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Review Article

Cardiovascular Research in Pregnancy: The Role of Animal Models

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Pages 413-437 | Published online: 07 Jul 2009

References

  • Martensson L. The pregnant rabbit, guinea-pig, sheep, and rhesus monkey as models in reproductive physiology. Europ J Obstet Gynec Reprod Biol. 1984; 169–82
  • Hutten JWM, Kuijpers JC, van Velzen D, Wallenburg HCS. Pathogenesis of pregnancy-induced hypertensive disorders: a review of experimental animal models. Clin Exp Hyperten in Preg. 1991; BIO(3)287–306
  • Chesley L C. Hypertensive disorders in pregnancy. Appleton-Century-Crofts, New York 1978
  • Paller M S. Decreased pressor responsiveness in pregnancy: studies in experimental animals. Am J Kidney Diseases 1987; 9: 308–11
  • Phippard AF, Horvath J S. Animal models of pre-eclampsia. Handbook of hypertension. v 10, Hypertension in pregnancy., P C Rubin. Elsevier, Amsterdam 1988; 168–85
  • Brown M A. Pregnancy-induced hypertension: pathogenesis and management. Aust NZ J Med. 1991; 21: 257–73
  • Harrison F A. Sheep and goats. The care and management of laboratory animals, T Poole. Longman Scientific and Technical, United Kingdom 1989; 517–24
  • Fuller EO, Galletti PM, Takeuchi T. Major and collateral components of blood flow to pregnant sheep uterus. Am J Physiol. 1975; 229: 279–85
  • Rosenfeld C R. Distribution of cardiac output in ovine pregnancy. Am J Physiol. 1977; 232: H231–35
  • Rosenfeld CR, Gant N F. The chronically instrumented ewe. A model for studying vascular reactivity to angiotensin II in pregnancy. J Clin Invest. 1981; 67: 486–92
  • Naden RP, Coultrup S, Arant BS, Rosenfeld C R. Metabolic clearance of angiotensin II in pregnant and non-pregnant sheep. Am J Physiol. 1985; 249: E49–Exx
  • Mackanjee HR, Shaul PW, Magness RR, Rosenfeld C R. Angiotensin II vascular smooth-muscle receptors are not down-regulated in near-term pregnant sheep. Am J Obstet Gynecol. 1991; 165: 1641–48
  • Magness RR, Osei-Boaten K, Mitchell MD, Rosenfeld C R. In vitro prostacyclin production by ovine uterine and systemic arteries. J Clin Invest. 1985; 76: 2206–12
  • Rosenfeld CR, Worley RJ, Gant N. Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion. Obstet Gynecol. 1977; 3: 304–7
  • Rosenfeld CR, West J. Circulatory response to systemic infusion of norepinephrine in the pregnant ewe. Am J Obstet Gynecol. 1977; 127: 376–83
  • Yang D, Clark K E. Effect of endothelin-1 in the uterine vasculature of the pregnant and estrogen-treated nonpregnant sheep. Am J Obstet Gynecol. 1992; 167: 1642–50
  • Broughton Pipkin F, Wallace C P. The effect of enalapril (MK421), an angiotensin converting enzyme inhibitor, on the conscious pregnant ewe and her foetus. Br J Pharmacol. 1986; 87: 533–42
  • Broughton Pipkin F, Symonds EM, Turner S R. The effect of captopnl (SQ 14,225) upon mother and fetus in the chronically cannulated ewe and in the pregnant rabbit. J Physiol. 1982; 323: 415–22
  • Alonso JG, Okai T, Longo LD, Gilbert R D. Cardiac function during long-term hypoxaeia in fetal sheep. Am J Physiol. 1989; 257: H581–89
  • Rankin JHG, Phernetton T M. The effect of uterine vascular arterial insufficiency on fetal arterial pressure and heart rate in the near-term sheep. Obstet Gynecol. 1977; 3: 299–303
  • Daniel SS, James LS, Stark RI, Tropper P J. Prevention of the normal expansion of maternal plasma volume: a model for chronic fetal hypoxaemia. J Develop Physiol. 1989; 11: 225–33
  • Thatcher CD, Keith J C. Pregnancy-induced hypertension: development of a model in the pregnant sheep. Am J Obstet Gynecol. 1986; 155: 201–7
