New insights into antioxidant strategies against paraquat toxicity

References

• Cicchetti F, Drouin-Ouellet J, Gross RE. Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?. Trends Pharmacol Sci 2009;30:475–583.
   PubMed Web of Science ®Google Scholar
• Vicente JA, Peixoto F, Lopes ML, Madeira VM. Differential sensitivities of plant and animal mitochondria to the herbicide paraquat. J Biochem Mol Toxicol 2001;15: 322–330.
   PubMed Web of Science ®Google Scholar
• Franco R, Li S, Rodriguez-Rocha H, Burns M, Panayiotidis MI. Molecular mechanisms of pesticide-induced neurotoxicity: relevance to Parkinson's disease. Chem Biol Interact 2010;188:289–300.
   PubMed Web of Science ®Google Scholar
• Zerin T, Kim YS, Hong SY, Song HY. Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol 2013; 33:1460–1467.
   PubMed Web of Science ®Google Scholar
• Suntres ZE. Role of antioxidants in paraquat toxicity. Toxicology 2002;180:65–77.
   PubMed Web of Science ®Google Scholar
• Moretto A, Colosio C. Biochemical and toxicological evidence of neurological effects of pesticides: the example of Parkinson's disease. Neurotoxicology 2011;32:383–391.
   PubMed Web of Science ®Google Scholar
• McCormack AL, Di Monte DA. Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration. J Neurochem 2003;85:82–86.
   PubMed Web of Science ®Google Scholar
• Tieu K. A guide to neurotoxic animal models of Parkinson's disease. Cold Spring Harb Perspect Med 2011, 1:a009316.
   PubMed Web of Science ®Google Scholar
• Berry C, La Vecchia C, Nicotera P. Paraquat and Parkinson's disease. Cell Death Differ 2010;17:1115–1125.
   PubMed Web of Science ®Google Scholar
• Awadalla EA. Efficacy of vitamin C against liver and kidney damage induced by paraquat toxicity. Exp Toxicol Phatol 2012;64: 431–434.
   PubMed Web of Science ®Google Scholar
• Zhi Q, Sun H, Qian X, Yang L. Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?. Int Immunopharmacol 2011;11:96–102.
   PubMed Web of Science ®Google Scholar
• Mayhew SG. The redox potential of dithionite and SO2 from equilibrium reactions with flavodoxins, methyl viologen and hydrogen plus hydrogenase. Eur J Biochem 1978;85: 535–547.
   PubMedGoogle Scholar
• Cochemé HM, Murphy MP. Chapter 22: the uptake and interactions of the redox cycler paraquat with mitochondria. Methods Enzymol 2009;456:395–417.
   PubMed Web of Science ®Google Scholar
• Cristovao AC, Choi DH, Baltazar G, Beal MF, Kim YS. The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death. Antiox Redox Signal 2009;11:2105–2118.
   PubMed Web of Science ®Google Scholar
• Witschi H, Kacew S, Hirai K, Cote MG. In vivo oxidation of reduced nicotinamide-adenine dinucleotide phosphate by paraquat and diquat in rat lung. Chem Biol Interact 1977; 19:143–160.
   PubMed Web of Science ®Google Scholar
• Kopaczyk-Locke K. Biochemical Measurements of Paraquat Toxicity. New York: Academic Press; 1977. pp. 99–115.
   Google Scholar
• Rossouw DJ, Engelbrecht FM. The effect of paraquat on the respiration of lung cell fractions. S Afr Med J 1978;54: 1101–1104.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Anno M, Sato T. Effects of paraquat on mitochondria of rat skeletal muscle. Comp Biochem Physiol C 1987;86:375–378.
   PubMed Web of Science ®Google Scholar
• Palmeira CM, Moreno AJ, Madeira VM. Mitochondrial bioenergetics is affected by the herbicide paraquat. Biochim Biophys Acta 1995;1229:187–192.
   PubMed Web of Science ®Google Scholar
• Sata T, Takeshige K, Takayanagi R, Minakami S. Lipid peroxidation by bovine heart submitochondrial particles stimulated by 1,1’-dimethyl-4,4’-bipyridylium dichloride (paraquat). Biochem Pharmacol 1983;32:13–19.
   PubMed Web of Science ®Google Scholar
• Cochemé HM, Murphy MP. Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem 2008;283:1786–1798.
   PubMed Web of Science ®Google Scholar
• Castello PR, Drechsel DA, Patel M. Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J Biol Chem 2007;282:14186–14193.
   PubMed Web of Science ®Google Scholar
• Shimada H, Hirai K, Simamura E, Hatta T, Iwakiri H, Mizuki K, et al. Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase. J Biol Chem 2009;42:28642–28649.
