Advanced search
Publication Cover
Hypertension in Pregnancy Volume 12, 1993 - Issue 2
Submit an article Journal homepage
2
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Single Dose of Pindolol in Normotensive Pregnancy: The Lack of Changes in Hemodynamics in Spite of Effective Beta-Receptor Binding

Harri Polvi Department of Obstetrics and Gynecology, Turku University Hospital, SF-20520, Turku, Finland
,
Jouko Pirhonen Department of Obstetrics and Gynecology, Turku University Hospital, SF-20520, Turku, Finland
,
Risto Erkkola Department of Obstetrics and Gynecology, Turku University Hospital, SF-20520, Turku, Finland
,
Timo Kaila Department of Clinical Pharmacology, Turku University Hospital, SF-20520, Turku, Finland
&
Esko Iisalo Department of Clinical Pharmacology, Turku University Hospital, SF-20520, Turku, Finland
Pages 173-181 | Published online: 07 Jul 2009

References

  • Gugler R, Herald W, Dengler H J. Pharmacokinetics of pindolol in man. Eur J Clin Pharmacol. 1974; 7: 17–24
  • McDevitt D G, Shand D G. Plasma concentrations and the time-course of beta-blockade due to propranolol. Clin Pharmacol Ther. 1975; 18: 708–13
  • Ishizaki T. Likely explanation for longer duration of pharmacological (antianginal) effects of propranolol in relation to its short half-life. Res Commun Chem Pathol Pharmacol. 1980; 27: 223–39
  • Wellstein A, Palm D, Pitschner H F, Belz G G. Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man. Eur J Clin Pharmacol. 1985; 29: 131–47
  • Kurjak A, Alfirevic Z, Miljan M. Conventional and color Doppler in the assessment of fetal and maternal circulation. Ultrasound Med Biol. 1988; 14: 337–54
  • Kaila T. A sensitive radioligand binding assay for timolol in plasma. J Pharm Sci. 1991; 80: 296–9
  • Lubbe W F. Hypertension in pregnancy: Whom and how to treat. Br J Clin Pharmacol. 1987; 24(Suppl 1)158
  • Fiddler G I. Propranolol and pregnancy. Lancet 1974; 2: 722–3
  • Kjellmer I, Dagbjartsson A, Hrbek A, Karlsson K, Rosen K G. Maternal beta-adrenoreceptor blockade reduces fetal tolerance to asphyxia. Acta Obstet Gynecol Scand Suppl. 1984, Suppl 118: 75–80
  • Butters L, Kennedy S, Rubin P C. Atenolol in essential hypertension during pregnancy. BMJ 1990; 301: 587–9
  • Dubois D, Petitcolas J, Temperville B, Klepper A. Treatment of hypertension in pregnancy with beta-adrenoreceptor antagonists. Br J Clin Pharmacol. 1982; 13: 375–8
  • Sukerman-Voldman E. Pindolol therapy in pregnant hypertensive patients. Br J Clin Pharmacol. 1982; 13: 379
  • Montan S, Ingemarsson I, Marsal K, Sjoberg N-O. Randomized controlled trial of atenolol and pindolol in human pregnancy: Effects on fetal haemodynamics. BMJ 1992; 304: 946–9
  • Hanson L. Beta-adrenergic blockade in essential hypertension. Acta Med Scand Suppl. 1973, Suppl 550: 1
  • Atterhög J H, Duner H, Pernow B. Experience with pindolol, a betareceptor blocker, in the treatment of hypertension. Am J Med. 1976; 60: 872
  • Lunell N O, Nylund L, Lewander R, Sarby B, Wager J. Uteroplacental blood flow in pregnancy hypertension after the administration of a beta-adrenoreceptor blocker, pindolol. Gynecol Obstet Invest. 1984; 18: 269–74
  • Tuimala R, Hartikainen-Sorri A-L. Randomized comparison of atenolol and pindolol for treatment of hypertension in pregnancy. Curr Ther Res. 1988; 44: 579–84
  • Ingemarsson I, Adaikan P G, Arulkumaran S, Kottegoda S R. Effect of a beta-adrenoreceptor antagonist, pindolol, on human uterine smooth muscle. Gynecol Obstet Invest. 1987; 24: 185–9
  • Egarter C, Meisner W, Kroboth W K, Grunberger W. Effect of beta-adrenoreceptor blockers on uterine contractility in a puerperal model. Acta Obstet Gynecol Scand. 1989; 68: 359–62
  • Juma F D. Pharmacokinetics of pindolol in Kenyan Africans. Eur J Clin Pharmacol. 1983; 25: 425–6
  • Gretzer I, Alvan G, Duner H, Garle M, Sjöqvist F. Beta-blocking effect and pharmacokinetics of pindolol in young and elderly hypertensive patients. Eur J Clin Pharmacol. 1986; 31: 415–9
  • Aellig W H. Clinical pharmacology of pindolol. Am Heart J. 1982; 104: 346–56

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.