Low-grade chronic inflammation and superoxide anion production by NADPH oxidase are the main determinants of physical frailty in older adults

References

• Studenski S, Perera S, Wallace D, Chandler JM, Duncan PW, Rooney E, . Physical performance measures in the clinical setting. J Am Geriatr Soc 2003;51:314–322.
   PubMed Web of Science ®Google Scholar
• Hardy SE, Perera S, Roumani YF, Chandler JM, Studenski SA. Improvement in usual gait speed predicts better survival in older adults. J Am Geriatr Soc 2007;55:1727–1734.
   PubMed Web of Science ®Google Scholar
• Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, . Gait speed and survival in older adults. JAMA 2011;305:50–58.
   PubMed Web of Science ®Google Scholar
• Cesari M, Kritchevsky SB, Penninx BW, Nicklas BJ, Simonsick EM, Newman AB, . Prognostic value of usual gait speed in well-functioning older people – results from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2005;53:1675–1680.
   PubMed Web of Science ®Google Scholar
• Abellan van Kan G, Rolland Y, Andrieu S, Bauer J, Beauchet O, Bonnefoy M, . Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging 2009;13:881–889.
   PubMed Web of Science ®Google Scholar
• Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, . Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39:412–423.
   PubMed Web of Science ®Google Scholar
• De Martinis M, Franceschi C, Monti D, Ginaldi L. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol 2006;80:219–227.
   PubMed Web of Science ®Google Scholar
• Kravitz BA, Corrada MM, Kawas CH. High levels of serum C-reactive protein are associated with greater risk of all-cause mortality, but not dementia, in the oldest-old: results from the 90 + study. J Am Geriatr Soc 2009;57:641–646.
   PubMed Web of Science ®Google Scholar
• Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:298–300.
   PubMedGoogle Scholar
• Ventura E, Durant R, Jaussent A, Picot MC, Morena M, Badiou S, . Homocysteine and inflammation as main determinants of oxidative stress in the elderly. Free Radic Biol Med 2009;46:737–744.
   PubMed Web of Science ®Google Scholar
• Gianni P, Jan KJ, Douglas MJ, Stuart PM, Tarnopolsky MA. Oxidative stress and the mitochondrial theory of aging in human skeletal muscle. Exp Gerontol 2004;39:1391–1400.
   PubMed Web of Science ®Google Scholar
• Wu IC, Shiesh SC, Kuo PH, Lin XZ. High oxidative stress is correlated with frailty in elderly Chinese. J Am Geriatr Soc 2009;57:1666–1671.
   PubMed Web of Science ®Google Scholar
• Semba RD, Ferrucci L, Sun K, Walston J, Varadhan R, Guralnik JM, . Oxidative stress and severe walking disability among older women. Am J Med 2007;120:1084–1089.
   PubMed Web of Science ®Google Scholar
• Parmelee PA, Thuras PD, Katz IR, Lawton MP. Validation of the Cumulative Illness Rating Scale in a geriatric residential population. J Am Geriatr Soc 1995;43:130–137.
   PubMed Web of Science ®Google Scholar
• Nagaratnam N, Gayagay G Jr. Validation of the Cumulative Illness Rating Scale (CIRS) in hospitalized nonagenarians. Arch Gerontol Geriatr 2007;44:29–36.
   PubMedGoogle Scholar
• Descamps-Latscha B, Goldfarb B, Nguyen AT, Landais P, London G, Haeffner-Cavaillon N, . Establishing the relationship between complement activation and stimulation of phagocyte oxidative metabolism in hemodialyzed patients: a randomized prospective study. Nephron 1991;59:279–285.
   PubMed Web of Science ®Google Scholar
• Fearon DT, Collins LA. Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures. J Immunol 1983;130: 370–375.
   PubMed Web of Science ®Google Scholar
• Durant R, Klouche K, Delbosc S, Morena M, Amigues L, Beraud JJ, . Superoxide anion overproduction in sepsis: effects of vitamin e and simvastatin. Shock 2004;22:34–39.
