Novel drug delivery system: an immense hope for diabetics

References

• Agrawal AK, Harde H, Thanki K, Jain S. (2014). improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration. Biomacromolecules 15:350–60
   PubMed Web of Science ®Google Scholar
• Ahmed OA, Afouna MI, El-Say KM, et al. (2014). Optimization of self-nanoemulsifying systems for the enhancement of in vivo hypoglycemic efficacy of glimepiride transdermal patches. Expert Opin Drug Deliv 11:1005–13
   PubMed Web of Science ®Google Scholar
• Alan S, Eric T. (2008). The PassPort System: a new transdermal patch for water-soluble drugs, proteins, and carbohydrates. Modified-Release Drug Delivery Technology 2:417–26
   Google Scholar
• Allen LV. (2008). Dosage form design and development. Clin Ther 30:2102–11
   PubMed Web of Science ®Google Scholar
• Al-Kassas RS, Al-Gohary OMN, Al-Faadhel MM. (2007). Controlling of systemic absorption of gliclazide through incorporation into alginate beads. Int J Pharm 341:230–7
   PubMed Web of Science ®Google Scholar
• Banga AK. (2009). Microporation applications for enhancing drug delivery. Expert Opin Drug Del 6:343–54
   PubMed Web of Science ®Google Scholar
• Barakat NS, Almurshedi AS. (2011). Design and development of gliclazide-loaded chitosan microparticles for oral sustained drug delivery: in-vitro/in-vivo evaluation. J Pharm Pharmacol 63:169–78
   PubMed Web of Science ®Google Scholar
• Barakat NS, Shazly GA, Almedany AH. (2013). Influence of polymer blends on the characterization of gliclazide–encapsulated into poly(ɛ-caprolactone) microparticles. Drug Dev Ind Pharm 39:352–62
   PubMed Web of Science ®Google Scholar
• Battaglia L, Trotta M, Gallarate M, et al. (2007). Solid lipid nanoparticles formed by solvent-in-water emulsion-diffusion technique: development and influence on insulin stability. J Microencapsul 24:660–72
   PubMed Web of Science ®Google Scholar
• Bayat A, Dorkoosh FA, Dehpour AR, et al. (2008). Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies. Int J Pharm 356:259–66
   PubMed Web of Science ®Google Scholar
• Benson HA. (2006). Transfersomes for transdermal drug delivery. Expert Opin Drug Del 3:727–37
   PubMed Web of Science ®Google Scholar
• Bi R, Shao W, Wang Q, Zhang N. (2008). Spray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary delivery. J Drug Targ 16:639–48
   PubMed Web of Science ®Google Scholar
• Bilati U, Allemann E, Doelker E. (2005). Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles. Eur J Pharm Biopharm 59:375–88
   PubMed Web of Science ®Google Scholar
• Bowey K, Swift BE, Flynn LE, Neufeld RJ. (2013). Characterization of biologically active insulin-loaded alginate microparticles prepared by spray drying. Drug Dev Ind Pharm 39:457–65
   PubMed Web of Science ®Google Scholar
• Brooking J, Davis SS, Illum L. (2001). Transport of nanoparticles across the rat nasal mucosa. J Drug Tar 9:267–79
   PubMed Web of Science ®Google Scholar
• Cetin M, Atila A, Sahin S, Vural I. (2013). Preparation and characterization of metformin hydrochloride loaded-Eudragit((R))RSPO and Eudragit((R))RSPO/PLGA nanoparticles. Pharm Dev Technol 18:570–6
   PubMed Web of Science ®Google Scholar
• Cevc G. (2003). Transdermal drug delivery of insulin with ultradeformable carriers. Clin Pharmacokin 42:461–74
   PubMed Web of Science ®Google Scholar
• Chalasani KB, Russell-Jones GJ, Yandrapu Sk, et al. (2007). A novel vitamin B12-nanosphere conjugates carrier system for peroral delivery of insulin. J Control Release 117:421–9
