Oxidative Modification of Low-Density Lipoprotein by the Human Hepatoma Cell Line HepG2

References

• Aden D. P., Fogel A., Plotkin S., Damjanov I., Knowles B. Controlled synthesis of HBsAg in a differenciated human liver carcinoma-derived cell line. Nature 1979; 282: 615–616
   PubMed Web of Science ®Google Scholar
• Knowles B. B., Howe C. C., Aden D. P. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 1980; 209: 497–499
   PubMed Web of Science ®Google Scholar
• Javitt N. B. HepG2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids. Federation American Society Experimental Biology journal 1990; 4: 161–168
   PubMed Web of Science ®Google Scholar
• Dixon J. L., Ginsberg H. N. Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells. journal of lipid research 1993; 34: 167–179
   PubMed Web of Science ®Google Scholar
• Hayashi K., Nakashima K., Saeki M., Kurushima H., Kurukawa J., Kuga Y., et al. Identification of a functional receptor differing from the LDL receptor that catabolizes chylomicron remnant in HepG2 cells. Atherosclerosis 1993; 104: 105–115
   Google Scholar
• Henriksen T., Mahoney E. M., Steinberg D. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proceedings of the National Academy of Sciences USA 1981; 78: 6499–6503
   PubMed Web of Science ®Google Scholar
• Henriksen T., Mahoney E. M., Steinberg D. Enhanced macrophage degradation of biologically modified LDL. Arteriosclerosis 1983; 3: 149–159
   PubMedGoogle Scholar
• Heinecke J. W., Rosen H., Chait A. Iron and copper promote modification of low density lipoprotein by human arterial smooth cells in culture. Journal of Clinical Investigation 1984; 74: 1890–1894
   PubMed Web of Science ®Google Scholar
• Lamb D. J., Wilkins G. M., Leake D. S. The oxidative modification of low density lipoprotein by human lymphocytes. Atherosclerosis 1992; 92: 187–192
   PubMed Web of Science ®Google Scholar
• Parthasarathy S., Printz D. J., Boyd D., Joy L., Steinberg D. Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis 1986; 6: 505–510
   PubMedGoogle Scholar
• Cathcart M. K., Morel D. W., Chisolm G. M. Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. Journal of Leukocyte Biology 1985; 38: 341–350
   PubMed Web of Science ®Google Scholar
• Kokkonen J. O., Kovanen P. T. Stimulation of mast cells leads to cholesterol accumulation in macrophages in vitro by a mast cell granule-mediated uptake of low density lipoprotein. Proceedings of the National Academy of Sciences USA 1987; 84: 2287–2291
   PubMed Web of Science ®Google Scholar
• Aviram T. L., Daukner G., Brook J. G. Platlet secretory products increase low density lipoprotein oxidation, enhance its uptake by macrophages and reduce its fluidity. Arteriosclerosis 1990; 10: 559–563
   Google Scholar
• Keane W. F., O'Doneell M. P., Kasiske B. L., Kim Y. Oxidative modification of low density lipoprotein by mesangial cells. Journal of the American Society of Nephrology 1993; 4: 187–194
   PubMed Web of Science ®Google Scholar
• Morgan J., Smith J. A., Wilkins G. M., Leake D. S. Oxidation of low density lipoprotein by bovine and porcine aortic endothelial cells in culture. Atherosclerosis 1993; 102: 209–216
   PubMed Web of Science ®Google Scholar
• Van Hinsbergh V. W. M., Scheffler M., Havekes L., Kempen H. J. M. Role of endothelial cells and their products in the modification of low density lipoproteins. Biochimica et Biophysica Acta 1986; 878: 49–64
   PubMed Web of Science ®Google Scholar
• Steinbrecher U. P. Role of superoxide in endothe-lial-cell modification of low density lipoproteins. Biochimica et Biophysica Acta 1988; 959: 20–30
   PubMed Web of Science ®Google Scholar
• Sparrow C. P., Olszewski J. Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions. Journal of Lipid Research 1993; 34: 1219–1228