   Google Scholar
• Shimada H, Hirai K, Simamura E, Pan J. Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat liver. Arch Biochem Biophys 1998;351:75–81.
   PubMed Web of Science ®Google Scholar
• Fukushima T, Yamada K, Isobe A, Shiwaku K, Yamane Y. Mechanism of cytotoxicity of paraquat. I. NADH oxidation and paraquat radical formation via complex I. Exp Toxicol Pathol 1993;45:345–349.
   PubMed Web of Science ®Google Scholar
• Drechsel DA, Patel M. Differential contribution of the mitochondrial respiratory chain complexes to reactive oxygen species production by redox cycling agents implicated in parkinsonism. Toxicol Sci 2009;112:427–434.
   PubMed Web of Science ®Google Scholar
• Brouillet E, Jacquard C, Bizat N, Blum D. 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. J Neurochem 2005;95:1521–1540.
   PubMed Web of Science ®Google Scholar
• Hanagasi HA, Ayribas D, Baysal K, Emre M. Mitochondrial complex I, II/III, and IV activities in familial and sporadic Parkinson's disease. Int J Neurosci 2005;115:479–493.
   PubMed Web of Science ®Google Scholar
• Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 2000;3:1301–1306.
   PubMed Web of Science ®Google Scholar
• Tawara T, Fukushima T, Hojo N, Isobe A, Shiwaku K, Setogawa T, Yamane Y. Effects of paraquat on mitochondrial electron transport system and catecholamine contents in rat brain. Arch Toxicol 1996;70:585–589.
   PubMed Web of Science ®Google Scholar
• Czerniczyniec A, Karadayian G, Bustamante J, Cutrera RA, Lores-Arnaiz S. Paraquat induces behavioral changes and cortical and striatal mitochondrial dysfunction. Free Radic Biol Med 2011;51:1428–1436.
   PubMed Web of Science ®Google Scholar
• Czerniczyniec A, Lores-Arnaiz S, Bustamante J. Mitochondrial susceptibility in a model of paraquat neurotoxicity. Free Radic Res2013;47:614–623.
   PubMed Web of Science ®Google Scholar
• Kaspar JW, Niture SK, Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Rad Biol Med 2009;47: 1304–1309.
   PubMed Web of Science ®Google Scholar
• Cuadrado A, Moreno-Murciano P, Pedraza-Chaverri J. The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease. Expert Opin Ther Targets 2009;13:319–329.
   PubMed Web of Science ®Google Scholar
• Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 1996;20:933–956.
   PubMed Web of Science ®Google Scholar
• Rajadurai M, Stanely Mainzen Prince P. Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences. Toxicology 2006;228:259–268.
   PubMed Web of Science ®Google Scholar
• Kanno S, Shouji A, Tomizawa A, Hiura T, Osana Y, Ujibe M, et al. Inhibitory effect of naringin on lipopolysaccharide- induced endotoxin shock in mice and nitric oxide production in RAW264.7 macrophages. Life Sci 2006;78:673–681.
   PubMed Web of Science ®Google Scholar
• Nie YC, Wu H, Li PB, Xie LM, Luo YL, Shen JG, Su WW. Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. Eur J Pharmacol 2012;690:207–213.
   PubMed Web of Science ®Google Scholar
• Liu Y, Wu H, Nie YC, Chen JL, Su WW, Li PB. Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. Int Immunopharmacol 2011;11:1606–1612.
   PubMed Web of Science ®Google Scholar
• Chen Y, Nie YC, Luo YL, Lin F, Zheng YF, Cheng GH, et al. Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food Chem Toxicol 2013;58:133–140.
   PubMed Web of Science ®Google Scholar
• Valenzuela A, Garrido A. Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin. Biol Res 1994;27:105–112.
   PubMed Web of Science ®Google Scholar
• Kren V, Walterová D. Silybin and silymarin–new effects and applications. Biomed Pap Med Fac Univ Palacký Olomouc Czech Repub 2005;149:29–41.
   PubMedGoogle Scholar
• Wen Z, Dumas TE, Schrieber SJ, Hawke RL, Fried MW, Smith PC. Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract. Drug Metab Dispos 2008;36:65–72.
   PubMed Web of Science ®Google Scholar
• Varga Z, Seres I, Nagy E, Ujhelyi L, Balla G, Balla J, Antus S. Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro. Phytomedicine 2006;13:85–93.
   PubMed Web of Science ®Google Scholar
• Dehmlow C, Murawski N, de Groot H. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sci 1996;58:1591–1600.
   PubMed Web of Science ®Google Scholar
• Polyak SJ, Morishima C, Lohmann V, Pal S, Lee DY, Liu Y, et al. Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci U S A 2010;107:5995–5999.
