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Original Article

Degradation of DMPO Adducts from Hydroxyl and 1-Hydroxyethyl Radicals by Rat Liver Microsomes

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Pages 467-474 | Received 20 Mar 1996, Published online: 07 Jul 2009

References

  • Rosen G. M., Rauckman E. J. Formation and reduction of a nitroxide radical by liver microsomes. Biochemical Pharmacology 1977; 26: 675–678
  • Iannone A., Bini A., Swartz H. M., Tomasi A., Vannini V. Metabolism in rat liver microsomes of the nitroxide spin probe Tempol. Biochemical Pharmacology 1989; 38: 2581–2586
  • Iannone A., Tomasi A., Vannini V., Swartz H. M. Metabolism of nitroxide spin labels in subcellular fraction of rat liver. I Reduction by microsomes. Biochimica el Biophysica Acta 1990; 1034: 285–289
  • Chen K., Morse P. D., II, Swartz H. M. Kinetics of enzyme-mediated reduction of lipid soluble nitroxide spin labels by living cells. Biochimica et Biophysica Acta 1988; 943: 477–484
  • Iannone A., Hu H., Tomasi A., Vannini V., Swartz H. M. Metabolism of aqueous soluble nitroxides in hepatocytes: effects of cell integrity, oxygen, and structure of nitroxides. Biochimica et Biophysica Acta 1989; 991: 90–96
  • Samuni A., Samuni A., Swartz H. M. The cellular-induced decay of DMPO spin adducts of OH and O2-. Free Radical Biology & Medicine 1989; 6: 179–183
  • McCay P. B., Reinke L. A., Rau J. M. Hydroxyl radicals are generated by hepatic microsomes during NADPH oxidation: relationship to ethanol metabolism. Free Radical Research Communications 1992; 6: 335–346
  • Reinke L. A., Bailey S. M., Rau J. M., McCay P. B. Oxygen radical formation in well-washed rat liver microsomes: spin trapping studies. Free Radical Research 1994; 20: 51–60
  • Reinke L. A., Moore D. R., Hague C. M., McCay P. B. Metabolism of ethanol to 1-hydroxyethyl radicals in rat liver microsomes: comparative studies with three spin trapping agents. Free Radical Research 1994; 21: 213–222
  • Reinke L. A., Rau J. M., McCay P. B. Characteristics of an oxidant formed during iron (II) autoxidation. Free Radical Biology & Medicine 1994; 16: 485–492
  • Lowry O. H., Rosebrough M. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Finkelstein E., Rosen G. M., Rauckman E. J. Spin trapping of superoxide and hydroxyl radical: practical aspects. Archives of Biochemistry and Biophysics 1980; 200: 1–16
  • Rauckman E. J., Rosen G. M., Kitchell B. B. Superoxide radical as an intermediate in the oxidation of hydroxylamines by mixed function amine oxidase. Molecular Pharmacology 1979; 15: 131–137
  • Samuni A., Murali C., Krishna Riesz P., Finkelstein E., Russo A. Superoxide reaction with nitroxide spin-adducts. Free Radical Biology & Medicine 1989; 6: 141–148
  • Kosaka H., Katsuki Y., Shiga T. Spin trapping study on the kinetics of Fe2+ autoxidation: Formation of spin adducts and their destruction by superoxide. Archives of Biochemistry and Biophysics 1992; 293: 401–408
  • Britigan B. E., Coffman T. J., Buettner G. R. Spin trapping evidence for the lack of significant hydroxyl radical production during the respiration burst of human phagocytes using a spin adduct resistant to superoxide-mediated destruction. Journal of Biological Chemistry 1990; 265: 2650–2656
  • Miller D. M., Buettner G. M., Aust S. D. Transition metals as catalysts of “autoxidation” reactions. Free Radical Biology & Medicine 1990; 8: 95–108
  • Reinke L. A., Moore D. R., Rau J. M., McCay P. B. Inorganic phosphate promotes redox cycling of iron in liver microsomes: effects on free radical reactions. Archives of Biochemistry and Biophysics 1995; 316: 758–764
  • Tadolini B. Iron autoxidation in MOPS and HEPES buffers. Free Radical Research Communications 1987; 4: 149–160
  • Kuthan H., Ullrich V. Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system. European journal of Biochemistry 1982; 126: 583–588
  • Morehouse L. A., Thomas C. E., Aust S. D. Superoxide generation by NADPH-cytochrome P-450 reductase: the effect of iron chelators and the role of superoxide in microsomal lipid peroxidation. Archives of Biochemistry and Biophysics 1984; 232: 366–377

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