Advanced topical drug delivery system for the management of vaginal candidiasis

References

• Abrams L, Weintraub H. (1983). Disposition of radioactivity following intravaginal administration of 3H-miconazole nitrate. Am J Obstetr Gynecol 147:970–1
   PubMed Web of Science ®Google Scholar
• Abruquah H. (2012). Prevalence and antifungal susceptibility of Candida species isolated from women attending a gynaecological clinic in Kumasi, Ghana. J Sci Technol (Ghana) 32:39–45
   Google Scholar
• Ahmad FJ, Alam MA, Khan ZI, et al. (2008). Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections. Acta pharmaceutica 58:407–19
   PubMed Web of Science ®Google Scholar
• Alexander NJ, Baker E, Kaptein M, et al. (2004). Why consider vaginal drug administration? Fertil Steril 82:1–12
   PubMed Web of Science ®Google Scholar
• Alli J, Okonko I, Odu N, et al. (2011). Detection and prevalence of Candida isolates among patients in Ibadan, Southwestern Nigeria. J Microbiol Biotechnol Res 1(3):176–184
   Google Scholar
• Ameen DW. (2011). Development and in vitro evaluation of bioadhesive vaginal tablet using econazole nitrate as a model drug. Iraqi J Pharmaceut Sci 57:57–65
   Google Scholar
• Bacci A, Montagnoli C, Perruccio K, et al. (2002). Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantation. J Immunol 168:2904–13
   PubMed Web of Science ®Google Scholar
• Bachhav YG, Patravale VB. (2009). Microemulsion-based vaginal gel of clotrimazole: formulation, in vitro evaluation, and stability studies. AAPS PharmSciTech 10:476–81
   PubMed Web of Science ®Google Scholar
• Basnet P, Hussain H, Tho I, et al. (2012). Liposomal delivery system enhances anti-inflammatory properties of curcumin. J Pharmaceut Sci 101:598–609
   PubMed Web of Science ®Google Scholar
• Bhalekar MR, Pokharkar V, Madgulkar A, et al. (2009). Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery. AAPS PharmSciTech 10:289–96
   PubMed Web of Science ®Google Scholar
• Bhat S, Shivakumar H. (2010a). Bioadhesive controlled release clotrimazole vaginal tablets. Trop J Pharmaceut Res 9(4): 339–46
   Web of Science ®Google Scholar
• Bhat SR, Shivakumar HG. (2010b). Formulation development and evaluation of thermosensitive gel for vaginal drug delivery. Latin Am J Pharm 29(7): 1093–9
   Web of Science ®Google Scholar
• Bhowmik BB, Nayak BS, Chatterjee A. (2009). Formulation development and characterization of metronidazole microencapsulated bioadhesive vaginal gel. Int J Pharm Pharm Sci 1:240–57
   Google Scholar
• Bilensoy E, Rouf MA, Vural I, et al. (2006). Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: β-cyclodextrin complex. AAPS PharmSciTech 7:E54–60
   PubMed Web of Science ®Google Scholar
• Brannon-Peppas L. (1993). Novel vaginal drug release applications. Adv Drug Deliv Rev 11:169–77
   Web of Science ®Google Scholar
• Cárdenas-Freytag L, Cheng E, Mayeux P, et al. (1999). Effectiveness of a vaccine composed of heat-killed Candida albicans and a novel mucosal adjuvant, LT (R192G), against systemic candidiasis. Infect Immun 67:826–33
   PubMed Web of Science ®Google Scholar
• Carr PL, Felsenstein D, Friedman RH. (1998). Evaluation and management of vaginitis. J Gen Intern Med 13:335–46
   PubMed Web of Science ®Google Scholar
• Cejtin HE, Mason ED. (2000). A guide to the diagnosis and treatment of vaginitis and cervicitis. Hosp Phys 53–63
   Google Scholar
