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Original Article

Subcellular Distribution of Two Spin Trapping Agents in Rat Heart: Possible Explanation for Their Different Protective Effects Against Doxorubicin-Induced Cardiotoxicity

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Pages 353-360 | Received 29 Jan 1991, Published online: 07 Jul 2009

References

  • Lefrak E.A., Pitha J., Rosenheim S., Gottlieb J.A. A clinicopatholgic analysis of adria-mycin cardiotoxicity. Cancer 1972; 32: 302–314
  • Young R.C., Ozols R.F., Myers C.E. The anthracycline antineoplastic drugs. New England Journal of Medicine 1981; 305: 139–153
  • Unverferth D.V., Magorien R.D., Leier C.V., Balcerzak S.P. Doxorubicin cardiotoxicity. Cancer Treatment Reviews 1982; 9: 149–164
  • Singal P.K., Deally C.M.R., Weinberg L. Subcellular effects of adriamycin in the heart: a concise review. Journal of Molecular and Cellular Cardiology 1987; 19: 817–828
  • Myers C.E., McGuire W.P., Liss R.H., Ifrim I., Grotzinger K., Young R.C. Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response. Science 1977; 197: 165–167
  • Doroshow J.H. Effect of anthracycline antibiotics on oxygen radical formation in rat heart. Cancer Research 1983; 43: 460–472
  • Bachur N.R., Gordon S.L., Gee M.V. Anthracycline antibiotic augmentation of micro-somal electron transport and free radical formation. Molecular Pharmacology 1977; 13: 901–910, (1977)
  • Davies K.J.A., Doroshow J.H. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. Journal of Biological Chemistry 1986; 261: 3060–3067
  • Doroshow J.H., Davies K.J.A. Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, an hydroxyl radical. Journal of Biological Chemistry 1986; 261: 3068–3074
  • Sinha B.K., Trush M.A., Kennedy K.A., Mimnaugh E.G. Enzymatic activation and binding of adriamycin to nuclear DNA. Cancer Research 1984; 44: 2892–2896
  • Monti E., Paracchini L., Perletti G., Piccinini F. Protective effects of spin-trapping agents on adriamycin-induced cardiotoxicity in isolated rat atria. Free Radical Research Communications 1991; 14: 41–45
  • Fleischer S., Kervina M. Subcellular fractionation of rat liver. Methods in Enzymology 1974; 1: 6–41
  • Tata J.R. Isolation of nuclei from liver and other tissues. Methods in Enzymology 1974; 1: 253–262
  • Pitts B.J.R. Stoichiometry of sodium-calcium exchange in cardiac sarcolemmal vesicles. Journal of Biological Chemistry 1979; 254: 6232–6235
  • Egorin M.J., Holdebrand R.C., Cimino E.F., Bachur N.R. Cytofluoresence localization of adriamycin and daunorubicin. Cancer Research 1974; 34: 2243–2245
  • Bates D.A., Fung H., Mackillop W.J. Adriamycin uptake, intracellular binding and citotoxicity in Chinese hamster ovary cells. Cancer Letters 1985; 28: 213–221
  • Bannister J.V., Thornalley P.J. The production of hydroxyl radicals by adriamycin in red blood cells. FEBS Letters 1983; 157: 170–172
  • Pou S., Hassett D.J., Britigan B.E., Cohen M.S., Rosen G.M. Problems associated with spin trapping oxygen-centered free radicals in biological systems. Analytical Biochemistry 1989; 177: 1–6
  • Bolli R., Patel B.S., Jeroudi M.O., Lai E.K., McCay P.B. Demonstration of free radical generation in “stunned” myocardium of intact dogs with the use of spin trap alpha-phenyl N-tert-butyl nitrone. Journal of Clinical Investigations 1988; 82: 476–485
  • Hearse D., Tosaki A. Reperfusion-induced arrhythmias and free radicals: studies in the rat heart with DMPO. Journal of Cardiovascular Pharmacology 1987; 9: 641–650
  • Hearse D., Tosaki A. Free radicals and reperfusion-induced arrhythmias: protection by spin trap agent PBN in the rat heart. Circulation Research 1987; 60: 375–383
  • Rajagopalan S., Politi P.M., Sinha B.K., Myers C.E. Adriamycin-induced free radical formation in perfused rat heart: implications for cardiotoxicity. Cancer Research 1988; 48: 4766–4769
  • Nohl H. Identification of the site of adriamycin activation in the heart cell. Biochemical Pharmacology 1988; 37: 2633–2637

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