   PubMed Web of Science ®Google Scholar
• Yagi K. A simple fluorometric assay for lipoper-oxide in blood plasma. Biochemical Medicine 1976; 15: 212–216
   PubMed Web of Science ®Google Scholar
• Vedie B., Myara I., Pech M. A., Maziere J. C., Maziere C., Caprani A., Moatti N. Fractionation of charge-modified low-density lipoprotein. journal of Lipid Research 1991; 32: 1359–1369
   PubMed Web of Science ®Google Scholar
• Bieri J. G., Tolliver T. J., Caliguari B. S. Simultaneous determination of vitamin E and retinol in plasma or red cells by high pressure-chromatography. American Journal of Nutrition 1979; 32: 2143–2149
   PubMed Web of Science ®Google Scholar
• Bilheimer D. N., Eisenberg S., Levy R. I. The metabolism of very low density lipoprotein proteins. I. Preliminary in vivo, in vitro observations. Biochimica et Biophysica Acta 1972; 260: 212–221
   PubMed Web of Science ®Google Scholar
• Goldstein J. L., Ho Y. K., Basu S. K., Brown M. S. Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. Journal of Biological Chemistry 1974; 249: 5153–5162
   PubMed Web of Science ®Google Scholar
• McCord J. M., Fridovich I. Superoxide dismutase: an enzymic function for erythrocuprein (hemocuprein). Journal of Biological Chemistry 1969; 244: 6049–6055
   PubMed Web of Science ®Google Scholar
• Peterson G. L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Analytical Biochemistry 1977; 83: 346–356
   PubMed Web of Science ®Google Scholar
• Steinbrecher U. P., Parthasarathy S., Leake D. S., Witztum J. L., Steinberg D. A. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein. Proceedings of the National Academy of Sciences USA 1984; 81: 3883–3887
   PubMed Web of Science ®Google Scholar
• Heinecke J. W., Baker L., Rosen H., Chait A. Superoxide-mediated modification of low density lipoprotein by arterial smooth cells. Journal of Clinical Investigation 1986; 77: 757–761
   PubMed Web of Science ®Google Scholar
• Cathcart M. K., Mc Nally A. K., Morel D. W., Chisolm G. M. Superoxide anion participation in human monocyte-mediated oxidation of low density lipoprotein and conversion of low density lipoprotein to a cytotoxin. Journal of Immunology 1989; 142: 1963–1969
   PubMed Web of Science ®Google Scholar
• Morel D. W., DiCorleto P. E., Chisolm G. M. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis 1984; 4: 357–364
   PubMedGoogle Scholar
• Esterbauer H., Dieber-Rotheneder M., Waeg G., Striegl G., Jiirgens G. Biochemical, structural and functional properties of oxidized low density lipoproteins. Chemical Research in Toxicology 1990; 3: 77–92
   PubMed Web of Science ®Google Scholar
• Esterbauer H., Gebicki J., Puhl H., Jiirgens G. The role of lipid peroxidation and antioxidants in oxidative modification of low density lipoprotein. Free Radical Biology and Medicine 1992; 13: 341–390
   PubMed Web of Science ®Google Scholar
• Hiramatsu K., Rosen H., Heinecke J. W., Wolfbauer G., Chait A. Superoxide initiates oxidation of low density lipoprotein by human monocytes. Arteriosclerosis 1987; 7: 55–60
   PubMedGoogle Scholar
• Morel D. W., Hessler J. R., Chisolm G. M. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid. Journal of Lipid Research 1983; 24: 1070–1076
   PubMed Web of Science ®Google Scholar
• Parthasarathy S., Wieland E., Steinberg D. A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proceedings of the National Academy of Sciences USA 1989; 86: 1046–1050
   PubMed Web of Science ®Google Scholar
• Mc Nally A., Chisolm G. M., III, Morel D. W., Cathcart M. K. Activated human monocytes oxidize low density lipoprotein by a lipoxygenase-dependent pathway. Journal of Immunology 1990; 145: 254–259
   Google Scholar
