Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells

References

• Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 2006;124:491–504.
   PubMed Web of Science ®Google Scholar
• Zhou B, Wu LJ, Li LH, Tashiro S, Onodera S, Uchiumi F, . Silibinin protects against Isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1. J Pharmacol Sci 2006;102:387–395.
   PubMed Web of Science ®Google Scholar
• Wang MJ, Lin WW, Chen HL, Chang YH, Ou HC, Kuo JS, . Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur J Neurosci 2002;16:2103–2112.
   PubMed Web of Science ®Google Scholar
• Lu P, Mamiya T, Lu LL, Mouri A, Niwa M, Kim H-C, . Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behav Brain Res 2010;207:387–393.
   PubMed Web of Science ®Google Scholar
• Kidd P, Head K. Review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Altern Med Rev 2005;10:193–203.
   PubMed Web of Science ®Google Scholar
• Wu J-W, Lin L-C, Hung S-C, Lin C-H, Chi C-W, Tsai T-H. Hepatobiliary excretion of silibinin in normal and liver cirrhotic rats. Am Soc Pharmacol Exp Ther 2008;36: 589–596.
   Google Scholar
• Wang Q, Zou L, Liu W, Hao W, Tashiro S, Onodera S, Inkejima T. Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence. Pharmacol Biochem Behav 2011;98:140–149.
   PubMed Web of Science ®Google Scholar
• Rui YC, Zhang DZ, Sun DX, Zeng GQ. Effects of silybin on production of oxygen free radical, lipoperoxide and leukotrienes in brain following ischemia and reperfusion. Zhongguo Yao Li Xue Bao 1990;11:418–421.
   PubMed Web of Science ®Google Scholar
• Westerink RHS, Ewing AG. The PC12 cell as model for neurosecretion. Acta Physiol (Oxf) 2008;192:273–285.
   PubMed Web of Science ®Google Scholar
• Liu S, Han Y, Zhang T, Yang Z. Protective effect of trifluoperazine on hydrogen peroxide-inducedapoptosis in PC12 cells. Brain Res Bull 2011;84:183–188.
   PubMed Web of Science ®Google Scholar
• Li X, Ye X, Li X, Sun X, Liang Q, Tao L, . Salidroside protects against MPP+-induced apoptosis in PC12cells by inhibiting the NO pathway. Brain Res 2011; Epub ahead of print.
   Web of Science ®Google Scholar
• Tan B, Luan Z, Wei X, He Y, Wei G, Johnstone BH, . AMPK mediates adipose stem cell-stimulated neuritogenesis of PC12 cells. Neuroscience 2011; Epub ahead of print.
   Web of Science ®Google Scholar
• Mittar D, Sehajpal PK, Lander HM. Nitric oxide activates Rap1 and Ral in a Ras-independent manner. Biochem Biophys Res Commun 2004;322:203–209.
   PubMed Web of Science ®Google Scholar
• Bolanos JP, Almeida A, Stewart V, Peuchen S, Land JM, Clark JB, Heales SJ. Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J Neurochem 1997;68:2227–2240.
   PubMed Web of Science ®Google Scholar
• Togo T, Katsuse O, Iseki E. Nitric oxide pathways in Alzheimer's disease and other neurodegenerative dementias. Neurol Res 2004;26:563–600.
   PubMed Web of Science ®Google Scholar
• Kühn K, Lotz M. Mechanisms of sodium nitroprusside-induced death in human chondrocytes. Rheumatol Int 2003; 23:241–247.
   PubMed Web of Science ®Google Scholar
• Gui J, Song Y, Reena Han N-L, Sheu F-S. Characterization of transcriptional regulation of neurogranin by nitric oxide and the role of neurogranin in SNP-induced cell death: implication of neurogranin in an increased neuronal susceptibility to oxidative stress. Int J Biol Sci 2007;3:212–224.
   PubMed Web of Science ®Google Scholar
• Pytlowany M, Strosznajder JN, Jęśko H, Cąkała M, Strosznajder RP. Molecular mechanism of PC12 cell death evoked by sodiumnitroprusside, a nitric oxide donor. Acta Biochim Polonica 2008;55:339–347.
   PubMed Web of Science ®Google Scholar
• Bartosz G. Reactive oxygen species: destroyers or messengers. Biochem Pharmacol 2009;77:1303–1315.