   PubMed Web of Science ®Google Scholar
• Chen X, Wu W, Guo Z, et al. (2011). Controlled insulin release from glucose-sensitive self-assembled multilayer films based on 21-arm star polymer. Biomaterials 32:1759–66
   PubMed Web of Science ®Google Scholar
• CIMS/MIMS India Medical Drug Information eBook in pdf format. Available from: http://wwwmedicalgeekcom/pharmacology/23913-download-cims-india-medical-drug-information-ebookhtml
   Google Scholar
• Coelho JF, Ferreira PC, Alves P, et al. (2010). Drug delivery systems: advanced technologies potentially applicable in personalized treatments. EPMA J 1:164–209
   PubMedGoogle Scholar
• Cremaschi D, Porta C, Ghirardelli R. (1996). The active transport of polypeptides in the rabbit nasal mucosa is supported by a specific vesicular transport inhibited by cytochalasin D. Biochim Biophys Acta 1283:101–5
   PubMed Web of Science ®Google Scholar
• Cui F, Shi K, Zhang L, et al. (2006). Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. J Control Release 114:242–50
   PubMed Web of Science ®Google Scholar
• Damge C, Maincent P, Ubrich N. (2007). Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release 117:163–70
   PubMed Web of Science ®Google Scholar
• Das S, Roy P, Pal R, et al. (2014). Engineered silybin nanoparticles educe efficient control in experimental diabetes. PLoS One 9:1–13
   Web of Science ®Google Scholar
• Dash TK, Konkimalla VB. (2011). Poly-є-caprolactone based formulations for drug delivery and tissue engineering: a review. J Control Release 58:15–33
   Google Scholar
• Desai P, Patlolla RR, Singh M. (2010). Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery. Mol Mem Bio 27:247–59
   PubMed Web of Science ®Google Scholar
• Ensign LM, Cone R, Hanes J. (2012). Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv Drug Deliver Rev 64:557–70
   PubMed Web of Science ®Google Scholar
• Faraji AH, Wipf P. (2009). Nanoparticles in cellular drug delivery. Bioorgan Med Chem 17:2950–62
   PubMed Web of Science ®Google Scholar
• Finotelli PV, Da Silva D, Sola-Penna M, et al. (2010). Microcapsules of alginate/chitosan containing magnetic nanoparticles for controlled release of insulin. Colloids Surf B 81:206–11
   PubMed Web of Science ®Google Scholar
• Furtado S, Abramson D, Burrill R, et al. (2008). Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres. Int J Pharm 347:149–55
   PubMed Web of Science ®Google Scholar
• Graf A, Rades T, Hook SM. (2009). Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: optimisation and in vivo evaluation. Eur J Pharm Sci 37:53–61
   PubMed Web of Science ®Google Scholar
• Gupta M, Agrawal U, Vyas SP. (2012). Nanocarrier-based topical drug delivery for the treatment of skin diseases. Expert Opin Drug Del 9:783–804
   PubMed Web of Science ®Google Scholar
• Guo Q, Wu Z, Zhang X, et al. (2014). Phenylboronate-diol crosslinked glycopolymeric nanocarriers for insulin delivery at physiological pH. Soft Matter 10:911–20
   PubMed Web of Science ®Google Scholar
• Gwinn MR, Vallyathan V. (2006). Nanoparticles: health effects—pros and cons. Environ Health Perspect 114:1818–25
   PubMed Web of Science ®Google Scholar
• Hamidi M, Azadi A, Rafiei P. (2008). Hydrogel nanoparticles in drug delivery. Adv Drug Deliver Rev 60:1638–49
   PubMed Web of Science ®Google Scholar
• Hasan AA, Madkor H, Wageh S. (2013). Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system. Drug Deliv 20:120–6
   PubMed Web of Science ®Google Scholar
