Publication Cover
Endothelium
Journal of Endothelial Cell Research
Volume 1, 1993 - Issue 3
2
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Hypoxia Inhibits Tissue-Type Plasminogen Activator Production in Cultured Human Endothelial Cells: Role of Oxygen Radicals

, , , , &
Pages 173-178 | Published online: 13 Jul 2009

References

  • Amiral J., Plassart V., Grosley M., Mimilla F., Contant G., Guyader A. M. Measurement of tPA-PAI. 1 complexes by ELISA using monoclonal antibodies: Clinical relevance. Thrombosis Research 1988; 99–113, suppl. VIII
  • Bach R. G., Arden M. E., Recht P. A., Levin R. I. Hypoxia modulates endothelial cell fibrinolytic potential. Circulation. 1988; 78: 11–183
  • Barnathan E. S., Kuo A., Vanderkeyl H., McCrae K. R., Larsen G. R., Cines D. B. Tissue type plasminogen activator binding to human endothelial cells. Evidence for two distinct binding sites. Journal of Biological Chemistry 1988; 263: 7792–7799
  • Declerck P. J., Alessi M. C., Verstreken M., Kruithof E. K. O., Juhan-Vague I., Collen D. Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay. Blood 1988; 71: 220–225
  • Ehrlich H. J., Gebbink R. K., Preissner K. T., Keijer J., Esmon N. L., Mertens K., Pannekoek H. Thrombin neutralizes plasminogen activator inhibitor-1 (PAI-1) that is com-plexed with vitronectin in the endothelial cell matrix. Journal of Cell Biology 1991; 115: 1773–1781
  • Erickson L. A., Schleef R. R., Ny T., Loskutoff D. J. The fibrinolytic system of the vascular wall. Clinical Haema-tology 1985; 14: 513–530
  • Van Hinsbergh V. W. M. Regulation of the synthesis and secretion of plasminogen activators by endothelial cells. Haemostasis 1988; 18: 307–327
  • Kluft C., Jie A. F. H. Comparison of specificities of antigen assays for plasminogen activator inhibitor PA1–1. Fibrinolysis 1990; 4: 136–137, suppl. 2
  • Markey B. A., Phan SH., Varani J., Ryan U. S., Ward P. A. Inhibition of cytotoxicity by intracellular superoxide dismutase supplementation. Free Radical Biology and Medicine 1990; 9: 307–314
  • Mc Cord J. M. Oxygen-derived radicals: A link between reperfusion injury and inflammation. Federation Proceedings 1987; 46: 2402–2406
  • Palluy O., Bonne C., Modat G. Hypoxia/reoxygenation alters endothelial prostacyclin synthesis. Protection by superoxide dismutase. Free Radical Biology and Medicine 1991; 11: 269–275
  • Palluy O., Morlière L., Gris J. C., Bonne C., Modat G. Hypoxia/reoxygenation stimulates endothelium to promote neutrophil adhesion. Free Radical Biology and Medicine 1992; 13: 21–30
  • Park Y., Kehrer J. P. Oxidative changes in hypoxic-reoxygenated rabbit heart: A consequence of hypoxia rather than reoxygenation. Free Radical Research Communications 1991; 14: 179–185
  • Pietri S., Culeazi M., Cozzone P. J. Real-time continuous-flow spin trapping of hydroxyl free radical in the ischemic and post-ischemic myocardium. European Journal of Biochemistry 1989; 186: 163–173
  • Preissner K. T., Jenne D. Structure of vitronectin and its biological role in haemostasis. Thrombosis and Haemostasis 1991; 66: 123–132
  • Ranby M., Bergsdorf N., Nilsson T., Mellbring G., Winblad B., Bucht G. Age dependence of tissue plasminogen activator concentration in plasma as studied by an improved enzyme-linked immunosorbent assay. Clinical Chemistry 1986; 32: 2160–2165
  • Ranby M., Nguyen G., Scarabin P. Y., Samama M. Immunoreactivity of tissue plasminogen activator and its inhibitor complexes. Biochemical and multicenter validation of a two site immunosorbent assay. Thrombosis Haemostasis 1989; 61: 409–414
  • Schleef R. R., Loskutoff D. J., Podor T. J. Immunoelectron microscopic localization of type-1 plasminogen activator inhibitor on the surface of activated endothelial cells. Journal of Cell Biology 1991; 113: 1413–1423
  • Shatos M. A., Doherty J. M., Stump DC., Thompson E. A., Collen D. Oxygen radicals generated during anoxia followed by reoxygenation reduce the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in human endothelial cell culture. Journal of Biological Chemistry 1990; 265: 20443–20448
  • Shatos M. A., Doherty J. M., Orfeo T., Hoak JC., Collen D., Stump D. C. Modulation of the fibrinolytic response of cultured human vascular endothelium by extracellularly generated oxygen radicals. Journal of Biological Chemistry 1992; 267: 597–601
  • Terada L. S., Guidot D. M., Leff J. A., Willingham I. R., Hanley M. E., Piermattei D., Repine J. E. Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity. Proceedings of the National Academy of Sciences of the United States of America 1992; 89: 3362–3366
  • Wojta J., Jones R. L., Binder B. R., Hoover RL. Reduction in pO2 decreases the fibrinolytic potential of cultured bovine endothelial cells derived from pulmonary arteries and lung microvasculature. Blood 1988; 71: 1703–1706

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.