177
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Differences in the Association between Maternal Serum Homocysteine and ADMA Levels in Women with Pregnancies Complicated by Preeclampsia and/or Intrauterine Growth Restriction

, MD, PhD, , MD & , MD, PhD
Pages 83-93 | Published online: 28 Dec 2012

REFERENCES

  • Winn VD, Gormley M, Paquet AC, . Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology 2009; 150(1):452–462.
  • Best LG, Nadeau M, Bercier S, . Genetic variants, endothelial function, and risk of preeclampsia among American Indians. Hypertens Pregnancy 2012; 31:1–10.
  • Mandruzzato G, Antsaklis A, Botet F, . Intrauterine restriction (IUGR). J Perinat Med 2008; 36:277–281.
  • Froen JF, Gardosi JO, Thurmann A, Francis A, Stray-Pedersen B. Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand 2004; 83:801–807.
  • Richardus JH, Graafmans WC, Verloove-Vanhorick SP, Mackenbach JP. Differences in perinatal mortality and suboptimal care between 10 European regions: Results of an international audit. Br J Obstet Gynaecol 2003; 110:97–105.
  • Faber VJ, Klumper FJ, Scherjon S, van Wijngaarden WJ. Severe pre-eclampsia and HELLP syndrome after massive fetomaternal hemorrhage following blunt abdominal trauma. Pregnancy Hypertens Int J Womens Cardiovas Health 2011; 1:197–199.
  • Akar F, Ark M, Uydeş BS, . Nitric oxide production by human umbilical vessels in severe pre-eclampsia. J Hypertens 1994; 12(11):1235–1241.
  • Vatish M, Randeva HS, Grammatopoulos DK. Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia. Trends Mol Med 2006; 12(5):223–233.
  • Mao D, Che J, Li K, . Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia. Arch Gynecol Obstet 2010; 282(4):371–375.
  • Lentz SR. Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost 2005; 3(8):1646–1654.
  • Hague WM. Homocysteine and pregnancy. Best Pract Res Clin Obstet Gynaecol 2003; 17(3):459–469.
  • Aubard Y, Darodes N, Cantaloube M. Hyperhomocysteinemia and pregnancy – review of our present understanding and therapeutic implications. Eur J Obstet Gynecol Reprod Biol 2000; 93(2):157–165.
  • Aubard Y, Darodes N, Cantaloube M, Aubard V, Diallo D, Teissier MP. Hyperhomocysteinemia and pregnancy: A dangerous association. J Gynecol Obstet Biol Reprod 2000; 29(4):363–372.
  • Budde MP, De Lange TE, Dekker GA, Chan A, Nguyen AM. Risk factors for placental abruption in a socio-economically disadvantaged region. J Matern Fetal Neonatal Med 2007; 20(9):687–693.
  • Ray JG, Laskin CA. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review. Placenta 1999; 20(7):519–529.
  • Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: A meta-analysis of published epidemiological studies. J Thromb Haemost 2005; 3(2):292–299.
  • Rodionov RN, Dayoub H, Lynch CM, . Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circ Res 2010; 106(3):551–558.
  • Kulkarni A, Mehendale S, Pisal H, . Association of omega-3 fatty acids and homocysteine concentrations in pre-eclampsia. Clin Nutr 2011; 30(1):60–64.
  • Dayal S, Rodionov RN, Arning E, . Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol 2008; 295(2):H816–H825.
  • Schwedhelm E, Maas R, Tan-Andresen J, Schulze F, Riederer U, Böger RH. High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 851(1–2):211–219.
  • Lubos E, Loscalzo J, Handy DE. Homocysteine and glutathione peroxidase-1. Antioxid Redox Signal 2007; 9(11):1923–1940.
  • Alkhoury K, Parkin SM, Homer-Vanniasinkam S, Graham AM. Chronic homocysteine exposure upregulates endothelial adhesion molecules and mediates leukocyte: Endothelial cell interactions under flow conditions. Eur J Vasc Endovasc Surg 2011; 41(3):429–435.
  • Siroen MPC, Teerlink T, Bolte AC, . No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia. Gynecol Obstet Invest 2006; 62:7–13.
  • Siroen MP, Teerlink T, Nijveldt RJ, Prins HA, Richir MC, van Leeuwen PA. The clinical significance of asymmetric dimethylarginine. Annu Rev Nutr 2006; 26:203–228.
  • Roberts JM, Redman CW. 1993. Pre-eclampsia: More than pregnancy-induced hypertension. Lancet 1993; 341:1447–1451.
  • Buhimschi IA, Saade GR, Chwalisz K, Garfield RE. The nitric oxide pathway in pre-eclampsia: Pathophysiological implications. Hum Reprod Update 1998; 4(1):25–42.
  • Myatt L, Eis AL, Brockman DE, Greer IA, Lyall F. Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies. Hum Reprod 1997; 12(1):167–172.
  • Kim YJ, Park HS, Lee HY, . Reduced L-arginine level and decreased placental eNOS activity in preeclampsia. Placenta 2006; 27(4–5):438–444.
  • McCormick ME, Goel R, Fulton D, Oess S, Newman D, Tzima E. Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression. Arterioscler Thromb Vasc Biol 2011; 31(3):643–649.
  • Pope AJ, Karrupiah K, Kearns PN, Xia Y, Cardounel AJ. Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production. J Biol Chem 2009; 284(51):35338–35347.
  • Fiedler LR, Bachetti T, Leiper J, . The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis. Arterioscler Thromb Vasc Biol 2009; 29(12):2117–2124.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.