339
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells

, , , , , , , & show all
Pages 1437-1445 | Received 05 Jul 2012, Accepted 22 Aug 2012, Published online: 27 Sep 2012

References

  • Wright JL, Levy RD and Churg A. Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment. Thorax 2005;60:605–609.
  • Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176:532–555.
  • MacNee W. Oxidants/antioxidants and COPD. Chest 2000;117:303S–317S.
  • Doi M, Nakano K, Hiramoto T, Kohno N. Significance of pulmonary artery pressure in emphysema patients with mild-to-moderate hypoxemia. Respir Med 2003;97:915–920.
  • Lee SD, Lee DS, Chun YG, Shim TS, Lim CM, Koh Y, . Cigarette smoke extract induces endothelin-1 via protein kinase C in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 2001;281:L403–L411.
  • Misonou Y, Asahi M, Yokoe S, Miyoshi E, Taniguchi N. Acrolein produces nitric oxide through the elevation of intracellular calcium levels to induce apoptosis in human umbilical vein endothelial cells: implications for smoke angiopathy. Nitric Oxide 2006;14:180–187.
  • Milkiewicz M, Mohammadzadeh F, Ispanovic E, Gee E, Haas TL. Static strain stimulates expression of matrix metalloproteinase-2 and VEGF in microvascular endothelium via JNK- and ERK-dependent pathways. J Cell Biochem 2007;100:750–761.
  • Wright JL, Dai J, Zay K, Price K, Gilks CB, Churg A. Effects of cigarette smoke on nitric oxide synthase expression in the rat lung. Lab Invest 1999;79:975–983.
  • Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, . Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol 2008;38:446–454.
  • Jang AS, Concel VJ, Bein K, Brant KA, Liu S, Pope-Varsalona H, . Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury. Am J Respir Cell Mol Biol 2011;44:483–490.
  • Jaimes EA, DeMaster EG, Tian RX, Raij L. Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation. Arterioscler Thromb Vasc Biol 2004;24:1031–1036.
  • Patel JM, Block ER. Acrolein-induced injury to cultured pulmonary artery endothelial cells. Toxicol Appl Pharmacol 1993;122:46–53.
  • Dossumbekova A, Berdyshev EV, Gorshkova I, Shao Z, Li C, Long P, . Akt activates NOS3 and separately restores barrier integrity in H2O2-stressed human cardiac microvascular endothelium. Am J Physiol Heart Circ Physiol 2008;295: H2417–H2426.
  • Kinnula VL, Whorton AR, Chang LY, Crapo JD. Regulation of hydrogen peroxide generation in cultured endothelial cells. Am J Respir Cell Mol Biol 1992;6:175–182.
  • Stone JR, Yang S. Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal 2006;8:243–270.
  • Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG, Weir EK. Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha- Kv1. 5O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol 2008;294: H570–H578.
  • Dong L, Xie MJ, Zhang P, Ji LL, Liu WC, Dong MQ, Gao F. Rotenone partially reverses decreased BK Ca currents in cerebral artery smooth muscle cells from streptozotocin-induced diabetic mice. Clin Exp Pharmacol Physiol 2009;36: e57–e64.
  • Serpillon S, Floyd BC, Gupte RS, George S, Kozicky M, Neito V, . Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH. Am J Physiol Heart Circ Physiol 2009;297:H153–H162.
  • Quintero M, Colombo SL, Godfrey A, Moncada S. Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci USA 2006;103:5379–5384.
  • Bychkov R, Pieper K, Ried C, Milosheva M, Bychkov E, Luft FC, Haller H. Hydrogen peroxide, potassium currents, and membrane potential in human endothelial cells. Circulation 1999;99:1719–1725.
  • Rogers PA, Dick GM, Knudson JD, Focardi M, Bratz IN, Swafford AN Jr, . H2O2-induced redox-sensitive coronary vasodilation is mediated by 4-aminopyridine-sensitive K+ channels. Am J Physiol Heart Circ Physiol 2006;291:H2473–H2482.
  • Avshalumov MV, Rice ME. Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release. Proc Natl Acad Sci USA 2003;100:11729–11734.
  • Silver MR, DeCoursey TE. Intrinsic gating of inward rectifier in bovine pulmonary artery endothelial cells in the presence or absence of internal Mg2+. J Gen Physiol 1990;96:109–133.
  • Johns A, Lategan TW, Lodge NJ, Ryan US, Van Breemen C, Adams DJ. Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells. Tissue Cell 1987;19:733–745.
  • Silver MR, Shapiro MS, DeCoursey TE. Effects of external Rb+on inward rectifierK+channels of bovine pulmonary artery endothelial cells. J Gen Physiol 1994;103:519–548.
  • Demirel E, Rusko J, Laskey RE, Adams DJ, van Breemen C. TEA inhibits ACh-induced EDRF release: endothelial Ca(2+)-dependent K+ channels contribute to vascular tone. Am J Physiol 1994;267:H1135–H1141.
  • Katnik C, Adams DJ. Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells. Am J Physiol 1997;272:H2507–H2511.
  • Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+current in vascular endothelial cells. Nature 1988;331:168–170.