• Choudhury A, Das S, Kar M. (2011). A review on novelty and potentiality of vaginal drug delivery. Int J PharmTech Res 3:1033–44
   Google Scholar
• D Amati G, Di Gioia C, Pannunzi LP, et al. (2003). Functional anatomy of the human vagina. J Endocrinol Investig 26:92–6
   Google Scholar
• Dangi AA, Sheth NR, Patel H, et al. (2011). Formulation and evaluation of once daily mucoadhesive vaginal tablet of clotrimazole using natural and synthetic polymers. Asian J. Pharm. Health Sci 1:176–82
   Google Scholar
• De Bernardis F, Amacker M, Arancia S, et al. (2012). A virosomal vaccine against candidal vaginitis: immunogenicity, efficacy and safety profile in animal models. Vaccine 30:4490–8
   PubMed Web of Science ®Google Scholar
• De Bernardis F, Boccanera M, Adriani D, et al. (2002). Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis. Infect Immun 70:2725–9
   PubMed Web of Science ®Google Scholar
• De Bernardis F, Liu H, O'Mahony R, et al. (2007). Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. J Infect Dis 195:149–57
   PubMed Web of Science ®Google Scholar
• De Blaey C, Polderman J. (1980). Rationales in the design of rectal and vaginal delivery forms of drugs. Drug Design 9:237–66
   Google Scholar
• De St Groth SF, Scheidegger D. (1980). Production of monoclonal antibodies: strategy and tactics. J Immunol Meth 35:1–21
   PubMed Web of Science ®Google Scholar
• Del Gaudio G, Lombardi L, Maisetta G, et al. (2013). Antifungal activity of the noncytotoxic human peptide hepcidin 20 against fluconazole-resistant Candida glabrata in human vaginal fluid. Antimicrob Agents Chemotherap 57:4314–21
   Web of Science ®Google Scholar
• Dhanaraj A, Jaya Raja Kumar, Jayachandran K, et al. (2013). Development and in vitro/in vivo evalution of tripolymers based clotrimazole in situ gel for oral thrush. Journal of pharmaceutical science and technology 3(10):985–95
   Google Scholar
• Dias LB, Melhem MDSC, Szeszs MW, et al. (2011). Vulvovaginal candidiasis in Mato Grosso, Brazil: pregnancy status, causative species and drugs tests. Brazil J Microbiol 42:1300–7
   PubMed Web of Science ®Google Scholar
• El-Din S, Reynolds M, Ashbee H, et al. (2001). An investigation into the pathogenesis of vulvo-vaginal candidosis. Sex Trans Infect 77:179–83
   PubMed Web of Science ®Google Scholar
• Ernest J. (1992). Topical antifungal agents. Obstetr Gynecol Clin N Am 19:587–607
   PubMed Web of Science ®Google Scholar
• Faraji R, Rahimi MA, Assarehzadegan M. (2012). Prevalence of vaginal candidiasis infection in women referred to Kermanshah hygienic centers, Iran in 2010. Life Sci J 6:2273–8
   Google Scholar
• Faro S. (1994). Systemic vs. topical therapy for the treatment of vulvovaginal candidiasis. Infect Dis Obstetr Gynecol 1:202–8
   PubMedGoogle Scholar
• Fong I. (1992). The value of chronic suppressive therapy with itraconazole versus clotrimazole in women with recurrent vaginal candidiasis. Genitourinary Med 68:374–7
   PubMedGoogle Scholar
• Francois M, Snoeckx E, Putteman P, et al. (2003). A mucoadhesive, cyclodextrin-based vaginal cream formulation of itraconazole. Aaps Pharmsci 5:50–4
   Google Scholar
• Gagandeep GT, Malik B, Rath G, Goyal AK. (2014). Development and characterization of nano-fiber patch for the treatment of glaucoma. Eur J Pharm Sci 53:10–6
   PubMed Web of Science ®Google Scholar
• Garg T, Bilandi A, Kapoor B. (2011). Scaffold: tissue engineering and regenerative medicine. Int Res J Pharm 2:37–42
