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Original Article

Alpha-Phenyl-Tert-Butyl-Nitrone (PBN) Attenuates Hydroxyl Radical Production During Ischemia-Reperfusion Injury of Rat Brain: An EPR Study

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Pages 255-265 | Received 10 May 1993, Published online: 07 Jul 2009

References

  • McCord J. M., Day E. D. Superoxide-dependent production of hydroxyl radical catalyzed by iron-EDTA complex. FEBS Letters 1978; 86: 139–142
  • Halliwell B., Gutteridge J. M.C. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Archives of Biochemistry and Biophysics 1986; 246: 501–514
  • Halliwell B. Oxidant and the central nervous system: some fundamental questions “Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke?”. Acta Neurologica Scandinavia-Supplementum 1989; 126: 23–33
  • Granger D. N. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. American Journal of Physiology 1988; 255: H1269–H1275
  • Britigan B. E., Roeder T. L., Buettner G. R. Spin traps inhibit formation of hydrogen peroxide via the dismutation of superoxide: implications for spin trapping the hydroxyl free radical. Biochimica Biophysica Acta 1991; 1075(3)213–22
  • Phillis J. W., Clough-Helfman C. Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-α-phenylnitrone (PBN). Neuroscience Letter 1990; 116: 315–319
  • Clough-Helfman C., Phillis J. W. The free radical trapping agent N-tert-butyl-α-phenylnitrone (PBN) attenuates cerebral ischemic injury in gerbils. Free Radical Research Communications 1991; 15(3)177–86
  • Carney J. M., Floyd R. A. Protection against oxidative damage to CNS by N-tert-butyl-α-phenylnitrone (PBN) and other spin trapping agents: a novel series of non lipid free radical scavengers. Journal of Molecular Neuroscience 1991; 3: 47–57
  • Zini I., Tomasi A., Grimaldi R., Vannini V., Agnati L. F. Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis. Neuroscience Letter 1992; 138: 279–282
  • Ozawa T., Hanaki A., Onodera K., Kasai M. Reaction of copper (II)-N-polycarboxylate complexes with hydrogen peroxide in the presence of biological reductants: ESR evidence for formation of hydroxyl radical. Biochemistry International 1990; 26(3)477–83
  • Oliver C. N., Starke-Reed P. E., Stadman E. R., Liu G. J., Carney J. M., Floyd R. A. Oxidative damage to brain proteins, loss of glutamine synthetase activity and production of free radicals during ischemia/reperfusion injury to gerbil brain. Proceedings of the National Academy of Sciences (USA) 1990; 87: 5144–5147
  • Lai E. K., Crossley C., Sridhar R., Misra H. P., Janzen E. G., McCay P. B. In vivo spin trapping of free radicals generated in brain, spleen and liver during γ radiation of mice. Archives of Biochemistry and Biophysics 1986; 244(1)156–160
  • Kirsch J. R., Phelan A. M., Lange D. G., Traystman R. J. Free radicals detected in brain during reperfusion from global ischemia. Federation Proceeedings 1987; 46: 799
  • Sakamoto S., Onishi S. T., Onishi T., Ago R. Protective effect of a new anti-oxidant on the rat brain exposed to ischemia-reperfusion injury: inhibition of free radical formation and lipid peroxidation. Free Radical Biology and Medicine 1991; 11: 385–391
  • Cheng H. Y., Liu T., Feurstein G., Barone F. C. Distribution of spin trapping compounds in rat blood and brain: in vivo microdialysis determination. Free Radical Biology and Medicine 1993; 14: 243–250
  • Lange D. G., Kirsch J. R., Helfaer M. A., Traystman R. J. A continuous in vivo model of ischemia/reperfusion induced free radical production in the CSF of pig using spin-trapping agents and EPR techniques. Free Radical Biology and Medicine 1990; 9(supplement-1)97
  • Buettner G. R., Jurkiewicz B. A. Ascorbate free radical as a marker of oxidative stress: an EPR study. Free Radical Biology and Medicine 1993; 14: 49–55
  • Grünewald R. A. Ascorbic acid in the brain. Brain Research Review 1993; 18: 123–133
  • Oriot D., Beharry K., Gordon J., Aranda J. V. CSF ascorbic acid during cerebral ischemia. FASEB Journal 1990; 4: A410
  • Kagan V. E., Serbinova E. A., Packer L. Generation and recycling of radicals from phenolic antioxidants. Archives of Biochemistry and Biophysics 1990; 280(1)33–39

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