Genes, Environment, and Individual Differences in Responding to Treatment for Depression

REFERENCES

• Hatcher S, Butler R, Oakley-Browne M. Evidence-based mental health care. London: Churchill Livingstone, 2005.
   Google Scholar
• Uher R, Maier W, Hauser J, Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. Br J Psychiatry 2009;194:252–9.
   PubMed Web of Science ®Google Scholar
• Sotsky SM, Glass DR, Shea MT, Patient predictors of response to psychotherapy and pharmacotherapy: findings in the NIMH Treatment of Depression Collaborative Research Program. Am J Psychiatry 1991;148:997–1008.
   PubMed Web of Science ®Google Scholar
• Uher R. The implications of gene-environment interactions in depression: will cause inform cure? Mol Psychiatry 2008;13:1070–8.
   PubMed Web of Science ®Google Scholar
• Uher R. The role of genetic variation in the causation of mental illness: an evolution-informed framework. Mol Psychiatry 2009;14:1072–82.
   PubMed Web of Science ®Google Scholar
• McGuffin P, Riley B, Plomin R. Genomics and behavior. Toward behavioral genomics. Science 2001;291:1232–49.
   PubMed Web of Science ®Google Scholar
• Shih RA, Belmonte PL, Zandi PP. A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. Int Rev Psychiatry 2004;16:260–83.
   PubMed Web of Science ®Google Scholar
• Stansfeld SA, Clark C, Rodgers B, Caldwell T, Power C. Repeated exposure to socioeconomic disadvantage and health selection as life course pathways to mid-life depressive and anxiety disorders. Soc Psychiatry Psychiatr Epidemiol 2010 April 11 [Epub ahead of print].
   Google Scholar
• Van Der Vegt EJ, Tieman W, Van Der Ende J, Ferdinand RF, Verhulst FC, Tiemeier H. Impact of early childhood adversities on adult psychiatric disorders: a study of international adoptees. Soc Psychiatry Psychiatr Epidemiol 2009;44:724–31.
   PubMed Web of Science ®Google Scholar
• Dohrenwend BP. The role of adversity and stress in psychopathology: some evidence and its implications for theory and research. J Health Soc Behav 2000;41:1–19.
   PubMed Web of Science ®Google Scholar
• Edelman GM, Gally JA. Degeneracy and complexity in biological systems. Proc Natl Acad Sci USA 2001;98:13763–8.
   PubMed Web of Science ®Google Scholar
• Rothman KJ, Greenland S, Lash TL. Modern epidemiology. 3rd ed. Philadephia: Lippincott Williams & Wilkins, 2008.
   Google Scholar
• Caspi A, McClay J, Moffitt TE, Role of genotype in the cycle of violence in maltreated children. Science 2002;297:851–4.
   PubMed Web of Science ®Google Scholar
• Taylor A, Kim-Cohen J. Meta-analysis of gene-environment interactions in developmental psychopathology. Dev Psychopathol 2007;19:1029–37.
   PubMed Web of Science ®Google Scholar
• Caspi A, Sugden K, Moffitt TE, Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386–9.
   PubMed Web of Science ®Google Scholar
• Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010;167:509–27.
   PubMed Web of Science ®Google Scholar
• Brown GW, Harris TO. Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction. J Affect Disord 2008;111:1–12.
   PubMed Web of Science ®Google Scholar
• Karg K, Shedden K, Burmeister M, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 2011;68:444–54.
   PubMed Web of Science ®Google Scholar
• Kahn RS, Khoury J, Nichols WC, Lanphear BP. Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. J Pediatr 2003;143:104–10.
   PubMed Web of Science ®Google Scholar
• Brookes KJ, Mill J, Guindalini C, A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry 2006;63:74–81.
   PubMed Web of Science ®Google Scholar
• Caspi A, Moffitt TE, Cannon M, Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry 2005;57:1117–27.
   PubMed Web of Science ®Google Scholar
• Zammit S, Thomas K, Thompson A, Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring. Br J Psychiatry 2009;195:294–300.
   PubMedGoogle Scholar
• Langley K, Turic D, Rice F, Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. Am J Med Genet B Neuropsychiatr Genet 2008;147B:49–53.
   PubMedGoogle Scholar
• Sheese BE, Voelker PM, Rothbart MK, Posner MI. Parenting quality interacts with genetic variation in dopamine receptor D4 to influence temperament in early childhood. Dev Psychopathol 2007;19:1039–46.
