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Research Article

Hypoxia induces nitric oxide synthase in rheumatoid synoviocytes: consequences on NADPH oxidase regulation

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Pages 628-636 | Received 05 Oct 2011, Accepted 26 Jan 2012, Published online: 12 Mar 2012

References

  • Lefèvre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, . Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 2009;15:1414–1420.
  • Hitchon CA, El-Gabalawy HS. Oxidation in rheumatoid arthritis. Arthritis Res Ther 2004;6:265–278.
  • Nagy G, Clark JM, Buzás EI, Gorman CL, Cope AP. Nitric oxide, chronic inflammation and autoimmunity. Immunol Lett 2007;111:1–5.
  • Migita K, Yamasaki S, Kita M, Ida H, Shibatomi K, Kawakami A, . Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase-3. Immunology 2001;103:362–367.
  • Jang D, Murrell GA. Nitric oxide in arthritis. Free Radic Biol Med 1998;24:1511–1519.
  • Borderie D, Hilliquin P, Hernvann A, Lemarechal H, Kahan A, Menkes CJ, . Inhibition of inducible NO synthase by TH2 cytokines and TGF beta in rheumatoid arthritic synoviocytes: effects on nitrosothiol production. Nitric Oxide 2002;6:271–282.
  • Hilliquin P, Borderie D, Hernvann A, Menkès CJ, Ekindjian OG. Nitric oxide as S-nitrosoproteins in rheumatoid arthritis. Arthritis Rheum 1997;40:1512–1517.
  • Chenevier-Gobeaux C, Lemarechal H, Bonnefont-Rousselot D, Poiraudeau S, Ekindjian OG, Borderie D, . Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1β and tumour necrosis factor-α. Inflamm Res 2006;55:483–490.
  • Afanas'ev IB. Signaling functions of free radicals superoxide & nitric oxide under physiological & pathological conditions. Mol Biotechnol 2007;37:2–4.
  • Biniecka M, Kennedy A, Fearon U, Ng CT, Veale DJ, O'Sullivan JN, . Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint. Ann Rheum Dis 2010;69:1172–1178.
  • Kennedy A, Ng CT, Chang TC, Biniecka M, O'Sullivan JN, Heffernan E, . TNF blocking therapy alters joint inflammation and hypoxia. Arthritis Rheum 2001;63:923–932.
  • Ng CT, Biniecka M, Kennedy A, McCormick J, Fitzgerald O, Bresnihan B, . Synovial tissue hypoxia and inflammation in vivo. Ann. Rheum Dis 2010;69:1389–1395.
  • Demasi M, Cleland LG, Cook-Johnson RJ, James MJ. Effects of hypoxia on the expression and activity of cyclooxygenase 2 in fibroblast-like synoviocytes: interactions with monocyte-derived soluble mediators. Arthritis Rheum 2004;50:2441–2449.
  • Charbonneau M, Harper K, Grondin F, Pelmus M, McDonald PP, Dubois CM, . Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells. J Biol Chem 2007;282: 33714–33724.
  • Ahn JK, Koh EM, Cha HS, Lee YS, Kim J, Bae EK, . Role of hypoxia-inducible factor-1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes. Rheumatology 2008;47:834–839.
  • Akhavani MA, Madden L, Buysschaert I, Sivakumar B, Kang N, Paleolog EM, . Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis. Arthritis Res Ther 2009;11:R64.
  • Del Rey MJ, Izquierdo E, Caja S, Usategui A, Santiago B, Galindo M, . Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1alpha/vascular endothelial growth factor-mediated pathway in immunodeficient mice. Arthritis Rheum 2009;60:2926–2934.
  • Del Rey MJ, Izquierdo E, Usategui A, Gonzalo E, Blanco FJ, Acquadro F, . The transcriptional response of normal and rheumatoid arthritis synovial fibroblasts to hypoxia. Arthritis Rheum 2010;62:3584–3594.
  • Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, . 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010;69:1580–1588.
  • Mellor HR, Snelling S, Hall MD, Modok S, Jaffar M, Hambley TW, . The influence of tumour microenvironmental factors on the efficacy of cisplatin and novel platinum(IV) complexes. Biochem Pharmacol 2005;70:1137–1146.
  • Wang JY, Shum AY, Wang JY. Hypoxia/reoxygenation induces cell injury via different mechanisms in cultured rat cortical neurons and glial cells. Neurosci Lett 2002;322: 187–191.
  • Tsikas D. Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids. Free Radic Res 2005;39:797–815.
  • Crow JP. Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species. Nitric Oxide 1997;1:145–157.
  • Daudin J-B, Monnet D, Kavian N, Espy C, Wang A, Chéreau C, . Protective effect of pristane on experimental autoimmune uveitis. Immunol Letters 2011;141:83–93.
  • Sohn HY, Krotz F, Gloe T, Keller M, Theisen K, Klauss V, . Differential regulation of xanthine and NAD(P)H oxidase by hypoxia in human umbilical vein endothelial cells. Role of nitric oxide and adenosine. Cardiovasc Res 2003;58:638–646.
  • Sivakumar B, Akhavani MA, Winlove CP, Taylor PC, Paleolog EM, Kang N, . Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis. J Hand Surg Am 2008;33:49–58.
  • Bosco MC, Delfino S, Ferlito F, Battaglia F, Puppo M, Gregorio A, . Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/CCL20 in juvenile idiopathic arthritis. Arthritis Rheum 2008;58:1833–1838.
  • Nagao K, Takenaka S, Yamaji R, Inui H, Nakano Y. Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxia. J Biochem 2003; 133:501–505.
  • Lu DY, Liou HC, Tang CH, Fu WM. Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha. Biochem Pharmacol 2006;72: 992–1000.
  • Schneider N, Mouithys-Mickalad AL, Lejeune JP, Deby-Dupont GP, Hoebeke M, Serteyn DA, . Synoviocytes, not chondrocytes, release free radicals after cycles of anoxia/re-oxygenation. Biochem Biophys Res Commun 2005; 334:669–673.
  • Park JW. Attenuation of p47phox and p67phox membrane translocation as the inhibitory mechanism of S-nitrosothiol on the respiratory burst oxidase in human neutrophils. Biochem Biophys Res Commun 1996;220:31–35.
  • Von Knethen A, Brüne B. Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst. J Immunol 2002;169:2619–2626.
  • Selemidis S, Dusting GJ, Peshavariya H, Kemp-Harper BK, Drummond GR. Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells. Cardiovasc Res 2007;75:349–358.
  • Foster MW, McMahon TJ, Stamler JS. S-nitrosylation in health and disease. Trends Mol Med 2003;9:160–168.
  • Inanami O, Johnson JL, Babior BM. The leukocyte NADPH oxidase subunit p47PHOX: the role of the cysteine residues. Arch Biochem Biophys 1998;350:36–40.

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