Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment of ligature-induced experimental periodontitis in Wistar rats

References

• Botelho MA, Rao VS, Carvalho CB, et al. (2007). Lippia sidoides and Myracrodruon urundeuva gel prevents alveolar bone resorption in experimental periodontitis in rats. J Ethnopharmacol 113:471–8
   PubMed Web of Science ®Google Scholar
• Botelho MA, Martins JG, Ruela RS, et al. (2009). Protective effect of locally applied carvacrol gel on ligature-induced periodontitis in rats: a tapping mode AFM study. Phytother Res 23:1439–48
   PubMed Web of Science ®Google Scholar
• Botelho MA, Martins JG, Ruela RS, et al. (2010). Nanotechnology in ligature-induced periodontitis: protective effect of a doxycycline gel with nanoparticules. J Appl Oral Sci 18:335–42
   PubMed Web of Science ®Google Scholar
• Bowen WH, Pearson SK, Jerussi TP. (2000). Influence of (S)-ketoprofen and fluoride on caries in rats. Oral Dis 6:12–4
   PubMed Web of Science ®Google Scholar
• Branco-de-Almeida LS, Franco GC, Castro ML, et al. (2012). Fluoxetine inhibits inflammatory response and bone loss in a rat model of ligature-induced periodontitis. J Periodontol 83:664–71
   PubMed Web of Science ®Google Scholar
• Cunha FQ, Boukili MA, da Motta JI, et al. (1993). Blockade by fenspiride of endotoxin-induced neutrophil migration in the rat. Eur J Pharmacol 238:47–52
   Google Scholar
• de Araújo Júnior RF, Souza TO, de Medeiros CA, et al. (2013). Carvedilol decrease IL-1β and TNF-α, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis. PLoS One 8:e66391
   PubMed Web of Science ®Google Scholar
• Hamouda T, Cao Z, Tonda R, et al. (1999). A novel surfactant nanoemulsion with broad spectrum sporicidal activity against bacillus species. J Infect Dis 180:1939–49
   PubMed Web of Science ®Google Scholar
• Jadhav BK, Khandelwal KR, Ketkar AR, Pisal SS. (2004). Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases. Drug Dev Ind Pharm 30:195–203
   PubMed Web of Science ®Google Scholar
• Javed S, Kohli K. (2010). Local delivery of minocycline: a therapeutic paradigm in periodontal diseases. Curr Drug Deliv 7:398–406
   PubMedGoogle Scholar
• Goldhaber P, Rabadjija L, Beyer WR, Kornhauser A. (1973). Bone resorption in tissue culture and its relevance to periodontal disease. J Am Dent Assoc 87:1027–33
   PubMed Web of Science ®Google Scholar
• Györfi A, Fazekas A, Suba Z, et al. (1994). Neurogenic component in ligature-induced periodontitis in the rat. J Clin Periodontol 21:601–5
   PubMed Web of Science ®Google Scholar
• Ku SK, Cho HR, Sung YS, et al. (2011). Effects of calcium gluconate on experimental periodontitis and alveolar bone loss in rats. Basic Clin Pharmacol Toxicol 108:241–50
   PubMed Web of Science ®Google Scholar
• Lawrence HP, Paquette DW, Smith PC. (1998). Pharmacokinetic and safety evaluations of ketoprofen gels in subjects with adult periodontitis. J Dent Res 77:1904–12
   PubMed Web of Science ®Google Scholar
• Lee HM, Ciancio SG, Tüter G, et al. (2004). Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug. J Periodontol 75:453–63
   PubMed Web of Science ®Google Scholar
• Li KL, Vogel R, Jeffcoat MK, et al. (1996). The effect of Ketoprofen creams on periodontal disease in rhesus monkeys. J Periodontal Res 31:525–32
   PubMed Web of Science ®Google Scholar
• Lima V, Vidal FD, Rocha FA, et al. (2004). Effects of tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide on alveolar bone loss in short-term experimental disease in rats. J Periodontol 75:162–8
   PubMed Web of Science ®Google Scholar
• Liu R, Li N, Liu N, et al. (2012). Effects of systemic ornidazole, systemic and local compound ornidazole and pefloxacin mesylate on experimental periodontitis in rats. Med Sci Monit 18:BR95–102
   PubMed Web of Science ®Google Scholar
• Miyauchi M, Hiraoka M, Oka H, et al. (2004). Immuno-localization of COX-1 and COX-2 in the rat molar periodontal tissue after topical application oflipopolysaccharide. Arch Oral Biol 49:739–46
   PubMed Web of Science ®Google Scholar
• Ozdemir H, Kara MI, Erciyas K, et al. (2012). Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study. J Periodontal Res 47:74–80
   PubMed Web of Science ®Google Scholar
• Pimentel SP, Barrella GE, Casarin RC, et al. (2012). Protective effect of topical Cordia verbenacea in a rat periodontitis model: immune-inflammatory, antibacterial and morphometric assays. BMC Complement Altern Med 12:224
   PubMed Web of Science ®Google Scholar
• Safieh-Garabedian B, Poole S, Allchorne A, et al. (1995). Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br J Pharmacol 115:1265–75
   PubMed Web of Science ®Google Scholar
• Samejima Y, Ebisu S, Okada H. (1990). Effect of infection with Eikenella corrodens on the progression of ligature-induced periodontitis in rats. J Periodontal Res 25:308–15
   PubMed Web of Science ®Google Scholar
• Semenoff TA, Semenoff SA, Bosco AF, et al. (2008). Histometric analysis of ligature-induced periodontitis in rats: a comparison of histological section planes. J Appl Oral Sci 16:251–6
   PubMed Web of Science ®Google Scholar
• Srinivas M, Medaiah S, Girish S. (2011). The effect of Ketoprofen in chronic periodontitis: a clinical double-blind study. J Indian Soc Periodontol 15:255–9
   PubMedGoogle Scholar
• Srivastava M, Kohli K, Ali M. (2014). Formulation development of novel in situ nanoemulgel (NEG) of ketoprofen for the treatment of periodontitis. Drug Deliv Apr 30:1–13. [Epub ahead of print]
   Google Scholar
• Xiao X, Li Y, Zhang G, et al. (2012). Detection of bacterial diversity in rat's periodontitis model under imitational altitude hypoxia environment. Arch Oral Biol 57:23–9
   PubMed Web of Science ®Google Scholar
• Xu Y, Wei WA. (2006). Comparative study of systemic subantimicrobial and topical treatment of minocycline in experimental periodontitis of rats. Arch Oral Biol 51:794–803
   PubMed Web of Science ®Google Scholar