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Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy Volume 2, 1983 - Issue 1
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Original Article

Disposition of the Adrenergic Blocker Metoprolol in the Late Pregnant Women, the Amniotic Fluid, the Cord Blood and the Neonate

B. Sandström Department of Gynaecology and Obstetrics, Hospital of Orebro and Hassle Reseach Laboratories, Sweden
,
S. Lindeberg Department of Gynaecology and Obstetrics, Hospital of Orebro and Hassle Reseach Laboratories, Sweden
,
P. Lundborg And Department of Gynaecology and Obstetrics, Hospital of Orebro and Hassle Reseach Laboratories, Sweden
&
C-G. Regårdh Department of Gynaecology and Obstetrics, Hospital of Orebro and Hassle Reseach Laboratories, Sweden
Pages 75-82 | Published online: 07 Jul 2009

References

  • Alvan G., von Bahr C, Seideman P., Sjöqvist F. High plasma concentrations of beta-receptor blocking drugs and deficient debrisoquine hydroxylation. Lancet, Febr. 1982; 6: 333
  • Bauer J. H., Pape B., Zajicek J., Groshong T. Propranolol in human plasma and breast milk. Am. J. Cardiol. 1979; 43: 860
  • Bianchetti G., Dubruc C, Vert P., Boutroy M. J., Morselli P. L. Placental transfer and pharmacokinetics of acebutolol in newborn infants. Clin. Pharm. Ther. 1981; 29: 233
  • Cottrill G. M., McAllister R. G., Jr, Gettes L., Noonan J. A. Propranolol therapy during pregnancy, labor and delivery: Evidence for transplacental drug transfer and impaired neonatal drug dispostion. Pediatrics. 1977; 91: 812
  • Ervik M. Quantitative determination of metoprolol in plasma and urine by gas chromatography. Acta Pharm. Tox. 1975; 36: 136
  • Liedholm H., Melander A., Bitzen P.-O., Helm G., Lonnerholm G., Mattiasson J., Nilsson B., Wahlin-Boll E. Accumulation of atenolol and metoprolol in human breast milk. Eur. J. Clin. Pharm. 1981; 20: 229
  • Lundborg P., Agren G., Ervik M., Lindeberg S., Sandström B. Disposition of metoprolol in the newborn. Br. J. Clin. Pharm. 1981; 12: 599
  • Melander A., Niklasson B., Ingemarsson J., Liedholm H., Schersten B., Sjoberg N.-O. Transplacental passage of atenolol in man. Eur. J. Clin. Pharm. 1978; 14: 93
  • Sandström B. Antihypertensive treatment with the adrenergic beta-receptor blocker, metoprolol, during pregnancy. Gynec. Obstet. Invest. 1978; 9: 195
  • Sandström B., Regårdh C.-G. Metoprolol excretion into breast milk. Br. J. Clin. Pharm. 1980; 9: 518
  • Sandström B. Adrenergic beta-receptor blockers in hypertension of pregnancy. Clin. Exp. Hypertension. 1982; B1(1)127

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