638
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Tissue distribution of 2-methoxyestradiol nanosuspension in rats and its antitumor activity in C57BL/6 mice bearing lewis lung carcinoma

, , , , , & show all
Pages 327-333 | Received 30 Apr 2012, Accepted 19 Jul 2012, Published online: 18 Sep 2012

References

  • Benttarari RR, Amit T, Youdim M. Binding of oestradiol, progesterone and prolactin in rat lung. J Endocrinol 1983;97:301–311.
  • Brannon-Peppas L, Blanchette JO. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 2004;56:1649–1659.
  • Dobos J, Tímár J, Bocsi J, Burián Z, Nagy K, Barna G, Peták I, Ladányi A. In vitro and in vivo antitumor effect of 2-methoxyestradiol on human melanoma. Int J Cancer 2004;112:771–776.
  • Du B, Li Y, Li XT, Youmei A, Zhang ZZ. LC with fluorescence detection for the tissue pharmacokinetics of 2-methoxyestradiol solution and liposome after intravenous administrations to rats. Chromatographia 2009;70:1287–1290.
  • Du B, Li XT, Zhao Y, A YM, Zhang ZZ. Preparation and characterization of freeze-dried 2-methoxyestradiol nanoparticle powders. Pharmazie 2010;65:471–476.
  • Garcia GE, Wisniewski HG, Lucia MS, Arevalo N, Slaga TJ, Kraft SL, Strange R, Kumar AP. 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-α-stimulated gene 6. Clin Cancer Res 2006;12:980–988.
  • Gratton SE, Ropp PA, Pohlhaus PD, Luft JC, Madden VJ, Napier ME, DeSimone JM. The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci USA 2008;105:11613–11618.
  • Gui Y, Zheng XL. 2-methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells. Hypertension 2006;47:271–280.
  • Chauhan D, Li G, Hideshima T, Podar K, Mitsiades C, Mitsiades N, Munshi N, Kharbanda S, Anderson KC. JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. J Biol Chem 2003;278:17593–17596.
  • Hany SM, Peters Y, Nicholas B. Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. Int J Pharm 2009;375:107–113.
  • Huang XH, Xiong PC, Xiong CM, Cai YL, Wei AH, Wang JP, Liang XF, Ruan JL. In vitro and in vivo antitumor activity of Macrothelypteris torresiana and its acute/subacute oral toxicity. Phytomedicine 2010;17:930–934.
  • Hughes RA, Harris T, Altmann E, McAllister D, Vlahos R, Robertson A, Cushman M, Wang Z, Stewart AG. 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure–activity relationships for DNA synthesis inhibition and estrogen receptor binding. Mol Pharmacol 2002;61:1053–1069.
  • Huh JI, Calvo A, Charles R, Green JE. Distinct tumor stage-specific inhibitory effects of 2-methoxyestradiol in a breast cancer mouse model associated with Id-1 expression. Cancer Res 2006;66:3495–3503.
  • Ireson CR, Chander SK, Purohit A, Perera S, Newman SP, Parish D, Leese MP, Smith AC, Potter BV, Reed MJ. Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. Br J Cancer 2004;90:932–937.
  • Lu B. New Techniques and New Dosage Forms of Drugs, 2nd ed. Bei Jing: People's Medical Publishing House, 2005:158–167.
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55–63.
  • Müller RH, Peters K. Nanosuspensions for the formulation of poorly soluble drugs: preparation by a size reduced technique. Int J Pharm 1998;160:229–237.
  • Peters K, Leitzke S, Diederichs JE, Borner K, Hahn H, Müller RH, Ehlers S. Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection. J Antimicrob Chemother 2000;45:77–83.
  • Sève P, Reiman T, Dumontet C. The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer. Lung Cancer 2010;67:136–143.
  • Spivey KA, Banyard J, Solis LM, Wistuba II, Barletta JA, Gandhi L, Feldman HA, Rodig SJ, Chirieac LR, Zetter BR. Collagen XXIII: a potential biomarker for the detection of primary and recurrent non-small cell lung cancer. Cancer Epidemiol Biomarkers Prev 2010;19:1362–1372.
  • Sweeney C, Liu G, Yiannoutsos C, Kolesar J, Horvath D, Staab MJ, Fife K, Armstrong V, Treston A, Sidor C, Wilding G. A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. Clin Cancer Res 2005;11:6625–6633.
  • Wang Y, Zhang D, Liu Z, Liu G, Duan C, Jia L, Feng F, Zhang X, Shi Y, Zhang Q. In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery. Nanotechnology 2010;21:155104–155110.
  • Zhang H, Hollis CP, Zhang Q, Li T. Preparation and antitumor study of camptothecin nanocrystals. Int J Pharm 2011;415:293–300.
  • Zheng D, Wang Y, Zhang D, Liu Z, Duan C, Jia L, Wang F, Liu Y, Liu G, Hao L, Zhang Q. In vitro antitumor activity of silybin nanosuspension in PC-3 cells. Cancer Lett 2011;307:158–164.
  • Zhu WJ, Han B, Sun Y, Wang ZY, Yang XH. Immunoregulatory effects of a glucogalactan from the root of Panax quinquefolium L. Carbohyd Polym 2011;87:2725–2729.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.