• Hinds KD, Campbell KM, Holland KM, et al. (2005). PEGylated insulin in PLGA microparticles. In vivo and in vitro analysis. J Control Release 104:447–60
   PubMed Web of Science ®Google Scholar
• Huang X, Du YZ, Yuan H, Hu FQ. (2009). Preparation and pharmacodynamics of low-molecular-weight chitosan nanoparticles containing insulin. Carbohyd Polym 76:368–73
   Web of Science ®Google Scholar
• Huang YY, Wang CH. (2006). Pulmonary delivery of insulin by liposomal carriers. J Control Release 113:9–14
   PubMed Web of Science ®Google Scholar
• Hughes GA. (2005). Nanostructure-mediated drug delivery. Nanomed Nanotechnol 1:22–30
   PubMed Web of Science ®Google Scholar
• Ilić I, Dreu R, Burjak M, et al. (2009). Microparticle size control and glimepiride microencapsulation using spray congealing technology. Int J Pharm 381:176–83
   PubMed Web of Science ®Google Scholar
• Illum L. (2007). Nanoparticulate systems for nasal delivery of drugs: a real improvement over simple systems. J Pharm Sci 96:473–83
   PubMed Web of Science ®Google Scholar
• International Diabetes Federation. (2013). IDF diabetes atlas. 6th ed. Brussels, Belgium: International Diabetes Federation
   Google Scholar
• Jain AK, Chalasani KB, Khar RK, et al. (2007a). Muco-adhesive multivesicular liposomes as an effective carrier for transmucosal insulin delivery. J Drug Targ 15:417–27
   PubMed Web of Science ®Google Scholar
• Jain AK, Khar RK, Ahmed FJ, Diwan PV. (2008). Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier. Eur J Pharm Biopharm 69:426–35
   PubMed Web of Science ®Google Scholar
• Jain S, Saraf S. (2009). Influence of processing variables and in vitro characterization of glipizide loaded biodegradable nanoparticles. Diabetes Metab Syndrome Clin Res Rev 3:113–17
   Google Scholar
• Jain SK, Agrawal GP, Jain NK. (2007b). Porous carrier based floating granular delivery system of repaglinide. Drug Dev Ind Pharm 33:381–91
   PubMed Web of Science ®Google Scholar
• Jain SK, Awasthi AM, Jain NK, Agrawal GP. (2005). Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: preparation and in vitro characterization. J Control Release 107:300–9
   PubMed Web of Science ®Google Scholar
• Jong WHD, Borm PGA. (2008). Drug delivery and nanoparticles: application and hazards. Int J Nanomed 3:133–49
   PubMed Web of Science ®Google Scholar
• Jose P, Sundar K, Anjali CH, Ravindran A. (2014). Metformin-loaded BSA nanoparticles in cancer therapy: a new perspective for an old antidiabetic drug. Cell Biochem Biophys
   PubMed Web of Science ®Google Scholar
• Jose S, Fangueiro JF, Smitha J, et al. (2012). Cross-linked chitosan microspheres for oral delivery of insulin: Taguchi design and in vivo testing. Colloid Surf B 92:175–9
   PubMed Web of Science ®Google Scholar
• Kalra S. (2013). Glucagon-like peptide-1 receptors agonists (GLP1 RA). J Pak Med Assoc 63:1312–15
   PubMed Web of Science ®Google Scholar
• Karathanasis E, Bhavane R, Annapragada AV. (2006). Triggered release of inhaled insulin from the agglomerated vesicles: pharmacodynamic studies in rats. J Control Release 113:117–27
   PubMed Web of Science ®Google Scholar
• Kim JY, Lee H, Oh KS, et al. (2013). Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus. Biomaterials 34:8444–9
   PubMed Web of Science ®Google Scholar
• Kofuji K, Murata Y, Kawashima S. (2005). Sustained insulin release with biodegradation of chitosan gel beads prepared by copper ions. Int J Pharm 303:95–103
   PubMed Web of Science ®Google Scholar