  • Malester B, Tong X, Ghiu I, Kontogeorgis A, Gutstein DE, Xu J, . Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion. FASEB J 2007;21:2162–2172.
  • Karamsetty MR, Wadsworth RM, Kane KA. Effect of K+ channel blocking drugs and nitric oxide synthase inhibition on the response to hypoxia in rat pulmonary artery rings. J Auton Pharmacol 1998;18:49–56.
  • Darly-Usmar VM, Rickwood D, Wilson MT. Mitochondria: a practical approch. Oxford, UK: ILR press; 1987.
  • Pearlstein DP, Ali MH, Mungai PT, Hynes KL, Gewertz BL, Schumacker PT. Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia. Arterioscler Thromb Vasc Biol 2002;22:566–573.
  • Shaikh SB, Nicholson LF. Effects of chronic low dose rotenone treatment on human microglial cells. Mol Neurodegener 2009;4:55.
  • Thompson RJ, Buttigieg J, Zhang M, Nurse CA. A rotenone-sensitive site and H2O2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells. Neuroscience 2007;145:130–141.
  • Frazziano G, Moreno L, Moral-Sanz J, Menendez C, Escolano L, Gonzalez C, . Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction. J Cell Physiol 2011;226:2633–2640.
  • O'Malley Y, Fink BD, Ross NC, Prisinzano TE, Sivitz WI. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. J Biol Chem 2006;281: 39766–36975.
  • Jin J, Davis J, Zhu D, Kashima DT, Leroueil M, Pan C, . Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells. BMC Neurosci 2007;8:67.
  • Misonou Y, Takahashi M, Park YS, Asahi M, Miyamoto Y, Sakiyama H, . Acrolein induces Hsp72 via both PKCdelta/JNK and calcium signaling pathways in human umbilical vein endothelial cells. Free Radic Res 2005;39:507–512.
  • Kanazawa H, Yoshikawa J. Elevated oxidative stress and reciprocal reduction of vascular endothelial growth factor levels with severity of COPD. Chest 2005;128:3191–3197.
  • Wright JL, Tai H, Churg A. Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig. J Appl Physiol 2006;100:672–678.
  • Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001;21:2–14.
  • Tao F, Gonzalez-Flecha B, Kobzik L. Reactive oxygen species in pulmonary inflammation by ambient particulates. Free Radic Biol Med 2003;35:327–340.
  • Finkel T. Oxygen radicals and signaling. Curr Opin Cell Biol 1998;10:248–253.
  • Burdon RH, Rice-Evans C. Free radicals and the regulation of mammalian cell proliferation. Free Radic Res Commun 1989;6:345–358.
  • Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000;279: L1005–L1028.
  • Moudgil R, Michelakis ED, Archer SL. The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Microcirculation 2006;13:615–632.
  • Steudel W, Watanabe M, Dikranian K, Jacobson M, Jones RC. Expression of nitric oxide synthase isoforms (NOS II and NOS III) in adult rat lung in hyperoxic pulmonary hypertension. Cell Tissue Res 1999;295:317–329.
  • Zellers TM, McCormick J, Wu Y. Interaction among ET-1, endothelium-derived nitric oxide, and prostacyclin in pulmonary arteries and veins. Am J Physiol 1994;267:H139–H147.
  • Li H, Wallerath T, Forstermann U. Physiological mechanisms regulating the expression of endothelial-type NO synthase. Nitric Oxide 2002;7:132–147.
  • Chakrabarti S, Rizvi M, Morin K, Garg R, Freedman JE. The role of CD40L and VEGF in the modulation of angiogenesis and inflammation. Vascul Pharmacol 2010;53:130–137.
  • Michaud SE, Dussault S, Groleau J, Haddad P, Rivard A. Cigarette smoke exposure impairs VEGF-induced endothelial cell migration: role of NO and reactive oxygen species. J Mol Cell Cardiol 2006;41:275–284.
  • Grishko V, Solomon M, Breit JF, Killilea DW, Ledoux SP, Wilson GL, Gillespie MN. Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene. FASEB J 2001;15:1267–1269.
  • Wright JL, Tai H, Churg A. Cigarette smoke induces persisting increases of vasoactive mediators in pulmonary arteries. Am J Respir Cell Mol Biol 2004;31:501–509.
  • Ushio-Fukai M. VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 2007;9:731–739.
  • Dröge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47–95.
  • Chen JX, Berry LC, Tanner M, Chang M, Myers RP, Meyrick B. Nitric oxide donors regulate nitric oxide synthase in bovine pulmonary artery endothelium. J Cell Physiol 2001;186: 116–123.
  • Fadel E, Mazmanian GM, Baudet B, Detruit H, Verhoye JP, Cron J, . Endothelial nitric oxide synthase function in pig lung after chronic pulmonary artery obstruction. Am J Respir Crit Care Med 2000;162:1429–1434.
  • Erdogan A, Schaefer CA, Schaefer M, Luedders DW, Stockhausen F, Abdallah Y, . Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells. J Vasc Res 2005;42: 368–376.
  • Lindberg RA, Dewhirst MW, Buckley BJ, Hughes CS, Whorton AR. Ca(2+)-dependent nitric oxide release in endothelial but not R 3230Ac rat mammary adenocarcinoma cells. Am J Physiol 1996;271:C332–C337.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.