168
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Effect of Nitric Oxide Inhibition on Blood Pressure and Renal Sodium Handling: A Dose–Response Study in Healthy Man

, , &
Pages 567-574 | Received 24 Jan 2012, Accepted 22 Feb 2012, Published online: 04 May 2012

REFERENCES

  • Johnson RA, Freeman RH. Renin release in rats during blockade of nitric oxide synthesis. Am J Physiol 1994; 266:1723–1729.
  • Lahera V, Salom MG, Miranda-Guardiola F, Moncada S, Romero JC. Effects of NG-nitro-L-arginine methyl ester on renal function and blood pressure. Am J Physiol 1991; 261:1033–1037.
  • Schricker K, Hamann M, Kurtz A. Nitric oxide and prostaglandins are involved in the macula densa control of the renin system. Am J Physiol 1995; 269:825–830.
  • Christensen FH, Stankevicius E, Hansen T, . Flow- and acetylcholine-induced dilatation in small arteries from rats with renovascular hypertension—effect of tempol treatment. Eur J Pharmacol 2007; 566:160–166.
  • Baylis C. Nitric oxide deficiency in chronic kidney disease. Am J Physiol Renal Physiol 2008; 294:1–9.
  • Mayer BX, Mensik C, Krishnaswami S, . Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with l-NMMA in humans. Br J Clin Pharmacol 1999; 47:539–544.
  • Brett SE, Cockcroft JR, Mant TG, Ritter JM, Chowienczyk PJ. Haemodynamic effects of inhibition of nitric oxide synthase and of l-arginine at rest and during exercise. J Hypertens 1998; 16:429–435.
  • Haynes WG, Noon JP, Walker BR, Webb DJ. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens 1993; 11:1375–1380.
  • Stewart AD, Millasseau SC, Kearney MT, Ritter JM, Chowienczyk PJ. Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans. Hypertension 2003; 42:915–918.
  • Wilkinson IB, MacCallum H, Cockcroft JR, Webb DJ. Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo. Br J Clin Pharmacol 2002; 53:189–192.
  • Bech JN, Nielsen CB, Pedersen EB. Effects of systemic NO synthesis inhibition on RPF, GFR, UNa, and vasoactive hormones in healthy humans. Am J Physiol 1996; 270:845–851.
  • Jkhorst-Oei LT, Rabelink TJ, Boer P, Koomans HA. Nifedipine attenuates systemic and renal vasoconstriction during nitric oxide inhibition in humans. Hypertension 1997; 29:1192–1198.
  • Shultz PJ, Tolins JP. Adaptation to increased dietary salt intake in the rat. Role of endogenous nitric oxide. J Clin Invest 1993; 91:642–650.
  • Nielsen CB, Bech JN, Pedersen EB. Effects of prostacyclin on renal haemodynamics, renal tubular function and vasoactive hormones in healthy humans. A placebo-controlled dose–response study. Br J Clin Pharmacol 1997; 44:471–476.
  • Matthesen SK, Larsen T, Vase H, Lauridsen TG, Pedersen EB. Effect of potassium supplementation on renal tubular function, ambulatory blood pressure and pulse wave velocity in healthy humans, Scand J Clin Lab Invest 2012; 72:78–86.
  • O’Rourke MF, Pauca A, Jiang XJ. Pulse wave analysis. Br J Clin Pharmacol 2001; 51:507–522.
  • Pagliaro P, Dalla VR, Gattullo D, Merletti A, Marsh NA. The heart rate after inhibition of nitric oxide release in the anaesthetized dog. Gen Pharmacol 1996; 27:695–699.
  • Laurent S, Cockcroft J, Van BL, . Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27:2588–2605.
  • Amar J, Ruidavets JB, Chamontin B, Drouet L, Ferrieres J. Arterial stiffness and cardiovascular risk factors in a population-based study. J Hypertens 2001; 19:381–387.
  • Wang MC, Tsai WC, Chen JY, Huang JJ. Stepwise increase in arterial stiffness corresponding with the stages of chronic kidney disease. Am J Kidney Dis 2005; 45:494–501.
  • Schmitt M, Avolio A, Qasem A, . Basal NO locally modulates human iliac artery function in vivo. Hypertension 2005; 46:227–231.
  • McEniery CM, Yasmin Hall IR, Qasem A, Wilkinson IB, Cockcroft JR. Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol 2005; 46:1753–1760.
  • Kurtz A, Wagner C. Role of nitric oxide in the control of renin secretion. Am J Physiol 1998; 275:849–862.
  • Griffin KA, Bidani AK, Ouyang J, Ellis V, Churchill M, Churchill PC. Role of endothelium-derived nitric oxide in hemodynamic adaptations after graded renal mass reduction. Am J Physiol 1993; 264:1254–1259.
  • Haynes WG, Hand MF, Dockrell ME, . Physiological role of nitric oxide in regulation of renal function in humans. Am J Physiol 1997; 272:364–371.
  • Johnson RA, Freeman RH. Pressure natriuresis in rats during blockade of the L-arginine/nitric oxide pathway. Hypertension 1992; 19:333–338.
  • Gardes J, Poux JM, Gonzalez MF, Henc-Gelas F, Menard J. Decreased renin release and constant kallikrein secretion after injection of L-NAME in isolated perfused rat kidney. Life Sci 1992; 50:987–993.
  • Ortiz PA, Garvin JL. Role of nitric oxide in the regulation of nephron transport. Am J Physiol Renal Physiol 2002; 282:777–784.
  • Bech JN, Nielsen EH, Pedersen RS, Svendsen KB, Pedersen EB. Enhanced sodium retention after acute nitric oxide blockade in mildly sodium loaded patients with essential hypertension. Am J Hypertens 2007; 20:287–295.
  • Pucci ML, Lin L, Nasjletti A. Pressor and renal vasoconstrictor effects of NG-nitro-L-arginine as affected by blockade of pressor mechanisms mediated by the sympathetic nervous system, angiotensin, prostanoids and vasopressin. J Pharmacol Exp Ther 1992; 261:240–245.
  • Yukimura T, Yamashita Y, Miura K, Okumura M, Yamanaka S, Yamamoto K. Renal effects of the nitric oxide synthase inhibitor, L-NG-nitroarginine, in dogs. Am J Hypertens 1992; 5:484–487.
  • Bech JN, Svendsen KB, Nielsen CB, Pedersen EB. The systemic and renal response to NO inhibition is not modified by angiotensin-II-receptor blockade in healthy humans. Nephrol Dial Transplant 1999; 14:641–647.
  • Broere A, Van Den Meiracker AH, Boomsma F, Derkx FH, Veld AJ, Schalekamp MA. Human renal and systemic hemodynamic, natriuretic, and neurohumoral responses to different doses of L-NAME. Am J Physiol 1998; 275: 870–877.
  • Montanari A, Tateo E, Fasoli E, . Angiotensin II blockade does not prevent renal effects of L-NAME in sodium-repleted humans. Hypertension 1997; 30:557–562.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.