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Free Radical Research Volume 25, 1996 - Issue 6
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Original Article

Spin Trapping Study in the Lungs and Liver of F344 Rats after Exposure to Ozone

Renaud Vincent Environmental Health Directorate, Health Canada, Tunney's Pasture, Ottawa, Ontario, CanadaCorrespondence[email protected]
,
Edward G. Janzen Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada; Department of MRI Facility, University of Guelph, Guelph, Ontario, Canada
,
Guoman Chen Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada; Department of Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
,
Prem Kumarathasan Environmental Health Directorate, Health Canada, Tunney's Pasture, Ottawa, Ontario, Canada
,
D. Lawrence Haire Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada
,
Josée Guénette Environmental Health Directorate, Health Canada, Tunney's Pasture, Ottawa, Ontario, Canada
,
Jane Z. Chen Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada
&
Tammy M. Bray Department of Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
 show all
Pages 475-488 | Received 10 Feb 1996, Published online: 07 Jul 2009

References

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  • Pryor A. W. How far does ozone penetrate into the pulmonary air/tissue boundary before it reacts?. Free Radical Biology Medicine 1992; 12: 83–88
  • Hatch G. E., Slade R., Harris L. P., McDonnel W. F., Devlin R. B., Koren H. S., Costa D. L., McKee J. Ozone dose and effects in humans and rats. A comparison using oxygen-18 labeling and bronchoalveolar lavage. American Journal of Respiratory and Critical Care Medicine 1994; 150: 676–683
  • Overton J. H., Graham R. C., Miller F. J. A model for the regional uptake of gaseous pollutants in the lung. II. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters. Toxicology and Applied Pharmacology 1987; 88: 418–432
  • Liu L., Kumarathasan P., Guenette J., Vincent R. Hydroxylation of salicylate in the lungs of Fischer 344 rats: effects of aging and exposure to ozone. American Journal of Physiology 1996, Lung Cellular and Molecular Physiology, in press
  • Pryor A. W., Church D. F. Aldehydes, hydrogen peroxide, and organic radicals as mediators of ozone toxicity. Free Radical Biology Medicine 1991; 11: 41–46
  • Kennedy C. H., Hatch G. E., Slade R., Mason R. P. Application of the EPR spin trapping technique to the detection of radicals produced in vivo during inhalation exposure of rats to ozone. Toxicology and Applied Pharmacology 1992; 114: 41–46
  • Kennedy C. H., Hatch G. E., Slade R., Mason R. P. The detection of radicals produced in vivo during inhalation exposure to ozone: use of various spin traps. Oxidative Damage and Repair, K. J. A. Davies. Pergamon Press, Oxford 1991; 528–532
  • Janzen E. G., Kotake Y., Hinton R. D. Stabilities of hydroxyl radical spin adducts of PBN-type spin traps. Free Radical Biology Medicine 1992; 12: 169–173
  • Janzen E. G., Hinton R. D., Kotake Y. Substituent effect on the stability of the hydroxyl radical adduct of α-phenyl N-tert-butyl nitrone (PBN). Tetrahedron Letters 1992; 33: 1257–1260
  • Chen G., Bray T. M., Janzen E. G., McCay P. B. Excretion, metabolism and tissue distribution of a spin trapping agent, α-phenyl-N-tert-butyl nitrone (PBN) in rats. Free Radical Research Communications 1990; 9: 317–323
  • Janzen E. G., Chen G., Bray T. M., Lindsay D. A., Lloyd S., McCay P. B. Preliminary study of metabolites of C-phenyl N-tert-butyl nitrone (PBN) obtained from rat. Free Radicals in the Environment, Medicine and Toxicology: Critical Aspects and Current Highlights, H. Nohl, H. Esterbauer, C. Rice-Evans. Richelieu Press. 1994; Vol VIII: 327–344
  • Haire D. L., Kotake Y., Janzen E. G. An EPR/ENDOR study of aminoxyls (nitroxides) capable of intramolecular hydrogen-bonding: hydroxyalkyl radical spin adducts of nitrones. Canadian Journal of Chemistry 1988; 66: 1901–1911
  • Janzen E. G., Chen G., Bray T. M., Reinke L. A., Poyer J. L., McCay P. B. Study of the isolation and stability of α-trichloromethylbenzyl tert-butyl aminoxyl, the trichloromethyl radical adduct of α-phenyl tert-butyl nitrone (PBN). Journal of the Chemical Society Perkin Transactions 1993; 2: 1983–1989
  • Janzen E. G., Krygsman P. H., Lindsay D. A., Haire Lawrence D. Detection of alkyl, alkoxyl and alkylperoxyl radicals from the thermolysis of azobis isobutyronitrile by ESR spin trapping. Use of chromatography, NMR, and mass spectroscopy. Journal of the American Chemical Society 1990; 112: 8279–8284
  • Kotake Y., Janzen E. G. Decay and fate of hydroxyl radical adduct of α-phenyl-N-tert-butyl nitrone in aqueous media. Journal of the American Chemical Society 1991; 113: 9503–9506
  • McCormick M. L., Buettner G. R., Britigan B. E. The spin trap α-(4-pyridyl-l-oxide)-N-tert-butyl-nitrone stimulates peroxidase-mediated oxidation of deferoxamine. Journal of Biological Chemistry 1995; 270(49)29265–29269
  • Vincent R., Vu D., Hatch G., Poon R., Dreher K., Guenette J., Bjarnason S., Potvin M., Norwood J., McMullen E. Sensitivity of the lungs of aging Fischer 344 rats to ozone: assessment by broncho-alveolar lavage. American Journal of Physiology 1996, Lung Cellular and Molecular Physiology, in press
  • Laskin D. L., Pendino K. J., Punjabi C. J., del Valle Rodriguez M., Laskin J. D. Pulmonary and hepatic effects of inhaled ozone in rats. Environmental Health Perspectives 1994; 102(Supp 10)61–64

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