• Sparrow C. P., Olszewski J. Cellular oxidative modification of low density lipoprotein does not require lipoxygenases. Proceedings of the National Academy of Sciences USA 1992; 89: 128–131
   PubMed Web of Science ®Google Scholar
• Jessup W., Darley-Usmar V., O'Leary V., Bedwell S. 5-lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein. Biochemical Journal 1991; 278: 163–169
   PubMed Web of Science ®Google Scholar
• Rankin S. M., Parthasarathy S., Steinberg D. Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. Journal of Lipid Research 1991; 32: 449–456
   PubMed Web of Science ®Google Scholar
• Parthasarathy S., Steinbrecher U. P., Barnett J., Witztum J. L., Steinberg D. A. Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein. Proceedings of the National Academy of Sciences USA 1985; 82: 3000–3004
   PubMed Web of Science ®Google Scholar
• Cathcart M. K., Chisolm G. M., Mc Nally A. K., Morel D. W. Oxidative modification of low density lipoprotein by activated human monocytes and the cell lines U 937 and HL 60. In vitro cellular and developmental biology 1988; 24: 1001–1008
   PubMed Web of Science ®Google Scholar
• Pech M. A., Myara I., Moatti N., Caprani A. Influence of culture medium characteristics on the ability to oxidize low density lipoproteins. Bioelectrochemistry and Bioenergetics 1993; 29: 277–288
   Google Scholar
• Aust S. D., Svingen B. A. The role of iron in enzymatic lipid peroxidation (1982) Free radicals in biology V. 1982; 1–28
   Google Scholar
• Wilkins G. M., Leake D. S. Free radicals and low density lipoprotein oxidation by macrophages. Biochemical Society Transactions 1990; 18: 1170–1171
   PubMed Web of Science ®Google Scholar
• Jessup W., Simpson J. A., Dean R. T. Does superoxide radical have a role in macrophage-mediated oxidative modification of LDL. Atherosclerosis 1993; 99: 107–120
   PubMed Web of Science ®Google Scholar
• Bedwell S., Dean R. T., Jessup W. The action of defined oxygen-centered free radicals on LDL structure and metabolism. Biochemical Journal 1989; 262: 707–712
   PubMed Web of Science ®Google Scholar
• Heinecke J. W. Free radical modification of low density lipoprotein: mechanisms and biological consequences. Free Radicals Biology and Medicine 1987; 3: 65–73
   PubMed Web of Science ®Google Scholar
• Heinecke J. W., Rosen H., Suzuki L. A., Chait A. The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. Journal of Biological Chemistry 1987; 262: 10098–10103
   PubMed Web of Science ®Google Scholar
• Bannai S., Ishii T. Transport of cystine and cysteine and cell growth in cultured human diploid fibroblasts: effects of glutamate and homocysteate. Journal of Cell Physiology 1982; 112: 265–272
   PubMed Web of Science ®Google Scholar
• Lu S. C., Huang H. Comparison of sulfur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes. Biochemical Pharmacology 1994; 47: 859–869
   Google Scholar
• Adamson G. M., Billings R. E. The role of xanthine oxidase in oxidative damage caused by cytokines in cultured mouse hepatocytes. Life Sciences 1994; 55: 1701–1709
   Google Scholar
• Parthasarathy S. Oxidation of low density lipoprotein by thiols compounds leads to its recognition by the acetyl-LDL receptor. Biochimica et Biophysica Acta 1987; 917: 337–340
   PubMed Web of Science ®Google Scholar
• Steinberg D., Parthasarathy S., Carew T. E., Khoo J. C., Witztum J. L. Beyond cholesterol: modifications of low density lipoprotein that increase its atherogenicity. New England Journal of Medicine 1989; 320: 915–924
   PubMed Web of Science ®Google Scholar
• Salonen J. T., Ylä-Herttuala S., Yamamoto R., Butler S., Korpela H., Salonen R., Nyyssönen K., Palinski W., Witztum J. L. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 1992; 339: 883–887
