3,911
Views
81
CrossRef citations to date
0
Altmetric
Original Article

Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics and in situ single pass intestinal perfusion (SPIP) studies

&
Pages 522-530 | Received 29 Dec 2013, Accepted 16 Jan 2014, Published online: 11 Feb 2014

References

  • Almeida L, Vaz-da-Silva M, Falcao A, et al. (2009). Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol Nutr Food Res 53: S7–15
  • Amri A, Chaumeil JC, Sfar S, Charrueau C. (2012). Administration of resveratrol: what formulation solutions to bioavailability limitations. J Control Release 158:182–93
  • Balakrishnan P, Lee BJ, OH DH. (2009). Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS). Eur J Pharm Biopharm 72:539–45
  • Balakumara K, Raghavana CV, Selvana NT, et al. (2013). Self-nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin calcium: design, formulation, bioavailability and pharmacokinetic evaluation. Colloids Surf B Biointerfaces 112:337–43
  • Bandyopadhyay S, Katare OP, Singh B. (2012). Optimized self-nano-emulsifying systems of ezetimibe with enhanced bioavailability potential using long chain and medium chain triglycerides. Colloids Surf B Biointerfaces 100:50–61
  • Basalious EB, Shawky N, Badr-Eldin SM. (2010). SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization. Int J Pharm 391:203–11
  • Chen F, Wang Y, Zheng F, et al. (2000). Studies on cloud point of agrochemical microemulsions. Colloids Surf A: Physicochem Eng Aspects 175:257–62
  • Date AA, Desai N, Dixit R, Nagarsenker M. (2010). Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine 5:1595–616
  • Elnaggar YSR, El-Massik MA, Abdallah OY. (2009). Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization. Int J Pharm 380:133–41
  • Elsheikh MA, Elnaggar YSR, Gohar EY, Abdallah OY. (2012). Nanoemulsion liquid preconcentrates for raloxifene hydrochloride: optimization and in vivo appraisal. Int J Nanomedicine 7:3787–802
  • Gao F, Zhang Z, Bu H. (2011). Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: performance and mechanism. J Control Release 149:168–74
  • Gupta S, Chavhan S, Sawant KK. (2011). Self-nanoemulsifying drug delivery system for adefovir dipivoxil: design, characterization, in vitro and ex vivo evaluation. Colloids Surf A: Physicochem Eng Aspects 392:145–55
  • Ho YF, Lai MY, Yu HY, et al. (2008). Application of rat in situ single-pass intestinal perfusion in the evaluation of presystemic extraction of indinavir under different perfusion rates. J Formos Med Assoc 107:37–45
  • Hung CF, Chen JK, Liao MH. (2006). Development and evaluation of emulsion-liposome blends for resveratrol delivery. J Nanosci Nanotechnol 6:2950–8
  • Jeevana JB, Sreelakshmi K. (2011). Design and evaluation of self-nanoemulsifying drug delivery system of flutamide. J Young Pharm 3:4–8
  • Lawrence MJ, Rees GD. (2000). Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 45:89–121
  • Marier JF, Vachon P, Gritsas A. (2002). Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J Pharmacol Exp Ther 302:369–73
  • Nam JB, Ryu JH, Kim JW, et al. (2005). Stabilization of resveratrol immobilized in monodisperse cyano-functionalized porous polymeric microspheres. Polymer 46:8956–63
  • Nielsen FS, Petersen KB, Müllertz A. (2008). Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state. Eur J Pharm Biopharm 69:553–62
  • Porter CJ, Charman WN. (2001). Intestinal lymphatic drug transport: an update. Adv Drug Deliv Rev 50:61–80
  • Porter CJ, Trevaskis NL, Charman WN. (2007). Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 6:231–48
  • Porter CJ, Charman WN. (2001). Transport and absorption of drugs via the lymphatic system. Adv Drug Deliv Rev 50:1–2
  • Singh G, Pai RS, Pandit V. (2013). In vivo pharmacokinetic applicability of a simple and validated HPLC method for orally administered trans-resveratrol loaded polymeric nanoparticles to rats. J Pharm Investigation. [Epub ahead of print]. doi:10.1007/s40005-013-0105-0
  • Singh G, Pai RS, Devi VK. (2012a). Response surface methodology and process optimization of sustained release pellets using Taguchi orthogonal array design and central composite design. J Adv Pharm Tech Res 3:30–40
  • Singh G, Pai RS, Devi VK. (2012b). Optimization of pellets containing solid dispersion prepared by extrusion/spheronization using central composite design and desirability function. J Young Pharm 4:146–56
  • Singh G, Pai RS. (2013). Pharmacokinetics and in vivo biodistribution of optimized PLGA nanoparticulate drug delivery system for controlled release of emtricitabine. Drug Deliv. [Epub ahead of print]. doi:10.3109/10717544.2013.867382
  • Sun M, Zhai X, Xue K, et al. (2011). Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation with oral bioavailabilities in rats. Eur J Pharm Sci 43:132–40
  • Swenson ES, Milisen WB, Curatolo W. (1994). Intestinal permeability enhancement: efficacy, acute local toxicity, and reversibility. Pharm Res 11:1132–42
  • Troche-Pesqueira E, Perez-Juste I, Navarro-Vazquez A, Cid MM. (2013). A β-cyclodextrin–resveratrol inclusion complex and the role of geometrical and electronic effects on its electronic induced circular dichroism. RSC Adv 3:10242–50
  • Wegiel LA, Mauer LJ, Edgar KJ, Taylor LS. (2013). Crystallization of amorphous solid dispersions of resveratrol during preparation and storage-impact of different polymers. J Pharm Sci 102:171–84

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.