Vitamin K3 suppressed inflammatory and immune responses in a redox-dependent manner

References

• Cranenburg EC, Schurgers LJ, Vermeer C. Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost 2007;98:120–125.
   PubMed Web of Science ®Google Scholar
• Lamson DW, Plaza SM. The anticancer effects of vitamin K. Altern Med Rev 2003;8:303–318.
   PubMedGoogle Scholar
• Akiyoshi T, Matzno S, Sakai M, Okamura N, Matsuyama K. The potential of vitamin K3 as an anticancer agent against breast cancer that acts via the mitochondria-related apoptotic pathway. Cancer Chemother Pharmacol 2009;65:143–150.
   PubMed Web of Science ®Google Scholar
• Acharya BR, Choudhury D, Das A, Chakrabarti G. Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry 2009;48:6963–6974.
   PubMed Web of Science ®Google Scholar
• Sandur SK, Ichikawa H, Sethi G, Ahn KS, Aggarwal BB. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. J Biol Chem 2006;281:17023–17033.
   PubMed Web of Science ®Google Scholar
• Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16:225–260.
   PubMed Web of Science ®Google Scholar
• Silverman N, Maniatis T. NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev 2001;15:2321–2342.
   PubMed Web of Science ®Google Scholar
• Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004;25:280–288.
   PubMed Web of Science ®Google Scholar
• Nutter LM, Ngo EO, Fisher GR, Gutierrez PL. DNA strand scission and free radical production in menadione-treated cells. Correlation with cytotoxicity and role of NADPH quinone acceptor oxidoreductase. J Biol Chem 1992;267:2474–2479.
   PubMed Web of Science ®Google Scholar
• Rossi L, Moore GA, Orrenius S, O'Brien PJ. Quinone toxicity in hepatocytes without oxidative stress. Arch Biochem Biophys 1986;251:25–35.
   PubMed Web of Science ®Google Scholar
• Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 2004;304:596–600.
   PubMed Web of Science ®Google Scholar
• Reynaert NL, van der Vliet A, Guala AS, McGovern T, Hristova M, Pantano C, . Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci USA 2006;103:13086–13091.
   PubMed Web of Science ®Google Scholar
• Kil IS, Kim SY, Park JW. Glutathionylation regulates IkappaB. Biochem Biophys Res Commun 2008;373:169–173.
   PubMed Web of Science ®Google Scholar
• Hancock JT, Desikan R, Neill SJ. Role of reactive oxygen species in cell signalling pathways. Biochem Soc Trans 2001;29:345–350.
   PubMed Web of Science ®Google Scholar
• Wu M, Bian Q, Liu Y, Fernandes AF, Taylor A, Pereira P, Shang F. Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome. Free Radic Biol Med 2009;46:62–69.
   PubMed Web of Science ®Google Scholar
• Sharma D, Kumar SS, Raghu R, Khanam S, Sainis KB. Differential modulation of mitogen driven proliferation and homeostasis driven proliferation of T cells by rapamycin, Ly294002 and chlorophyllin. Mol Immunol 2007;44:2831–2840.
   PubMedGoogle Scholar
• Checker R, Chatterjee S, Sharma D, Gupta S, Variyar P, Sharma A, Poduval TB. Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol 2008;8: 661–669.
   PubMedGoogle Scholar
• Checker R, Sharma D, Sandur SK, Subrahmanyam G, Krishnan S, Poduval TB, Sainis KB. Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols. J Cell Biochem 2010;110:1082–1093.
   PubMed Web of Science ®Google Scholar
• Sharma D, Sandur SK, Rashmi R, Maurya DK, Suryavanshi S, Checker R, . Differential activation of NF-kappaB and nitric oxide in lymphocytes regulates in vitro and in vivo radiosensitivity. Mutat Res 2010;703:149–157.
   PubMed Web of Science ®Google Scholar
• Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 2006;1:3159–3165.
   PubMed Web of Science ®Google Scholar
• Takada Y, Aggarwal BB. Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. J Immunol 2003;171:3278–3286.
   PubMed Web of Science ®Google Scholar
• Checker R, Sharma D, Sandur SK, Khanam S, Poduval TB. Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes. Int Immunopharmacol 2009;9:949–958.
   PubMed Web of Science ®Google Scholar
• Takahashi N, Schreiber J, Fischer V, Mason RP. Formation of glutathione-conjugated semiquinones by the reaction of quinones with glutathione: an ESR study. Arch Biochem Biophys 1987;252:41–48.
   PubMed Web of Science ®Google Scholar
• Schulze-Luehrmann J, Ghosh S. Antigen-receptor signaling to nuclear factor kappa B. Immunity 2006;25:701–715.
   PubMedGoogle Scholar
• Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H, . Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. Embo J 2007;26:1794–1805.
   PubMed Web of Science ®Google Scholar
• Paule B, Terry S, Kheuang L, Soyeux P, Vacherot F, de la Taille A. The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches? World J Urol 2007;25:477–489.
   PubMedGoogle Scholar
• Sica A, Dorman L, Viggiano V, Cippitelli M, Ghosh P, Rice N, Young HA. Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J Biol Chem 1997;272: 30412–30420.
   PubMed Web of Science ®Google Scholar
• Rocha B, Dautigny N, Pereira P. Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur J Immunol 1989;19:905–911.
   PubMedGoogle Scholar
• Sharma D, Kumar SS, Checker R, Raghu R, Khanam S, Krishnan S, Sainis KB. Spatial distribution, kinetics, signaling and cytokine production during homeostasis driven proliferation of CD4 + T cells. Mol Immunol 2009;46:2403–2412.
   PubMedGoogle Scholar
• Vodanovic-Jankovic S, Hari P, Jacobs P, Komorowski R, Drobyski WR. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood 2006;107:827–834.
   PubMed Web of Science ®Google Scholar