Growth Inhibition of Plasmodium Falciparum Involving Carbon Centered Iron-Chelate Radical (L., X^-)-Fe(III) Based on Pyridoxal-Betaine. A Novel Type of Antimalarials Active Against Chloroquine-Resistant Parasites

References

• Harvey P.W.J., Heywood P.P., Nesheim M.C., Galme K., Zegans M., Habicht J-P., Stephenson L.S., Radimer K.L., Brabin B., Forsyth K., Alpers M.P. The effect of iron therapy on malarial infection in Papua New Guinean school children. American Journal of Tropical Medicine and Hygiene 1989; 40: 12–18
   PubMed Web of Science ®Google Scholar
• Oppenheimer S.J., Gibson F.D., Macfarlene S.B., Moody J.B., Harrison C., Spencer A., Bunari O. Iron supplementation increases prevalence and effects of malaria: Clinical studies in Papua New Guinea. Transactions of the Royal Society of Tropical Medicine and Hygiene 1986; 80: 603–612
   PubMed Web of Science ®Google Scholar
• Iheanacho E.N., Samuni A., Avramovici-Grisaru S., Sarel S., Spira D.T. Transactions of the Royal Society of Tropical Medicine and Hygiene 1989; 89: 213–216
   Google Scholar
• Heppner D.G., Hallaway P.E., Kontoghiorghes G.J., Eaton J.W. Antimalarial properties of orally active iron chelators. Blood 1988; 72: 358–361
   PubMed Web of Science ®Google Scholar
• Stahel E., Mazier D., Guillouzo A., Miltgen F., Landau I., Mellouk S., Beaudoin R.L., Langbois P., Gentilini M. Iron chelators: In vitro effect on the liver stage of rodent and human malaria. American Journal of Tropical Medicine and Hygiene 1988; 39: 236–240
   PubMed Web of Science ®Google Scholar
• Yinnon A.M., Iheanacho E.N., Grady R.W., Spira D.T., Hershko C. Antimalarial effect of HBED and other phenolic and catecholic iron chelators. Blood 1989; 74: 2166–2171
   PubMed Web of Science ®Google Scholar
• Saltman P. Oxidative stress: A radical view. Seminars in Hematology 1989; 26: 249–256
   PubMed Web of Science ®Google Scholar
• Orji A.U., Banyal H.S., Chevli R., Fitch C.D. Hemin lyses malaria parasites. Science 1981; 214: 667–669
   PubMedGoogle Scholar
• Dockrell H.M., Playfair J.H.L. Killing of blood stage murine malaria parasites by hydrogen peroxide. Infection and Immunity 1983; 39: 456–459
   PubMed Web of Science ®Google Scholar
• Miller J., Golenzer J., Spira D.T., Kosower N.S. Plasmodium falciparum: Thiol status and growth in normal and G6PD deficient human erythrocytes. Experimental Parasitology 1984; 57: 239–247
   PubMed Web of Science ®Google Scholar
• Zhang Y., Hempelmann E., Schirmer R.H. Glutathione reductase inhibitors as potential antimalarial drugs. Effects of Nitrosoureas on Plasmodium falciparum in vitro. Biochemical Pharmacology 1988; 37: 855–860
   PubMedGoogle Scholar
• Grankvist K., Marklund S.L., Taljedal I.B. CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochemical Journal 1981; 199: 393–398
   PubMed Web of Science ®Google Scholar
• Clark I.A., Hunt N.H. Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria. Infection and Immunity 1983; 39: 1–6
   PubMed Web of Science ®Google Scholar
• Schirmer R.H., Schollhammer T., Eisenbrand G., Krauth-Siegel R.L. Oxidative stress as a defense mechanism parasitic infections. Free Radical Research Communications 1987; 3: 3–12
   PubMedGoogle Scholar
• Golenser J., Casuto D., Pollack Y. Plasmodium falciparum: In vitro induction of resistance to aminoprotein. Experimental Parasilology 1981; 52: 371–377
   PubMed Web of Science ®Google Scholar
• Lambros C., Vanderberg J.P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. Journal of Parasitologv 1979; 65: 418–420
   PubMed Web of Science ®Google Scholar
• Jensen J.B. Concentration from continuous culture of erythrocytes infected with trophozoites and schizonts of Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene 1978; 27: 1274–1276
   PubMed Web of Science ®Google Scholar
• Ambruso D.R., Johnston R.B. Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil paniculate fractions and an enzymatic generating system. Journal of Clinical Investigations 1981; 67: 352–360
