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Free Radical Research Volume 21, 1994 - Issue 2
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Original Article

Transient Iron-Overload with Bleomycin-Detectable Iron Present During Cardiopulmonary Bypass Surgery

John R. Pepper Departments of Cardiothoracic Surgery and Anaesthesia & Intensive Care, Unit of Critical Care, Royal Brompton National Heart & Lung Hospital, Sydney Street, London, SW3 6NP
,
Sharon Mumby Departments of Cardiothoracic Surgery and Anaesthesia & Intensive Care, Unit of Critical Care, Royal Brompton National Heart & Lung Hospital, Sydney Street, London, SW3 6NP
&
John M.C. Gutteridge Departments of Cardiothoracic Surgery and Anaesthesia & Intensive Care, Unit of Critical Care, Royal Brompton National Heart & Lung Hospital, Sydney Street, London, SW3 6NP
Pages 53-58 | Received 17 Jan 1994, Published online: 07 Jul 2009

References

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  • Gutteridge J. M.C., Halliwell B. Iron toxicity and oxygen radicals. Clinical Haematology. Iron Chelating Therapy, C. Hershko. Bailliere Tindall, London 1989; Vol 2: 195–256, No 2
  • Gutteridge J. M.C., Rowley D., Halliwell B. Superoxide-dependant formation of hydroxyl radicals in the presence of iron salts. Detection of ‘free’ iron in biological systems by using bleomycin-dependant degradation of DNA. Biochemical Journal 1981; 199: 263–265
  • Gutteridge J. M.C., Hou Y. Iron complexes and their reactivity in the bleomycin assay for radical promoting loosely-bound iron. Free Radical Research Communications 1986; 2: 143–151
  • Moat N. E., Evans T. E., Quinlan G. J., Gutteridge J. M.C. Chelatable iron and copper can be released from extracorporeally circulated blood during cardiopulmonary bypass. Federation of European Biochemical Societies Letters 1993; 328: 103–106
  • Gutteridge J. M.C. Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. Federation of European Biochemical Societies Letters 1986; 201: 291–295
  • Gutteridge J. M.C. The measurements of malondialdehyde in peroxidised ox-brain phospholipid liposomes. Analytical Biochemistry 1977; 82: 76–82
  • Gutteridge J. M.C., Paterson S. K., Segal A. W., Halliwell B. Inhibition of lipid peroxidation by the iron-binding protein lactoferrin. Biochemical Journal 1981; 199: 259–261
  • Gutteridge J. M.C., Quinlan G. J. Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: The important primary role for iron-binding and iron-oxidising proteins. Biochimica et Biophysica Acta 1992; 159: 248–254
  • Kirklin J. K. Prospects for understanding and eliminating the deleterious effects of cardiopulmonary bypass. Annals of Thoracic Surgery 1991; 51: 529–31
  • Giloni L., Takeshita M., Johnson F., Iden C., Grollman A. P. Bleomycin-induced strand-scission of DNA. Mechanisms of deoxyribose cleavage. Journal of Biological Chemistry 1981; 256: 8608–8615
  • Halliwell B. Superoxide, iron, vascular endothelium and reperfusion injury. Free Radical Research Communications 1989; 5: 315–318

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