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Original Article

Clastogenic and Mutagenic Actions of Active Species Generated in the 6-Hydroxydopamine/Oxygen Reaction: Effects of Scavengers of Active Oxygen, Iron, and Metal Chelating Agents

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Pages 1-10 | Received 14 Aug 1991, Published online: 07 Jul 2009

References

  • Cronkite E.P., Bullis J.E., Inoue T., Drew R.T. Benzene inhalation produces leukemia in mice. Toxicology and Applied Pharmacology 1984; 75: 358–361
  • Laughton M.J., Halliwell B., Evans P.J., Hoult J.R.S. Antioxidant and pro-oxidant actions of the plant pheolics quercetin, gossypol and myricetin. Biochemical Pharmacology 1989; 17: 2859–2865
  • Josephy P.D., Lord H.L., Snieckus V.A. Inhibition of benzo[a] pyrene dihydrodiol epoxide mutagenicity by synthetic analogues of ellagic acid. Mutation Research 1990; 242: 143–149
  • Stich H.F., Rosin M., Wu C.H., Powrie W.D. The action of transition metals on the genotoxicity of simple phenols. Cancer Letters 1981; 14: 251–260
  • Hatcher J.F., Bryan G.T. Factors affecting the mutagenic activity of quercetin for Salmonella typhimurium TA98: metal ions, antioxidants and pH. Mutation Research 1985; 148: 13–23
  • Hanham A.F., Dunn B.P., Stich H.F. Clastogenic activity of caffeic acid and its relationship to hydrogen peroxide generated during autoxidation. Mutation Research 1983; 116: 333–339
  • Moldeus P., Nordenskjold M., Bolcsfoldi G., Eiche A., Haglund U., Lambert B. Genetic toxicity of dopamine. Mutation Research 1983; Y2A: 9–24
  • Chesis P.L., Levin D.E., Smith M.T., Ernster L., Ames B.N. Mutagenicity of quinones: pathways of metabolic activation and detoxification. Proceedings of the National Academy of Science USA 1984; 81: 1696–1700
  • Rosin M. The influence of pH on the convertogenic activity of plant phenolics. Mutation Research 1984; 135: 109–113
  • Ames B.N. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 1983; 221: 1256–1264
  • Halliwell B., Aruoraa O.I. DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Letters 1991; 281: 9–19
  • Aruoma O.I., Halliwell B., Gajewski E., Dizdaroglu M. Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochemical Journal 1991; 273: 601–604
  • Hecht S., Carmella S., Mori H., Hoffmann D. A study of tobacco carcinogenesis. Role of catechol as a major cocarcinogen in the weakly acidic fraction of smoke condensate. Journal of the National Cancer Institute 1981; 66: 163–169
  • Greenlee W.F., Gross E.A., Irons R.D. Relationship between benzene toxicity and the disposition of 14C-labeled benzene metabolites in the rat. Chemico-Biological Interactions 1981; 33: 285–299
  • Smith M.T., Yager J.W., Steinmetz K.L., Eastmond D.A. Peroxidase-dependent metabolism of benzene's phenolic metabolites and its potential role in benzene toxicity and carcinogenicity. Environmental Health Perspectives 1989; 82: 23–29
  • Lewis J.G., Steward W., Adams D.O. Role of oxygen radicals in induction of DNA damage by metabolites of benzene. Cancer Research 1988; 48: 4762–4765
  • Davison A.J., Legault N.A., Steele D.W. Effect of 6-hydroxydopamine on polymerization of tubulin. Protection by superoxide dismutase, catalase, or anaerobic conditions. Biochemical Pharmacology 1986; 35: 1411–1417
  • Yager J.W., Eastmond D.A., Robertson M.L., Paradisin W.M., Smith M.T. Characterization of micronuclei induced in human lymphocytes by benzene metabolites. Cancer 1990; 50: 593–399
  • Kawanishi S., Inoue S., Kawanishi M. Human DNA damage induced by 1,2,4-ben-zenetriol, a benzene metabolite. Cancer Research 1989; 49: 164–168
  • Yamada K., Shirahata S., Murakami H., Nishiyama K., Shinohara K., Omura H. DNA breakage by phenyl compounds. Agricultural and Biological Chemistry 1985; 49: 1423–1428
  • Pellack-Walker P., Blumer J.L. DNA damage in L5178YS cells following exposure to benzene metabolites. Molecular Pharmacology 1986; 30: 42–47
  • Tiffany-Castiglioni E., Saneto R.P., Proctor P.H., Perez-Polo J.R. Participation of active oxygen species in 6-hydroxydopamine toxicity to a human neuroblastoma cell line. Biochemical Pharmacology 1982; 31: 181–189
  • Bandy B., Moon J., Davison A.J. Multiple actions of superoxide dismutase: why can it both inhibit and stimulate reduction of oxygen by hydroquinones?. Free Radical Biology & Medicine 1990; 9: 143–148
  • Glatt H., Padykula R., Berchtold G.A., Ludewig G., Piatt K.L., Klein J., Oesch F. Multiple activation pathways of benzene leading to products with varying genotoxic characteristics. Environmental Health Perspectives 1989; 82: 81–89
  • Cohen G., Heikkila R.E. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. Journal of Biological Chemistry 1974; 249: 2447–2452
  • Sullivan S.G., Stern A. Effects of superoxide dismutase and catalase on catalysis of 6-hydroxydopamine and 6-aminodopamine autoxidation by iron and ascorbate. Biochemical Pharmacology 1981; 30: 2279–2285
  • Gee P., Davison A.J. 6-Hydroxydopamine does not reduce molecular oxygen directly, but requires a coreductant. Archives of Biochemistry and Biophysics 1984; 231: 164–169
  • Davison A.J., Gee P. Redox state of cytochrome C in the presence of the 6-hydroxy-dopamine/oxygen couple: oscillations dependent on the presence of hydrogen peroxide or superoxide. Archives of Biochemistry and Biophysics 1984; 233: 761–771
  • Gee P., Davison A.J. Effects of scavengers of oxygen free radicals on the anaerobic oxidation of 6-hydroxydopamine by H2O2. Biochimica el Biophysica Acta 1985; 838: 183–190
  • Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutation Research 1983; 113: 173–215
  • San R.H.C., Stich H.F. DNA repair and chromatid anomalies in mammalian cells exposed to 4-nitroquinoline N-oxide. Mutation Research 1970; 10: 389–404
  • Levin D.E., Hollstein M., Christman M.F., Schwiers E.A., Ames B.N. A new Salmonella tester strain (TA102) with A:T base pairs at the site of mutation detects oxidative mutagens. Proceedings of the National Academy of Science USA 1982; 79: 7445–7449
  • Wayner D.D., Burton G.W., Ingold K.U., Barclay L.R., Locke S.J. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochimica et Biophysica Acta 1987; 942: 408–419
  • Halliwell B. Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates: is it a mechanism for hydroxyl radical production in biochemical systems?. FEBS Letters 1978; 92: 321–326

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