   PubMed Web of Science ®Google Scholar
• Martel MM, Nikolas M, Jernigan K, The dopamine receptor D4 gene (DRD4) moderates family environmental effects on ADHD. J Abnorm Child Psychol 2011;39:1–10.
   PubMed Web of Science ®Google Scholar
• Binder EB, Bradley RG, Liu W, Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008;299:1291–305.
   PubMed Web of Science ®Google Scholar
• Bradley RG, Binder EB, Epstein MP, Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 2008;65:190–200.
   PubMed Web of Science ®Google Scholar
• Polanczyk G, Caspi A, Williams B, Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch Gen Psychiatry 2009;66:978–85.
   PubMed Web of Science ®Google Scholar
• Bet PM, Penninx BW, Bochdanovits Z, Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: new evidence for a gene-environment interaction. Am J Med Genet B Neuropsychiatr Genet 2009;150B:660–9.
   PubMedGoogle Scholar
• Hosang GM, Uher R, Keers R, Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder. J Affect Disord 2010;125:345–9.
   PubMed Web of Science ®Google Scholar
• Stevens SE, Kumsta R, Kreppner JM, Brookes KJ, Rutter M, Sonuga-Barke EJ. Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: developmental continuities in gene-environment interplay. Am J Med Genet B Neuropsychiatr Genet 2009;150B:753–61.
   PubMed Web of Science ®Google Scholar
• Van Der Zwaluw CS, Engels RC, Vermulst AA, Interaction between dopamine D2 receptor genotype and parental rule-setting in adolescent alcohol use: evidence for a gene-parenting interaction. Mol Psychiatry 2010;15:727–35.
   PubMedGoogle Scholar
• Belsky J, Jonassaint C, Pluess M, Vulnerability genes or plasticity genes? Mol Psychiatry 2009;14:746–54.
   PubMed Web of Science ®Google Scholar
• Boyce WT, Ellis BJ. Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Dev Psychopathol 2005;17:271–301.
   PubMed Web of Science ®Google Scholar
• Doornbos B, jck-Brouwer DA, Kema IP, The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:1250–4.
   PubMed Web of Science ®Google Scholar
• Sanjuan J, Martin-Santos R, Garcia-Esteve L, Mood changes after delivery: role of the serotonin transporter gene. Br J Psychiatry 2008;193:383–8.
   PubMed Web of Science ®Google Scholar
• Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000;157:1552–62.
   PubMed Web of Science ®Google Scholar
• McGuffin P, Katz R, Watkins S, Rutherford J. A hospital-based twin register of the heritability of DSM-IV unipolar depression. Arch Gen Psychiatry 1996;53:129–36.
   PubMedGoogle Scholar
• Lewis CM, Ng MY, Butler AW, Genome-wide association study of major recurrent depression in the U.K. population. Am J Psychiatry 2010;167:949–57.
   PubMed Web of Science ®Google Scholar
• Muglia P, Tozzi F, Galwey NW, Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol Psychiatry 2010;15:589–601.
   PubMed Web of Science ®Google Scholar
• Shi J, Potash JB, Knowles JA, Genome-wide association study of recurrent early-onset major depressive disorder. Mol Psychiatry 2011;16:193–201.
   PubMed Web of Science ®Google Scholar
• Shyn SI, Shi J, Kraft JB, Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol Psychiatry 2011;16:202–15.
   PubMed Web of Science ®Google Scholar
• Sullivan PF, de Geus EJ, Willemsen G, Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 2009;14:359– 75.
   PubMed Web of Science ®Google Scholar
• Kaufman J, Yang BZ, Douglas-Palumberi H, Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 2006;59:673–80.
   PubMed Web of Science ®Google Scholar
• Wilhelm K, Mitchell PB, Niven H, Life events, first depression onset and the serotonin transporter gene. Br J Psychiatry 2006;188:210–5.
   PubMed Web of Science ®Google Scholar
• Bakermans-Kranenburg MJ, van Ijzendoorn MH. Gene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers. Dev Psychobiol 2006;48:406–9.
   PubMed Web of Science ®Google Scholar
• Bakermans-Kranenburg MJ, van Ijzendoorn MH, Pijlman FT, Mesman J, Juffer F. Experimental evidence for differential susceptibility: dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers’ externalizing behavior in a randomized controlled trial. Dev Psychol 2008;44:293–300.