   Google Scholar
• Garg T, Goyal AK. (2012). Iontophoresis: drug delivery system by applying an electrical potential across the skin. Drug Deliv Lett 2:270–80
   Google Scholar
• Garg T, Goyal AK. (2014a). Biomaterial-based scaffolds - current status and future directions. Expert Opin Drug Deliv 11:767–89
   PubMed Web of Science ®Google Scholar
• Garg T, Goyal AK. (2014b). Liposomes: targeted and controlled delivery system. Drug Deliv Lett 4:62–71
   Google Scholar
• Garg T, Rath G, Goyal AK. (2014a). Comprehensive review on additives of topical dosage forms for drug delivery. Drug Deliv
   PubMed Web of Science ®Google Scholar
• Garg T, Rath G, Goyal AK. (2014b). Novel technology to improve drug loading in polymeric nanofibers. Drug Deliv Lett 4:79–86
   Google Scholar
• Garg T, Singh O, Arora S, Murthy R. (2012). Scaffold: a novel carrier for cell and drug delivery. Crit Rev Ther Drug Carrier Syst 29:1–63
   PubMed Web of Science ®Google Scholar
• Garg T, Singh S, Goyal AK. (2013). Stimuli-sensitive hydrogels: an excellent carrier for drug and cell delivery. Crit Rev Ther Drug Carrier Syst 30:369–409
   PubMed Web of Science ®Google Scholar
• Gearhart MO. (1994). Worsening of liver function with fluconazole and review of azole antifungal hepatotoxicity. Ann Pharmacother 28:1177–81
   PubMed Web of Science ®Google Scholar
• Goyal G, Garg T, Malik B, et al. (2013). Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv
   PubMed Web of Science ®Google Scholar
• Gupta NV, Natasha S, Getyala A, Bhat RS. (2013). Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal Candidiasis. Acta Pharmaceutica 63:359–72
   PubMed Web of Science ®Google Scholar
• Haas TA, Plow EF. (1994). Integrin-ligarid interactions: a year in review. Curr Opin Cell Biol 6:656–62
   PubMed Web of Science ®Google Scholar
• Han Y, Morrison RP, Cutler JE. (1998). A vaccine and monoclonal antibodies that enhance mouse resistance to Candida albicans vaginal infection. Infect Immun 66:5771–6
   PubMed Web of Science ®Google Scholar
• Han Y, Ulrich MA, Cutler JE. (1999). Candida albicans mannan extract—protein conjugates induce a protective immune response against experimental candidiasis. J Infect Dis 179:1477–84
   PubMed Web of Science ®Google Scholar
• Hani U, Shivakumar H. (2013). Development of miconazole nitrate thermosensitive bioadhesive vaignal gel for vaginal candidiasis. American Journal of Advanced Drug Delivery 3:358–368
   Google Scholar
• Hani U, Shivakumar H, Gowrav M. (2014). Formulation design and evaluation of a novel vaginal delivery system of clotrimazole. International Journal of Pharmaceutical Science and Research 5(1):220–27
   Google Scholar
• Hay RJ. (1993). Risk/benefit ratio of modern antifungal therapy: focus on hepatic reactions. J Am Acad Dermatol 29:S50–4
   PubMed Web of Science ®Google Scholar
• Hussain A, Ahsan F. (2005). The vagina as a route for systemic drug delivery. J Control Rel 103:301–13
   PubMed Web of Science ®Google Scholar
• Hwang S, Owada E, Suhardja L, et al. (1977). Systems approach to vaginal delivery of drugs IV: methodology for determination of membrane surface pH. J Pharmaceut Sci 66:778–81
   PubMed Web of Science ®Google Scholar
• Hwang S, Owada E, Yotsuyanagi T, et al. (1976). Systems approach to vaginal delivery of drugs II: in situ vaginal absorption of unbranched aliphatic alcohols. J Pharmaceut Sci 65:1574–78
   PubMed Web of Science ®Google Scholar
