Advanced search
Publication Cover
Clinical and Experimental Hypertension. Part A: Theory and Practice Volume 10, 1988 - Issue sup1
Journal homepage
4
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Endogenous Opioid Involvement in the Cardiovascular Effects of Clonidine in Rats: Role of the Parasympathetic Nervous System

George Kunos Dept. of Pharmacology, McGill University, Montreal, Quebec, Canada; Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, 12501 Washington Avenue, Rockville, MD, 20852
&
Rogelio Mosqueda-garcia Dept. of Pharmacology, McGill University, Montreal, Quebec, Canada
Pages 369-374 | Published online: 03 Jul 2009

References

  • Mosqueda-Garcia R., Eskay R., Zamir N., Palkovits M., Kunos G. Opioid-mediated cardiovascular effects of clonidine in spontaneously hypertensive rats: elimination by neonatal treatment with monosodium glutamate. Endocrinology 1986; 118: 1814–1822
  • Kunos G., Mosqueda-Garcia R., Mastrianni J. A. Endorphinergic mechanism in the central cardiovascular and analgesic effects of clonidine. Canad. J. Physiol. Pharmacol. 1987; 65: 1624–1632
  • Mosqueda-Garcia R., Kunos G. Opiate receptors and the endorphin mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced μ-subtype to δ-subtype changes. Proc. Natl. Acad. Sci. USA 1987; 84: 8637–8641
  • Mastrianni J. A., Ingenito A. J. On the relationship between clonidine hypotension and brain β-endorphin in the spontaneously hypertensive rat: studies with alpha adrenergic and opiate blockers. J. Pharmacol. Exp. Ther. 1987; 242: 378–387
  • van Giersbergen P. L.M., De Jong W. Antagonism of the hypotension and bradycardia induced by α-methyldopa in conscious normotensive rats. J. Pharmacol. Exp. Ther. 1988; 244: 341–347
  • Onesti G., Schwartz A. B., Kim K. E., Swartz C., Brest A. N. Pharmacodynamic effects of a new antihypertensive drug. Catapres (ST-155). Circulation 1969; 39: 219–226
  • De Jonge A., Timmermans P. B.M.W.M., van Zwieten P. A. Participation of cardiac presynaptic α2-adrenoceptors in the bradicardiac effects of clonidine and analogues. Naunyn Schmiedebergs Arch. Pharmacol. 1981; 317: 8–12
  • Mosqueda-Garcia R., Kunos G. Peripheral opiate receptors are not involved in the naloxone-sensitive cardiovascular effects of clonidine in rats. Brain Research 1988; 442: 119–123

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.