   PubMed Web of Science ®Google Scholar
• Maggi E., Marchesi E., Ravetta V., Falaschi F., Finardi G., Bellomo G. Low density lipoprotein oxidation in essential hypertension. Journal of Hypertension 1993; 11: 1103–1111
   PubMed Web of Science ®Google Scholar
• Armstrong V. W., Wieland E., Diedrich F., Renner A., Rath W., Kreuzer H., Kuhn W., Oellerich M. Serum antibodies to oxidized low density lipoprotein in preeclampsia and coronary heart disease. Lancet 1994; 343: 1570
   Google Scholar
• Palinski W., Rosenfeld M. E., Yla-Herttuala S., Gurtner G. C., Socher S. S., Butler S. W., Parthasarathy S., Carew T. E., Steinberg D., Witztum J. L. Low density lipoprotein undergoes oxidative modification in vivo. Proceedings of the National Academy of Sciences USA 1989; 86: 1372–1376
   PubMed Web of Science ®Google Scholar
• Virella G., Virella I., Leman R. B., Pryor M. B., Lopes-Virella M. F. Anti-oxidized low density lipoprotein antibodies in patients with coronary heart disease and normal healthy volunteers. International Journal of Clinical and Laboratory Research 1993; 23: 95–101
   PubMedGoogle Scholar
• Parums D. V., Brown D. L., Mitchinson M. J. Serum antibodies to oxidized low density lipoprotein and ceroid in chronic periaortitis. Archives of Pathology and Laboratory Medicine 1990; 114: 383–387
   PubMed Web of Science ®Google Scholar
• Aho K., Seuri M., Leikola J., Alfthan G., Vaarala O., Palosuo T. Serum antibodies to oxidized low density lipoprotein. Lancet 1994; 344: 199–200
   Google Scholar
• Craig W. Y., Ledue T. B. Changes in serum antibodies to oxidised low density lipoprotein with age. Lancer 1994; 344: 411
   Google Scholar
• Glickman R. M., Sabesin S. M. The liver: biology and pathology, 3rd edition. Raven Press, Ltd., New York 1994; 23: 391–414
   Google Scholar
• Poli G., Albano E., Dianzani M. U. The role of lipid peroxidation in liver damage. Chemistry and Physics of Lipids 1987; 45: 117–142
   PubMed Web of Science ®Google Scholar
• Panasenko O. M., Sdvigova A. G., Sergienko V. I., Lopukhin Y. M. The rabbit liver in experimental atherosclerosis secretes oxidized lipoproteins. Bulletin of Experimental Biology and Medicine (English Translation) 1992; 113: 181–183
   Google Scholar
• Panasenko O. M., Sergienko V. I. Free radical modification of blood lipoproteins and atherosclerosis. Biologicals Memories 1994; 7: 323–364
   Google Scholar
• Wehr H., Bednarska-Makaruk M., Pozniak M., Rodo M. Antibodies against unmodified and modified low density lipoproteins in patients with coronary heart disease. (Abstract). Atherosclerosis 1994; 10: 221
   Google Scholar
• Van Berkel T. J. C., De Rijke Y. B., Kruijt J. K. Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Journal of Biological Chemistry 1991; 266: 2282–2289
   PubMed Web of Science ®Google Scholar
• Nagelkerke J. F., Barto K. P., Van Berkel T. J. C. In vivo, in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. Journal of Biological Chemistry 1983; 258: 12221–12227
   PubMed Web of Science ®Google Scholar
• Pieters M. N., Esbach S., Schouten D., Brouwer A., Knook D. L., Van Berkel T. J. C. Cholesteryl esters from oxidized low-density lipoproteins are in vivo rapidly hydrolyzed in rat Kupffer cells and transported to liver parenchymal cells and bile. Hepatology 1994; 19: 1459–1467
   PubMed Web of Science ®Google Scholar
• Stone W. L., Heimberg M., Scott R. L., LeClair I., Wilcox H. G. Altered hepatic catabolism of low-density lipoprotein subjected to lipid peroxidation in vitro. Biochemical Journal 1994; 297: 573–579
   Google Scholar
• Nagelkerke J. F., Havekes L., Van Hinsbergh V. W. M., Van Berkel T. J. C. In vivo catabolism of biologically modified LDL. Arteriosclerosis 1984; 4: 256–264
   PubMedGoogle Scholar