   PubMed Web of Science ®Google Scholar
• Brody GH, Beach SR, Philibert RA, Chen YF, Murry VM. Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design. Child Dev 2009;80:645–61.
   PubMed Web of Science ®Google Scholar
• Huezo-Diaz P, Uher R, Smith R, Moderation of antidepressant response by the serotonin transporter gene. Br J Psychiatry 2009;195:30–8.
   PubMed Web of Science ®Google Scholar
• Serretti A, Kato M, De RD, Kinoshita T. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry 2007;12: 247–57.
   PubMed Web of Science ®Google Scholar
• Zhang JP, Lencz T, Malhotra AK. D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis. Am J Psychiatry 2010;167:763–72.
   PubMed Web of Science ®Google Scholar
• Perlis RH, Patrick A, Smoller JW, Wang PS. When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study. Neuropsychopharmacology 2009;34:2227– 36.
   PubMed Web of Science ®Google Scholar
• McMahon FJ, Buervenich S, Charney D, Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet 2006;78:804–14.
   PubMed Web of Science ®Google Scholar
• Need AC, Keefe RS, Ge D, Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Eur J Hum Genet 2009;17:946–57.
   PubMedGoogle Scholar
• Uher R, Huezo-Diaz P, Perroud N, Genetic predictors of response to antidepressants in the GENDEP project. Pharmacogenomics J 2009;9:225–33.
   PubMed Web of Science ®Google Scholar
• Horstmann S, Binder EB. Pharmacogenomics of antidepressant drugs. Pharmacol Ther 2009;124:57–73.
   PubMed Web of Science ®Google Scholar
• Garriock HA, Kraft JB, Shyn SI, A genomewide association study of citalopram response in major depressive disorder. Biol Psychiatry 2010;67:133–8.
   PubMed Web of Science ®Google Scholar
• Ising M, Lucae S, Binder EB, A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Arch Gen Psychiatry 2009;66:966–75.
   PubMed Web of Science ®Google Scholar
• Uher R, Perroud N, Ng MY, Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am J Psychiatry 2010;167:555–64.
   PubMed Web of Science ®Google Scholar
• Binder EB, Salyakina D, Lichtner P, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 2004;36:1319–25.
   PubMed Web of Science ®Google Scholar
• van Rossum EF, Binder EB, Majer M, Polymorphisms of the glucocorticoid receptor gene and major depression. Biol Psychiatry 2006;59:681–8.
   PubMed Web of Science ®Google Scholar
• Paddock S, Laje G, Charney D, Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. Am J Psychiatry 2007;164:1181–8.
   PubMed Web of Science ®Google Scholar
• Garriock HA, Tanowitz M, Kraft JB, Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder. Am J Psychiatry 2010;167:565–73.
   PubMed Web of Science ®Google Scholar
• Rudge JS, Eaton MJ, Mather P, Lindsay RM, Whittemore SR. CNTF induces raphe neuronal precursors to switch from a serotonergic to a cholinergic phenotype in vitro. Mol Cell Neurosci 1996;7:204–21.
   PubMedGoogle Scholar
• Widom CS, DuMont K, Czaja SJ. A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch Gen Psychiatry 2007;64:49–56.
   PubMed Web of Science ®Google Scholar
• Wise LA, Zierler S, Krieger N, Harlow BL. Adult onset of major depressive disorder in relation to early life violent victimisation: a case-control study. Lancet 2001;358:881–7.
   PubMed Web of Science ®Google Scholar
• Scott KM, Smith DR, Ellis PM. Prospectively ascertained child maltreatment and its association with DSM-IV mental disorders in young adults. Arch Gen Psychiatry 2010;67: 712–9.
   PubMed Web of Science ®Google Scholar
• Widom CS, Czaja SJ, Paris J. A prospective investigation of borderline personality disorder in abused and neglected children followed up into adulthood. J Pers Disord 2009;23:433–46.
   PubMed Web of Science ®Google Scholar
• Fisher H, Morgan C, Dazzan P, Gender differences in the association between childhood abuse and psychosis. Br J Psychiatry 2009;194:319–25.
   PubMed Web of Science ®Google Scholar
• Jonas S, Bebbington P, McManus S, Sexual abuse and psychiatric disorder in England: results from the 2007 Adult Psychiatric Morbidity Survey. Psychol Med 2010;1– 11.