• Koo OM, Rubinstein I, Onyuksel H. (2005). Role of nanotechnology in targeted drug delivery and imaging: a concise review. Nanomed Nanotechnol 1:193–212
   PubMed Web of Science ®Google Scholar
• Kumar GP, Rajeshwarrao P. (2011). Nonionic surfactant vesicular systems for effective drug delivery: an overview. Acta Pharma Sin B 1:208–19
   Web of Science ®Google Scholar
• Lekshmi UMD, Poovi G, Kishore N, Reddy PN. (2010). In vitro characterization and in vivo toxicity study of repaglinide loaded poly(methyl methacrylate) nanoparticles. Int J Pharm 396:194–203
   PubMed Web of Science ®Google Scholar
• Leong KH, Chung LY, Noordin MI, et al. (2011). Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery. Carbohyd Polym 86:555–65
   Web of Science ®Google Scholar
• Liu B, Dong Q, Wang M, et al. (2010). Preparation, characterization, and pharmacodynamics of exenatide-loaded poly(DL-lactic-co-glycolic acid) microspheres. Chem Pharm Bull 58:1474–9
   PubMed Web of Science ®Google Scholar
• Liu H, Gong T, Fu HL, et al. (2008a). Solid lipid nanoparticles for pulmonary delivery of insulin. Int J Pharm 356:333–44
   PubMed Web of Science ®Google Scholar
• Liu Z, Jiao Y, Wang Y, et al. (2008b). Polysaccharides-based nanoparticles as drug delivery systems. Adv Drug Deliver Rev 60:1650–62
   PubMed Web of Science ®Google Scholar
• Ma Z, Lim TM, Lim LY. (2005). Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. Int J Pharm 293:271–80
   PubMed Web of Science ®Google Scholar
• Madhusudhan S, Panda AK, Parimalakrishnan S, et al. (2010). Design, in vitro and in vivo evaluation of glipizide Eudragit microparticles. J Microencapsul 27:281–91
   PubMed Web of Science ®Google Scholar
• Maiti S, Ranjit S, Mondol R, et al. (2011). Al+3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide. Carbohyd Polym 85:164–72
   Web of Science ®Google Scholar
• Management of Diabetes. (2012). Federal Bureau of Prisons Clinical Practice Guidelines, 4–18. https://doi.org/http://www.bop.gov/resources/pdfs/diabetes.pdf
   Google Scholar
• Mesiha MS, Sidhom MB, Fasipe B. (2005). Oral and subcutaneous absorption of insulin poly(isobutylcyanoacrylate) nanoparticles. Int J Pharm 288:289–93
   PubMed Web of Science ®Google Scholar
• Misra GP, Singh RS, Aleman TS, et al. (2009). Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina. Biomaterials 30:6541–7
   PubMed Web of Science ®Google Scholar
• Misra P, Upadhyay RP, Misra A, Anand K. (2011). A review of the epidemiology of diabetes in rural India. Diabetes Res Clin Pr 92:303–11
   PubMed Web of Science ®Google Scholar
• Mutalik S, Udupa N, Kumar S, et al. (2006). Glipizide matrix transdermal systems for diabetes mellitus: preparation, in vitro and preclinical studies. Life Sci 79:1568–77
   PubMed Web of Science ®Google Scholar
• Ning M, Guo Y, Pan H, et al. (2005). Niosomes with Sorbitan Monoester as a carrier for vaginal delivery of insulin: studies in rats. Drug Deliv 12:399–407
   PubMed Web of Science ®Google Scholar
• Nishimura A, Hayakawa T, Yamamoto Y, et al. (2012). Controlled release of insulin from self-assembling nanofiber hydrogel, PuraMatrix™: application for the subcutaneous injection in rats. Eur J Pharm Sci 45:1–7
   PubMed Web of Science ®Google Scholar
• Nnamani PO, Attama AA, Ibezim EC, Adikwu MU. (2010). SRMS142-based solid lipid microparticles: Application in oral delivery of glibenclamide to diabetic rats. Eur J Pharm Biopharm 76:68–74
   PubMed Web of Science ®Google Scholar
• Pal D, Nayak AK. (2012). Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery: in vitro-in vivo evaluation. Drug Deliv 19:123–31