   PubMed Web of Science ®Google Scholar
• Podder B, Kim YS, Zerin T, Song HY. Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line. Food Chem Toxicol 2012;50:3206–3214.
   PubMed Web of Science ®Google Scholar
• Toyoda K, Fujii K, Kamouchi M, Nakane H, Arihiro S, Okada Y, et al. Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. J Neurol Sci 2004; 221:11–17.
   PubMed Web of Science ®Google Scholar
• Watanabe T, Tanaka M, Watanabe K, Takamatsu Y, Tobe A. Research and development of the free radical scavenger edaravone as a neuroprotectant. Yakugaku Zasshi 2004;124: 99–111.
   PubMed Web of Science ®Google Scholar
• Mao YF, Yan N, Xu H, Sun JH, Xiong YC, Deng XM. Edaravone, a free radical scavenger, is effective on neuropathic pain in rats. Brain Res 2009;1248:68–75.
   PubMed Web of Science ®Google Scholar
• Ito K, Ozasa H, Horikawa S. Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. Free Radic Biol Med 2005;38:369–374.
   PubMed Web of Science ®Google Scholar
• Doi K, Suzuki Y, Nakao A, Fujita T, Noiri E. Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. Kidney Int 2004;65: 1714–1723.
   PubMed Web of Science ®Google Scholar
• Russo A, Borrelli F. Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine 2005;12:305–317.
   PubMed Web of Science ®Google Scholar
• Nunes LG. Phytochemistry prospection and mutagenicity evaluate in vitro of tree species vegetables: Strychnos Pseudoquina A. St.-Hill., Coutarea Hexandra (Jacq.) K. Schum and Bathysa cuspidata (A. St.-Hil.) Hook [thesis]. Viçosa (Minas Gerais): Federal University of Viçosa; 2008. 97 p. Available from: UFV Digital Library of theses and dissertations.
   Google Scholar
• Kim KS, Suh GJ, Kwon WY, Kwak YH, Lee K, Lee HJ, et al. Antioxidant effects of selenium on lung injury in paraquat intoxicated rats. Clin Toxicol (Phila) 2012;50:749–753.
   PubMed Web of Science ®Google Scholar
• Novaes RD, Gonçalves RV, Cupertino MC, Marques DC, Rosa DD, Peluzio Mdo C, et al. Bark extract of Bathysa cuspidata attenuates extra-pulmonary acute lung injury induced by paraquat and reduces mortality in rats. Int J Exp Pathol 2012;93: 225–233.
   PubMed Web of Science ®Google Scholar
• Novaes RD, Gonçalves RV, Marques DC, Cupertino Mdo C, Peluzio Mdo C, Leite JP, Maldonado IR. Effect of bark extract of Bathysa cuspidata on hepatic oxidative damage and blood glucose kinetics in rats exposed to paraquat. Toxicol Pathol 2012;40:62–70.
   PubMed Web of Science ®Google Scholar
• Gorąca A, Huk-Kolega H, Piechota A, Kleniewska P, Ciejka E, Skibska B. Lipoic acid - biological activity and therapeutic potential. Pharmacol Rep 2011;63:849–858.
   PubMed Web of Science ®Google Scholar
• Packer L. Free radical scavengers and antioxidants in prophylaxy and treatment of brain diseases. In: Packer L, Prilipko L, Christen Y (eds.). Free Radicals in the Brain: Aging, Neurological, and Mental Disorders. Berlin: Springer-Verlag; 1992. Pp. 1–20.
   Google Scholar
• Ghibu S, Richard C, Vergely C, Zeller M, Cottin Y, Rochette L. Antioxidant properties of an endogenous thiol: alpha-lipoic acid, useful in the prevention of cardiovascular diseases. J Cardiovasc Pharmacol 2009;54:391–398.
   PubMed Web of Science ®Google Scholar
• Azuma A, Nukiwa T, Tsuboi E, Suga M, Abe S, Nakata K, et al. Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2005;171:1040–1047.
   PubMed Web of Science ®Google Scholar
• Taniguchi H, Ebina M, Kondoh Y, Ogura T, Azuma A, Suga M, et al. Pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J 2010;35:821–829.
   PubMed Web of Science ®Google Scholar
• Shihab FS, Bennett WM, Yi H, Andoh TF. Effect of pirfenidone on apoptosis-regulatory genes in chronic cyclosporine nephrotoxicity. Transplantation 2005;79:419–426.
   PubMed Web of Science ®Google Scholar
• Seifirad S, Keshavarz A, Taslimi S, Aran S, Abbasi H, Ghaffari A. Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats. Clin Toxicol (Phila) 2012;50: 754–758.
