Differential Inhibition of Vascular Prostacyclin and Platelet Thromboxane Synthesis by Different Doses Aspirin and by the Thromboxane Inhibitor Ridogrel (R 68070)

References

• Beaufils M., Uzan S., Donsimoni R., Colan J. C. “Prevention of preeclampsia by early antiplatelet therapy,”. Lancet 1985; 1(840)
   PubMedGoogle Scholar
• Benigni A., Gregorini G., Frusca T., Chiabrando C., Ballerini S., Valcamonico A., Orisio S., Picinelli A., Pinciroli V., Fanelli R., Castaldi A., Remuzzi G. “Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension,”. N. Engl. J. 1989; 321: 357
   PubMed Web of Science ®Google Scholar
• Deckmyn H., Van Houtte E., Verstraete M., Vermylen J. “Manipulation of the local thromboxane and prostacyclin balance in vivo by the antithrombotic compounds dazoxiben, acetylsalicylic acid and nafazatrom,”. Biochem. Pharmacol. 1983; 32: 2757
   PubMedGoogle Scholar
• De Clerck F., Beetens J., de Chaffoy de Courcelles P., Freyne E., Janssen P. “R68070 : Thromboxane A2 Synthetase Inhibition and Thromboxane A2/Prostaglandin Endoperoxide Receptor Blockade Combined in one Molecule,” 1. Biochemical Profile in Vitro. Thrombosis and Haemostasis 1989; 61: 35
   PubMedGoogle Scholar
• Hanley S. P., Cockbill S. R., Bevan J. Heptinstall, “Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis,”. Lancet 1981; i(969)
   Google Scholar
• Harris P. A., Riegelman S. “Influence of the route ofadministration on the area under the plasma concentrationcurve,”. J. Pharm. Sci. 1969; 58: 71
   PubMed Web of Science ®Google Scholar
• Kalmann R., Nieuwenhuis H. K., de Groot Ph., Van Gijn J., Siama J. J. “Effects of low doses of aspirin, 10 mg and 30 mg daily, on bleeding time, thromboxane production and 6-keto-PGFi a excretion in healthy subjects,”. Thromb. Res. 1987; 45: 355
   PubMedGoogle Scholar
• Keith G. C., Miller K., Eggleston M. K., Kutruff J., Howerton T., Konczal C., McDaniels C. “Effects of thromboxane synthetase inhibition on maternal-fetal homeostasis in gravid ewes with ovine pregnancy-induced hypertension,”. Am. J. Obstet. Gynecol. 1989; 161: 1305
   PubMed Web of Science ®Google Scholar
• Ligumsky M., Golanska E. M., Hansen P. G., Kaufman G. L., Jr. “Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat,”. Gastroenterology 1983; 84(4)756
   PubMedGoogle Scholar
• Myatt L. Eicosanoids and blood pressure regulation. Hypertension in pregnancy, F. Sharp, E. M. Symonds. Perinatology Press, Ithaca, New York 1987; 169
   Google Scholar
• Patrignani P., Filabozzi P., Patrono C. “Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects,”. J. Clin. Invest. 1982; 69: 1366
   PubMed Web of Science ®Google Scholar
• Pedersen A. K., Fitzgerald G. A. “Dose-related kinetics of aspirin. Presystemic Acetylation of Platelet Cyclo-oxygenase,”. N. Engl. J. Med. 1984; 311: 1206
   PubMed Web of Science ®Google Scholar
• Preston F. E., Whipps S., Jackson C. A., French A. J., Wyld P. J., Stoddard C. J. “Inhibition of prostacyclin and platelet thromboxane A2 after low-dose aspirin,”. N. Engl. J. Med. 1988; 304: 76
   Google Scholar
• Sibai B. M., Mirro R., Chesney C., Leffler C. “Low-Dose Aspirin in Pregnancy,”. Obstet. Gynecol. 1988; 74: 551
   Google Scholar
• Schiff E., Peley E., Goldenberg M., Rosenthal T., Ruppin E., Tamarkin M., Barkai G., Ben-Baruch G., Yahal I., Blankstein J., Goldman B., Mashiach S. “The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies,”. N. Engl. J. Med. 1989; 321: 351
   PubMed Web of Science ®Google Scholar
• Spitz B. “Prostacyclin-thromboxane A₂ in normal and hypertensive pregnancy,”. Doctoral thesis, Catholic University, LeuvenBelgium 1988
   Google Scholar
• Spitz B., Magness R., Cox S., Brown C., Rosenfeld C., Gant N. “Low-dose aspirin. Effect on angiotensin II pressor responses and blood prostaglandin concentrations in pregnant women sensitive to angiotensin II,”. Am. J. Obstet. Gynecol. 1988; 159: 1035
   PubMed Web of Science ®Google Scholar
• Toivanen J., Ylikorkala O., Viinikka L. “One milligramme of acetylsalicylic acid daily inhibits platelet thromboxane A2 production,”. Thromb. Res. 1984; 35: 681
   PubMed Web of Science ®Google Scholar
• Trudinger B. J., Cook C. M., Thompson R. S., Giles W. B., Connelly A. “Low-dose aspirin therapy improves fetal weight in umbilical insufficiency,”. Am. J. Obstet. Gynecol. 1988; 159: 681
   PubMed Web of Science ®Google Scholar
• Van Assche F. A., Spitz B. “Thromboxane synthetase inhibition in pregnancy-induced hypertension,”. Am. J. Obstet. Gynecol. 1988; 159: 1015
   PubMedGoogle Scholar
• Van Assche F. A., Spitz B., Vermylen J. Deckmyn. “Preliminary observations on treatment of pregnancy induced hypertension with a thromboxane synthetase inhibitor,”. Am. J. Obstet. Gynecol. 1984; 148: 216
   PubMed Web of Science ®Google Scholar
• Wallenburg H. C.S. “Changes in the coagulation system and platelets in pregnancy-incuced hypertension and pre-eclampsia,”. Hypertension in pregnancy, F. Sharp, E. M. Symonds. Perinatology Press, Ithaca, New York 1987; 227
   Google Scholar
• Wallenburg H. C.S., Dekker G. A., Makovitz J. W., Rotmans P. “Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae,”. Lancet 1986; 1(1)
   PubMedGoogle Scholar
• Weksler B. B., Pett S. B., Alonso D., Richter R. C., Stelzer P., Subramanian V., Tack-Goldman K., Gay W. A. “Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients,”. N. Engl. J. Med. 1983; 308: 800
   PubMed Web of Science ®Google Scholar
• Zaragoza R., Le Breton G. C. “Effects of Single-Dose Aspirin on TXA2 and PGI2 Cyclo-oxygenases in vivo,”. Haemostasis 1987; 7(40)
   Google Scholar