   PubMed Web of Science ®Google Scholar
• Pardakhty A, Varshosaz J, Rouholamini A. (2007). In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin. Int J Pharm 328:130–41
   PubMed Web of Science ®Google Scholar
• Peng Q, Zhang ZR, Gong T, et al. (2012). A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. Biomaterials 33:1583–8
   PubMed Web of Science ®Google Scholar
• Pereswetoff-Morath L. (1998). Microspheres as nasal drug delivery systems. Adv Drug Deliver Rev 29:185–94
   PubMed Web of Science ®Google Scholar
• Pradhan SK. (2011). Microsponges as the versatile tool for drug delivery system. Int J Res Pharm Chem 1:243–58
   Google Scholar
• Pund S, Shete Y, Jagadale S. (2014). Multivariate analysis of physicochemical characteristics of lipid based nanoemulsifying cilostazol by quality by design. Coll and Surf B 115:29–36
   PubMed Web of Science ®Google Scholar
• Qi F, Wu J, Fan Q, et al. (2013). Preparation of uniform-sized exenatide-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency and bio-stability. Colloids Surfaces B 112:492–8
   PubMed Web of Science ®Google Scholar
• Rastogi R, Anand S, Dinda AK, Koul V. (2010a). Investigation on the synergistic effect of a combination of chemical enhancers and modulated iontophoresis for transdermal delivery of insulin. Drug Dev Ind Pharm 36:993–1004
   PubMed Web of Science ®Google Scholar
• Rastogi R, Anand S, Koul V. (2010b). Electroporation of polymeric nanoparticles: an alternative technique for transdermal delivery of insulin. Drug Dev Ind Pharm 36:1303–11
   PubMed Web of Science ®Google Scholar
• Reis CP, Ribeiro AJ, Houng S, et al. (2007). Nanoparticulate delivery system for insulin: design, characterization and in vitro/in vivo bioactivity. Euro J Pharm Sci 30:392–7
   PubMed Web of Science ®Google Scholar
• Rekha MR, Sharma CP. (2009). Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption. J Control Release 135:144–51
   PubMed Web of Science ®Google Scholar
• Ryan GJ, Moniri NH, Smiley DD. (2013). Clinical effects of once-weekly exenatide for the treatment of type 2 diabetes mellitus. Am J Health Syst Pharm 70:1123–31
   PubMed Web of Science ®Google Scholar
• Salmaso S, Bersani S, Elvassore N, et al. (2009). Biopharmaceutical characterisation of insulin and recombinant human growth hormone loaded lipid submicron particles produced by supercritical gas micro-atomisation. Int J Pharm 379:51–8
   PubMed Web of Science ®Google Scholar
• Schmid MH, Korting HC. (1996). Therapeutic progress with topical liposome drugs for skin disease. Adv Drug Deliver Rev 18:335–42
   Web of Science ®Google Scholar
• Shimkunas RA, Robinson E, Lam R, et al. (2009). Nanodiamond–insulin complexes as pH-dependent protein delivery vehicles. Biomaterials 30:5720–8
   PubMed Web of Science ®Google Scholar
• Siekmeier R, Scheuch G. (2008). Inhaled insulin – does it become reality? J Physiol Pharmacol 59:81–113
   PubMed Web of Science ®Google Scholar
• Silva CM RA, Figueiredo SV, Goncalves AR, Veiga F. (2006). Alginate microspheres prepared by internal gelation: development and effect on insulin stability. Int J Pharm 311:1–10
   PubMed Web of Science ®Google Scholar
• Sinha VR, Singla AK, Wadhawan S, et al. (2004). Chitosan microspheres as a potential carrier for drugs. Int J Pharm 274:1–33
   PubMed Web of Science ®Google Scholar
• Sonaje K, Lin YH, Juang JH, et al. (2009). In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 30:2329–39