   PubMed Web of Science ®Google Scholar
• Fenton H.J.H. Oxidation of tartaric acid in presence of iron. J Chem Soc Trans 1894;65:899–911.
   Google Scholar
• Oravecz K, Bazsó-Dombi E, Jeney F, Nagy K, Gecse M, Zs.-Nagy I. The involvement of hydroxyl free radicals in differentiation of the PC-12 rat pheochromocytoma cell line. Arch Gerontol Geriatr 2001;33:61–69.
   PubMed Web of Science ®Google Scholar
• Lockshin RA, Zakeri Z. Apoptosis, autophagy, and more. Int J Biochem Cell Biol 2004;36:2405–2419.
   PubMed Web of Science ®Google Scholar
• Levine B. Autophagy and cancer. Nature 2007;446:745–747.
   PubMed Web of Science ®Google Scholar
• Mariño G, López-Otín C. Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci 2004;61:1439–1454.
   PubMed Web of Science ®Google Scholar
• Pan T, Rawal P, Wu Y, Xie W, Jankovic J, Le W. Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience 2009;164:541–551.
   PubMed Web of Science ®Google Scholar
• Wang Y, Singh R, Massey AC, Kane SS, Kaushik S, Grant T, . Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J Biol Chem 2008;283:4766–4777.
   PubMed Web of Science ®Google Scholar
• Choi YT, Jung CH, Lee SR, Bae JH, Baek WK, Suh MH, . The green tea polyphenol (−)-epigallocatechin gallate attenuates–amyloid-induced neurotoxicity in cultured hippocampal neurons. Life Sci 2001;70:603–614.
   PubMed Web of Science ®Google Scholar
• Nalini K, Rayudu G, Usha G, Jinah C, Henry JF. Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-κB activation in the murine macrophage J774A.1 Cell line. Arch Biochem Biophys 1998;350:206–221.
   Web of Science ®Google Scholar
• Rizzardini M, Lupi M, Bernasconi S, Mangolini A, Cantoni L. Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid. J Neurol Sci 2003;207:51–58.
   PubMed Web of Science ®Google Scholar
• Rego AC, Vesce S, Nicholls DG. The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells. Cell Death Diff 2001;8:995–1003.
   PubMed Web of Science ®Google Scholar
• Pocernich CB, La Fontaine M, Butterfield DA. In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain. Neurochem Int 2000;36:185–191.
   PubMed Web of Science ®Google Scholar
• Ross D. Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection. Pharmacol Ther 1988;37: 231–249.
   PubMed Web of Science ®Google Scholar
• Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001;2:330–335.
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, . LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720–5728.
   PubMed Web of Science ®Google Scholar
• Palmer AM. Pharmacotherapy for Alzheimer's disease: progress and prospects. Trends Pharmacol Sci 2002;23:426–433.
   PubMed Web of Science ®Google Scholar
• Blennow K, de Leon MJ, Zetterberg H. Alzheimer's disease. Lancet 2006;368:387–403.
   PubMed Web of Science ®Google Scholar
• Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, Itoh A, . Restraining tumor necrosis factor-alpha by thalidomide prevents the Amyloid b-induced impairment of recognition memory in mice. Behav Brain Res 2008;189:100–106.
   PubMed Web of Science ®Google Scholar
• Smith MA, Richey Harris PL, Sayre LM, Beckman JS, Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci 1997;17:2653–2657.
   PubMed Web of Science ®Google Scholar
• Lichtenstein MP, Carriba P, Masgrau R, Pujol A, Galea Staging E. Anti-inflammatory therapy in alzheimer's disease. Front Ageing Neurosci 2010;2:142–142.
   PubMed Web of Science ®Google Scholar
• Lu P, Mamiya T, Lu LL, Mouri A, Niwa M, Hiramatsu M, . Silibinin attenuates amyloid β25-35peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-α in mice. JPET 2009;331: 319–326.
   PubMed Web of Science ®Google Scholar
• Hou YC, Liou KT, Chern CM, Wang YH, Liao JF, Chang S, . Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation. Phytomedicine 2010;17:963–973.
   PubMed Web of Science ®Google Scholar
• Bannwart CF, Peraçoli JC, Nakaira-Takahagi E, Peraçoli MT. Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes. Nat Prod Res 2010;24:1747–1757.