• Ibrahim AS, Spellberg BJ, Avenissian V, et al. (2005). Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity. Infect Immun 73:999–1005
   PubMed Web of Science ®Google Scholar
• Jain SK, Singh R, Sahu B. (1997). Development of a liposome based contraceptive system for intravaginal administration of progesterone. Drug Dev Indust Pharm 23:827–30
   Web of Science ®Google Scholar
• Jindal N, Gill P, Aggarwal A. (2007). An epidemiological study of vulvovaginal candidiasis in women of childbearing age. Ind J Med Microbiol 25:175
   PubMedGoogle Scholar
• Johnson T, Greer I, Kelly R, Calder A. (1992). The effect of pH on release of PGE2 from vaginal and endocervical preparations for induction of labour: an in-vitro study. BJOG: An Int J Obstetr & Gynaecol 99:877–80
   Web of Science ®Google Scholar
• Jouault T, El Abed-El Behi M, Martínez-Esparza M, et al. (2006). Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling. J Immunol 177:4679–87
   PubMed Web of Science ®Google Scholar
• Jyotsana M, Sagar B, Mahesh D. (2010). Mucosal drug delivery system. IJRAP 1:63–7
   Google Scholar
• Kang J-W, Davaa E, Kim Y-T, Park J-S. (2010). A new vaginal delivery system of amphotericin B: a dispersion of cationic liposomes in a thermosensitive gel. J Drug Target 18:637–44
   PubMed Web of Science ®Google Scholar
• Karavana SY, Rençber S, Şenyiğit ZA, Baloğlu E. (2012). A new in-situ gel formulation of itraconazole for vaginal administration. Pharmacol Pharm 3(4):417–26
   Google Scholar
• Kast CE, Valenta C, Leopold M, Bernkop-Schnürch A. (2002). Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole. J Control Rel 81:347–54
   PubMed Web of Science ®Google Scholar
• Kataria K, Garg T, Goyal AK, Rath G. (2014). Novel technology to improve drug loading in polymeric nanofibers. Drug Deliv Lett 4:79–86
   Google Scholar
• Katz DF, Dunmire EN. (1993). Cervical mucus: problems and opportunities for drug delivery via the vagina and cervix. Adv Drug Deliv Rev 11:385–401
   Web of Science ®Google Scholar
• Kaur M, Garg T, Rath G, Goyal AK. (2014). Current nanotechnological strategies for effective delivery of bioactive drug molecules in the treatment of tuberculosis. Crit Rev Ther Drug Carrier Syst 31:49–88
   PubMed Web of Science ®Google Scholar
• Khan F, Baqai R. (2010). In vitro antifungal sensitivity of fluconazole, clotrimazole and nystatin against vaginal candidiasis in females of childbearing age. J Ayub Med Coll Abbottabad 22:197–200
   PubMedGoogle Scholar
• Kim SW, Bae YH, Okano T. (1992). Hydrogels: swelling, drug loading, and release. Pharmaceut Res 9:283–90
   PubMed Web of Science ®Google Scholar
• Lee CH, Anderson M, Chien YW. (1996). Characterization of in-vitro spermicidal activity of chelating agent against human sperm. J Pharmaceut Sci 85:649–54
   PubMed Web of Science ®Google Scholar
• Lee V. (1990). Peptide and protein drug delivery. Boca Raton, FL: CRC Press
   Google Scholar
• Liu Y, Filler SG. (2011). Candida albicans Als3, a multifunctional adhesin and invasin. Eukaryotic Cell 10:168–73
   PubMed Web of Science ®Google Scholar
• Loza L, Fu Y, Ibrahim AS, et al. (2004). Functional analysis of the Candida albicans ALS1 gene product. Yeast 21:473–82
   PubMed Web of Science ®Google Scholar
• Masters WH, Johnson VE. (1966). Human sexual response. Boston (MA): Little, Brown & Co
   Google Scholar
