References
- Laakso M. Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 1999;48:937–942.
- NIH. Diabetes Statistics. 2011.
- Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, . Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000;342:454–460.
- Ghosh S, Golbidi S, Werner I, Verchere BC, Laher I. Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview. Clin Sci (Lond) 2010;119:57–74.
- Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23: 599–622.
- Ghosh S, Khazaei M, Moien-Afshari F, Ang LS, Granville DJ, Verchere CB, . Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice. Am J Physiol Renal Physiol 2009;296:F700–F708.
- Moien-Afshari F, Ghosh S, Elmi S, Khazaei M, Rahman MM, Sallam N, Laher I. Exercise restores coronary vascular function independent of myogenic tone or hyperglycemic status in db/db mice. Am J Physiol Heart Circ Physiol 2008;295:H1470–H1480.
- Moien-Afshari F, Ghosh S, Elmi S, Rahman MM, Sallam N, Khazaei M, . Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. Diabetologia 2008;51:1327–1337.
- Mendoza-Nunez VM, Rosado-Perez J, Santiago-Osorio E, Ortiz R, Sanchez-Rodriguez MA, Galván-Duarte RE. Aging linked to type 2 diabetes increases oxidative stress and chronic inflammation. Rejuvenation Res 2011;14:25–31.
- Ji LL. Exercise at old age: does it increase or alleviate oxidative stress?Ann N Y Acad Sci 2001;928:236–247.
- Ji LL, Leeuwenburgh C, Leichtweis S, Gore M, Fiebig R, Hollander J, Bejma J. Oxidative stress and aging. Role of exercise and its influences on antioxidant systems. Ann N Y Acad Sci 1998;854:102–117.
- Navarro A, Gomez C, Lopez-Cepero JM, Boveris A. Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am J Physiol Regul Integr Comp Physiol 2004; 286:R505–R511.
- Koo JR, Vaziri ND. Effects of diabetes, insulin and antioxidants on NO synthase abundance and NO interaction with reactive oxygen species. Kidney Int 2003;63:195–201.
- Ghosh S, Pulinilkunnil T, Yuen G, Kewalramani G, An D, Qi D, . Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion. Am J Physiol Heart Circ Physiol 2005;289:H768–H776.
- Leeuwenburgh C, Ji LL. Glutathone and glutathione ethyl ester supplementation of mice alter glutathione homeostasis during exercise. J Nutr 1998;128:2420–2426.
- Ghosh S, Sulistyoningrum DC, Glier MB, Verchere CB, Devlin AM. Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice. J Biol Chem 2011;286:42483–42493.
- Devlin AM, Singh R, Wade RE, Innis SM, Bottiglieri T, Lentz SR. Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. J Biol Chem 2007;282:37082–37090.
- Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J Immunol 2009;182:7264–7271.
- Iwata K, Nishinaka T, Matsuno K, Yabe-Nishimura C. Increased gene expression of glutathione peroxidase-3 in diabetic mouse heart. Biol Pharm Bull 2006;29:1042–1045.
- Ishikawa T, Esterbauer H, Sies H. Role of cardiac glutathione transferase and of the glutathione S-conjugate export system in biotransformation of 4-hydroxynonenal in the heart. J Biol Chem 1986;261:1576–1581.
- Aragno M, Mastrocola R, Alloatti G, Vercellinatto I, Bardini P, Geuna S, . Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats. Endocrinology 2008; 149:380–388.
- McCaffrey TA, Consigli S, Du B, Falcone DJ, Sanborn TA, Spokojny AM, Bush HL Jr. Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1. J Clin Invest 1995;96:2667–2675.
- Shearer J, Ross KD, Hughey CC, Johnsen VL, Hittel DS, . Exercise training does not correct abnormal cardiac glycogen accumulation in the db/db mouse model of type 2 diabetes. Am J Physiol Endocrinol Metab 2011;301:E31–E39.
- Howarth FC, Jacobson M, Shafiullah M, Adeghate E. Long-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats. Exp Physiol 2005;90:827–835.