  • Ferris TF, Herdson PB, Dunnill MS, Radcliffe L M. Toxaemia of pregnancy in sheep: a clinical, physiological and pathological study. J Clin Invest. 1969; 48: 1643–55
  • Abitbol M M. A simplified technique to produce toxaemia in the pregnant dog. Am J Obstet Gynecol. 1981; 139: 526–34
  • Abitbol M M. Hemodynamic studies in experimental toxaemia of the dog. Obstet Gynecol. 1977; 50: 293–8
  • Hodari A A. Chronic uterine ischaemia and reversible experimental “toxaemia of pregnancy”. Am J Obstet Gynecol. 1967; 97: 597–607
  • Kumar D. Chronic placental ischaemia in relation to toxaemia of pregnancy. Am J Obstet Gynecol. 1962; 84: 1323–9
  • MacArthur J A. The dog. The care and management of laboratory animals, T Poole. Longman Scientific and Technical, United Kingdom 1989; 456–75
  • Carter A M. Placental circulation. Comparative placentation, essays in structure and function, D H Steven. Academic Press, London 1975; 109–60
  • Woods L L. Importance of prostaglandins in hypertension during reduced uteroplacental perfusion pressure. Am J Physiol. 1989; 257: R1558–61
  • Woods LL, Brooks V L. Role of the renin-angiotensin system in hypertension during reduced uteroplacental perfusion pressure. Am J Physiol. 1989; 257: R204–9
  • Weihe W H. The laboratory rat. The care and management of laboratory animals, T Poole. Longman Scientific and Technical, United Kingdom 1989; 309–30
  • Del Campo CH, Ginther O J. Vascular anatomy of the uterus and ovaries and the umbilical luteolytic effect of the uterus: guinea pigs, rats, hamsters, and rabbits 1972; 33: 2561–78
  • Enders A C. A comparative study of the fine structure of the trophoblast in several hemochorial placentas. Am J Anat. 1965; 116: 29–68
  • Paller M S. Mechanism of decreased responsiveness to ANGII, NE, and vasopressin in pregnant rats. Am J Physiol. 1981; 247: H100-8
  • Molnar M, Hertelendy K. Nw-nitro-l-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents. Am J Obstet Gynecol. 1992; 166: 1560–70
  • Molnar M, Hertelendy F. Pressor responsiveness to endothelin is not attenuated in gravid rats. Life Sci. 1991; 47: 1463–8
  • Wallenburg HCS. Haemodynamics in hypertensive pregnancy. Handbook of hypertension, v 10, Hypertension in pregnancy., P C Rubin. Elsevier, Amsterdam 1988; 66–101
  • Baylis C, Engels K. Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of nitric oxide (NO) in the rat. Clin Exper Hyper. Hyper in Preg. 1993, in press
  • Hutten JWM, Kuijpers JC, van Velzen D, Wallenburg HCS. Pregnancy-induced hypertension in crossbred rats. 1: Maternal and fetal outcome of pregnancy. Int J Feto-Maternal Med. 1988; 1: 51–6
  • Adams C E. The laboratory rabbit. The care and management of laboratory animals, T Poole. Longman Scientific and Technical, United Kingdom 1989; 415–35
  • Abitbol MM, Driscoll SG, Ober W B. Placental lesions in experimental toxaemia in the pregnant rabbit. Am J Obstet Gynecol. 1976; 124: 460–70
  • Losonczy G, Todd H, Palmer DC, Hertelendy F. Prostaglandins, norepinephrine, angiotensin II and blood pressure changes induced by uteroplacental ischaemia in rabbits. Clin Exp Hyper. Hyper in Preg. 1986–87; B5(3)271–93
  • Berssenbrugge AD, Goodfriend TL, Ball DL, Rankin JHG. The effect of pregnancy on the angiotensin II pressor response in the rabbit. Am J Obstet Gynecol. 1980; 136: 762–7
  • Donker AJM, Inkee M, Venuto R C. The conscious instrumented rabbit: a model for the study of mechanisms of blood pressure regulation during pregnancy. Hyperten. 1983; 5: 514–20
  • Minsker DH, Bagdon WJ, MacDonald JS, Robertson RT, Bokelman D L. Maternal and fetotoxicity of an angiotensin-converting enzyme inhibitor, enalapril, in rabbits. Fundam Appl Toxicol. 1990; 14: 461–70