• Mathiowitz E, Chickering III DE, Lehr C-M. (2013). Bioadhesive drug delivery systems: fundamentals, novel approaches, and development. Boca Raton, FL: CRC Press
   Google Scholar
• Mcgregor JA, Ismail M, Mccormack WM. (1998). A pilot study of metronidazole vaginal gel versus oral metronidazole for the treatment of Trichomonas vaginalis vaginitis. Sex Trans Dis 25:176–9
   PubMed Web of Science ®Google Scholar
• Miller RA, Maloney DG, Warnke R, Levy R. (1982). Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. New Engl J Med 306:517–22
   PubMed Web of Science ®Google Scholar
• Newson L. (2013). Management of vulvovaginal infections in primary care part 1: Candidiasis. Br J Fam Med 1:3
   Google Scholar
• Ning M, Guo Y, Pan H, et al. (2005). Preparation, in vitro and in vivo evaluation of liposomal/niosomal gel delivery systems for clotrimazole. Drug Dev Industr Pharm 31:375–83
   PubMed Web of Science ®Google Scholar
• Novak A, De La Loge C, Abetz L, Van Der Meulen E. (2003). The combined contraceptive vaginal ring, NuvaRing®: an international study of user acceptability. Contraception 67:187–94
   PubMed Web of Science ®Google Scholar
• Ogunshe AA, Lawal OA, Iheakanwa CI. (2008). Effects of Simulated Preparations of Plants used in Nigerian Traditional Medicine on Candida spp. Associated with Vaginal Candidiasis. Ethnobot Res Appl 6:373–83
   Google Scholar
• Owen DH, Dunmire EN, Plenys AM, Katz DF. (1999). Factors influencing nonoxynol-9 permeation and bioactivity in cervical mucus. J Control Rel 60:23–34
   PubMed Web of Science ®Google Scholar
• Paavonen J. (1982). Physiology and ecology of the vagina. Scandi J Infect Dis. Suppl 40:31–5
   Google Scholar
• Pachl J, Svoboda P, Jacobs F, et al. (2006). A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis. Clin Infect Dis 42:1404–13
   PubMed Web of Science ®Google Scholar
• Parnami N, Garg T, Rath G, Goyal AK. (2013). Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. Artif Cells Nanomed Biotechnol
   PubMed Web of Science ®Google Scholar
• Patel A, Patel J. (2012). Mucoadhesive microemulsion based prolonged release vaginal gel for anti-fungal drug. Am J PharmTech Res 2:649–61
   Google Scholar
• Patel A, Patel K, Patel J. (2012). Design, development and in vitro evaluation of sertaconazole mucoadhesive vaginal tablet. Der Pharmacia Lettre 4:418–27
   Google Scholar
• Patel GM, Patel AP. (2010). A novel effervescent bioadhesive vaginal tablet of ketoconazole: formulation and invitro evaluation. Int J PharmTech Res 2(1):656
   Google Scholar
• Patel N, Rajesh K. (2014). Ophthalmic in situ gel. Pharmagene 1:29–33
   Google Scholar
• Pavelić Ž, Škalko-basnet N, Jalšenjak I. (1999). Liposomes containing drugs for treatment of vaginal infections. Eur J Pharmaceut Sci 8:345–51
   PubMed Web of Science ®Google Scholar
• Pavelić Ž, Škalko-Basnet N, Schubert R. (2001). Liposomal gels for vaginal drug delivery. Int J Pharmaceut 219:139–49
   PubMed Web of Science ®Google Scholar
• Peppas N, Bures P, Leobandung W, Ichikawa H. (2000). Hydrogels in pharmaceutical formulations. Eur J Pharmaceut Biopharmaceut 50:27–46
   PubMed Web of Science ®Google Scholar
• Pietrella D, Rachini A, Torosantucci A, et al. (2010). A β-glucan-conjugate vaccine and anti-β-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. Vaccine 28:1717–25
   PubMed Web of Science ®Google Scholar