   PubMed Web of Science ®Google Scholar
• Gutteridge J.M.C., Paterson S.K., Segal A.W., Halliwell B. Inhibition of lipid peroxidation by the iron binding protein lactoferrin. Biochemical Journal 1981; 199: 259–261
   PubMed Web of Science ®Google Scholar
• Gutteridge J.M.C., Rowley D.A., Halliwell B. Superoxide dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Biochemical Journal 1982; 206: 604–609
   Google Scholar
• Youngman R.J. Oxygen activation: Is the hydroxyl radical always relevant?. Trends in Bio- chemical Sciences 1984; 9: 280–283
   Web of Science ®Google Scholar
• Vercellotti G.M., VanAsbeck B.S., Jacob H.S. Oxygen radical induced erythrocyte hemolysis by neutrophils — critical role of iron and lactoferrin. Journal of Clinical Investigation 1985; 76: 956–962
   PubMedGoogle Scholar
• Fritsch G., Sawatzki G., Treumer J., Jung A., Spira D.T. Plasmodium falciparum: Inhibition in vitro with lactoferrin, desferroferrithiocin, and desferricrocin. Experimental Parasitology 1987; 63: 1–9
   PubMed Web of Science ®Google Scholar
• Halliwell B., Gutteridge J.M.C. The importance of free radicals and catalytic metal ions in human diseases. Molecular Aspects of Medicine 1985; 8: 89–193
   PubMed Web of Science ®Google Scholar
• Floyd R.A. Direct demonstration that ferrous ion complexes of di- and triphosphate nucleo- tides catalyze hydroxyl free radical formation from hydrogen peroxide. Archieves of Biochemistry and Biophysics 1983; 225: 263–270
   PubMed Web of Science ®Google Scholar
• Wills E.D. Lipid peroxide formation in microsomes: The role of non-haem iron. Biochemical Journal 1969; 113: 325–332
   PubMed Web of Science ®Google Scholar
• Gutteridge J.M.C., Richmond R., Halliwell B. Superoxide dependent formation of hydroxyl radicals from Superoxide and of lipid peroxidation by Desferrioxamine. Biochemical Journal 1982; 184: 469–472
   Google Scholar
• Halliwell B., Gutteridge J.M.C. Oxygen toxicity, oxygen radicals transition metals and disease. Biochemical Journal 1984; 229: 1–14
   Google Scholar
• Clark LA., Cowden W.B., Buther G.A. Free oxygen radical generators as antimalarial drugs. Lancet 1983; i: 234
   Google Scholar
• Vennerstrom J.L., Eaton J.W. Oxidants, Oxidant drugs, and Malaria. Journal of Medicinal Chemistry 1988; 31: 1269–1277
   PubMed Web of Science ®Google Scholar
• Iheanacho E.N., Sarel S., Samuni A., Avramovici-Grisaru S., Spira D.T. Growth inhibition of P. falciparum by iron-chelate radical involving damage to DNA. Free Rod Res. Comm. 1990; 11(6)307–315
   Google Scholar
• Floyd R.A. DNA-ferrous catalyzed hydroxyl free radical formation from hydrogen peroxide. Biochemical and Biophysical Research Communications 1981; 99: 1209–1215
   PubMed Web of Science ®Google Scholar
• Birnboim H.C., Kanabus-Kaminska M. The production of DNA strand breaks in human leukocytes by superoxide anion may involve a metabolic process. Proceedings of the National Academcy of Sciences 1985; 82: 6820–6824
   PubMed Web of Science ®Google Scholar
• Brault D., Neta P. Reactions of iron porphyrins with methyl radicals. Journal of American Chemical Society 1981; 103: 2705–2710
   Google Scholar
• Sorek Y., Cohen H., Meyerstein D. Reactions of Iron(II) Protophyrin with strongly reducing free radicals in aqueous solution. Journal of the Chemical Society, Faraday Transactions 1 1985; 81: 233–239
   Google Scholar
• Cochrane C.G., Schraufstatter I.U., Hyslop P., Jackson J. Cellular and Biochemical events in oxidative injury. Oxygen radicals and tissue injury symposium (Proceedings), B. Halliwell. Federation of American Societies for Experimental Biology, Bethesda 1988; 49–54
   Google Scholar
• Mello Filho A.C., Meneghini R. Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species. Biochimica et Biophysica Acta 1985; 847: 92–89
   Google Scholar
• Wozencraft A.O. Damage to malaria infected erythrocytes following exposure to oxidant generating systems. Parasitology 1986; 92: 559–567
   PubMed Web of Science ®Google Scholar