The contributions of oxidative stress, oxidised lipoproteins and AMPK towards exercise-associated PPARγ signalling within human monocytic cells

References

• Jackson MJ. Control of reactive oxygen species production in contracting skeletal muscle. Antioxid Redox Signal 2011;15:2477–2486.
   PubMed Web of Science ®Google Scholar
• Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 2008;88:1243–1276.
   PubMed Web of Science ®Google Scholar
• Hey-Mogensen M, Højlund K, Vind BF, Wang L, Dela F, Beck-Nielsen H, et al. Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes. Diabetologia 2010;53:1976–1985.
   PubMed Web of Science ®Google Scholar
• Radak Z, Chung HY, Koltai E, Taylor AW, Goto S. Exercise, oxidative stress and hormesis. Ageing Res Rev 2007;7: 34–42.
   Google Scholar
• Vasilaki A, Mansouri A, Van Remmen H, van der Meulen JH, Larkin L, Richardson AG, et al. Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity. Aging Cell 2006;5:109–117.
   PubMed Web of Science ®Google Scholar
• Palomero J, Pye D, Kabayo T, Spiller DG, Jackson MJ. In situ detection and measurement of intracellular reactive oxygen species in single isolated mature skeletal muscle fibers by real time fluorescence microscopy. Antioxid Redox Signal 2008;10:1463–1474.
   PubMed Web of Science ®Google Scholar
• McArdle F, Spiers S, Aldemir H, Vasilaki A, Beaver A, Iwanejko L, et al. Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice. J Physiol 2004;561:233–244.
   PubMed Web of Science ®Google Scholar
• Petridou A, Tsalouhidou S, Tsalis G, Schulz T, Michna H, Mougios V. Long-term exercise increases the DNA binding activity of peroxisome proliferator-activated receptor gamma in rat adipose tissue. Metabolism 2007;56:1029–1036.
   Google Scholar
• Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol 2009;106:929–934.
   PubMed Web of Science ®Google Scholar
• Mahoney DJ, Parise G, Melov S, Safdar A, Tarnopolsky MA. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J 2005;19:1498–1500.
   PubMed Web of Science ®Google Scholar
• Keller P, Vollaard NB, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, et al. A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol 2011;110:46–59.
   PubMed Web of Science ®Google Scholar
• Plutzky J. The potential role of PPARs on inflammation in type 2 diabetes and atherosclerosis. Am J Cardiol 2003;92:34–41.
   Web of Science ®Google Scholar
• Smith SA. Central role of the adipocyte in the insulin- sensitizing and cardiovascular risk modifying actions of the thiazolidinediones. Biochimie 2003;85:1219–1230.
   PubMed Web of Science ®Google Scholar
• Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator- activated receptor gamma (PPAR gamma). J Biol Chem 1995;270:12953–12956.
   PubMed Web of Science ®Google Scholar
• DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators, Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet 2006;368:1096–1105.
   PubMed Web of Science ®Google Scholar
• Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes, N. Eng J Med 2007;356:2457–2471.
   PubMed Web of Science ®Google Scholar
• Singh S, Loke YK, Furberg CD. Thiazolidinediones and Heart Failure: A Teleo-Analysis. Diabetes Care 2007;30: 2148–2153.
   PubMed Web of Science ®Google Scholar
• Rosen CJ. Revisiting the Rosiglitazone story – lessons learned. New England Journal of Medicine 2010;363:803–806.
   PubMed Web of Science ®Google Scholar
• Leal I, Romio SA, Schuemie M, Oteri A, Sturkenboom M, Trifirò G. Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: a focus on the effects of safety warnings about rosiglitazone. Br J Clin Pharmacol 2013;75:861–868.
   PubMed Web of Science ®Google Scholar
• Nunn AV, Bell J, Barter P. The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balanceNucl Recept2007;5:1–13.
   Google Scholar
• Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A 2009;106:8665–8670.
   PubMed Web of Science ®Google Scholar
• Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training- induced adaptations in endurance performance. Am J Clin Nutr 2008;87:142–149.
   PubMed Web of Science ®Google Scholar
• Kang C, O’Moore KM, Dickman JR, Ji LL. Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling is redox sensitive. Free Radic Biol Med 2009;47:1394–1400.
   PubMed Web of Science ®Google Scholar
• Khassaf M, McArdle A, Esanu C, Vasilaki A, McArdle F, Griffiths RD, et al. Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle. J Physiol 2003;549:645–652.
   PubMed Web of Science ®Google Scholar
• Petersen AC, McKenna MJ, Medved I, Murphy KT, Brown MJ, Della Gatta P, Cameron-Smith D. Infusion with the antioxidant N-acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle. Acta Physiol (Oxf) 2012;204:382–392.
   PubMed Web of Science ®Google Scholar
• Strobel NA, Peake JM, Matsumoto A, Marsh SA, Coombes JS, Wadley GD. Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis. Med Sci Sports Exerc 2011;43:1017–1024.
   PubMed Web of Science ®Google Scholar
• Calabrese EJ, Baldwin LA. Defining hormesis. Hum Exp Toxicol 2002;21:91–97.
