Vitamin C inhibits NO-induced stabilization of HIF-1α in HUVECs

References

• Wang GL, Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 1993;268:21513–21518.
   PubMed Web of Science ®Google Scholar
• Bruick RK, McKnight SL. Oxygen sensing gets a second wind. Science 2002;295:807–808.
   PubMed Web of Science ®Google Scholar
• Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337–1340.
   PubMed Web of Science ®Google Scholar
• Schofield CJ, Ratcliffe PJ. Signalling hypoxia by HIF hydroxylases. Biochem Biophys Res Commun 2005;338:617–626.
   PubMed Web of Science ®Google Scholar
• Cioffi CL, Qin Liu X, Kosinski PA, Garay M, Bowen BR. Differential regulation of HIF-1[alpha] prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochem Biophys Res Commun 2003;303:947–953.
   PubMed Web of Science ®Google Scholar
• emenza, GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 2001;7: 345–350.
   PubMed Web of Science ®Google Scholar
• Knowles HJ, Raval RR, Harris AL, Ratcliffe PJ. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res 2003;63:1764–1768.
   PubMed Web of Science ®Google Scholar
• Vissers MCM, Gunningham SP, Morrison MJ, Dachs GU, Currie MJ. Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radic Biol Med 2007;42:765.
   PubMed Web of Science ®Google Scholar
• Solzbach U, Hornig B, Jeserich M, Just H. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation 1997;96:1513–1519.
   PubMed Web of Science ®Google Scholar
• Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, Keaney JF Jr, Vita JA. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol Heart Circ Physiol 2001;280:H528–H534.
   Web of Science ®Google Scholar
• Gokce N, Keaney JF Jr, Frei B, Holbrook M, Olesiak M, Zachariah BJ, Leeuwenburgh C, Heinecke JW, Vita JA. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1999;99:3234–3240.
   PubMed Web of Science ®Google Scholar
• Sherman DL, Keaney JF Jr, Biegelsen ES, Duffy SJ, Coffman JD, Vita JA. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension 2000;35:936–941.
   PubMed Web of Science ®Google Scholar
• Hernández-Guerra M, García-Pagán JC, Turnes J, Bellot P, Deulofeu R, Abraldes JG, Bosch J. Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension. Hepatology 2006;43:485–491.
   PubMed Web of Science ®Google Scholar
• Anderson RA, Evans LM, Ellis GR, Khan N, Morris K, Jackson SK, Rees A, Lewis MJ, Frenneaux MP. Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type2 diabetes. Diabetic Med 2006;23:258–264.
   PubMed Web of Science ®Google Scholar
• Huang A, Vita JA, Venema RC, Keaney JF Jr. Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem 2000;275:17399–17406.
   PubMed Web of Science ®Google Scholar
• Heller R, Unbehaun A, Schellenberg B, Mayer B, Werner-Felmayer G, Werner ER. L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. J Biol Chem 2001;276:40–47.
   PubMed Web of Science ®Google Scholar
• Kim-Shapiro DB, Schechter AN, Gladwin MT. Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics. Arterioscler Thromb Vasc Biol 2006;26:697–705.
   PubMed Web of Science ®Google Scholar
• Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem 2004;279:2550–2558.
   PubMed Web of Science ®Google Scholar
• Crawford JH, Isbell TS, Huang Z, Shiva S, Chacko BK, Schechter AN, Darley-Usmar VM, Kerby JD, Lang JD Jr, Kraus D, Ho C, Gladwin MT, Patel RP. Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood 2006;107:566–574.
   PubMed Web of Science ®Google Scholar
• Kleinbongard P, Dejam A, Lauer T, Jax T, Kerber S, Gharini P, Balzer J, Zotz RB, Scharf RE, Willers R, Schechter AN, Feelisch M, Kelm M. Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med 2006;40:295–302.
   PubMed Web of Science ®Google Scholar
• Dalsgaard T, Simonsen U, Fago A. Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities. Am J Physiol Heart Circ Physiol 2007;292:H3072–H3078.
   Web of Science ®Google Scholar
• Agani FH, Puchowicz M, Chavez JC, Pichiule P, LaManna J. Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia. Am J Physiol Cell Physiol 2002;283:C178–C186.
   PubMed Web of Science ®Google Scholar
• Natarajan R, Fisher BJ, Fowler AA. Regulation of hypoxia inducible factor-1 by nitric oxide in contrast to hypoxia in microvascular endothelium. FEBS Lett 2003;549:99–104.