  • Bjellin L, Carter A M. Circulatory adjustments to pregnancy in the rabbit. Biol of Reproduction 1977; 16: 112–6
  • Sutherland SD, Festing MFW. The guinea-pig. The care and management of laboratory animals, T Poole. Longman Scientific and Technical, United Kingdom 1989; 393–410
  • Challis JRG, Heap RB, Illingworth D V. Concentrations of oestrogen and progesterone in the plasma of non-pregnant, pregnant and lactatmg guinea-pigs. J Endocrin. 1971; 51: 333–45
  • Weiner C, Hdez M, Chestnut D, Wang JP, Herrig J. The interaction between serotonin and angiotensin II in the chronically instrumented guinea pig and its alteration by indomethacin. Am J Obstet Gynecol. 1987; 156: 869–75
  • Peeters LLH, Grutters G, Martin C B. Distribution of cardiac output in the unstressed pregnant guinea pig. Am J Obstet Gynecol. 1980; 138: 1177–84
  • Weiner CP, Martinez E, Zhu LK, Ghodsi A, Chestnut D. In vitro release of endothelium-derived relaxing factor by acetylcholine is increased during the guinea pig pregnancy. Am J Obstet Gynecol. 1989; 161: 1599–1605
  • Weiner CP, Thompson LP, Liu K, Herrig J E. Endothelium-derived relaxing factor and indomethacin-sensitive contracting factor alter arterial contractile responses to thromboxane during pregnancy. Am J Obstet Gynecol. 1992; 166: 1171–81
  • Seidl DC, Hughes HC, Bertolet R, Lang C M. True pregnancy toxaemia (preeclampsia) in the guinea pig (Cavia porcellus). Lab Anim Sci. 1979; 29: 472–78
  • Storrs E E. Armadillos. The care and management of laboratory animals, T Poole. Longman Scientific and Technical, United Kingdom 1989; 229–39
  • Fridman EP, Popova V N. Species of the Genus Papio (Cercopithecidae) as subjects of biomedical reseach: I. biological basis of experiments on baboons. J Med Primatol. 1988; 17: 291–307
  • Fridman EP, Popova V N. Species of the Genus Papio (Cercopithecidae) as subjects of biomedical research: II. quantitative characteristics of contemporary use of baboon species in medical and biological investigations. J Med Primatol. 1988; 17: 309–18
  • Huser H.-J. Atlas of comparative primate hematology. Academic Press, London 1970
  • Chesley LC, Williams L O. Renal glomerular and tubular functions in relation to the hyperuricaemia of pre-eclampsia and eclampsia. Am J Obstet Gynecol. 1945; 50: 367–75
  • Lees MH, Hill JD, Ochsner AJ, Thomas C L. Novy MJ. Maternal placental and myometrial blood flow of the rhesus monkey during uterine contractions. Am J Obstet Gynecol. 1971; 110: 68–81
  • Nonhuman primates in perinatal research, Y W Brans, T J Kuehl. Wiley, New York 1988
  • Herring JM, Fortman JD, Anderson RJ, Bennett BT. Ultrasonic determination of fetal parameters in baboons (Papio anubis). Lab Anim Sci. 1991; 41: 602–5
  • Brans YW, Kuehl TJ, Hayashi RH, Reyes P. Maternal blood pressure and fetal ultrasonography in normal baboon pregnancies. J Med Primatol. 1990; 19: 641–9
  • Devonald KJ, Harewood WJ, Phippard AF, Ell wood DA, Fisk N. Monkey business: establishing normal biometric ranges in the baboon (Papio hamadryas). Proc Austral Soc Ultra Medicine 1991
  • Maclean JM, Phippard AF, Garner MG, Duggin GG, Horvath JS, Tiller D J. Group housing of hamadryas baboons: a new cage design based upon field studies of field organisation. Lab Anim Sci. 1987; 37: 89–93
  • Santillan-Doherty SM, Mayagoitia L, Mondragon-Ceballos R. Presence of adult or juvenile relatives increases live-birth chances on captive stumptail macaques (Macaca arctoides). J Med Primatol. 1991; 20: 140–2