   PubMed Web of Science ®Google Scholar
• Lowe DA, Warren GL, Ingalls CP, Boorstein DB, Armstrong RB. Muscle function and protein metabolism after initiation of eccentric contraction-induced injury. J Appl Physiol 1995;79:1260–1270.
   PubMed Web of Science ®Google Scholar
• Ricote M, Huang JT, Welch JS, Glass CK. The peroxisome proliferator-activated receptor(PPARgamma) as a regulator of monocyte/macrophage function. J Leukoc Biol 1999;66: 733–739.
   PubMed Web of Science ®Google Scholar
• Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, et al. Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 2007;117:1658–1669.
   PubMed Web of Science ®Google Scholar
• Gratchev A, Sobenin I, Orekhov A, Kzhyshkowska J. Monocytes as a diagnostic marker of cardiovascular diseases. Immunobiology 2012;217:476–482.
   PubMed Web of Science ®Google Scholar
• Butcher L, Backx K, Roberts A, Thomas A, Webb R, Morris K. Low-intensity exercise exerts beneficial effects on plasma lipids via PPARγ. Med Sci Sports Exerc 2008;40:1–7.
   Google Scholar
• Moir H, Hughes MG, Potter S, Sims C, Butcher LR, Davies NA, et al. Exercise-induced Immuno-suppression: The roles of reactive oxygen species and AMPK dephosphorylation within immune cells. J Applied Physiol 2010;108:1284–1292.
   Google Scholar
• Thomas AW, Davies NA, Moir H, Watkeys L, Ruffino JS, Isa SA, et al. Exercise-associated generation of PPARγ ligands activates PPARγ signalling events and upregulates genes related to lipid metabolism. J Appl Physiol 2012;112:806–815.
   PubMed Web of Science ®Google Scholar
• Yakeu G, Butcher LR, Isa SA, Webb R, Roberts AW, Thomas AW, et al. Low-intensity exercise triggers monocyte polarisation into the M2 anti-inflammatory phenotype. Atherosclerosis 2010;212:668–673.
   PubMed Web of Science ®Google Scholar
• Nagy L, Tontonoz P, Alvarez JGA, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell 1998;93:229–240.
   PubMed Web of Science ®Google Scholar
• Marsin AS, Bouzin C, Bertrand L, Hue L. The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem 2002;277:30778–30783.
   PubMed Web of Science ®Google Scholar
• Toyoda T, Hayashi T, Miyamoto L, Yonemitsu S, Nakano M, Tanaka S. Possible involvement of AMPKα1 in oxidative stress-stimulated glucose transport in skeletal muscle. Am J Physiol 2004;287:E166–E173.
   PubMedGoogle Scholar
• Jäger S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 2007;104:12017–12022.
   PubMed Web of Science ®Google Scholar
• Irrcher I, Ljubicic V, Hood DA. Interactions between ROS and AMPK activity in the regulation of PGC-1alpha transcription in skeletal muscle cells Am J Physiol Cell Physiol 2009;296:C116–C123.
   PubMed Web of Science ®Google Scholar
• Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K. Establishment and Characterization of a Human Acute Monocytic Leukemia Cell line (THP-1 cells). Int J Cancer 1980;26:171–176.
   PubMed Web of Science ®Google Scholar
• Hirpara JL, Clément MV, Pervaiz S. Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J Biol Chem 2001;276:514–521.
   PubMed Web of Science ®Google Scholar
• Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase – development of the energy sensor concept. J Physiol 2006;574:7–15.
   PubMed Web of Science ®Google Scholar
• Hodgkinson CP, Ye S. Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages. Biochem Biophys Res Commun 2003;308:505–510.
   PubMed Web of Science ®Google Scholar
• Hondares E, Mora O, Yubero P, Rodriguez de la Concepción M, Iglesias R, Giralt M, Villarroya F. Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation. Endocrinology 2006;147:2829–2838.
   PubMed Web of Science ®Google Scholar
• Erusalimsky JD, Moncada S. Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler Thromb Vasc Biol 2007;27:2524–2531.
   PubMed Web of Science ®Google Scholar
• Quintero M, Colombo SL, Godfrey A, Moncada S. Mitochondria as signalling organelles in the vascular endothelium. Proc Nat Acad Sci 2006;103:5379–5384.
   PubMed Web of Science ®Google Scholar
• Chen K, Suh J, Carr AC, Morrow JD, Zeind J, Frei B. Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload. Am J Physiol Endocrinol Metab 2000;279:E1406–E1412.
   PubMed Web of Science ®Google Scholar
• Higashida K, Kim SH, Higuchi M, Holloszy JO, Han DH. Normal adaptations to exercise despite protection against oxidative stress. Am J Physiol Endocrinol Metab 2011; 301:E779–E784.
   PubMed Web of Science ®Google Scholar
• Steinberg GR. Role of AMPK in regulating fatty acid metabolism during exercise. Appl Physiol Nutr Metab 2009;34:315–322.
   PubMedGoogle Scholar
• Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 2003;100:8466–8471.
   PubMed Web of Science ®Google Scholar
• Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 2000;11:212–217.
   PubMed Web of Science ®Google Scholar
• Phielix E, Meex R, Moonen-Kornips E, Hesselink MK, Schrauwen P. Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals. Diabetologia 2010;53:1714–1721.
   PubMed Web of Science ®Google Scholar