   Google Scholar
• Clark C, Caldwell T, Power C, Stansfeld SA. Does the influence of childhood adversity on psychopathology persist across the lifecourse? A 45-year prospective epidemiologic study. Ann Epidemiol 2010;20:385–94.
   PubMed Web of Science ®Google Scholar
• Jordanova V, Stewart R, Goldberg D, Age variation in life events and their relationship with common mental disorders in a national survey population. Soc Psychiatry Psychiatr Epidemiol 2007;42:611–6.
   PubMed Web of Science ®Google Scholar
• Ritchie K, Jaussent I, Stewart R, Association of adverse childhood environment with late-life depression. J Clin Psychiatry 2009;70:1281–8.
   PubMed Web of Science ®Google Scholar
• Brown GW, Moran P. Clinical and psychosocial origins of chronic depressive episodes. I: a community survey. Br J Psychiatry 1994;165:447–56.
   PubMed Web of Science ®Google Scholar
• Wiersma JE, Hovens JG, van Oppen P, The importance of childhood trauma and childhood life events for chronicity of depression in adults. J Clin Psychiatry 2009;70:983–9.
   PubMed Web of Science ®Google Scholar
• Wainwright NW, Surtees PG. Childhood adversity, gender and depression over the life-course. J Affect Disord 2002;72:33–44.
   PubMedGoogle Scholar
• Bernet CZ, Stein MB. Relationship of childhood maltreatment to the onset and course of major depression in adulthood. Depress Anxiety 1999;9:169–74.
   PubMedGoogle Scholar
• Zlotnick C, Mattia J, Zimmerman M. Clinical features of survivors of sexual abuse with major depression. Child Abuse Negl 2001;25:357–67.
   PubMed Web of Science ®Google Scholar
• Brown GW, Bifulco A, Harris TO. Life events, vulnerability and onset of depression: some refinements. Br J Psychiatry 1987;150:30–42.
   PubMed Web of Science ®Google Scholar
• Wainwright NW, Surtees PG. Time-varying exposure and the impact of stressful life events on onset of affective disorder. Stat Med 2002;21:2077–91.
   PubMedGoogle Scholar
• Brown GW, Harris TO. Social origins of depression. A study of psychiatric disorder in women. 5th ed. London: Routledge, 1978.
   Google Scholar
• Brown GW, Craig TK, Harris TO. Parental maltreatment and proximal risk factors using the Childhood Experience of Care & Abuse (CECA) instrument: a life-course study of adult chronic depression—5. J Affect Disord 2008;110:222–33.
   PubMed Web of Science ®Google Scholar
• Brown GW, Craig TK, Harris TO, Handley RV. Parental maltreatment and adulthood cohabiting partnerships: a life-course study of adult chronic depression—4. J Affect Disord 2008;110:115–25.
   PubMed Web of Science ®Google Scholar
• Widom CS, Czaja SJ, Dutton MA. Childhood victimization and lifetime revictimization. Child Abuse Negl 2008;32:785–96.
   PubMed Web of Science ®Google Scholar
• Zielinski DS. Child maltreatment and adult socioeconomic well-being. Child Abuse Negl 2009;33:666–78.
   PubMed Web of Science ®Google Scholar
• Kaplan MJ, Klinetob NA. Childhood emotional trauma and chronic posttraumatic stress disorder in adult outpatients with treatment-resistant depression. J Nerv Ment Dis 2000;188:596–601.
   PubMed Web of Science ®Google Scholar
• Nemeroff CB, Heim CM, Thase ME, Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proc Natl Acad Sci U S A 2003;100:14293–6.
   PubMed Web of Science ®Google Scholar
• Enns MW, Cox BJ. Psychosocial and clinical predictors of symptom persistence vs remission in major depressive disorder. Can J Psychiatry 2005;50:769–77.
   PubMed Web of Science ®Google Scholar
• Johnstone JM, Luty SE, Carter JD, Childhood neglect and abuse as predictors of antidepressant response in adult depression. Depress Anxiety 2009;26:711–7.
   PubMed Web of Science ®Google Scholar
• Miniati M, Rucci P, Benvenuti A, Clinical characteristics and treatment outcome of depression in patients with and without a history of emotional and physical abuse. J Psychiatr Res 2010;44:302–9.