   PubMed Web of Science ®Google Scholar
• Rabesandratana H, Fournier AM, Chateau MT, Serre A, Dornand J. Increased oxidative metabolism in PMA-activated lymphocytes: a flow cytometric study. Int J Immunopharmacol 1992;14:895–902.
   PubMed Web of Science ®Google Scholar
• Morena M, Patrier L, Jaussent I, Bargnoux AS, Dupuy AM, Badiou S, . Reduced glomerular filtration rate, inflammation and HDL cholesterol as main determinants of superoxide production in non-dialysis chronic kidney disease patients. Free Radic Res 2011;45:735–745.
   PubMed Web of Science ®Google Scholar
• Wonisch W, Falk A, Sundl I, Winklhofer-Roob BM, Lindschinger M. Oxidative stress increases continuously with BMI and age with unfavourable profiles in males. Aging Male 2012:1–7.
   PubMedGoogle Scholar
• Dupuy AM, Jaussent I, Lacroux A, Durant R, Cristol JP, Delcourt C. Waist circumference adds to the variance in plasma C-reactive protein levels in elderly patients with metabolic syndrome. Gerontology 2007;53:329–339.
   PubMedGoogle Scholar
• Helmersson J, Larsson A, Vessby B, Basu S. Active smoking and a history of smoking are associated with enhanced prostaglandin F2 [alpha], interleukin-6 and F2-isoprostane formation in elderly men. Atherosclerosis 2005;181:201–207.
   PubMed Web of Science ®Google Scholar
• Cohen HJ, Harris T, Pieper CF. Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am J Med 2003;114: 180–187.
   PubMed Web of Science ®Google Scholar
• Reiner AP, Aragaki AK, Gray SL, Wactawski-Wende J, Cauley JA, Cochrane BB, . Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women. Am J Med 2009;122:947–954.
   PubMed Web of Science ®Google Scholar
• Ridker PM. C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus. J Am Coll Cardiol 2007;49:2129–2138.
   PubMed Web of Science ®Google Scholar
• Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 1998;279:1477–1482.
   PubMed Web of Science ®Google Scholar
• Danesh J, Lewington S, Thompson SG, Lowe GD, Collins R, Kostis JB, . Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA 2005;294:1799–1809.
   PubMed Web of Science ®Google Scholar
• Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000;408:239–247.
   PubMed Web of Science ®Google Scholar
• Chan SS, Monteiro HP, Deucher GP, Abud RL, Abuchalla D, Junqueira VB. Functional activity of blood polymorphonuclear leukocytes as an oxidative stress biomarker in human subjects. Free Radic Biol Med 1998;24:1411–1418.
   PubMedGoogle Scholar
• Braga PC, Sala MT, Dal Sasso M, Pecile A, Annoni G, Vergani C. Age-associated differences in neutrophil oxidative burst (chemiluminescence). Exp Gerontol 1998;33:477–484.
   PubMedGoogle Scholar
• Leng SX, Xue QL, Tian J, Huang Y, Yeh SH, Fried LP. Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies I. Exp Gerontol 2009;44: 511–516.
   PubMed Web of Science ®Google Scholar
• Schumann MA, Leung CC, Raffin TA. Activation of NADPH-oxidase and its associated whole-cell H + current in human neutrophils by recombinant human tumor necrosis factor alpha and formyl-methionyl-leucyl-phenylalanine. J Biol Chem 1995; 270:13124–13132.
   PubMed Web of Science ®Google Scholar
• Kabe Y, Ando K, Hirao S, Yoshida M, Handa H. Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal 2005;7:395–403.
   PubMed Web of Science ®Google Scholar
• Blain H, Jaussent A, Beziat S, Dupuy AM, Bernard PL, Mariano-Goulart D, . Low serum IL-6 is associated with high 6-minute walking performance in asymptomatic women aged 20 to 70 years. Exp Gerontol 2012;47:143–148.
   PubMedGoogle Scholar
• Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, . Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc 2002;50: 1947–1954.
   PubMed Web of Science ®Google Scholar
• Artur Y, Herbeth B, Guemouri L, Lecomte E, Jeandel C, Siest G. Age-related variations of enzymatic defenses against free radicals and peroxides. Exs 1992;62:359–367.
   PubMedGoogle Scholar