysis 1994b; 5: 63–72
  • Patterson C. E., Rhoades R. A., Garcia J. G.N. Evans blue dye as a marker of albumin clearance in cultured endotheliai monolayer and isolated lung. Journal of Applied Physiology 1992; 72: 865–873
  • Patterson C. E., Stasek J. E., Schaphorst K. L., Davis H. W., Garcia J. G.N. Mechanisms of pertussis toxin-induced permeability in endothelial cell monolayers. American Journal of Physiology: Lung Cellular Molecular Physiology 1995; 268: L926–L934
  • Rabiet M. J., Plantier J., Rival Y., Genoux Y., Lampugnani M., Dejana H. Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organization. Arteriosclerosis, Thrombosis and Vascular Biology 1996; 16: 488–496
  • Rassmusen H., Rassmussen J. Calcium as intracellular messenger: from simplicity to complexity. Current Topics in Cell Regulation 1990; 31: 1–109
  • Schaphorst K. L., Patterson C. E., Garcia J. G.N. The role of adherens junctions in endothelial cell barrier function. J. Cell Biochem 1999, In press
  • Schaphorst K., Pavalko F., Patterson C. E., Garcia J. G.N. Thrombin-mediated focal adhesion plaque reorganization in endothelium. American Journal of Respiratory and Cell Molecular Biology 1997; 17: 443–455
  • Sehnittler A., Wilke A., Gress T., Suttorp N., Drenckhahn D. Role of actin and myosin in the control of paracellular permeability in pig, rat, and human vascular endothelium. Journal of Physiology, Great Britain 1990; 431: 379–401
  • Schulze C., Smales C., Rubinm L. L., Staddon J. M. Lysophosphulidic acid increases tight junction permeability in cultured brain endothelial cells. Journal of Neurochcmistry 1997; 68: 991–1000
  • Shasby D. M., Shasby S. S. Effects of calcium on transendothelial albumin transfer and electrical resistance. Journal of Applied Physiology 1986; 60: 71–79
  • Shasby D., Shasby S., Sullivan J., Peach M. The role of endolhelial cytoskeleton in the control of endolhelial permeability. Circulation Research 1992; 51: 657–661
  • Sheldon R., Moy A., Lindsley K., Shasby S., Shasby D. M. Role of niyosin light chain phosphorylation in endothelial cell retraction. American Journal of Physiology: Lang Cellular Molecular Physiology 1993; 265: L606–L612
  • Stasek J., Patterson C. E., Garcia J. G.N. PKC phosphorylates caldesmon77/vimentin & enhances albumin permeability of BPAEC monolayers. Journal of Cellular Physiology 1992; 153: 62–75
  • Slelzner T., Weil J., O'Brien R. Role of cyclic adenosine monophosphate in induction of endothelial barrier proper-lies. Journal of Cellular Physiology 1989; 139: 157–166
  • Stevens T., Nakahashim Y., Cornfield D., McMurtry I., Cooper D., Rodman D. Ca2+-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function. Proceedings of the National Academy of Sciences USA 1995; 92: 2696–2700
  • Stull J. T., Hsu L., Tansey M. G., Kamm K. E. Myosin light chain kinase phosphorylation in tracheal smooth muscle. J. Biol. Chcm 1990; 265: 16683–16690
  • Suttorp N., Weber U., Welsch T., Schudt C. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. Journal of Clinical Investigation 1993; 91: 1421–1428
  • Takcichi M. Cadherin. Annual Review of Biochemistry 1990; 59: 237–252
  • Takaishi K., Sakaki T., Kotani H., Takai Y. Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells. Journal of Cell Biology 1997; 139: 1047–1059
  • Tigyi G., Fischer D. J., Sebokm A., Marshall M., Dyer D. L., Miledi R. Lysophjosphatidic acid-induced neurile retraction in PC 12 cells: neurite-protective effects of c AMP signaling. Journal of Neiirocheinistry 1996; 66: 549–558
  • Tiruppathi C., Malik A. B., Del Vecchio P. J., Keese C. R., Giaever I. Electrical method for detection of endothelial cell shape change in real time: Assessment of endothelial barrier function. Proceedings of the National Academy of Sciences USA 1992; 89: 7919–7923
  • Verin A. D., Cooke C., Herenyiova M., Patterson C. E., Garcia J. G.N. Role of Ca2+/calmodulin-dependenl phosphatase 2B in thrombin-induced endothelial cell contractile responses. American Journal of Physiology: Lung Cellular Molecular Physiology 1998a; 275: L788–L799
  • Verin A. D., McClain L., Patterson C. E., Garcia J. G.N. Biochemical regulation of the non-muscle niyosin light chain kinase isolorm in bovine endothelium. American Journal of Respiratory and Cell Molecular Biology 1998b; 19: 767–776
  • Volberg T., Zick Y., Dror R., Sabanay I., Gilan C., Levinski A., Geiger B. The effect of tyrosine-specific protein phosphorylation in the assembly of adherens type junctions. EMBO Journal 1992; 11: 1733–172
  • Wong M. K., Gotlieb A. I. Endothelial cell monolayer integrity: characterization of the dense peripheral band. Arteriosclerosis 1986; 6: 212–219
  • Wong M. K., Gotlieb A. I. Endothelial monlayer integrity: Perturbation of F-aetin filaments and the dense peripheral band-vinculin network. Arteriosclerosis 1990; 10: 76–84
  • Wyslomerski R. B., Lagunoff D. Involvement of myosin light chain kinase in endothelial cell retraction. Proceedings of the National Academy of Sciences USA 1990; 87: 16–20
  • Zar J. H. Biostatistical Analysis 2nd ed. Prentice Hall, Englewood Cliffs, NJ 1980

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