   PubMed Web of Science ®Google Scholar
• Preston SJ, Arnold MH, Beller EM, Brooks PM, Buchanan WW. Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis. Br J Clin Pharmacol 1989; 27:607–611.
   PubMed Web of Science ®Google Scholar
• Huang WD, Wang JZ, Lu YQ, Di YM, Jiang JK, Zhang Q. Lysine acetylsalicylate ameliorates lung injury in rats acutely exposed to paraquat. Chin Med J 2011;124: 2496–2501.
   PubMed Web of Science ®Google Scholar
• Mugesh G, du Mont WW, Sies H. Chemistry of biologically important synthetic organoselenium compounds. Chem Rev 2001;101:2125–2179.
   PubMed Web of Science ®Google Scholar
• Nogueira CW, Zeni G, Rocha JB. Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev 2004;104:6255–6285.
   PubMed Web of Science ®Google Scholar
• Cheng W, Fu YX, Porres JM, Ross DA, Lei XG. Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein. FASEB J 1999;13:1467–1475.
   PubMed Web of Science ®Google Scholar
• Moskaug JO, Carlsen H, Myhrstad M, Blomhoff R. Molecular imaging of the biological effects of quercetin and quercetin-rich foods. Mech Ageing Dev 2004;125:315–324.
   PubMed Web of Science ®Google Scholar
• Serafini M, Maiani G, Ferro-Luzzi A. Alcohol-free red wine enhances plasma antioxidant capacity in humans. J Nutr 1998; 128:1003–1007.
   PubMed Web of Science ®Google Scholar
• Kahraman A, Erkasap N, Koken T, Serteser M, Aktepe F, Erkasap S. The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology 2003; 183:133–142.
   PubMed Web of Science ®Google Scholar
• Molina MF, Sanchez-Reus I, Iglesias I, Benedi J. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol Pharm Bull 2003;26:1398–1402.
   PubMed Web of Science ®Google Scholar
• Park HK, Kim SJ, Kwon do Y, Park JH, Kim YC. Protective effect of quercetin against paraquat-induced lung injury in rats. Life Sci 2010;87:181–186.
   PubMed Web of Science ®Google Scholar
• Lissi EA, Pizarro M, Aspee A, Romay C. Kinetics of phycocyanine bilin groups destruction by peroxyl radicals. Free Radic Biol Med 2000;28:1051–1055.
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhang J, Yan Y, Chi M, Chen W, Sun P, Qin S. The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats. Environ Toxicol Pharmacol 2011; 32:168–174.
   PubMed Web of Science ®Google Scholar
• Rastogi S, Pal R, Kulshreshtha DK. Bacoside A3-a triterpenoid saponin from Bacopa monniera. Phytochemistry 1994; 36:1133–1137.
   Web of Science ®Google Scholar
• Rajasekar N, Dwivedi S, Tota SK, Kamat PK, Hanif K, Nath C, Shukla R. Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice. Eur J Pharmacol 2013;715:381–394.
   PubMed Web of Science ®Google Scholar
• Shinomol GK, Muralidhara, Bharath MM. Exploring the Role of “Brahmi” (Bocopa monnieri and Centella asiatica) in brain function and therapy. Recent Pat Endocr Metab Immune Drug Discov 2011;5:33–49.
   PubMedGoogle Scholar
• Singh M, Murthy V, Ramassamy C. Standardized extracts of Bacopa monniera protect against MPP+- and paraquat-induced toxicity by modulating mitochondrial activities, proteasomal functions, and redox pathways. Toxicol Sci 2012;125:219–232.
   PubMed Web of Science ®Google Scholar
• Auer BL, Auer D, Rodgers AL. The effect of ascorbic acid ingestion on the biochemical and physicochemical risk factors associated with calcium oxalate kidney stone formation. Clin Chem Lab Med 1998;36:143–147.
   PubMed Web of Science ®Google Scholar
• Menzel DB. The toxicity of air pollution in experimental animals and humans: the role of oxidative stress. Toxicol Lett 1994;72:269–277.
   PubMed Web of Science ®Google Scholar
• Carr A, Frei B. Does vitamin C act as a pro-oxidant under physiological conditions?. FASEB J 1999;13:1007–1024.
   PubMed Web of Science ®Google Scholar
• Moon JM, Chun BJ. The efficacy of high doses of vitamin C in patients with paraquat poisoning. Hum Exp Toxicol 2011; 30:844–850.
   PubMed Web of Science ®Google Scholar
• Du WD, Yuan ZR, Sun J, Tang JX, Cheng AQ, Shen DM, et al. Therapeutic efficacy of high-dose vitamin C on acute pancreatitis and its potential mechanisms. World J Gastroenterol 2003;9:2565–2569.
   PubMed Web of Science ®Google Scholar