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Hypertension in Pregnancy Volume 34, 2015 - Issue 4
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Original Articles

The Frequency of Peripheral Blood CD4+FoxP3+ Regulatory T Cells in Women With Pre-eclampsia and Those With High-risk Factors for Pre-eclampsia

Shiho NagayamaDepartment of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan,
,
Akihide OhkuchiDepartment of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan, Correspondence[email protected]
,
Koumei ShirasunaDivision of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan, ;Laboratory of Animal Reproduction, Department of Agriculture, Tokyo University of Agriculture, Atsugi, Kanagawa, Japan, and
,
Kayo TakahashiDepartment of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan,
,
Hirotada SuzukiDepartment of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan,
,
Chikako HirashimaDepartment of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan,
,
Asuka SakataDivision of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
,
Satoshi NishimuraDivision of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
,
Masafumi TakahashiDivision of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan,
&
Shigeki MatsubaraDepartment of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan,
show all
Pages 443-455 | Received 30 Mar 2015, Accepted 21 Jun 2015, Published online: 11 Sep 2015

REFERENCES

  • Hsu P, Nanan RK. Innate and adaptive immune interactions at the fetal-maternal interface in healthy human pregnancy and pre-eclampsia. Front Immunol 2014;5:125
  • Nagaya K, Fetters MD, Ishikawa M, et al. Causes of maternal mortality in Japan. JAMA 2000;283:2661–7
  • Yamauchi A, Minakami H, Ohkuchi A, et al. Causes of stillbirth: an analysis of 77 cases. J Obstet Gynaecol Res 1999;25:419–24
  • Roberts JM, Taylor RN, Musci TJ, et al. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989;161:1200–4
  • Tsukimori K, Maeda H, Shingu M, et al. The possible role of endothelial cells in hypertensive disorders during pregnancy. Obstet Gynecol 1992;80:229–33
  • Lau SY, Guild SJ, Barrett CJ, et al. Tumor necrosis factor-alpha, interleukin-6, and interleukin-10 levels are altered in preeclampsia: a systematic review and meta-analysis. Am J Reprod Immunol 2013;70:412–27
  • Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010;63:601–10
  • Paeschke S, Chen F, Horn N, et al. Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood. Am J Reprod Immunol 2005;54:384–9
  • Sasaki Y, Darmochwal-Kolarz D, Suzuki D, et al. Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia. Clin Exp Immunol 2007;149:139–45
  • Hu D, Chen Y, Zhang W, et al. Alteration of peripheral CD4+CD25+ regulatory T lymphocytes in pregnancy and pre-eclampsia. Acta Obstet Gynecol Scand 2008;87:190–4
  • Steinborn A, Haensch GM, Mahnke K, et al. Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia? Clin Immunol 2008;129:401–12
  • Toldi G, Svec P, Vásárhelyi B, et al. Decreased number of FoxP3+ regulatory T cells in preeclampsia. Acta Obstet Gynecol Scand 2008;87:1229–33
  • Prins JR, Boelens HM, Heimweg J, et al. Preeclampsia is associated with lower percentages of regulatory T cells in maternal blood. Hypertens Pregnancy 2009;28:300–11
  • Santner-Nanan B, Peek MJ, Khanam R, et al. Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J Immunol 2009;183:7023–30
  • Toldi G, Rigó J Jr, Stenczer B, et al. Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia. Am J Reprod Immunol 2011;66:223–9
  • Steinborn A, Schmitt E, Kisielewicz A, et al. Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs. Clin Exp Immunol 2012;167:84–98
  • Darmochwal-Kolarz D, Kludka-Sternik M, Tabarkiewicz J, et al. The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia. J Reprod Immunol 2012;93:75–81
  • Toldi G, Saito S, Shima T, et al. The frequency of peripheral blood CD4+ CD25high FoxP3+ and CD4+ CD25-FoxP3+ regulatory T cells in normal pregnancy and pre-eclampsia. Am J Reprod Immunol 2012;68:175–80
  • Hsu P, Santner-Nanan B, Dahlstrom JE, et al. Altered decidual DC-SIGN+ antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia. Am J Pathol 2012;181:2149–60
  • Zeng B, Kwak-Kim J, Liu Y, Liao AH. Treg cells are negatively correlated with increased memory B cells in pre-eclampsia while maintaining suppressive function on autologous B-cell proliferation. Am J Reprod Immunol 2013;70:454–63
  • Takahashi K, Ohkuchi A, Suzuki H, et al. Biophysical interaction between blood pressure and uterine artery Doppler for the occurrence of early-onset preeclampsia: a prospective cohort study. Pregnancy Hypertens 2013;3:270–7
  • Hirashima C, Ohkuchi A, Takahashi K, et al. A novel three-step approach for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation. Hypertens Res 2014;37:519–25
  • Takahashi K, Ohkuchi A, Hirashima C, et al. Establishing reference values for mean notch depth index, pulsatility index and resistance index in the uterine artery at 16-23 weeks' gestation. J Obstet Gynaecol Res 2012;38:1275–85
  • Watanabe K, Naruse K, Tanaka K, et al. Outline of definition and classification of “Pregnancy induced Hypertension (PIH)”. Hypertens Res Pregnancy 2013;1:3–4
  • Brown MA, Mangos G, Davis G, Homer C. The natural history of white coat hypertension during pregnancy. BJOG 2005;112:601–6
  • Minakami H, Maeda T, Fujii T, et al. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition. J Obstet Gynaecol Res 2014;40:1469–99

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