  • Phippard AF, Garner MG, Thompson JF, Maclean JM, Fletcher PJ, Horvath JS, Duggin GG, Tiller D J. Nonocclusive chronic vascular catheterisation of conscious unrestrained baboons. J Appl Physiol. 1986; 61(5)1955–8
  • The baboon in medical research, H Vagtborg. University of Texas Press, Austin 1965; 2
  • Ramsey EM, Donner M W. Placental vasculature and circulation. Georg Thieme Publishers, Stuttgart 1980
  • Wynn RM, Panigel M, MacLennan A H. Fine structure of the placenta and fetal membranes of the baboon. Am J Obstet Gynecol. 1971; 109: 638–48
  • Khong T Y. The Robertson-Brosens-Dixon hypothesis: evidence for the role of haemochorial placentation in pregnancy success. Br J Obstet Gynecol. 1991; 98: 1195–9
  • Wallenburg HCS, Hutchinsin D L. A radiographic study of the effects of catecholamines on uteroplacental blood flow in the rhesus monkey. J Med Primatol. 1979; 8: 57
  • Embryology of the baboon, A G Hendrickx. University of Chicago Press, Chicago 1971
  • Reproductive biology of the primates, W P Luckett. Karger, Basel 1974
  • Harewood W F. Fetotoxicity of angiotensin converting enzyme inhibition in the primate. [Dissertation], University of Sydney. 1993
  • Abitbol MM, Ober WB, Gallo GR, Driscoll SG, Pirani C L. Experimental toxaemia of pregnancy in the monkey. Am J Pathol. 1977; 86: 573
  • Rao PS, Cavanagh D, Knuppel R A. Pregnancy-induced hypertension; experimental studies in the nonhuman primate, with clinical correlation. Nonhuman primates in perinatal research, Y W Brans, T J Keuhl. Wiley, New York 1988; 79–99
  • Cavanagh D, Rao PS, Tsai CC, O'Connor T. Experimental toxaemia in the pregnant primate. Am J Obstet Gynecol. 1977; 128: 75–85
  • Cavanagh D, Rao PS, Knuppel RA, Desai U, Balis J U. Pregnancy-induced hypertension: development of a model in the pregnant primate (Papio anubis). Am J Obstet Gynecol. 1985; 151: 987–99
  • Misenhimer HR, Ramsey EM, Martin CB, et al. Chronically impaired uterine artery blood flow. Obstet Gynecol. 1970; 36: 415–419
  • Phippard AF, Horvath JS, Glynn EM, Garner MG, Fletcher PJ, Duggin GG, Tiller D J. Circulatory adaptation to pregnancy—serial studies of haemodynamics, blood volume, renin and aldosterone in the baboon (Papio hamadryas). J Hyperten. 1986; 4: 773–9
  • Clapp JF, Seaward BL, Sleamaker RH, Hiser J. Maternal physiologic adaptations to early human pregnancy. Am J Obstet Gynecol. 1988; 159: 1456–60
  • Phippard AF, Horvath JS, Fletcher PJ, Garner MG, Duggin GG, Tiller D J. Angiotensin II vascular reactivity and angiotensin II metabolism in pregnant and non-pregnant baboons (Papio hamadryas). Clin Exp Hyper in Preg. Hyper in Preg. 1986–1987; B5(3)301–14
  • Schrier RW, Briner V A. Peripheral arterial vasodilation hypothesis of sodium and water retention in pregnancy: implications for pathogenesis of pre-eclampsia. Obstet Gynecol. 1991; 77: 632–9
  • Harewood WJ, Phippard AF, Hennessy A, Horvath JS, Tiller D J. The role of angiotensin II in regulation of glomerular filtration rate during pregnancy. Clin Exper Hyper. Hyper in Preg. 1993, in press
  • Harewood WJ, Phippard AF, Hennessy A, Duggin GG, Horvath J S. Perinatal morbidity and mortality complicating converting enzyme (ACE) inhibition in baboons. Clin Exper Hyper. Hyper in Preg. 1993, in press
  • Barton JR, Sibai BM, Ahokas RA, Whybrew D, Mercer B M. Magnesium sulfate therapy in preeclampsia is associated with increased cyclic guanosine monophosphate excretion 1992; 167: 931–4
  • Loeb AL, Longnecker D E. Inhibition of endothelium-derived relaxing factor-dependent circulatory control in intact rats. Am J Physiol. 1991; 262: H1494–H1500
  • Aisaka K, Gross SS, Griffith OW, Levi R. Ng-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?. Biochem Biophys Res Comm. 1989; 160: 881–6