   PubMed Web of Science ®Google Scholar
• Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. (2001). Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 70:1–20
   PubMed Web of Science ®Google Scholar
• Sun S, Liang N, Piao H, et al. (2010). Insulin-S.O (sodium oleate) complex-loaded PLGA nanoparticles: formulation, characterization and in vivo evaluation. J Microencapsul 27:471–8
   PubMed Web of Science ®Google Scholar
• Sutradhar KB, Sumi CD. (2014). Implantable microchip: the futuristic controlled drug delivery system. Drug Deliv [early online]
   Google Scholar
• Tozuka Y, Sugiyama E, Takeuchi H. (2010). Release profile of insulin entrapped on mesoporous materials by freeze-thaw method. Int J Pharm 386:172–7
   PubMed Web of Science ®Google Scholar
• Tuomilehto J, Lindström J, Eriksson JG, et al. (2001). Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New Engl J Med 344:1343–50
   PubMed Web of Science ®Google Scholar
• Vinod KR, Kumar MS, Anbazhagan S, et al. (2012). Critical issues related to transfersomes – novel vesicular system. Acta Sci Pol Technol Aliment 11:67–82
   PubMedGoogle Scholar
• Wang J, Tabata Y, Morimoto K. (2006). Aminated gelatin microspheres as a nasal delivery system for peptide drugs: evaluation of in vitro release and in vivo insulin absorption in rats. J Control Release 113:31–7
   PubMed Web of Science ®Google Scholar
• Wei W, Ma GH, Wang LY, et al. (2010). Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin. Acta Biomater 6:205–9
   PubMed Web of Science ®Google Scholar
• Woitiski CB, Neufeld RJ, Veiga F, et al. (2010). Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles. Eur J Pharm Sci 41:556–63
   PubMed Web of Science ®Google Scholar
• Xuan J, Lin Y, Huang J, et al. (2013). Exenatide-loaded PLGA microspheres with improved glycemic control: in vitro bioactivity and in vivo pharmacokinetic profiles after subcutaneous administration to SD rats. Peptides 46:172–9
   PubMed Web of Science ®Google Scholar
• Ye Q, Asherman J, Stevenson M, et al. (2000). DepoFoam™ technology: a vehicle for controlled delivery of protein and peptide drugs. J Control Release 64:155–66
   PubMed Web of Science ®Google Scholar
• Yin L, Ding J, He C, et al. (2009). Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 30:5691–700
   PubMed Web of Science ®Google Scholar
• Yu L, Li C, Le Y, et al. (2011). Stabilized amorphous glibenclamide nanoparticles by high-gravity technique. Mater Chem Phys 130:361–6
   Web of Science ®Google Scholar
• Zhang XG, Zhang HJ, Wu ZM, et al. (2008). Nasal absorption enhancement of insulin using PEG-grafted chitosan nanoparticles. Eur J Pharm Biopharm 68:526–34
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wei W, Lv P, et al. (2011). Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin. Eur J Pharm Biopharm 77:11–19
   PubMed Web of Science ®Google Scholar
• Zhao X, Zu Y, Zu SC, et al. (2010). Insulin nanoparticles for transdermal delivery: preparation and physicochemical characterization and in vitro evaluation. Drug Dev Ind Pharm 36:1177–85
   PubMed Web of Science ®Google Scholar
• Zheng J, Yue X, Dai Z, et al. (2009). Novel iron–polysaccharide multilayered microcapsules for controlled insulin release. Acta biomaterialia 5:1499–507
   PubMed Web of Science ®Google Scholar
• Zu Y, Zhang Y, Zhao X, et al. (2012). Preparation and characterization of chitosan-polyvinyl alcohol blend hydrogels for the controlled release of nano-insulin. Int J Bio Macromol 50:82–7
   PubMed Web of Science ®Google Scholar