   PubMed Web of Science ®Google Scholar
• Duan WJ, Li QS, Xia MY, Tashiro S, Onodera S, Ikejima T Silibinin. Activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-Terminal kinase pathways. Biol Pharm Bull 2011;34:47–53.
   PubMed Web of Science ®Google Scholar
• Wang HJ, Wei XF, Jiang YY, Huang H, Yang Y, Fan SM, ET AL. Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells. Free Radic Res 2010;44:577–584.
   PubMed Web of Science ®Google Scholar
• Nagy K, Pa'sti G, Bene L, Zs.-Nagy I. Induction of granulocytic maturation of HL-60 human leukemia cells by free radicals. A hypothesis of cell differentiation involving hydroxyl radicals. Free Rad Res Commun 1993;19:10–15.
   Google Scholar
• Nagy K, Pa'sti G, Bene L, Zs.-Nagy I. Involvement of Fenton reaction products in differentiation induction of K562 human leukemia cells. Leukemia Res 1995;19:203–212.
   PubMed Web of Science ®Google Scholar
• Bishop NA, Liu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature 2010;464125:529–535.
   Google Scholar
• Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, . The tumor suppressor PTEN positively regulates macro-autophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2001; 276:35243–35246.
   PubMed Web of Science ®Google Scholar
• Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098–1101.
   PubMed Web of Science ®Google Scholar
• Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005;5:726–734.
   PubMed Web of Science ®Google Scholar
• Lefranc F, Kiss R. Autophagy, the Trojan horse to combat glioblastomas. Neurosurg Focus 2006;20:E7.
   PubMedGoogle Scholar
• Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098–1101.
   PubMed Web of Science ®Google Scholar
• Schmitz KJ, Wohlschlaeger J, Alakus H, Bohr J, Stauder MA, Worm K, . Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. Virchows Arch 2007;450:151–159.
   PubMed Web of Science ®Google Scholar
• Yamamoto S, Tomita Y, Hoshida Y, Morooka T, Nagano H, Dono K, . Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. Clin Cancer Res 2004;10:2846–2850.
   PubMed Web of Science ®Google Scholar
• Settakorn J, Kaewpila N, Burns GF, Leong AS. FAT, E-cadherin, beta catenin, HER 2/neu; Ki67 immuno-expression, and histological grade in intrahepatic cholangiocarcinoma. J Clin Pathol 2005;59:1249–1254.
   Google Scholar
• Watanabe S, Itoh T, Arai K. JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells. J Biol Chem 1996;271: 12681–12686.
   PubMed Web of Science ®Google Scholar
• Tian SS, Tapley P, Sincich C, Stein RB, Rosen J, Lamb P. Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes. Blood 1996;88:4435–4444.
   PubMed Web of Science ®Google Scholar
• Chang F, Lee JT, Navolanic PM, Steelman JG, Blalock WL, Franklin RA, . Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 2003;17: 590–603.
   PubMed Web of Science ®Google Scholar
• Chang F, Steelman LS, Shelton JG, Lee JT, Navolanic PN, Blalock WL, . Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway. Int J Oncol 2003;22:469–480.
   PubMed Web of Science ®Google Scholar
• Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL, . Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 2003;17:1263–1293.
   PubMed Web of Science ®Google Scholar
• Yan J, Roy S, Apolloni A, Lane A, Hancock JF. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J Biol Chem 1998;273:24052–24056.
   PubMed Web of Science ®Google Scholar
• Matallanas D, Arozarena I, Berciano MT, Aaronson DS, Pellicer A, Lafarga M, . Differences on the inhibitory specificities of HRas, K-Ras and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization. J Biol Chem 2003;278:4572–4581.
   PubMed Web of Science ®Google Scholar
• Pells S, Divjak M, Romanowski P, Impey H, Hawkins NJ, Clarke AR, . Developmentally-regulated expression of murine K-ras isoforms. Oncogene 1997;15:781–786.
   PubMed Web of Science ®Google Scholar
• Jiang H, Zhang L, Koubi D, Kuo J, Groc L, Rodriguez AI, . Roles of Ras-Erk in apoptosis of PC12 cells induced by trophic factor withdrawal or oxidative stress. J Mol Neurosci 2005;25:133–140.
   PubMed Web of Science ®Google Scholar
• Lee SB, Hong SH, Kim H, Um HD. Co-induction of cell death and survival pathways by phosphoinositide 3-kinase. Life Sci 2005;78:81–91.
   Web of Science ®Google Scholar