2,669
Views
62
CrossRef citations to date
0
Altmetric
Original Article

Pectin nanoparticle enhances cytotoxicity of methotrexate against hepG2 cells

, &
Pages 1-9 | Received 16 Jun 2012, Accepted 09 Oct 2012, Published online: 08 Dec 2012

References

  • Avivi-Green C, Madar Z, Schwartz B. Pectin-enriched diet affects distribution and expression of apoptosis-cascade proteins in colonic crypts of dimethylhydrazine-treated rats. Int J Mol Med 2000a;6:689–698.
  • Avivi-Green C, Polak-Charcon S, Madar Z, Schwartz B. Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: correlation with colon cancer inhibition. Oncol Res 2000b;12:83–95.
  • Cascone MG, Lazzeri L, Carmignani C, Zhu Z. Gelatin nanoparticles produced by a simple W/O emulsion as delivery system for methotrexate. J Mater Sci Mater Med 2002;13:523–526.
  • Chang WC, Chapkin RS, Lupton JR. Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis 1997;18:721–730.
  • Chauhan D, Li G, Podar K, Hideshima T, Neri P, He D et al. A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells. Cancer Res 2005;65:8350–8358.
  • Chavanpatil MD, Khdair A, Panyam J. Nanoparticles for cellular drug delivery: mechanisms and factors influencing delivery. J Nanosci Nanotechnol 2006;6:2651–2663.
  • Chen YH, Tsai CY, Huang PY, Chang MY, Cheng PC, Chou CH et al. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharm 2007;4:713–722.
  • Heitman DW, Hardman WE, Cameron IL. Dietary supplementation with pectin and guar gum on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Carcinogenesis 1992;13:815–818.
  • Hirsjärvi S, Passirani C, Benoit JP. Passive and active tumour targeting with nanocarriers. Curr Drug Discov Technol 2011;8:188–196.
  • Ho ML, Fu YC, Wang GJ, Chen HT, Chang JK, Tsai TH et al. Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite. J Control Release 2008;128:142–148.
  • Jackson CL, Dreaden TM, Theobald LK, Tran NM, Beal TL, Eid M et al. Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Glycobiology 2007;17:805–819.
  • Javadzadeh Y, Hamishehkar H. Enhancing percutaneous delivery of methotrexate using different types of surfactants. Colloids Surf B Biointerfaces 2011;82:422–426.
  • Kaasgaard T, Andresen TL, Jensen SS, Holte RO, Jensen LT, Jørgensen K. Liposomes containing alkylated methotrexate analogues for phospholipase A(2) mediated tumor targeted drug delivery. Chem Phys Lipids 2009;157:94–103.
  • Kosasih A, Bowman BJ, Wigent RJ, Ofner CM 3rd. Characterization and in vitro release of methotrexate from gelatin/methotrexate conjugates formed using different preparation variables. Int J Pharm 2000;204:81–89.
  • Kossoy G, Ben-Hur H, Stark A, Zusman I, Madar Z. Effects of a 15% orange-pulp diet on tumorigenesis and immune response in rats with colon tumors. Oncol Rep 2001;8:1387–1391.
  • Lin YK, Huang ZR, Zhuo RZ, Fang JY. Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery. Int J Nanomedicine 2010;5:117–128.
  • Lu F, Wu SH, Hung Y, Mou CY. Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles. Small 2009;5:1408–1413.
  • Malam Y, Lim EJ, Seifalian AM. Current trends in the application of nanoparticles in drug delivery. Curr Med Chem 2011;18:1067–1078.
  • Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer 2006;6:583–592.
  • Morris G, Kök S, Harding S, Adams G. Polysaccharide drug delivery systems based on pectin and chitosan. Biotechnol Genet Eng Rev 2010;27:257–284.
  • Mukesh U, Kulkarni V, Tushar R, Murthy RS. Methotrexate loaded self stabilized calcium phosphate nanoparticles: a novel inorganic carrier for intracellular drug delivery. J Biomed Nanotechnol 2009;5:99–105.
  • Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R et al. Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J Natl Cancer Inst 2002;94:1854–1862.
  • Olano-Martin E, Rimbach GH, Gibson GR, Rastall RA. Pectin and pectic-oligosaccharides induce apoptosis in in vitro human colonic adenocarcinoma cells. Anticancer Res 2003;23:341–346.
  • Opanasopit P, Apirakaramwong A, Ngawhirunpat T, Rojanarata T, Ruktanonchai U. Development and characterization of pectinate micro/nanoparticles for gene delivery. AAPS PharmSciTech 2008;9:67–74.
  • Pastan I, Gottesman M. Multiple-drug resistance in human cancer. N Engl J Med 1987;316:1388–1393.
  • Pienta KJ, Naik H, Akhtar A, Yamazaki K, Replogle TS, Lehr J et al. Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst 1995;87:348–353.
  • Platt D, Raz A. Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin. J Natl Cancer Inst 1992;84:438–442.
  • Reddy LH, Murthy RR. Influence of polymerization technique and experimental variables on the particle properties and release kinetics of methotrexate from poly(butylcyanoacrylate) nanoparticles. Acta Pharm 2004;54:103–118.
  • Seo DH, Jeong YI, Kim DG, Jang MJ, Jang MK, Nah JW. Methotrexate-incorporated polymeric nanoparticles of methoxy poly(ethylene glycol)-grafted chitosan. Colloids Surf B Biointerfaces 2009;69:157–163.
  • Shi W, Wang J, Fan X, Gao H. Size and shape effects on diffusion and absorption of colloidal particles near a partially absorbing sphere: implications for uptake of nanoparticles in animal cells. Phys Rev E Stat Nonlin Soft Matter Phys 2008;78:061914.
  • Takimoto CH. New Antifolates: Pharmacology and Clinical Applications. Oncologist 1996;1:68–81.
  • Thierry B. Drug nanocarriers and functional nanoparticles: applications in cancer therapy. Curr Drug Deliv 2009;6:391–403.
  • Trapani A, Denora N, Iacobellis G, Sitterberg J, Bakowsky U, Kissel T. Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors. AAPS PharmSciTech 2011;12:1302–1311.
  • van Haandel L, Stobaugh JF. Bioanalytical method development for a generation 5 polyamidoamine folic acid methotrexate conjugated nanoparticle. Anal Bioanal Chem 2010;397:1841–1852.
  • Yang X, Zhang Q, Wang Y, Chen H, Zhang H, Gao F et al. Self-aggregated nanoparticles from methoxy poly(ethylene glycol)-modified chitosan: synthesis; characterization; aggregation and methotrexate release in vitro. Colloids Surf B Biointerfaces 2008;61:125–131.
  • Yu CY, Cao H, Zhang XC, Zhou FZ, Cheng SX, Zhang XZ et al. Hybrid nanospheres and vesicles based on pectin as drug carriers. Langmuir 2009;25:11720–11726.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.