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Clinical and Experimental Hypertension Volume 34, 2012 - Issue 2
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Research Article

Vasodilator Effect of Phlomis bracteosa Constituents Is Mediated through Dual Endothelium-Dependent and Endothelium-Independent Pathways

Arif-ullah KhanCenter for Natural Products Research and Drug Discovery, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;Institute of Pharmaceutical Sciences, Kohat University of Science and Technology, Kohat, PakistanCorrespondence[email protected]
,
Riaz UllahDepartment of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan
,
Asifullah KhanH.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
,
Mohamad Rais MustafaCenter for Natural Products Research and Drug Discovery, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
,
Javid HussainDepartment of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan;Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa, Oman
,
Dharmani Devi MuruganCenter for Natural Products Research and Drug Discovery, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
&
A. Hamid Bin A. HadiDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
 show all
Pages 132-139 | Received 02 Mar 2011, Accepted 13 Mar 2011, Published online: 03 Oct 2011

REFERENCES

  • Albaladejo RG, Aparicio S. Variation patterns in the Phlomis composite (Lamiaceae) hybrid complex in Iberian peninsula. Bot J Linn Soc 2004; 145:97–108.
  • Kyriakopoulo I, Magiatis P, Skaltounis AI, Aligiannis N, Samioside HC. A new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia. J Nat Prod 2001; 64:1095–1097.
  • Calis I. Kırmızıbekmez H. Glycoside from Phlomis lunariifolia. Phytochemistry 2004; 65:2619–2625.
  • Sarkhail P, Hamid RME, Gholam RA, Mohammad HSS, Abass S. Phytochemical study of Phlomis olivieri Benth. and Phlomis persica Boiss. DARU J Pharm Sci 2006; 14:115–121.
  • Kamel MS, Mohamed KM, Hassanean HA, . Iridoid and megastigmane glycosides from Phlomis aurea. Phytochemistry 2001; 55:353–357.
  • Hussain J, Riaz-ullah KA, Mabood F, . Antispasmodic and Ca++ antagonist potential of marrubiin, a labdane type diterpene from Phlomis bracteosa. J Pharm Res 2011; 4:178–180.
  • Hussain J, Riaz-ullah KA, Khan F, Mohammad Z, Shah MR. Phlomeoic acid: A new diterpene from Phlomis bracteosa. Nat Prod Commun 2011; 6: 171–173.
  • Williamson EM, Okpako DT, Evans FJ. Selection, Preparation and Pharmacological Evaluation of Plant Material. Chichester, UK: John Wiley & Sons, 1998, 15–23.
  • National Research Council. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press, 1996, 1–7.
  • Khan A, Gilani AH. Cardiovascular inhibitory effects of Hyoscyamus niger. Methods Fin Exp Clin Pharmacol 2008; 30:295–300.
  • Khan A, Gilani AH. Pharmacodynamic evaluation of Terminalia bellerica for its antihypertensive effect. J Food Drug Anal 2008; 16:6–14.
  • Karaki H, Ozaki H, Hori M, . Calcium movements, distribution and functions in smooth muscle. Pharmacol Rev 1997; 49:157–230.
  • Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 1986; 38:321–416.
  • Wang GJ, Shum AY, Lin YL, . Calcium channel blockade in vascular smooth muscle cells: major hypotensive mechanism of S-petasin, a hypotensive sesquiterpene from Petasites formosanus. J Pharmacol Exp Ther 2001; 297:240–246.
  • Vanhoutte PM, Rubanyi GM, Miller VM, Houston DS. Modulation of vascular smooth muscle contraction by endothelium. Ann Rev Physiol 1986; 48:307–330.
  • Furchgott RF, Zawadski JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 299:373–376.
  • Johansen PL Hemodynamic effects of calcium antagonists in hypertension. In: Epstein M, Ed. Calcium Antagonists in Clinical Medicine. Philadelphia, PA: Hanley and Belfus, 1992, 69–88.
  • Ajay M, Gilani AH, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci 2003; 74:603–612.
  • Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol 2005; 45:74–80.
  • Ghayur MN, Gilani AH, Afridi MB, Houghton PJ. Cardiovascular effects of Ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. Vascular Pharmacol 2005; 43:234–241.
  • Musha S, Watanabe M, Ishida Y, . A phenoxazine compound, 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one reverses the phenylephrine or high-K+ induced contractions of smooth muscles in rat aorta and guinea-pig tenia cecum. Biol Pharm Bull 2005; 28:1521–1523.
  • Cauvin C, Malik S. Induction of calcium influx and calcium release in isolated rat aorta and mesenteric resistance vessels by norepinephrine activation of α-receptors. J Pharmacol Exp Ther 1984; 230:413–418.
  • Okmura K, Ichihara K, Nagaska M, Oda N, Tajima K. Calcium entry blocking activities of MPC-1304 and of its enantiomers and metabolites. Eur J Pharmacol 1993; 235:69–74.
  • Chan SS, Choi AO, Jones RL, Lin G. Mechanisms underlying the vasorelaxing effects of butylidenephthalide, an active constituent of Ligusticum chuanxiong in rat isolated aorta. Eur J Pharmacol 2006; 537:111–117.
  • Andreopouos S, Papapetropoulos A. Molecular aspects of soluble guanyl cyclase regulation. Gen Pharmacol 2000; 34:147–157.
  • Thorin E, Huang PL, Fishman MC, Bevan JA. Nitric oxide inhibits alpha2-adrenoceptor-mediated endothelium-dependent vasodilation. Circ Res 1998; 82:1323–1329.

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