• Pirotta MV, Garland SM. (2006). Genital Candida species detected in samples from women in Melbourne, Australia, before and after treatment with antibiotics. J Clin Microbiol 44:3213–17
   PubMed Web of Science ®Google Scholar
• Polonelli L, Seguy N, Conti S, et al. (1997). Monoclonal yeast killer toxin-like candidacidal anti-idiotypic antibodies. Clin Diagnos Lab Immunol 4:142–6
   PubMedGoogle Scholar
• Rauceo JM, De Armond R, Otoo H, et al. (2006). Threonine-rich repeats increase fibronectin binding in the Candida albicans adhesin Als5p. Eukaryotic Cell 5:1664–73
   PubMed Web of Science ®Google Scholar
• Richter SS, Galask RP, Messer SA, et al. (2005). Antifungal susceptibilities of Candida species causing vulvovaginitis and epidemiology of recurrent cases. J Clin Microbiol 43:2155–62
   PubMed Web of Science ®Google Scholar
• Robinson JR, Bologna WJ. (1994). Vaginal and reproductive system treatments using a bioadhesive polymer. J Control Rel 28:87–94
   Web of Science ®Google Scholar
• Sandini S, La Valle R, De Bernardis F, et al. (2007). The 65 kDa mannoprotein gene of Candida albicans encodes a putative β-glucanase adhesin required for hyphal morphogenesis and experimental pathogenicity. Cell Microbiol 9:1223–38
   PubMed Web of Science ®Google Scholar
• Santoni G, Spreghini E, Lucciarini R, et al. (2001). Involvement of αvβ3 integrin-like receptor and glycosaminoglycans in Candida albicans germ tube adhesion to vitronectin and to a human endothelial cell line. Microbial Pathogen 31:159–72
   PubMed Web of Science ®Google Scholar
• Shafik SA, Hassan YM, Eldin AK. (2007). Vaginal candidiasis: incidence, etiology and pathogenesis. JASMR 2:115–27
   Google Scholar
• Sharma G, Jain S, Tiwari A, Kaur G. (2006). Once daily bioadhesive vaginal clotrimazole tablets: design and evaluation. Acta Pharmaceutica-Zagreb- 56:337
   PubMedGoogle Scholar
• Singh A, Sharma PK, Garg VK, Garg G. (2010). Hydrogels: a review. Int J Pharmaceut Sci Rev Res 4(2): 97–105
   Google Scholar
• Singh H, Sharma R, Joshi M, et al. (2014). Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers. Artif Cells Nanomed Biotechnol
   Web of Science ®Google Scholar
• Sjöberg I, Cajander S, Rylander E. (1988). Morphometric characteristics of the vaginal epithelium during the menstrual cycle. Gynecol Obstetr Invest 26:136–44
   PubMed Web of Science ®Google Scholar
• Sobel JD, Brooker D, Stein GE, et al. (1995). Single oral dose fluconazole compared with conventional clotrimazole topical therapy of Candida vaginitis. Am J Obstetr Gynecol 172:1263–8
   PubMed Web of Science ®Google Scholar
• Sobel JD, Wiesenfeld HC, Martens M, et al. (2004). Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis. N Engl J Med 351:876–83
   PubMed Web of Science ®Google Scholar
• Song Y, Wang Y, Thakur R, et al. (2004). Mucosal drug delivery: membranes, methodologies, and applications. Crit Rev™ Therapeut Drug Carrier Syst 21(3): 195–256
   PubMedGoogle Scholar
• Spellberg BJ, Ibrahim AS, Avanesian V, et al. (2006). Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis. J Infect Dis 194:256–60
   PubMed Web of Science ®Google Scholar
• Spreghini E, Gismondi A, Piccoli M, Santoni G. (1999). Evidence for αvβ3 and αvβ5 integrin-like vitronectin (VN) receptors in Candida albicans and their involvement in yeast cell adhesion to VN. J Infect Dis 180:156–66
   PubMed Web of Science ®Google Scholar
• Stein GE, Gurwith D, Mummaw N, Gurwith M. (1986). Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis. Antimicrob Agents Chemother 29:969–71