- Rouyer O, Zoll J, Daussin F, Damge C, Helms P, Talha S, . Effect of angiotensin-converting enzyme inhibition on skeletal muscle oxidative function and exercise capacity in streptozotocin-induced diabetic rats. Exp Physiol 2007;92: 1047–1056.
- Lee S, Park Y, Zhang C. Exercise Training Prevents Coronary Endothelial Dysfunction in Type 2 Diabetic Mice. Am J Biomed Sci 2011;3:241–252.
- Gutkowska J, Broderick TL, Bogdan D, Wang D, Lavoie JM, Jankowski M. Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy. J Physiol 2009;587:4725–4736.
- Lawler JM, Kwak HB, Kim JH, Suk MH. Exercise training inducibility of MnSOD protein expression and activity is retained while reducing prooxidant signaling in the heart of senescent rats. Am J Physiol Regul Integr Comp Physiol 2009;296:R1496–R1502.
- Kojda G, Hambrecht R. Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy? Cardiovasc Res 2005;67:187–197.
- Roubaud V, Sankarapandi S, Kuppusamy P, Tordo P, Zweier JL. Quantitative measurement of superoxide generation using the spin trap 5-(diethoxyphosphoryl)-5-methyl- 1-pyrroline-N-oxide. Anal Biochem 1997;247:404–411.
- Antunes F, Han D, Cadenas E. Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions. Free Radic Biol Med 2002;33:1260–1267.
- Gomez-Cabrera MC, Domenech E, Vina J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med 2008;44:126–131.
- Ristow M, Zarse K, Oberbach A, Kloting N, Birringer M, Kiehntopf M, . Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci USA 2009;106:8665–8670.
- Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med 1999; 27:922–935.
- Santos DL, Palmeira CM, Seica R, Dias J, Mesquita J, Moreno AJ, Santos MS. Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat. Mol Cell Biochem 2003;246:163–170.
- Simmons TW, Jamall IS. Relative importance of intracellular glutathione peroxidase and catalase in vivo for prevention of peroxidation to the heart. Cardiovasc Res 1989;23:774–779.
- Ghosh S, Ting S, Lau H, Pulinilkunnil T, An D, Qi D, . Increased efflux of glutathione conjugate in acutely diabetic cardiomyocytes. Can J Physiol Pharmacol 2004;82: 879–887.
- Fruehauf JP, Zonis S, al-Bassam M, Kyshtoobayeva A, Dasgupta C, Milovanovic T, . Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res 1997;10:236–249.
- Schisler NJ, Singh SM. Modulation of selenium-dependent glutathione peroxidase (Se-GSH-Px) activity in mice. Free Radic Biol Med 1988;4:147–153.
- Lewis P, Stefanovic N, Pete J, Calkin AC, Giunti S, Thallas-Bonke V, . Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice. Circulation 2007;115: 2178–2187.
- Liu RM, Gaston Pravia KA. Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med 2009;48:1–15.
- Arsalane K, Dubois CM, Muanza T, Begin R, Boudreau F, Asselin C, Cantin AM. Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase. Am J Respir Cell Mol Biol 1997;17:599–607.
- Meurer SK, Lahme B, Tihaa L, Weiskirchen R, Gressner AM. N-acetyl-L-cysteine suppresses TGF-beta signaling at distinct molecular steps: the biochemical and biological efficacy of a multifunctional, antifibrotic drug. Biochem Pharmacol 2005;70:1026–1034.
- Vayalil PK, Iles KE, Choi J, Yi AK, Postlethwait EM, Liu RM. Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter. Am J Physiol Lung Cell Mol Physiol 2007;293:L1281–L1292.
- Samiec PS, Drews-Botsch C, Flagg EW, Kurtz JC, Sternberg P Jr. , Reed RL, Jones DP. Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes. Free Radic Biol Med 1998;24: 699–704.
- Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, . Efficacy and safety of antioxidant treatment with alpha-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care 2011;34:2054–2060.
- Kutlu M, Naziroglu M, Simsek H, Yilmaz T, Sahap Kukner A. Moderate exercise combined with dietary vitamins C and E counteracts oxidative stress in the kidney and lens of streptozotocin-induced diabetic-rat. Int J Vitam Nutr Res 2005;75:71–80.