   PubMedGoogle Scholar
• Barbe RP, Bridge JA, Birmaher B, Kolko DJ, Brent DA. Lifetime history of sexual abuse, clinical presentation, and outcome in a clinical trial for adolescent depression. J Clin Psychiatry 2004;65:77–83.
   PubMed Web of Science ®Google Scholar
• Shirk SR, Kaplinski H, Gudmundsen G. School-based cognitive-behavioral therapy for adolescent depression. J Emot Behav Disord 2009;17:106–17.
   Web of Science ®Google Scholar
• Asarnow JR, Emslie G, Clarke G, Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response. J Am Acad Child Adolesc Psychiatry 2009;48:330–9.
   PubMed Web of Science ®Google Scholar
• Lewis CC, Simons AD, Nguyen LJ, Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry 2010;49:132–40.
   PubMed Web of Science ®Google Scholar
• Coryell W, Winokur G, Maser JD, Akiskal HS, Keller MB, Endicott J. Recurrently situational (reactive) depression: a study of course, phenomenology and familial psychopathology. J Affect Disord 1994;31:203–10.
   PubMedGoogle Scholar
• Kessing LV. Endogenous, reactive and neurotic depression—diagnostic stability and long-term outcome. Psychopathology 2004;37:124–30.
   PubMedGoogle Scholar
• McGuffin P, Katz R, Bebbington P. The Camberwell Collaborative Depression Study. III. Depression and adversity in the relatives of depressed probands. Br J Psychiatry 1988;152:775–82.
   PubMed Web of Science ®Google Scholar
• Bock C, Bukh JD, Vinberg M, Gether U, Kessing LV. Do stressful life events predict medical treatment outcome in first episode of depression? Soc Psychiatry Psychiatr Epidemiol 2009;44:752–60.
   PubMedGoogle Scholar
• Bulmash E, Harkness KL, Stewart JG, Bagby RM. Personality, stressful life events, and treatment response in major depression. J Consult Clin Psychol 2009;77:1067–77.
   PubMed Web of Science ®Google Scholar
• Garvey MJ, Schaffer CB, Tuason VB. Comparison of pharmacological treatment response between situational and non-situational depressions. Br J Psychiatry 1984; 145:363–5.
   PubMedGoogle Scholar
• Mazure CM, Bruce ML, Maciejewski PK, Jacobs SC. Adverse life events and cognitive-personality characteristics in the prediction of major depression and antidepressant response. Am J Psychiatry 2000;157:896–903.
   PubMed Web of Science ®Google Scholar
• Brown GW, Harris TO, Kendrick T, Antidepressants, social adversity and outcome of depression in general practice. J Affect Disord 2010;121:239–46.
   PubMed Web of Science ®Google Scholar
• Schwartz S. Modern epidemiology approaches to interaction: application to the study of genetic interactions. In: Hernandez LM, Blazer DG, eds. Genes, behavior, and the social environment: moving beyond the nature/nurture debate. Washington, DC: National Academies, 2006.
   Google Scholar
• Uher R. Gene-environment interaction: overcoming methodological challenges. Novartis Found Symp 2008;293: 13–26.
   PubMedGoogle Scholar
• Mandelli L, Marino E, Pirovano A, Interaction between SERTPR and stressful life events on response to antidepressant treatment. Eur Neuropsychopharmacol 2009;19: 64–7.
   PubMed Web of Science ®Google Scholar
• Keers R, Uher R, Huezo-Diaz P, Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project. Pharmacogenomics J 2011;11:138–45.
   PubMed Web of Science ®Google Scholar
• Bukh JD, Bock C, Vinberg M, Werge T, Gether U, Kessing LV. No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment. Eur Neuropsychopharmacol 2010;20:327–35.
   PubMed Web of Science ®Google Scholar
• Hammen C. Stress generation in depression: reflections on origins, research, and future directions. J Clin Psychol 2006;62:1065–82.
   PubMed Web of Science ®Google Scholar
• Harkness KL, Lumley MN, Truss AE. Stress generation in adolescent depression: the moderating role of child abuse and neglect. J Abnorm Child Psychol 2008;36:421–32.
   PubMed Web of Science ®Google Scholar
• Reiss D, Leve LD. Genetic expression outside the skin: clues to mechanisms of Genotype x Environment interaction. Dev Psychopathol 2007;19:1005–27.
   PubMed Web of Science ®Google Scholar
• Hayden EP, Klein DN, Dougherty LR, The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene-environment correlation and gene-environment interaction. Psychiatr Genet 2010;20:304–10.
