Advanced search
Publication Cover
Drug Delivery Volume 16, 2009 - Issue 8
Submit an article Journal homepage
1,564
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Preparation of N,O-carboxymethyl chitosan nanoparticles as an insulin carrier

Chuen-Chang LinDepartment of Chemical & Materials Engineering, National Yunlin University of Science and Technology, 123 University Road Sec. 3, Douliu, Yunlin 64002, TaiwanCorrespondence[email protected]
&
Cheng-Wei LinDepartment of Chemical & Materials Engineering, National Yunlin University of Science and Technology, 123 University Road Sec. 3, Douliu, Yunlin 64002, Taiwan
Pages 458-464 | Received 05 Aug 2009, Accepted 17 Sep 2009, Published online: 20 Oct 2009

References

  • Calvo, P., Remuñán-López, C., Vila-Jato, J.L., Alonso, M.J. (1997). Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci. 63:125–32.
  • Chen, S.C., Wu, Y.C., Mi, F.L., Lin, Y.H., Yu, L.C., Sung, H.W. (2004). A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. J Contr Rel. 96:285–300.
  • Fernández-Urrusuno, R., Calvo, P., Remuñán-López, C., Vila-Jato, J.L., Alonso, M.J. (1999). Enhancement of nasal absorption of insulin using chitosan nanoparticles. Pharm Res. 16:1576–81.
  • Grenha, A., Seijo, B., Remuñán-López, C. (2005). Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci. 25:427–37.
  • Hayes, E.R. (1986). N,O-carboxymethyl chitosan and preparative method therefore. US Patent 4,619,995.
  • Ko, J.A., Park, H.J., Hwang, S.J., Park, J.B., Lee, J.S. (2002). Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int J Pharm. 249:165–74.
  • Ma, Z., Yeoh, H.H., Lim, L.Y. (2002). Formulation pH modulates the interaction of insulin with chitosan nanoparticles. J Pharm Sci. 91:1396–404.
  • Mi, F.L., Shyu, S.S., Chen, C.T., Lai, J.Y. (2002). Adsorption of indomethacin onto chemically modified chitosan beads. Polymer. 43:757–65.
  • Pan, Y., Li, Y.J., Zhao, H.Y., Zheng, J.M., Xu, H., Wei, G., Hao, J.S., Cui, F.D. (2002). Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm. 249:139–47.
  • Shu, X.Z., Zhu, K.J. (2000). A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery. Int J Pharm. 201:51–8.
  • Shu, X.Z., Zhu, K.J. (2002). The influence of multivalent phosphate structure on the properties of ionically cross-linked chitosan films for controlled drug release. Eur J Pharm Biopharm. 54:235–43.
  • Sugimoto, M., Morimoto, M., Sashiwa, H., Saimoto, H., Shigemasa, Y. (1998). Preparation and characterization of water-soluble chitin and chitosan derivatives. Carbohydr Polym. 36:49–59.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.