370
Views
24
CrossRef citations to date
0
Altmetric
Research Articles

Cordycepin inhibits albumin-induced epithelial-mesenchymal transition of renal tubular epithelial cells by reducing reactive oxygen species production

, , , , , , , , , , & show all
Pages 174-183 | Received 12 Sep 2011, Accepted 05 Dec 2011, Published online: 23 Jan 2012

References

  • Zeisberg M, Neilson EG. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 2010;21(11):1819–1834.
  • Singh DK, Winocour P, Farrington K. Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy. Nat Clin Pract 2008;4(4):216–226.
  • Zeisberg M, Duffield JS. Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol 2010;21(8):1247–1253.
  • Liu Y. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 2010;21(2):212–222.
  • Zoja C, Benigni A, Remuzzi G. Cellular responses to protein overload: key event in renal disease progression. Curr Opin Nephrol Hypertens 2004;13(1):31–37.
  • Wen Q, Huang Z, Zhou SF, Li XY, Luo N, Yu XQ. Urinary proteins from patients with nephrotic syndrome alters the signalling proteins regulating epithelial-mesenchymal transition. Nephrology (Carlton) 2010;15(1):63–74.
  • Tang R, Yang C, Tao JL, You YK, An N, Li SM, . Epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells induced by urinary proteins requires the activation of PKC-alpha and betaI isozymes. Cell Biol Int 2011; 35(9):953–959.
  • Djamali A, Reese S, Yracheta J, Oberley T, Hullett D, Becker B. Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathy. Am J Transplant 2005;5(3): 500–509.
  • Lee JY, Chang JW, Yang WS, Kim SB, Park SK, Park JS, . Albumin-induced epithelial-mesenchymal transition and ER stress are regulated through a common ROS-c-Src kinase-mTOR pathway: effect of imatinib mesylate. Am J Physiol 2011;300(5):F1214–F1222.
  • Djamali A. Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts. Am J Physiol 2007;293(2):F445–F455.
  • Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh ST, . Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 2005;16(3):667–675.
  • Lee YJ, Han HJ. Troglitazone ameliorates high glucose- induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3{beta}, Snail1, and {beta}-catenin in renal proximal tubule cells. Am J Physiol Renal Physiol. 2009 Dec 16. [Epub ahead of print]
  • Chang J, Jiang Z, Zhang H, Zhu H, Zhou SF, Yu X. NADPH oxidase-dependent formation of reactive oxygen species contributes to angiotensin II-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells. Int J Mol Med 2011;28(3):405–412.
  • Zhang A, Jia Z, Guo X, Yang T. Aldosterone induces epithelial- mesenchymal transition via ROS of mitochondrial origin. Am J Physiol 2007;293(3):F723–F731.
  • Zhou G, Dada LA, Wu M, Kelly A, Trejo H, Zhou Q, . Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. Am J Physiol Lung Cell Mol Physiol 2009;297(6): L1120–L1130.
  • Whaley-Connell AT, Morris EM, Rehmer N, Yaghoubian JC, Wei Y, Hayden MR, . Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells. Am J Nephrol 2007;27(1):15–23.
  • Jiang Y, Yao YJ. Names related to cordyceps sinensis anamorph. Mycotaxon 2002;84:245–254.
  • Xun C, Shen N, Li B, Zhang Y, Wang F, Yang Y, . Radiation mitigation effect of cultured mushroom fungus Hirsutella Sinensis (CorImmune) isolated from a Chinese/Tibetan herbal preparation -Cordyceps Sinensis. Int J Radiat Biol 2008;84(2):139–149.
  • Cheng Z, He W, Zhou X, Lv Q, Xu X, Yang S, . Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro. Eur J Pharmacol 2011;664 (1–3):20–28.
  • Won KJ, Lee SC, Lee CK, Lee HM, Lee SH, Fang Z, . Cordycepin attenuates neointimal formation by inhibiting reactive oxygen species-mediated responses in vascular smooth muscle cells in rats. J Pharmacol Sci 2009;109(3):403–412.
  • Jeong JW, Jin CY, Park C, Hong SH, Kim GY, Jeong YK, . Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol Vitro 2011;25(4):817–824.
  • Zhu YF, Chen YP, Rui HL, Dong HR, Hu Z. Protective effects of Hirsutella sinensis on renal interstitial fibrosis: experiment with rat model of chronic aristolochic acid nephropathy. Zhonghua yi xue za zhi 2007;87(38):2667–2671.
  • Chai JJ, Chen YP, Rui HL. Effects of Hirsutella sinensis on TGF-beta1 and Snail expressions and transdifferentiation of tubular epithelial-myofibroblast in renal tissue of rats with chronic aristolochic acid nephropathy. Chi J Integrated Tradit Wes Med 2009;29(4):325–329.
  • Wu JN, Liu BC, Xia HL, Liu DG. Effect of Cordyceps polysaccharide (Cp) on the transition of tubular epithelial mesenchymal in mice with unilateral ureteral obstructive. Chin J Integrated Tradit West Nephrol 2008;9(9):400–402.
  • Zhuang G, Xiao-liang Z. Chinese herb Cordyceps polysaccharide inhibits transforming growth factor β1-induced epithelial-to-mesenchymal transition in proximal tubular epithelial cells. Chin J Nephrol 2008;24(9):651–656.
  • Sun L, Xiao L, Nie J, Liu FY, Ling GH, Zhu XJ, . p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway. Am J Physiol 2010;299(5):F1014–F1025.
  • Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, . Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circ Res 2002;90(11):1205–1213.
  • Sun L, Zhang DS, Liu FY, Xian XD, Ling GH, Xiao L, . Low-dose Paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192. J Pathol 2011; 225(3):364–377.
  • Cabello-Verrugio C, Acuna MJ, Morales MG, Becerra A, Simon F, Brandan E. Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells. Biochem Biophys Res Comm 2011;410(3):665–670.
  • Chabrashvili T, Tojo A, Onozato ML, Kitiyakara C, Quinn MT, Fujita T, . Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension 2002;39(2):269–274.
  • Geiszt M, Kopp JB, Varnai P, Leto TL. Identification of renox, an NAD(P)H oxidase in kidney. Proc Nat Acad Sci USA 2000;97(14):8010–8014.
  • Babior BM, Lambeth JD, Nauseef W. The neutrophil NADPH oxidase. Arch Biochem Biophys 2002;397(2): 342–344.
  • Kim JY, Yu SJ, Oh HJ, Lee JY, Kim Y, Sohn J. Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species. Apoptosis 2011;16(4):347–358.
  • Malam Z, Parodo J, Waheed F, Szaszi K, Kapus A, Marshall JC. Pre-B cell colony-enhancing factor (PBEF/Nampt/ visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase. J Immunol 2011;186(11):6474–6484.
  • Edlund J, Fasching A, Liss P, Hansell P, Palm F. The roles of NADPH-oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney. Diabetes/Metabol Res Rev 2010;26(5):349–356.
  • Jeong JW, Jin CY, Kim GY, Lee JD, Park C, Kim GD, . Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. Int Immunopharm 2010;10(12):1580–1586.
  • Kitamura M, Kato H, Saito Y, Nakajima S, Takahashi S, Johno H, . Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine. Cell Death Differ 2011;18(12):1876–1888.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.