   PubMed Web of Science ®Google Scholar
• Uher R, Caspi A, Houts R, Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. J Affect Disord 2011 Mar 23 [Epub ahead of print].
   Google Scholar
• McClung CA, Nestler EJ. Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 2008;33:3–17.
   PubMed Web of Science ®Google Scholar
• Weake VM, Workman JL. Inducible gene expression: diverse regulatory mechanisms. Nat Rev Genet 2010;11:426–37.
   PubMed Web of Science ®Google Scholar
• McGowan PO, Sasaki A, D'Alessio AC, Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009;12:342–8.
   PubMed Web of Science ®Google Scholar
• Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA. Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet B Neuropsychiatr Genet 2010;153B:710–3.
   PubMed Web of Science ®Google Scholar
• Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 2009;65:760–9.
   PubMed Web of Science ®Google Scholar
• Murgatroyd C, Patchev AV, Wu Y, Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009;12:1559–66.
   PubMed Web of Science ®Google Scholar
• Covington HE, III, Maze I, LaPlant QC, Antidepressant actions of histone deacetylase inhibitors. J Neurosci 2009;29:11451–60.
   PubMed Web of Science ®Google Scholar
• Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 2006;9:519–25.
   PubMed Web of Science ®Google Scholar
• Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A 2010;107:2669–74.
   PubMed Web of Science ®Google Scholar
• Cole SW, Arevalo JM, Takahashi R, Computational identification of gene-social environment interaction at the human IL6 locus. Proc Natl Acad Sci U S A 2010;107:5681–6.
   PubMed Web of Science ®Google Scholar
• LaPlant Q, Vialou V, Covington HE, III, Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci 2010;13:1137–43.
   Google Scholar
• van Ijzendoorn MH, Caspers K, Bakermans-Kranenburg MJ, Beach SR, Philibert R. Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. Biol Psychiatry 2010;68:405–7.
   PubMed Web of Science ®Google Scholar
• Philibert R, Madan A, Andersen A, Cadoret A, Packer H, Sandhu H. Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Am J Med Genet B Neuropsychiatr Genet 2007;144B:101–5.
   PubMed Web of Science ®Google Scholar
• Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 2004;306:879–81.
   PubMed Web of Science ®Google Scholar
• Holmes A, Yang RJ, Lesch KP, Crawley JN, Murphy DL. Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology 2003;28:2077–88.
   PubMed Web of Science ®Google Scholar
• Santarelli L, Saxe M, Gross C, Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003;301:805–9.
   PubMed Web of Science ®Google Scholar
• Tardito D, Perez J, Tiraboschi E, Musazzi L, Racagni G, Popoli M. Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol Rev 2006;58:115– 34.
   PubMed Web of Science ®Google Scholar
• Landgrebe J, Welzl G, Metz T, Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling. J Psychiatr Res 2002;36:119–29.
   PubMedGoogle Scholar
• Schroeder FA, Lin CL, Crusio WE, Akbarian S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry 2007;62:55–64.
   PubMed Web of Science ®Google Scholar
• Gundersen BB, Blendy JA. Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety. Neuropharmacology 2009;57:67–74.
   Google Scholar
• Papakostas GI. Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder. J Clin Psychiatry 2009;70 suppl 5:18–22.
   PubMed Web of Science ®Google Scholar
• Deutsch SI, Rosse RB, Long KD, Gaskins BL, Burket JA, Mastropaolo J. Sodium butyrate, an epigenetic interventional strategy, attenuates a stress-induced alteration of MK-801's pharmacologic action. Eur Neuropsychopharmacol 2008;18:565–8.
   PubMedGoogle Scholar
• Leve LD, Harold GT, Ge X, Structured parenting of toddlers at high versus low genetic risk: two pathways to child problems. J Am Acad Child Adolesc Psychiatry 2009;48:1102–9.
   PubMedGoogle Scholar
• Malki K, Uher R, Paya-Cano J, Convergent animal and human evidence suggests a role of the PPM1A gene in response to antidepressants. Biol Psychiatry 2011;69: 360–5.
   PubMedGoogle Scholar
• Becker-Blease KA, Freyd JJ. Research participants telling the truth about their lives: the ethics of asking and not asking about abuse. Am Psychol 2006;61:218–26.
   PubMed Web of Science ®Google Scholar