  • Klabunde RE, Ritger RC, Helgren M C. Cardiovascular actions of inhibitors of endothelium-derived relaxing factor (nitric oxide) formation/release in anaesthetised dogs. Eur J Pharmacol. 1991; 199: 51–9
  • Phippard AF, Whitworth JA, Thompson JF, Horvath J S. Haemodynamics of the hypertensive response to nitro-l-arginine in conscious unrestrained baboons (Papio hamadryas). Proc High Blood Pressure Research Council 1991
  • Hennessy A, Phippard AF, Horvath JS, Tiller D J. Effect of chronic nitric oxide inhibition on arterial pressure in the baboon (Papio hamadryas). Kidney Inter. 1993, (in press)
  • Hennessy A, Phippard AF, Duggin GG, Horvath J S. Effects of endothelium-derived nitric oxide synthesis inhibition on circulatory adaptation to pregnancy in the baboon. (Papio hamadryas). Proc Aust Soc Med Res 1992
  • Hennessy A, Phippard AF, Duggin GG, Horvath JS, Tiller D J. Vasoactive mediators are altered by chronic nitric oxide inhibition in baboon (Papio hamadryas) pregnancy. Clin Exper Hyper. Hyper in Preg. 1993, [in press]
  • Yanagisawa M, Kurihara H, Tomobe Y, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411–5
  • Taylor RN, Varma M, Teng NNH, Roberts J M. Women with preeclampsia have higher endothelin levels that women with normal pregnancies. J Clin Endocrinol Metabolism. 1990; 71: 1675–7
  • Maclean JM, Phippard AF, Thompson JF, Gillin AG, Horvath JS, Duggin GG, Tiller D J. Haemodynamics of conscious unrestrained baboons, including cardiac output. J Appl Physiol. 1990; 68(6)2373–9
  • Maclean JM, Phippard AF, Gillin AG, Horvath J S. A backpack system for chronically instrumented unrestrained baboons. Aust Primatol. 1988; 3: 7–8
  • Horvath JS, Phippard AF, Gillin AG, Thompson JF, Duggin GG, Tiller D J. A model of pre-eclampsia including renal histology, in the baboon (Papio hamadryas). Clin Exp Hyper. Hyper in Preg. 1991; B10: 82
  • Gillin AG, Phippard AF, Horvath JS, Thompson JF, Duggin GG, Tiller D J. Experimental pre-eclampsia in the conscious unrestrained baboon (Papio hamadryas). Am J Hyperten. 1990; 3: 63A
  • Gillin AG, Phippard AF, Painter DM, Horvath JS, Duggin GG, Tiller D J. Pathology of the glomerulus associated with placental ischaemia in a baboon model of preeclampsia. Kidney Int. 1990; 38(3)554–5
  • Hennessy A, Phippard AF, Kirwan PD, Painter DM, Horvath J S. Electron microscopy of glomerular changes in experimental pre-eclampsia. Kidney Int. 1992; 42: 1052
  • Hennessy A, Phippard AF, Harewood WF, Painter DM, Kirwan PD, Horvath J S. Histomorphometry of the renal lesions in baboons with placental ischaemia. Clin Exp Hyper. Hyper in Preg. 1993, [in press]
  • Hennessy A, Phippard AF, Harewood WF, Painter DM, Kirwan PD, Horvath J S. Ultrastructural analysis of the renal lesion in baboons with placental ischaemia. Kidney Int. 1993, [in press]
  • Schrier RW, Briner V A. Peripheral arterial vasodilation hypothesis of sodium and water retention in pregnancy: implications for pathogenesis of preeclampsia-eclampsia. Obstet Gynecol. 1991; 77: 632–9
  • De Swiet M. The physiology of normal pregnancy. Handbook of hypertension, v 10, Hypertension in pregnancy., P C Rubin. Elsevier, Amsterdam 1988; 1–9
  • Gant NF, Daley GL, Chand S, Whalley PJ, Macdonald SPC. A study of angiotensin II pressor response throughout primigravid pregnancy. J Clin Invest. 1973; 52: 2682–9
  • Roberts JM, Taylor RN, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hyperten. 1991; 4: 700–8
  • The care and management of laboratory animals, T Poole. Longman Scientific and Technical, United Kingdom 1989

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