   PubMed Web of Science ®Google Scholar
• Brune B, Zhou J. The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha). Curr Med Chem 2003;10:845–855.
   PubMed Web of Science ®Google Scholar
• Metzen E, Zhou J, Jelkmann W, Fandrey J, Brune B. Nitric oxide impairs normoxic degradation of HIF-1{alpha} by inhibition of prolyl hydroxylases. Mol Biol Cell 2003;14: 3470–3481.
   PubMed Web of Science ®Google Scholar
• Palmer LA, Gaston B, Johns RA. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol Pharmacol 2000;58:1197–1203.
   PubMed Web of Science ®Google Scholar
• Sumbayev VV, Budde A, Zhou J, Brune B. HIF-1[alpha] protein as a target for S-nitrosation. FEBS Lett 2003;535: 106–112.
   PubMed Web of Science ®Google Scholar
• May JM, Qu Z-C. Nitric oxide-induced oxidant stress in endothelial cells: amelioration by ascorbic acid. Arch Biochem Biophys 2004;429:106–113.
   PubMed Web of Science ®Google Scholar
• Davies KJA. Degradation of oxidized proteins by the 20S proteasome. Biochimie 2001;83:301–310.
   PubMed Web of Science ®Google Scholar
• Glockzin S, von Knethen A, Scheffner M, Brune B. Activation of the cell death program by nitric oxide involves inhibition of the proteasome. J Biol Chem 1999;274:19581–19586.
   PubMed Web of Science ®Google Scholar
• Laggner H, Schmid S, Goldenberg H. Hypericin and photodynamic treatment do not interfere with transport of vitamin C during respiratory burst. Free Radic Res 2004;38:1073–1081.
   PubMed Web of Science ®Google Scholar
• Lykkesfeldt J, Loft S, Poulsen HE. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection—are they reliable biomarkers of oxidative stress? Anal Biochem 1995;229:329.
   PubMed Web of Science ®Google Scholar
• Borenfreund E, Puerner J. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett 1985;24:119–124.
   PubMed Web of Science ®Google Scholar
• Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. PNAS 1996;93:3704–3709.
   PubMed Web of Science ®Google Scholar
• Kohl R, Zhou J, Brune B. Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1[alpha] stabilization. Free Radic Biol Med 2006;40:1430–1442.
   PubMed Web of Science ®Google Scholar
• Dhariwal KR, Hartzell WO, Levine M. Ascorbic acid and dehydroascorbic acid measurements in human plasma and serum. Am J Clin Nutr 1991;54:712–716.
   PubMed Web of Science ®Google Scholar
• Wilson JX, Dixon SJ, Yu J, Nees S, Tyml K. Ascorbate uptake by microvascular endothelial cells of rat skeletal muscle. Microcirculation 1996;2:211–221.
   Google Scholar
• Ek A, Strom K, Cotgreave IA. The uptake of ascorbic acid into human umbilical vein endothelial cells and its effect on oxidant insult. Biochem Pharmacol 1995;50:1339.
   PubMed Web of Science ®Google Scholar
• Malinski T, Radomski MW, Taha Z, Moncada S. Direct electrochemical measurement of nitric oxide released from human platelets. Biochem Biophys Res Commun 1993;194: 960–965.
   PubMed Web of Science ®Google Scholar
• Grune T, Reinheckel T, Davies KJA. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem 1996;271:15504–15509.
   PubMed Web of Science ®Google Scholar
• Jung T, Bader N, Grune T. Oxidized proteins: intracellular distribution and recognition by the proteasome. Arch Biochem Biophys 2007;462:231–237.
   PubMed Web of Science ®Google Scholar
• Grune T, Klotz L-O, Gieche J, Rudeck M, Sies H. Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite. Free Radic Biol Med 2001;30:1243–1253.
   PubMed Web of Science ®Google Scholar
• Kong X, Alvarez-Castelao B, Lin Z, Castano JG, Caro J. Constitutive/hypoxic degradation of HIF-{alpha} proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein. J Biol Chem 2007;282:15498–15505.
   PubMed Web of Science ®Google Scholar
• Tschank G, Sanders J, Baringhaus KH, Dallacker F, Kivirikko KI, Günzler V. Structural requirements for the utilization of ascorbate analogues in the prolyl 4-hydroxylase reaction. Biochem J 1994;300:75–79.
   PubMed Web of Science ®Google Scholar
• Sullivan, M, Galea, P, Latif, S. What is the appropriate oxygen tension for in vitro culture? Mol Hum Reprod 2006; 12:653.
   Web of Science ®Google Scholar