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Free Radical Research Communications Volume 10, 1990 - Issue 3
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Original Article

Bleomycin-Iron Damage To Dna With Formation Of 8-Hydroxydeoxyguanosine and Base Propenals. Indications That Xanthine Oxidase Generates Superoxide From Dna Degradation Products

John M.C. Gutteridge Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, 825 NE 13th, Oklahoma City, OK, 73104, USA
,
Melinda West Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, 825 NE 13th, Oklahoma City, OK, 73104, USA
,
Kent Eneff Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, 825 NE 13th, Oklahoma City, OK, 73104, USA
&
Robert A. Floyd Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, 825 NE 13th, Oklahoma City, OK, 73104, USA
Pages 159-165 | Received 12 Feb 1990, Published online: 07 Jul 2009

References

  • Gutteridge J. M.C., Halliwell B. Radical promoting loosely-bound iron in biological fluids and the bleomycin assay. Life Chemistry Reports 1987; 4: 113–142
  • Sausville E. A., Peisach J., Horwitz S. B. The effect of chelating agents and metal ions on the degradation of DNA by bleomycin. Biochemistry 1978; 17: 2740–2746
  • Takeshita M., Grollman A. P., Ohtsubo E., Ohtsubo H. Interactions of bleomycin with DNA. Proceedings of the National Academy of Sciences 1987; 75: 5983–5987
  • Oberley L. W., Buettner G. R. The production of hydroxyl radical by bleomycin and iron (II). Federation of European Biochemical Societies, Letters 1979; 97: 47–49
  • Gutteridge J. M.C., Beard A., Quinlan G. J. Catalase enhances damage to DNA by bleomycin-iron (II). The role of hydroxyl radicals. Biochemistry International 1985; 0: 441–449
  • Gilone L., Takeshita M., Johnson F., Iden C., Grollman A. P. Bleomycin-induced strand-scission of DNA. Journal Biological Chemistry 1981; 256: 8608–8615
  • Gutteridge J. M.C. Identification of malondialdehyde as the TBA-reactant formed by bleomycin-iron free radical damage to DNA. Federation of European Biochemical Societies. Letters 1979; 105: 278–282
  • Kasao H., Nishimura S. Hydroxylation of deoxyguanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion. Japanese Journal of Cancer Research 1984; 75: 565–566
  • Floyd R. A., Watson J. J., Wong P. K., Altmiller D. H., Rickard R. C. Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation. Free Radical Research Communications 1986; 1: 163–172
  • Gutteridge J. M.C. A method for removal of trace iron contamination from biological buffers. Federation of European Biochemical Societies, Letters 1987; 214: 362–364
  • Floyd R. A., West M. S., Eneff K. L., Hoggett W. E., Tingey D. T. Hydroxyl free radical mediated formation of 8-hydroxyguanine in isolated DNA. Archives Biochemistry Biophysics 1988; 262: 266–272
  • Gutteridge J. M.C., Toeg D. Iron-dependent free radical damage to DNA and deoxyribose. Separation of TBA-reactive intermediates. International Journal Biochemistry 1982; 14: 891–893
  • Burger R. M., Horwitz S. B., Peisach J. Stimulation of iron () bleomycin activity by phosphate-containing compounds. Biochemistry 1985; 24: 3623–3629
  • Rajagopalan K. V. Xanthine oxidase and aldehyde oxidase. Enzymic basis of detoxication 1980; I: 295–309
  • Topham R. W., Jackson M. R., Joslin S. A., Walker M. C. Studies of the ferroxidase activity of native and chemically modified xanthine oxidoreductase. Biochemistry Journal 1986; 235: 39–44
  • Melnyk D. L., Horwitz S. B., Peisach J. Redox potential of Iron-Bleomycin. Biochemistry 1981; 20: 5237–5331
  • Gutteridge J. M.C., Maidt L., Brueggemann G., McCay P. B. Superoxide-dependent formation of oxidizing radicals from ferric-EDTA and hydrogen peroxide: Problems with the use of DMPO as a spin trap to detect resulting Fenton chemistry. 1990, 1990 Submitted
  • Kohda K., Kasai H., Ogawa T., Suzuki T., Kawazoe Y. Deoxyribonucleic acid (DNA) damage induced by Bleomycin-Fe(II) in vitro: Formation of 8-hydroxyguanine residues in DNA. Chemical and Pharmaceutical Bulletin 1989; 37: 1028–1030

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