   PubMed Web of Science ®Google Scholar
• Stein GE, Mummaw N. (1993). Placebo-controlled trial of itraconazole for treatment of acute vaginal candidiasis. Antimicrob Agents Chemother 37:89–92
   PubMed Web of Science ®Google Scholar
• Stewart-Tull D. (1964). Evidence that vaginal lactobacilli do not ferment glycogen. Am J Obstetr Gynecol 88:676
   PubMed Web of Science ®Google Scholar
• Syed TS, Braverman PK. (2004). Vaginitis in adolescents. Adolesc Med Clin 15:235–51
   PubMedGoogle Scholar
• Torosantucci A, Bromuro C, Chiani P, et al. (2005). A novel glyco-conjugate vaccine against fungal pathogens. J Exp Med 202:597–606
   PubMed Web of Science ®Google Scholar
• Torosantucci A, Chiani P, Bromuro C, et al. (2009). Protection by anti-β-glucan antibodies is associated with restricted β-1, 3 glucan binding specificity and inhibition of fungal growth and adherence. PLoS One 4:e5392
   PubMed Web of Science ®Google Scholar
• Vanic Z, Hafner A, Bego M, Škalko-basnet N. (2013). Characterization of various deformable liposomes with metronidazole. Drug Dev Indus Pharm 39:481–8
   PubMed Web of Science ®Google Scholar
• Vermesh M, Fossum GT, Kletzky OA. (1988). Vaginal bromocriptine: pharmacology and effect on serum prolactin in normal women. Obstetr Gynecol 72:693–8
   PubMed Web of Science ®Google Scholar
• Vermitsky J-P, Self MJ, Chadwick SG, et al. (2008). Survey of vaginal-flora Candida species isolates from women of different age groups by use of species-specific PCR detection. J Clin Microbiol 46:1501–3
   PubMed Web of Science ®Google Scholar
• Vukovich R, Heald A, Darragh A. Vaginal absorption of 2 imidazole antifungal agents, econazole and miconazole. Clinical pharmacology & therapeutics. St Louis (MO): Westline Industrial DR, Mosby-Year Book INC. 11830;1977:121–21
   Google Scholar
• Wang L, Tang X. (2008). A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: design, in vitro and ‘in vivo’evaluation. Int J Pharmaceut 350:181–7
   PubMed Web of Science ®Google Scholar
• Washington N, Washington C, Wilson C. (2000). Physiological pharmaceutics: barriers to drug absorption. Boca Raton, FL: CRC Press
   Google Scholar
• Watson C, Pirotta M. (2011). Recurrent vulvovaginal candidiasis: current management. Austral Fam Phys 40:149
   PubMed Web of Science ®Google Scholar
• Woolfson AD, Malcolm RK, Gallagher R. (2000). Drug delivery by the intravaginal route. Crit Rev™ Therapeut Drug Carrier Syst 17(5): 509–55
   PubMed Web of Science ®Google Scholar
• Yamashita A, Oshima S, Matsuo K, et al. (1991). [Pharmacological studies of intravaginally applied dehydroepiandrosterone sulfate (DHA-S)]. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 98:31–9
   PubMed Web of Science ®Google Scholar
• Yang H, Parniak MA, Isaacs CE, et al. (2008). Characterization of cyclodextrin inclusion complexes of the anti-HIV non-nucleoside reverse transcriptase inhibitor UC781. AAPS J 10:606–13
   PubMed Web of Science ®Google Scholar
• Yellanki SK, Goranti S, Deb SK. (2010). Development of metronidazole intravaginal gel for the treatment of bacterial vaginosis: effect of mucoadhesive natural polymers on the release of metronidazole. Int J PharmTech Res 2(3): 1746–50
   Google Scholar
• Yun Chang J, Oh Y-K, Soo Kong H, et al. (2002). Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. J Control Rel 82:39–50
   PubMed Web of Science ®Google Scholar